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2. Impact of Sars-CoV-2 prophylaxis with tixagevimab-cilgavimab in high-risk patients with B-cell malignancies: a single-center retrospective study.

Author

Giovanni Manfredi Assanto ,, Matteo Totaro, Poggiali Rebecca, Delli Paoli Adele, Annechini Giorgia, D’Elia Gianna Maria, Aji Francesco, Petrucci Luigi, Fazio Francesca, Del Giudice Ilaria, Martelli Maurizio, Micozzi Alessandra, and Giuseppe Gentile

Subjects
B-cell malignancies, COVID-19, tixagevimab-cilgavimab, Pre-exposure prophylaxis, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Severe Acute Respiratory Syndrome CoronaVirus‐2 (SARS‐CoV‐2) infection can result in different clinical manifestations (COVID-19), starting from asymptomatic disease to life threatening respiratory insufficiency. Onco-haematologic patients are at higher risk to develop severe COVID-19. In particular, patients affected by lymphoproliferative diseases, given the impaired cell-mediated and antibody-mediated immunity and treatment toxicity, develop more often a symptomatic and a more serious disease of Covid-19. Various therapeutic and prophylactic agents are being used against COVID‐19 such as antiviral drugs, vaccines and antiviral S‐protein monoclonal antibodies. Pre-exposure prophylaxis with AZD442/Evusheld (tixagevimab-cilgavimab) may be a complementary strategy to decrease the incidence or severity of COVID-19 for patients with B-cell malignancies. Tixagevimab-cilgavimab is a combination of two monoclonal antibodies that bind SARS-CoV-2 spike protein and inhibits the attachment to the surface of cells, preventing viral entry in the cell and COVID-19 development. In the setting of hematology real-life, few data are available on the impact of pre-exposure prophylaxis, given the multiple factors involved in the clinical behavior of SARS-CoV-2 . Our aim was to evaluate the clinical benefit and the safety of this strategy at our center.

Published
2023
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4. An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis

Author

Nevone, Alice, Girelli, Maria, Mangiacavalli, Silvia, Paiva, Bruno, Milani, Paolo, Cascino, Pasquale, Piscitelli, Maggie, Speranzini, Valentina, Cartia, Claudio Salvatore, Benvenuti, Pietro, Goicoechea, Ibai, Fazio, Francesca, Basset, Marco, Foli, Andrea, Nanci, Martina, Mazzini, Giulia, Caminito, Serena, Sesta, Melania Antonietta, Casarini, Simona, Rognoni, Paola, Lavatelli, Francesca, Petrucci, Maria Teresa, Olimpieri, Pier Paolo, Ricagno, Stefano, Arcaini, Luca, Merlini, Giampaolo, Palladini, Giovanni, and Nuvolone, Mario

Published
2022
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8. THEATRE OF THE POSSIBLE: FEMINISM AND COUNTER-NARRATIVES IN THE PUPPETRY OF MARTA CUSCUNÀ.

Author

Di Fazio, Francesca

Subjects
HIGH school girls, GENDER-based violence, ANTI-fascist movements, DOMESTIC violence, LATEX gloves, PUPPETS, IMAGINATION, PUPPET theater, VIOLENCE against women
Abstract

Marta Cuscunà is an Italian author, director, and puppeteer who creates puppetry performances that address feminist issues. Her trilogy of plays explores feminist themes through historical events and contemporary issues. One play tells the story of Ondina, a woman who experienced psychological splitting in a concentration camp. Another focuses on cloistered nuns organizing a silent revolution against forced monasticism. The final play reconstructs the events of eighteen high school girls becoming pregnant together to create a female community separate from violence. Cuscunà's work aims to provide positive counter-narratives from the perspective of marginalized women. [Extracted from the article]

Published
2024

9. Belantamab mafodotin in triple‐refractory multiple myeloma patients: A retro‐prospective observational study in Italy.

Author

Fazio, Francesca, Petrucci, Maria Teresa, Corvatta, Laura, Piciocchi, Alfonso, Pepa, Roberta Della, Tacchetti, Paola, Musso, Maurizio, Zambello, Renato, Belotti, Angelo, Bringhen, Sara, Antonioli, Elisabetta, Conticello, Concetta, Renzo, Nicola Di, De Stefano, Valerio, Musto, Pellegrino, Gamberi, Barbara, Derudas, Daniele, Boccadoro, Mario, Offidani, Massimo, and Morè, Sonia

Published
2024
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10. Patients' Perception of Usability and Utility of a Digital Health Tool for Electronic Patient-Reported Outcomes Monitoring in Real-Life Hematology Practice: Evidence from the Gimema-Alliance Platform

Author

Efficace, Fabio, primary, Luppi, Mario, additional, Potenza, Leonardo, additional, Sparano, Francesco, additional, Caocci, Giovanni, additional, Fazio, Francesca, additional, Breccia, Massimo, additional, Petrucci, Maria Teresa, additional, Patriarca, Andrea, additional, Baldi, Thomas, additional, Santopietro, Michelina, additional, Battistini, Roberta, additional, Tafuri, Agostino, additional, Margiotta Casaluci, Gloria, additional, Colaci, Elisabetta, additional, Giusti, Davide, additional, Pioli, Valeria, additional, De Fabritiis, Paolo, additional, Ardu, Nicolina Rita, additional, Niscola, Pasquale, additional, Mulas, Olga, additional, Fozza, Claudio, additional, Siragusa, Sergio, additional, Mancuso, Salvatrice, additional, Boggione, Paola, additional, De Paoli, Lorenzo, additional, Leporace, Anna Paola, additional, Bianchi, Maria Paola, additional, Carmosino, Ida, additional, Cartoni, Claudio, additional, Di Rocco, Alice, additional, Capodanno, Isabella, additional, Pini, Massimo, additional, Romano, Alessandra, additional, Fazi, Paola, additional, and Vignetti, Marco, additional

Published
2023
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12. MULTIPARAMETRIC FLOW CYTOMETRY REFINES RISK STRATIFICATION IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS

Author

Fazio, Francesca, primary, Lapietra, Gianfranco, additional, Limongi, Maria Zaira, additional, Intoppa, Stefania, additional, Milani, Maria Laura, additional, Piciocchi, Alfonso, additional, Martelli, Maurizio, additional, Guarini, Anna, additional, Foà, Robin, additional, De Propris, Maria Stefania, additional, and Petrucci, Maria Teresa, additional

Published
2023
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13. P971: EFFECT OF DARATUMUMAB ON STEM CELL YIELDS IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: REPORT FROM THE MULTIPLE MYELOMA LAZIO GROUP.

Author

Fazio, Francesca, primary, Passucci, Mauro, additional, Lisi, Chiara, additional, Micozzi, Jacopo, additional, Fianchi, Luana, additional, Landro, Francesca DI, additional, Za, Tommaso, additional, Gumenyuk, Svitlana, additional, Ferraro, Silvia, additional, Anaclerico, Barbara, additional, De Padue, Laura, additional, Annibali, Ombretta, additional, Rago, Angela, additional, Piciocchi, Alfonso, additional, Bongarzoni, Velia, additional, Cupelli, Luca, additional, Mengarelli, Andrea, additional, De Stefano, Valerio, additional, Martelli, Maurizio, additional, and Petrucci, Maria-Teresa, additional

Published
2023
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14. P895: DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION: UPDATED ANALYSIS OF THE DEDALO PHASE II TRIAL

Author

Montefusco, Vittorio, primary, Maria Cafro, Anna, additional, Margiotta-Casaluci, Gloria, additional, Patriarca, Francesca, additional, Mina, Roberto, additional, D’agostino5, Mattia, additional, Palma, Anna Benedetta Dalla, additional, Rizzi, Rita, additional, Genua, Angelo, additional, Fazio, Francesca, additional, Paris, Laura, additional, Belotti, Angelo, additional, Rizzello, Ilaria, additional, Conticello, Concetta, additional, Carlo-Stella, Carmelo, additional, and Boccadoro, Mario, additional

Published
2023
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16. Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity

Author

Natoni, Alessandro, primary, Cerreto, Marina, additional, De Propris, Maria Stefania, additional, Petrucci, Maria Teresa, additional, Fazio, Francesca, additional, Intoppa, Stefania, additional, Milani, Maria Laura, additional, Kirkham-McCarthy, Lucy, additional, Henderson, Robert, additional, Swan, Dawn, additional, Guarini, Anna, additional, O’Dwyer, Michael, additional, and Foà, Robin, additional

Published
2023
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18. Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome

Author

Santilli, Francesca, Blardi, Patrizia, Scapellato, Carlo, Bocchia, Monica, Guazzi, Gianni, Terzuoli, Lucia, Tabucchi, Antonella, Silvietti, Antonella, Lucani, Benedetta, Gioffrè, Walter Renato, Scarpini, Francesca, Fazio, Francesca, Davì, Giovanni, and Puccetti, Luca

Published
2015
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21. The puppet and its drama. Dramaturgies for contemporary puppet theatre in France and Italy (1980-2020)

Author

Di Fazio, Francesca <1991>, Pitozzi, Enrico, and Plassard, Didier

Subjects
L-ART/05 Discipline dello spettacolo
Abstract

Le théâtre de marionnettes a connu, depuis la fin du XXe siècle, de profondes mutations, tant sur le plan esthétique que sur celui du dispositif dramaturgique. Si en France des expériences plurielles de collaboration entre écrivains et marionnettistes se sont développées, en Italie ont émergé des expérimentations dramatiques de la part des marionnettistes eux-mêmes, auteurs de textes aux qualités littéraires. Au fil des rencontres avec la scène marionnettique, la posture de l’auteur devient « fluide », allant de l’écrivain extérieur répondant à une commande, au dramaturge et au co-créateur des spectacles. Une attention accrue aux enjeux dramaturgiques a renforcé les relations des arts de la marionnette avec le théâtre d’acteurs. En vertu de cette osmose, certaines caractéristiques du régime contemporain de l’écriture pour la scène, comme la « rhapsodisation » des textes mise en évidence par Jean-Pierre Sarrazac et les traits « postdramatiques » décrits par Hans-Thies Lehmann, sont à l’œuvre dans les pièces pour marionnettes écrites depuis les années 1980. La comparaison des créations françaises (par Daniel Lemahieu et François Lazaro, Jean Cagnard et la Cie Arketal, Kossi Efoui et Théâtre Inutile, Dennis Cooper et Gisèle Vienne) et italiennes (par Guido Ceronetti, Giuliano Scabia, Gigio Brunello et Gyula Molnár, Marta Cuscunà, Fabiana Iacozzilli, entre autres) montre comment elles exploitent la marionnette afin d’agencer la parole aux images suscitées par l’objet. Bien que l’on puisse observer un plus grand élan innovateur en France, tandis que les relations avec les différentes traditions régionales restent ancrées en Italie, l’analyse de textes nous apprend que les motifs les plus récurrents sont communs aux deux territoires, en vertu des possibilités de figuration qu’offre la marionnette : la confrontation avec les problèmes actuels et les traumatismes de l’histoire, la plongée dans l’esprit humain, l’imagination de territoires post-anthropocentriques, la rencontre avec le trouble et la mort, Since the end of the 20th century, puppet theatre has undergone profound changes, both in terms of aesthetics and dramaturgy. While in France there have been many experiences of collaboration between playwrights and puppeteers, in Italy there have been playwriting experiments by the puppeteers themselves, composing texts of a more literary quality. In the course of these encounters with the stage, the position of the author of puppet theatre becomes “fluid”, going from the external writer answering a commission, to the dramaturge, to the co-creator of the shows. A greater attention to dramaturgical issues has strengthened the relationship between puppetry and acting. By virtue of this osmosis, certain characteristics of the contemporary regime of writing, such as the “rhapsodisation” of texts, highlighted by Jean-Pierre Sarrazac, and some features of the postdramatic theatre described by Hans-Thies Lehmann, are at work in the puppet plays composed since the 1980s. The comparison of French creations (by Daniel Lemahieu and François Lazaro, Jean Cagnard and Cie Arketal, Kossi Efoui and Théâtre Inutile, Dennis Cooper and Gisèle Vienne) and Italian ones (by Guido Ceronetti, Giuliano Scabia, Gigio Brunello and Gyula Molnár, Marta Cuscunà, Fabiana Iacozzilli, among others) shows how they exploit the puppet and its multiple techniques of manipulation in order to interweave the word to the images generated by the object. Although a greater innovative impulse can be observed in France, while the relations with the different regional traditions remain more anchored in Italy, the analysis of several texts attests that the most recurrent poetics and motifs are common to both territories, by virtue of the possibilities of figuration offered by puppets: the confrontation with current problems and the traumas of history, the dive into the human mind, the imagination of post-anthropocentric territories, the encounter with disorder and death.

Published
2022

22. Immunogenicity of SARS-CoV-2 vaccination in patients undergoing autologous stem cell transplantation. A multicentric experience

Author

Autore, Francesco, primary, Stirparo, Luca, additional, Innocenti, Idanna, additional, Papa, Elena, additional, Marchesi, Francesco, additional, Togni, Chiara, additional, Mariani, Sabrina, additional, Torrieri, Lorenzo, additional, Salvatori, Martina, additional, Fazio, Francesca, additional, Metafuni, Elisabetta, additional, Giammarco, Sabrina, additional, Sora, Federica, additional, Falcucci, Paolo, additional, Ferrari, Antonella, additional, Trisolini, Silvia Maria, additional, Capria, Saveria, additional, Tafuri, Agostino, additional, Chiusolo, Patrizia, additional, Sica, Simona, additional, and Laurenti, Luca, additional

Published
2022
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23. Prevalence of Type 1 Gaucher Disease in Patients with Multiple Myeloma: Updated Interim Analysis of a Prospective, Multicentre, Observational Study

Author

Offidani, Massimo, primary, Zizzo, Carmela, additional, Rupoli, Serena, additional, Federici, Irene, additional, Morè, Sonia, additional, Bossi, Alessandra, additional, Manieri, Valentina Maria, additional, Petrucci, Maria Teresa, additional, Caravita DI Toritto, Tommaso, additional, Brunori, Marino, additional, Gozzetti, Alessandro, additional, Tordi, Attilio, additional, Fazio, Francesca, additional, Lisi, Chiara, additional, Melaccio, Assunta, additional, Ciuffreda, Lucia, additional, Falcone, Antonietta Pia, additional, Fioritoni, Francesca, additional, Gentili, Silvia, additional, Siniscalchi, Agostina, additional, Trastulli, Fabio, additional, Corvatta, Laura, additional, Morsia, Erika, additional, Olivieri, Attilio, additional, and Duro, Giovanni, additional

Published
2022
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24. Clinical Features and Treatment Response in Patients with Multiple Myeloma and CD20 Expression: Real-Life Experience of the Centro-Italy Multiple Myeloma Macroregional District

Author

Fiorini, Alessia, primary, Panichi, Valentina, additional, Chavez, Maria Gabriela, additional, Cordone, Iole, additional, Montanaro, Guido, additional, Fazio, Francesca, additional, Bassi, Loredana, additional, Tomarchio, Valeria, additional, Sbraga, Edoardo, additional, Poscente, Monica, additional, Merola, Roberta, additional, De Propris, Maria Stefania, additional, Mengarelli, Andrea, additional, Licci, Stefano, additional, Giancola, Raffaella, additional, Latagliata, Roberto, additional, Annibali, Ombretta, additional, Rago, Angela, additional, Fioritoni, Francesca, additional, Petrucci, Maria Teresa, additional, and Andriani, Alessandro, additional

Published
2022
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25. Long Term Survival in Multiple Myeloma Patients: A Multicenter Italian Experience

Author

Fazio, Francesca, primary, Gherardini, Martina, additional, Za, Tommaso, additional, Rossi, Elena, additional, Di Landro, Francesca, additional, Morè, Sonia, additional, Manieri, Maria Valentina, additional, Fioritoni, Francesca, additional, Bongarzoni, Velia, additional, Gumenyuk, Svitlana, additional, Rago, Angela, additional, Garzia, Maria Grazia, additional, Angelini, Stefano, additional, Masucci, Chiara, additional, Franceschini, Luca, additional, Piciocchi, Alfonso, additional, Galieni, Piero, additional, De Rosa, Luca, additional, Pisani, Francesco, additional, Pulini, Stefano, additional, Offidani, Massimo, additional, De Stefano, Valerio, additional, Martelli, Maurizio, additional, and Petrucci, Maria Teresa, additional

Published
2022
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26. Lenalidomide-based triplet regimens in first relapsed multiple myeloma patients: real-world evidence from a propensity score matched analysis

Author

Mangiacavalli, Silvia, primary, Cartia, Claudio Salvatore, additional, Galli, Monica, additional, Pezzatti, Sara, additional, Belotti, Angelo, additional, Fazio, Francesca, additional, Mina, Roberto, additional, Marcatti, Magda, additional, Cafro, Anna, additional, Zambello, Renato, additional, Paris, Laura, additional, Barilà, Gregorio, additional, Olivares, Cecilia, additional, Pompa, Alessandra, additional, Mazza, Rita, additional, Farina, Francesca, additional, Soldarini, Martina, additional, Benvenuti, Pietro, additional, Pagani, Giuseppina, additional, Palumbo, Michele, additional, Masoni, Valeria, additional, Ferretti, Virginia Valeria, additional, Klersy, Catherine, additional, Arcaini, Luca, additional, and Petrucci, Maria Teresa, additional

Published
2022
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27. La Iena di San Giorgio. Da leggenda popolare a mito burattinesco

Author

Di Fazio, Francesca

Abstract

Quella della Iena di San Giorgio è una leggenda popolare entrata a far parte dei repertori di diverse famiglie d’arte burattinaia. Tra i copioni pubblicati intorno alla storia del macellaio assassino, quello di Gualberto Niemen ricostruisce, a fine secolo, la memoria dello spettacolo che portava in giro nella prima metà del Novecento. Proprio una sua rappresentazione ispira Guido Ceronetti a farne una moderna riscrittura, che diventa il primo testo rappresentato dal Teatro dei Sensibili (1970). Sempre a inizio anni ’70, Giuliano Scabia rivisita la leggenda per renderla racconto mitico di un mondo distrutto dal consumismo. Attraverso il confronto tra le versioni si vedrà come la vicenda, nel corso di un secolo, si trasformi da storia moralizzatrice ad affermazione dell’ineluttabilità del male., DNA – Di Nulla Academia, Vol. 3 No. 1 (2022): Inferno e postinferno - II

Published
2022
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28. <scp>Single‐molecule real‐time</scp> sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies

Author

Cascino, Pasquale, Nevone, Alice, Piscitelli, Maggie, Scopelliti, Claudia, Girelli, Maria, Mazzini, Giulia, Caminito, Serena, Russo, Giancarlo, Milani, Paolo, Basset, Marco, Foli, Andrea, Fazio, Francesca, Casarini, Simona, Massa, Margherita, Bozzola, Margherita, Ripepi, Jessica, Sesta, Melania Antonietta, Acquafredda, Gloria, De Cicco, Marica, Moretta, Antonia, Rognoni, Paola, Milan, Enrico, Ricagno, Stefano, Lavatelli, Francesca, Petrucci, Maria Teresa, Miho, Enkelejda, Klersy, Catherine, Merlini, Giampaolo, Palladini, Giovanni, Nuvolone, Mario, University of Zurich, Palladini, Giovanni, and Nuvolone, Mario

Subjects
Settore BIO/10 - Biochimica, 2720 Hematology, 10051 Rheumatology Clinic and Institute of Physical Medicine, Paraproteinemias, 570 Life sciences, biology, Humans, 610 Medicine & health, 10071 Functional Genomics Center Zurich, Hematology, Precision Medicine, Multiple Myeloma, 10026 Clinic for Obstetrics, Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Published
2022
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29. High Levels of Circulating Tumor Plasma Cells as a Key Hallmark of Aggressive Disease in Transplant-Eligible Patients With Newly Diagnosed Multiple Myeloma

Author

Bertamini, Luca, primary, Oliva, Stefania, additional, Rota-Scalabrini, Delia, additional, Paris, Laura, additional, Morè, Sonia, additional, Corradini, Paolo, additional, Ledda, Antonio, additional, Gentile, Massimo, additional, De Sabbata, Giovanni, additional, Pietrantuono, Giuseppe, additional, Pascarella, Anna, additional, Tosi, Patrizia, additional, Curci, Paola, additional, Gilestro, Milena, additional, Capra, Andrea, additional, Galieni, Piero, additional, Pisani, Francesco, additional, Annibali, Ombretta, additional, Monaco, Federico, additional, Liberati, Anna Marina, additional, Palmieri, Salvatore, additional, Luppi, Mario, additional, Zambello, Renato, additional, Fazio, Francesca, additional, Belotti, Angelo, additional, Tacchetti, Paola, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, and Gay, Francesca, additional

Published
2022
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30. Single‐molecule real‐time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies

Author

Cascino, Pasquale, primary, Nevone, Alice, additional, Piscitelli, Maggie, additional, Scopelliti, Claudia, additional, Girelli, Maria, additional, Mazzini, Giulia, additional, Caminito, Serena, additional, Russo, Giancarlo, additional, Milani, Paolo, additional, Basset, Marco, additional, Foli, Andrea, additional, Fazio, Francesca, additional, Casarini, Simona, additional, Massa, Margherita, additional, Bozzola, Margherita, additional, Ripepi, Jessica, additional, Sesta, Melania Antonietta, additional, Acquafredda, Gloria, additional, De Cicco, Marica, additional, Moretta, Antonia, additional, Rognoni, Paola, additional, Milan, Enrico, additional, Ricagno, Stefano, additional, Lavatelli, Francesca, additional, Petrucci, Maria Teresa, additional, Miho, Enkelejda, additional, Klersy, Catherine, additional, Merlini, Giampaolo, additional, Palladini, Giovanni, additional, and Nuvolone, Mario, additional

Published
2022
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32. P-149: Prevalence of type 1 Gaucher disease in patients with multiple myeloma: interim analysis of a prospective, multicentre, observational study

Author

Offidani, Massimo, primary, Zizzo, Carmela, additional, Rupoli, Serena, additional, Federici, Irene, additional, Morè, Sonia, additional, Bossi, Alessandra, additional, Manieri, Valentina Maria, additional, Petrucci, Maria Teresa, additional, di Toritto, Tommaso Caravita, additional, Brunori, Marino, additional, Gozzetti, Alessandro, additional, Tordi, Attilio, additional, Fazio, Francesca, additional, Lisi, chiara, additional, Melaccio, Assunta, additional, Ciuffreda, Lucia, additional, Falcone, Antonietta Pia, additional, Fioritoni, Francesca, additional, Gentili, Silvia, additional, Siniscalchi, Agostina, additional, Trastulli, Fabio, additional, Morsia, Erika, additional, Corvatta, Laura, additional, Olivieri, Attilio, additional, and Duro, Giovanni, additional

Published
2022
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33. GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells

Author

Kosta, Andrea, primary, Mekhloufi, Abdelilah, additional, Lucantonio, Lorenzo, additional, Zingoni, Alessandra, additional, Soriani, Alessandra, additional, Cippitelli, Marco, additional, Gismondi, Angela, additional, Fazio, Francesca, additional, Petrucci, Maria Teresa, additional, Santoni, Angela, additional, Stabile, Helena, additional, and Fionda, Cinzia, additional

Published
2022
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34. Les représentations du diable dans la dramaturgie du théâtre de marionnettes contemporain

Author

di Fazio, Francesca and Robert, Paul

Subjects
Horizon 2020, Écriture dramatique, répertoire, PuppetPlays, Dramaturgie contemporaine, Puppet theatre, ERC, Repertoire, Théâtre de marionnettes, Contemporary dramaturgy, Playwriting
Abstract

Puppets’ fictitious nature allows them to figure raw themes in all their concreteness on stage. In a close alternation of tragic and comic tones, contemporary puppet theatre faces the darkest fantasies appealing to traditional techniques and post-dramatic staging. Four different plays from the second half of the twentieth century and the early 2000s of the French and Italian repertoires reveal how the scenic space of the puppet booth may become a landscape inhabited by obscure figures. Ceronetti’s La iena di San Giorgio creates a modern anti-hero out of an old popular gory legend. In Brunello’s and Molnár’s Macbeth all’improvviso, glove puppets abandon comedy to collapse into a tragic situation with no escape. In La Chpocalypse, Lépinois employs the character’s typical routines to draw on the page a macabre dance. In Jerk, Cooper, Vienne, and Capdevielle concert their skills as authors, directors, and performers to stage a text that spellbinds a heinous story. Moreover, the plays analysed provide several examples of how the use of puppets activates dramaturgical processes that impact the text’s mechanism, creating a link between the writing and its staging. Keywords: puppet theatre dramaturgy; figure theatre; contemporary dramaturgy; playwriting; repertoire, Skenè. Journal of Theatre and Drama Studies, Vol. 8 No. 1 (2022): Puppet, Death, and the Devil: Presences of Afterlife in Puppet Theatre

Published
2022
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35. Immunogenicity of SARS-CoV-2 vaccination in patients undergoing autologous stem cell transplantation. A multicentric experience

Author

Autore, Francesco, Stirparo, Luca, Innocenti, Idanna, Papa, Elena, Marchesi, Francesco, Togni, Chiara, Mariani, Sabrina, Torrieri, Lorenzo, Salvatori, Martina, Fazio, Francesca, Metafuni, Elisabetta, Giammarco, Sabrina, Sora', Federica, Falcucci, Paolo, Ferrari, Antonella, Trisolini, Silvia Maria, Capria, Saveria, Tafuri, Agostino, Chiusolo, Patrizia, Sica, Simona, Laurenti, Luca, Sora, Federica (ORCID:0000-0002-9607-5298), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Sica, Simona (ORCID:0000-0003-2426-3465), Laurenti, Luca (ORCID:0000-0002-8327-1396), Autore, Francesco, Stirparo, Luca, Innocenti, Idanna, Papa, Elena, Marchesi, Francesco, Togni, Chiara, Mariani, Sabrina, Torrieri, Lorenzo, Salvatori, Martina, Fazio, Francesca, Metafuni, Elisabetta, Giammarco, Sabrina, Sora', Federica, Falcucci, Paolo, Ferrari, Antonella, Trisolini, Silvia Maria, Capria, Saveria, Tafuri, Agostino, Chiusolo, Patrizia, Sica, Simona, Laurenti, Luca, Sora, Federica (ORCID:0000-0002-9607-5298), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Sica, Simona (ORCID:0000-0003-2426-3465), and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

COVID-19 disease has a strong impact on hematological patients; those receiving autologous hematopoietic stem cell transplantation (aHSCT) represent a particularly vulnerable group, in which the effectiveness of vaccination is very variable. Chiarucci et al. showed that patients affected by non-Hodgkin lymphoma (NHL) and treated with rituximab experienced a lower rate of immunization against SARS-CoV-2 (54%), as well as significantly lower IgG antibody titers. In our multicenter retrospective observational study, we included 82 patients who underwent aHSCT, divided into two groups: 58 patients vaccinated after aHSCT (group A) and 24 vaccinated before getting transplantation (group B). In group A, 39 (67%) patients had positive serology, and the rate of positivity increased with time after aHSCT. In the subgroup of patients with NHL the administration of rituximab predicted negative serology, particularly when administered in the 6 months before vaccination (13% response rate). Patients affected by plasma cells had a higher rate of positivity (83% overall), independently of the time to aHSCT. In group B, no patient who initially showed positive serology became negative after transplantation, so the aHSCT did not affect the response to the vaccination. Our study confirmed the role of rituximab as a negative predictor of response to SARS-CoV-2 vaccination, whereas the conditioning and transplantation procedure itself seemed to be less important.

Published
2022

36. La marionnette et son drame. Les dramaturgies pour le théâtre de marionnettes contemporain en France et en Italie (1980-2020)

Author

Pitozzi, Enrico, Plassard, Didier, Di Fazio, Francesca <1991>, Pitozzi, Enrico, Plassard, Didier, and Di Fazio, Francesca <1991>

Abstract

Le théâtre de marionnettes a connu, depuis la fin du XXe siècle, de profondes mutations, tant sur le plan esthétique que sur celui du dispositif dramaturgique. Si en France des expériences plurielles de collaboration entre écrivains et marionnettistes se sont développées, en Italie ont émergé des expérimentations dramatiques de la part des marionnettistes eux-mêmes, auteurs de textes aux qualités littéraires. Au fil des rencontres avec la scène marionnettique, la posture de l’auteur devient « fluide », allant de l’écrivain extérieur répondant à une commande, au dramaturge et au co-créateur des spectacles. Une attention accrue aux enjeux dramaturgiques a renforcé les relations des arts de la marionnette avec le théâtre d’acteurs. En vertu de cette osmose, certaines caractéristiques du régime contemporain de l’écriture pour la scène, comme la « rhapsodisation » des textes mise en évidence par Jean-Pierre Sarrazac et les traits « postdramatiques » décrits par Hans-Thies Lehmann, sont à l’œuvre dans les pièces pour marionnettes écrites depuis les années 1980. La comparaison des créations françaises (par Daniel Lemahieu et François Lazaro, Jean Cagnard et la Cie Arketal, Kossi Efoui et Théâtre Inutile, Dennis Cooper et Gisèle Vienne) et italiennes (par Guido Ceronetti, Giuliano Scabia, Gigio Brunello et Gyula Molnár, Marta Cuscunà, Fabiana Iacozzilli, entre autres) montre comment elles exploitent la marionnette afin d’agencer la parole aux images suscitées par l’objet. Bien que l’on puisse observer un plus grand élan innovateur en France, tandis que les relations avec les différentes traditions régionales restent ancrées en Italie, l’analyse de textes nous apprend que les motifs les plus récurrents sont communs aux deux territoires, en vertu des possibilités de figuration qu’offre la marionnette : la confrontation avec les problèmes actuels et les traumatismes de l’histoire, la plongée dans l’esprit humain, l’imagination de territoires post-anthropocentriques, la rencont, Since the end of the 20th century, puppet theatre has undergone profound changes, both in terms of aesthetics and dramaturgy. While in France there have been many experiences of collaboration between playwrights and puppeteers, in Italy there have been playwriting experiments by the puppeteers themselves, composing texts of a more literary quality. In the course of these encounters with the stage, the position of the author of puppet theatre becomes “fluid”, going from the external writer answering a commission, to the dramaturge, to the co-creator of the shows. A greater attention to dramaturgical issues has strengthened the relationship between puppetry and acting. By virtue of this osmosis, certain characteristics of the contemporary regime of writing, such as the “rhapsodisation” of texts, highlighted by Jean-Pierre Sarrazac, and some features of the postdramatic theatre described by Hans-Thies Lehmann, are at work in the puppet plays composed since the 1980s. The comparison of French creations (by Daniel Lemahieu and François Lazaro, Jean Cagnard and Cie Arketal, Kossi Efoui and Théâtre Inutile, Dennis Cooper and Gisèle Vienne) and Italian ones (by Guido Ceronetti, Giuliano Scabia, Gigio Brunello and Gyula Molnár, Marta Cuscunà, Fabiana Iacozzilli, among others) shows how they exploit the puppet and its multiple techniques of manipulation in order to interweave the word to the images generated by the object. Although a greater innovative impulse can be observed in France, while the relations with the different regional traditions remain more anchored in Italy, the analysis of several texts attests that the most recurrent poetics and motifs are common to both territories, by virtue of the possibilities of figuration offered by puppets: the confrontation with current problems and the traumas of history, the dive into the human mind, the imagination of post-anthropocentric territories, the encounter with disorder and death.

Published
2022

37. Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing.

Author

Vulpis, Elisabetta, Loconte, Luisa, Cassone, Chiara, Antonangeli, Fabrizio, Caracciolo, Giulio, Masuelli, Laura, Fazio, Francesca, Petrucci, Maria Teresa, Fionda, Cinzia, Soriani, Alessandra, Cerboni, Cristina, Cippitelli, Marco, Santoni, Angela, and Zingoni, Alessandra

Subjects
KILLER cells, EXTRACELLULAR vesicles, MULTIPLE myeloma, INNATE lymphoid cells, CELLULAR recognition
Abstract

Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. NKG2D is an activating receptor that binds to MIC and ULBP molecules typically induced on damaged, transformed, or infected cells. The secretion of NKG2D ligands (NKG2DLs) through protease-mediated cleavage or in an extracellular vesicle (EV) is a mode to control their cell surface expression and a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. EVs are emerging as important players in mediating cell-to-cell communication due to their ability to transfer biological material to acceptor cells. Herein, we investigated the spreading of NKG2DLs of both MIC and ULBP molecules through the EV-mediated cross-dressing on multiple myeloma (MM) cells. We focused our attention on two MICA allelic variants, namely MICA*008 and MICA*019, representing the prototype of short and long MICA alleles, respectively, and on ULBP-1, ULBP-2, and ULBP-3. Our findings demonstrate that both ULBP and MICA ligands can be acquired from tumor cells through EVs enhancing NK cell recognition and killing. Moreover, besides MICA, EVs expressing ULBP-1 but not ULBP-2 and 3 were detected in bone marrow aspirates derived from a cohort of MM patients. Our findings shed light on the role of EV-associated MICA allelic variants and ULBP molecules in the modulation of NKG2D-mediated NK cell immunosurveillance in the tumor microenvironment. Moreover, the EV-mediated transfer of NKG2DLs could suggest novel therapeutic approaches based on the usage of engineered nanoparticles aimed at increasing cancer cell immunogenicity. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Autologous stem cell transplantation in multiple myeloma patients over 70 years: AGIMEMALazio Working Group experience in a retrospective case–control study

Author

Rago, Angela, primary, Annibali, Ombretta, additional, Tomarchio, Valeria, additional, Coppetelli, Ugo, additional, Fazio, Francesca, additional, Cupelli, Luca, additional, Fiorini, Alessia, additional, Piciocchi, Alfonso, additional, Tafuri, Agostino, additional, and Caravita di Toritto, Tommaso, additional

Published
2022
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39. Comment signifier l'altérité et les corps diasporiques par la marionnette. Deux pièces de Kossi Efoui

Author

di Fazio, Francesca and Robert, Paul

Subjects
Tragedy, Décolonisation, Horizon 2020, Marionnettes, Puppetry, ERC, myth, identité, Decolonization, entertainment, divertissement, Togo, PuppetPlays, tragédie, France, identity, Mythe
Abstract

Author of various theatre plays, French-speaking writer of Togolese origin Kossi Efoui transfers in his texts, relying on the puppet’s medium, his experience of political exile from his native country and statelessness, as well as search for an identity, in his adoptive country, France. In the texts "Io (tragédie)" (2006) and "En Guise de divertissement" (2013), the basic themes of Efoui’s writings find their best concretization in the staging carried out with puppets. This research has been funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement 835193., Auteur de diverses pièces de théâtre, l'écrivain francophone d'origine togolaise Kossi Efoui transfère dans ses textes, en s'appuyant sur le médium de la marionnette, son expérience de l'exil politique de son pays natal, ainsi que de la recherche d'une identité dans son pays d'adoption, la France. Dans les textes « Io (tragédie) » (2006) et En « Guise de divertissement » (2013), les thèmes fondamentaux de l'écriture d'Efoui trouvent leur meilleure concrétisation dans la mise en scène réalisée avec des marionnettes. This research has been funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement 835193.

Published
2022
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45. Physicians’ Perceptions of Clinical Utility of a Digital Health Tool for Electronic Patient-Reported Outcome Monitoring in Real-Life Hematology Practice. Evidence From the GIMEMA-ALLIANCE Platform

Author

Efficace, Fabio, primary, Patriarca, Andrea, additional, Luppi, Mario, additional, Potenza, Leonardo, additional, Caocci, Giovanni, additional, Tafuri, Agostino, additional, Fazio, Francesca, additional, Cartoni, Claudio, additional, Petrucci, Maria Teresa, additional, Carmosino, Ida, additional, Moia, Riccardo, additional, Margiotta Casaluci, Gloria, additional, Boggione, Paola, additional, Colaci, Elisabetta, additional, Giusti, Davide, additional, Pioli, Valeria, additional, Sparano, Francesco, additional, Cottone, Francesco, additional, De Fabritiis, Paolo, additional, Ardu, Nicolina Rita, additional, Niscola, Pasquale, additional, Capodanno, Isabella, additional, Leporace, Anna Paola, additional, Pelliccia, Sabrina, additional, Lugli, Elisabetta, additional, La Sala, Edoardo, additional, Rigacci, Luigi, additional, Santopietro, Michelina, additional, Fozza, Claudio, additional, Siragusa, Sergio, additional, Breccia, Massimo, additional, Fazi, Paola, additional, and Vignetti, Marco, additional

Published
2022
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46. Blast morphology in the diagnostic work-up of Ph-like acute lymphoblastic leukemia

Author

Fazio, Francesca, primary, Cunsolo, Gabriella, additional, Mancini, Francesca, additional, De Propris, Maria Stefania, additional, Piciocchi, Alfonso, additional, Arena, Valentina, additional, Messina, Monica, additional, Ansuinelli, Michela, additional, Taherinasab, Akram Taherinasab, additional, Apicella, Valerio, additional, Vitale, Antonella, additional, Chiaretti, Sabina, additional, Guarini, Anna, additional, del Giudice, Ilaria, additional, and Foà, Robin, additional

Published
2022
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47. Daratumumab combined with dexamethasone and lenalidomide or bortezomib in relapsed/refractory multiple myeloma (RRMM) patients: Report from the multiple myeloma GIMEMA Lazio group

Author

Fazio, Francesca, primary, Franceschini, Luca, additional, Tomarchio, Valeria, additional, Rago, Angela, additional, Garzia, Maria Grazia, additional, Cupelli, Luca, additional, Bongarzoni, Velia, additional, Andriani, Alessandro, additional, Gumenyuk, Svitlana, additional, Tafuri, Agostino, additional, Siniscalchi, Agostina, additional, Piciocchi, Alfonso, additional, De Fabritiis, Paolo, additional, De Rosa, Luca, additional, Caravita di Toritto, Tommaso, additional, Annibali, Ombretta, additional, Cantonetti, Maria, additional, and Petrucci, Maria Teresa, additional

Published
2022
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48. Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle‐associated MICA: Dual role in cancer immunosurveillance

Author

Vulpis, Elisabetta, primary, Loconte, Luisa, additional, Peri, Agnese, additional, Molfetta, Rosa, additional, Caracciolo, Giulio, additional, Masuelli, Laura, additional, Tomaipitinca, Luana, additional, Peruzzi, Giovanna, additional, Petillo, Sara, additional, Petrucci, Maria Teresa, additional, Fazio, Francesca, additional, Simonelli, Lucilla, additional, Fionda, Cinzia, additional, Soriani, Alessandra, additional, Cerboni, Cristina, additional, Cippitelli, Marco, additional, Paolini, Rossella, additional, Bernardini, Giovanni, additional, Palmieri, Gabriella, additional, Santoni, Angela, additional, and Zingoni, Alessandra, additional

Published
2022
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49. Animatronica e componentistica industriale applicate alla scena

Author

Cuscunà, Marta, Di Fazio, Francesca, Représenter, Inventer la Réalité, du Romantisme au XXIe siècle (RIRRA 21), Université Paul-Valéry - Montpellier 3 (UPVM), and European Project: ERC-GA 835193

Subjects
Arts de la scène, Teatro di figura, Earthbound, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, [SHS.LITT]Humanities and Social Sciences/Literature, Scénographie -- Théâtre, Théâtre de marionnettes, Il canto della caduta, Teatro contemporaneo, [SHS]Humanities and Social Sciences, Animatronica, Marta Cuscunà, Scenografia, Arti performative
Abstract

International audience

Published
2021
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50. Multiparametric Flow Cytometry in Newly Diagnosed Multiple Myeloma Patients: An Italian Monocentric Experience.

Author

Fazio, Francesca, Lapietra, Gianfranco, Limongi, Maria Zaira, Intoppa, Stefania, Milani, Maria Laura, Piciocchi, Alfonso, Martelli, Maurizio, Guarini, Anna, Foà, Robin, Stefania De Propris, Maria, and Petrucci, Maria Teresa

Subjects
*MULTIPLE myeloma, *FLOW cytometry, *PLASMACYTOMA, *CELL surface antigens, *BONE marrow cells, *CHROMOSOMAL translocation
Abstract

Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of surface antigens. Our study aimed at describing the antigenic profile detected by MFC in a series of newly diagnosed MM patients to correlate the level of expression with other features of the disease. Between April 2018 and June 2022, 84 consecutive MM patients were studied at presentation. CD56 and CD117 were commonly detected, while CD45, CD28, CD20, CD19, CD13 and CD33 were less recurrent. CD20 expression was associated with the type of secretory MM (p=0.041) and with a higher disease burden (p=0.038). CD28 positivity correlated with a lower platelet count at baseline (p=0.005) and with a lower rate of complete response (p=0.038). Furthermore, CD28 positivity and a lower CD138 expression tended to associate with the high-risk chromosomal translocations t(14;16) and t(4;14). The results of this study indicate that in the diagnostic workup of MM, MFC may help to identify different patient subsets and improve risk stratification. These observations need to be validated in larger series of patients with a longer follow-up. [ABSTRACT FROM AUTHOR]

Published
2023
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