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2. Special considerations for the treatment of multiple myeloma according to advanced age, comorbidities, frailty and organ dysfunction

Author

Fraz, Muhammad Asad, Warraich, Faiza Hassan, Warraich, Sami Ullah, Tariq, Muhammad Junaid, Warraich, Zabih, Khan, Ali Younas, Usman, Muhammad, Ijaz, Awais, Tenneti, Pavan, Mushtaq, Adeela, Akbar, Faisal, Shahid, Zaina, Ali, Zeeshan, Fazeel, Hafiz Muhammad, Rodriguez, Cesar, Nasar, Aboo, McBride, Ali, and Anwer, Faiz

Published
2019
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3. Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

Author

Ahsan, Muhammad Junaid, primary, Fazeel, Hafiz Muhammad, additional, Haque, Syed Mansur Ul, additional, Malik, Saad Ullah, additional, Latif, Azka, additional, Lateef, Noman, additional, Batool, Syeda Sabeeka, additional, Kousa, Omar, additional, Ahsan, Mohammad Zoraiz, additional, Anwer, Faiz, additional, Andukuri, Venkata, additional, and Smer, Aiman, additional

Published
2021
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4. Prognostic Impact of Red Cell Distribution Width on the Development of Contrast Induced Nephropathy, Major Adverse Cardiac Events, and Mortality in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention.

Author

Latif, Azka, primary, Ahsan, Muhammad Junaid, additional, Lateef, Noman, additional, Kapoor, Vikas, additional, Fazeel, Hafiz Muhammad, additional, Razzaq, Faryal, additional, Iftikhar, Ahmad, additional, Ashfaq, Muhammad Zubair, additional, Anwer, Faiz, additional, Mirza, Mohsin, additional, and Kabach, Amjad, additional

Published
2021
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7. A SYSTEMATIC REVIEW AND META-ANALYSIS ON EFFECTS OF BASELINE THROMBOCYTOPENIA ON CARDIOVASCULAR OUTCOMES IN CORONARY ARTERY DISEASE PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION AT THE LONGEST FOLLOW-UP

Author

Ahsan, Muhammad J., primary, Mansoor, Kanaan, additional, Fazeel, Hafiz Muhammad, additional, Batool, Syeda Sabeeka, additional, Hassan, Syeda, additional, Mobeen, Sadia, additional, Ashraf, Aqsa, additional, Thandra, Abhishek, additional, Mirza, Mohsin, additional, and Core, Michael Del, additional

Published
2020
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8. A SYSTEMATIC REVIEW AND META-ANALYSIS ON THE PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH ON DEVELOPMENT OF CONTRAST INDUCED NEPHROPATHY IN CORONARY ARTERY DISEASE PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Author

Ahsan, Muhammad J., primary, Malik, Saad Ullah, additional, Kousa, Omar, additional, Fazeel, Hafiz Muhammad, additional, Javed, Nisma, additional, Tahseen, Sidra, additional, Latif, Azka, additional, Hashmi, Mydah, additional, Shaikh, Kashif, additional, Andukuri, Venkata, additional, and Holmberg, Mark, additional

Published
2020
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9. A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROGNOSTIC SIGNIFICANCE OF ACQUIRED THROMBOCYTOPENIA AFTER PERCUTANEOUS CORONARY INTERVENTION ON IN-HOSPITAL AND 30-DAY CARDIOVASCULAR OUTCOMES IN CORONARY ARTERY DISEASE PATIENTS

Author

Ahsan, Muhammad J., primary, Fazeel, Hafiz Muhammad, additional, Lateef, Noman, additional, Malik, Saad Ullah, additional, Anwar, Anosha, additional, Hassan, Syeda, additional, Hassan, Muryum, additional, Latif, Azka, additional, Ullah, Muhammad Qudrat, additional, Ashraf, Aqsa, additional, Townley, Theresa, additional, and Koster, Nancy, additional

Published
2020
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11. Bispecific T-Cell Engager (BiTE) Antibody Based Immunotherapy for Treatment of Relapsed Refractory Multiple Myeloma (RRMM): A Systematic Review of Preclinical and Clinical Trials

Author

Shah, Zunairah, primary, Malik, Mustafa Nadeem, additional, Batool, Syeda Sabeeka, additional, Kotapati, Sravanthi, additional, Akhtar, Aisha, additional, Rehman, Owais ur, additional, Ghani, Marium, additional, Sadiq, Maryam, additional, Akbar, Arshia, additional, Ashraf, Aqsa, additional, Farooqui, Arafat Ali Ali, additional, Yousaf, Muhammad Abdullah, additional, Ahmad, Muhaddis Ejaz, additional, Fazeel, Hafiz Muhammad, additional, and Anwer, Faiz, additional

Published
2019
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12. Role of B-Cell Maturation Antigen (BCMA) Targeted Immunotherapies in Relapsed and Refractory Multiple Myeloma- a Systematic Review

Author

Shah, Zunairah, primary, Batool, Syeda Sabeeka, additional, Fazeel, Hafiz Muhammad, additional, Malik, Mustafa Nadeem, additional, Sadiq, Maryam, additional, Hassan, Syeda Fatima, additional, Syed, Tariq Iqtidar Sadiq, additional, Abdullah, Syed Maaz, additional, Javed, Nisma, additional, Ashraf, Aqsa, additional, Farooqui, Arafat Ali Ali, additional, Yousaf, Muhammad Abdullah, additional, Ahmad, Muhaddis Ejaz, additional, Ghani, Marium, additional, Akbar, Arshia, additional, and Anwer, Faiz, additional

Published
2019
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13. Gene Therapy for Thalassemia and Sickle Cell Anemia Poses Acceptable Toxicity and Efficacy: Clinical Outcomes in Forty-Seven Cases

Author

Fazeel, Hafiz Muhammad, primary, Abu Zar, Muhammad, additional, Malik, Saad Ullah, additional, Kamal, Ahmad, additional, Malik, Mustafa Nadeem, additional, Hassan, Syed Shabee, additional, Batool, Syeda Sabeeka, additional, Durer, Ceren, additional, Durer, Seren, additional, Aslam, Shehroz, additional, Shafqat, Madeeha, additional, Ijaz, Faiqa, additional, Anwer, Faiz, additional, and Hashmi, Shahrukh K., additional

Published
2018
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14. Presentation Patterns and Management Strategies for Central Nervous System Involvement in Multiple Myeloma: A Systematic Review of Literature

Author

Jose, Jemin Aby, primary, Selene, Insija Ilyas, additional, Malik, Mustafa Nadeem, additional, Qureshi, Anum, additional, Rafae, Abdul, additional, Fazeel, Hafiz Muhammad, additional, Abu Zar, Muhammad, additional, Kamal, Ahmad, additional, Malik, Saad Ullah, additional, Durer, Ceren, additional, Durer, Seren, additional, Jamil, Faiza, additional, Shafqat, Madeeha, additional, Usman, Muhammad, additional, Mahdi, Giyth Mithim, additional, and Anwer, Faiz, additional

Published
2018
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15. Concomitant Use of Blinatumomab and Donor Lymphocyte Infusion for Post-Transplant Relapsed CD19 Positive Acute Lymphoblastic Leukemia: Systematic Review

Author

Durer, Ceren, primary, Durer, Seren, additional, Shafqat, Madeeha, additional, Shah, Zunairah, additional, Sadiq, Maryam, additional, Fraz, Muhammad Asad, additional, Ahmad, Malik Qistas, additional, Fazeel, Hafiz Muhammad, additional, Samuel, Sharoon, additional, Malik, Mustafa Nadeem, additional, Lakhani, Midhat, additional, Sohail, Chaudhry Saad, additional, Qureshi, Anum, additional, and Anwer, Faiz, additional

Published
2018
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16. Diagnostic and Prognostic Role of Fecal Calprotectin As a Biomarker for Gastrointestinal Graft Versus Host Disease: A Systematic Review of Literature

Author

Rafae, Abdul, primary, Malik, Mustafa Nadeem, additional, Khan, Ali Younas, additional, Qureshi, Anum, additional, Abu Zar, Muhammad, additional, Durer, Ceren, additional, Durer, Seren, additional, Kamal, Ahmad, additional, Selene, Insija Ilyas, additional, Jose, Jemin Aby, additional, Khalil, Muhammad Jahanzeb, additional, Fazeel, Hafiz Muhammad, additional, Usman, Muhammad, additional, Ijaz, Awais, additional, and Anwer, Faiz, additional

Published
2018
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17. Reduced-Intensity Conditioning Versus Myeloablative Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients with Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis of Randomized Trials

Author

Kamal, Ahmad, primary, Abu Zar, Muhammad, additional, Fazeel, Hafiz Muhammad, additional, Durer, Seren, additional, Durer, Ceren, additional, Hassan, Syed Shabee, additional, Malik, Mustafa Nadeem, additional, Rafae, Abdul, additional, Ijaz, Faiqa, additional, Aslam, Shehroz, additional, Anwer, Faiz, additional, and Hamadani, Mehdi, additional

Published
2018
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18. Myelofibrosis Drug Development through the Decade: Novel JAK Inhibitors

Author

Khan, Ali Younas, primary, Tariq, Muhammad Junaid, additional, Usman, Muhammad, additional, Ijaz, Awais, additional, Rafae, Abdul, additional, Malik, Mustafa Nadeem, additional, Fazeel, Hafiz Muhammad, additional, Nunes Cavalcante Parr, Nadia Carenina, additional, Fraz, Muhammad Asad, additional, Khalil, Muhammad Jahanzeb, additional, Jose, Jemin Aby, additional, Durer, Seren, additional, Durer, Ceren, additional, and Anwer, Faiz, additional

Published
2018
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19. Efficacy and Safety of Daratumumab Based Regimens for Multiple Myeloma: A Systematic Review and Meta-Analysis

Author

Abu Zar, Muhammad, primary, Kamal, Ahmad, additional, Khan, Ali Younas, additional, Malik, Saad Ullah, additional, Malik, Mustafa Nadeem, additional, Rafae, Abdul, additional, Durer, Ceren, additional, Durer, Seren, additional, Selene, Insija Ilyas, additional, Qureshi, Anum, additional, Jose, Jemin Aby, additional, Fazeel, Hafiz Muhammad, additional, Shah, Zunairah, additional, Rehman, Muhammad Adil, additional, and Anwer, Faiz, additional

Published
2018
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20. An unmet challenge of primary plasma cell leukemia: A systematic review of its unique biology, efficacy of conventional, and high dose therapy.

Author

Malik, Saad, primary, Raina, Ammad, additional, Akbar, Faisal, additional, Fazeel, Hafiz Muhammad, additional, Ahmad, Malik Qistas, additional, Kumar, Vijay, additional, Faridi, Warda, additional, Malik, Asad, additional, Tenneti, Pavan, additional, Sardar, Muhammad, additional, Lal, Amar, additional, Warraich, Zabih, additional, Rauf, Abdul, additional, Iftikhar, Ahmad, additional, Warraich, Sami, additional, and Anwer, Faiz, additional

Published
2018
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21. Abstract 16460: Dual Antiplatelet Therapy for Three Months Followed by Monotherapy is Non-inferior to One Year Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention- A Systematic Review and Meta-Analysis

Author

Anwar, Muhammad Fazeel, Khan, Behram A, Hassan, Syeda Fatima, Nasreen, Sarwat, Malik, Saad Ullah, Fazeel, Hafiz Muhammad, Tameez Ud Din, Asim, Chung, Jacqueliene, and Mirza, Mohsin

Abstract

Introduction:Dual antiplatelet therapy (DAPT) is recommended as a standard treatment for patients with the acute coronary syndrome (ACS) who have undergone percutaneous coronary intervention (PCI) using drug-eluting stents (DES).The optimal duration for DAPT has been an ongoing debate. Purpose of our study is to compare the safety and efficacy of shorter therapy i.e. DAPT for 3 months, from longer therapy i.e. DAPT for 12 months.Methods:We searched PubMed, Ovid Embase, Web of science, Cochrane library and Clinicaltrials.gov for studies reporting the comparative use of DAPT for 3 months versus 12 months after PCI in patients with ACS. The primary endpoint was all-cause mortality. Secondary outcomes were cardiovascular mortality (CVM), post-PCI myocardial infarction (MI), stent thrombosis, major adverse cardiovascular events (MACE) and target vessel revascularization (TVR).Results:Four studies- three randomized control trials and one retrospective study, with N= 22016 were included. Out of these, 11263 patients received shorter DAPT while 10753 patients received longer DAPT. Our results indicated that shorter DAPT showed similar efficacy to longer DAPT in regards to of all-cause mortality [RR = 0.86 (0.66-1.12), p= 0.225] and CVM [RR = 0.82 (0.52-1.29), p= 0.381]. In terms of safety, there was no difference between the two groups in rates of post-PCI MI [RR = 1.01 (0.86-1.18), p= 0.927], MACE [RR = 0.933 (0.82-1.06), p= 0.274], stroke [RR= 0.98 (0.73-1.31), p= 0.885], stent thrombosis [RR: 0.99 (0.73-1.34), p= 0.937], bleeding events [RR = o.91 (0.75-1.10), p= 0.314] and TVR [.RR= 0.91 (0.81-1.03), p= 0.133].Conclusion:Our study supports that DAPT given for only 3 months followed by monotherapy(either with plavix or ticagrelor) shows comparable efficacy and safety to treatment with DAPT over 12 months in patients post-PCI with DES placement especially after non-ST segment elevation ACS.

Published
2019
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22. Abstract 17211: Safety and Effectiveness of Trans-Catheter versus Surgical Aortic Valve Replacement in Nonagenarians With Severe Aortic Stenosis: A Systematic Review and Meta-Analysis

Author

Ahsan, Muhammad Junaid, Fazeel, Hafiz Muhammad, Malik, Saad Ullah, tameez ud din, asim, Hassan, Syeda, Khan, Behram Ahmed, Hashmi, Mydah S, and Mirza, Mohsin M

Abstract

Introduction:Nonagenarians i.e. age > 90 are usually not considered for surgical aortic valve replacement (SAVR) owing to their increased surgical risk. This patient population is also under represented in clinical trials that have evaluated the role of trans-catheter aortic valve replacement (TAVR) for severe aortic stenosis.So the effectiveness of TAVR as compared to SAVR remains unknown.Objective:To compare safety and effectiveness of TAVR versus SAVR in nonagenarians.Methods:Literature search was performed using PubMed, Embase, Web of science, Cochrane library and clinicaltrials.gov. Databases were systematically searched up to 5-21-2019. Primary end point was 30-day mortality. Secondary end points were post-operative incidences of stroke or transient ischemic attacks, vascular access related complications, acute renal failure, transfusion requirement, length of hospital stay, respectively.The main summary estimate was random effects Risk ratio(RR) with 95% confidence intervals (CIs).Results:Four retrospective studies were included (N= 8389). TAVR was performed in 3112 patients while 5277 patients underwent SAVR. Our study found no difference in 30-days mortality between TAVR and SAVR [RR = 0.91 (0.76 - 1.10), p= 0.318]. TAVR was associated with a significantly reduced risk of post-operative ARF [RR = 0.72 (0.62 - 0.83), p<0.001] and a lower transfusion requirement [RR = 0.71 (0.62 - 0.81), p < 0.001], respectively. There was no difference in risk of stroke/TIA between two groups [RR = 1.01 (0.70 - 1.45), p= 0.957] and risk of vascular access complications was significantly higher with TAVR [RR = 3.39 (2.65 - 4.333), p<0.001].On an average, Length of hospital stay was 3 days less in patients undergoing TAVR (p= 0.037).Conclusion:TAVR was not shown to have an increased risk of short term mortality or stroke along with a better post-operative outcomes when weighed against SAVR in nonagenarians.

Published
2019
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