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Medicinal herbs are modern feed additives for poultry that have antioxidant, anti-microbial, and immune-modulatory impacts. In this study, the protective effects of medicinal natural herbs (Herb-AllTM LIVER) on performance, litter, immunity, biochemical changes, and histopathological changes in broilers fed Mycotoxins-contaminated diets were assessed. One-day-old chicks were randomly assigned into 4 groups (n=120). Group A was fed a standard commercial diet; Group B was fed a standard diet + (Herb-AllTM LIVER); Group C (positive control) was fed a Mycotoxins-contaminated diet, and Group D received a Mycotoxins-contaminated diet + Herb-AllTM LIVER. Performance, litter hygiene, immunity, and histopathological changes were determined. Results indicated that herbal supplements (B and D) significantly improved the body weight gain and FCR of birds. Also, litter hygiene, blood indices, antibody titers, and organ functions were enhanced. In group D, liver and kidney histological architectures were mostly restored, as well as Caspase-3 and TNF expressions were moderately enhanced. It can be concluded that using Herb-AllTM LIVER as a feed additive reduces the adverse effects of Mycotoxins on broilers. [ABSTRACT FROM AUTHOR]