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303 results on '"Fay, Renaud"'

1. Coronary Embolism Among Patients With ST‐Segment–Elevation Myocardial Infarction and Atrial Fibrillation: An Underrecognized But Deadly Association

Author

Popovic, Batric, primary, Varlot, Jeanne, additional, Humbertjean, Lisa, additional, Sellal, Jean Marc, additional, Pace, Nathalie, additional, Hammache, Nefissa, additional, Fay, Renaud, additional, Eggenspieler, Florian, additional, Metzdorf, Pierre Adrien, additional, and Camenzind, Edoardo, additional

Published
2024
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15. Outcomes of patients with decreased arterial oxyhaemoglobin saturation on pulmonary arterial hypertension drugs

Author

Valentin, Simon, primary, Maurac, Arnaud, additional, Sitbon, Olivier, additional, Beurnier, Antoine, additional, Gomez, Emmanuel, additional, Guillaumot, Anne, additional, Textoris, Laura, additional, Fay, Renaud, additional, Savale, Laurent, additional, Jaïs, Xavier, additional, Montani, Davis, additional, Picard, Francois, additional, Mornex, Jean-Francois, additional, Prevot, Grégoire, additional, Chabot, Francois, additional, Humbert, Marc, additional, and Chaouat, Ari, additional

Published
2021
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20. NEW DIALYSIS TECHNIQUES

Author

Laville, Maurice, Dorval, Marc, Fort Ros, Joan, Fay, Renaud, Cridlig, Joelle, Nortier, Joelle L, Juillard, Laurent, Dębska-Ślizień, Alicja, Fernandez Lorente, Loreto, Thibaudin, Damien, Franssen, Casper FM, Schulz, Michael, Moureau, Frederique, Loughraieb, Nathalie, and Rossignol, Patrick

Published
2014

21. Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post-discharge

Author

Rossignol, Patrick, Fay, Renaud, Girerd, Nicolas, Zannad, Faiez, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), PR, RF, NG, and FZ are supported by the RHU Fight‐HF, a public grant overseen by the French National Research Agency (ANR) as part of the second 'Investissements d'Avenir' program (ANR‐15‐RHUS‐0004) and by the French PIA project 'Lorraine Université d'Excellence' (ANR‐15‐IDEX‐04‐LUE), ANR-15-IDEX-0004,LUE,Isite LUE(2015), ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), BOZEC, Erwan, ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID, Combattre l'insuffisance cardiaque - - FIGHT-HF2015 - ANR-15-RHUS-0004 - RHUS - VALID, Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), and ANR-15-IDEX-0004,LUE (ISITE),Lorraine Université d'Excellence(2016)

Subjects
Heart Failure, lcsh:Diseases of the circulatory (Cardiovascular) system, Monitoring, Short Communication, Aftercare, Heart failure with reduced ejection fraction, Patient Discharge, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Kidney function, Hyperkalaemia, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, lcsh:RC666-701, Creatinine, Estimated plasma volume, Potassium, Humans, Plasma Volume, Hypokalaemia
Abstract

International audience; Aims: Congestive status, serum potassium, and renal function are major determinants of outcomes as well as critical elements for adjusting drug therapy in heart failure (HF) patients. This study aimed at describing the daily variations in estimated plasma volume (ePV, a surrogate of congestion computed from haemoglobin and haematocrit), blood potassium, and estimated glomerular filtration rate during 2 months post-hospitalization for decompensated HF with reduced ejection fraction.Methods and results: The study was conducted in a single tertiary referral centre. Capillary blood samples were drawn by study nurses at home (7-12 am), and haematocrit, blood haemoglobin, creatinine, and potassium were measured using an approved home-based device (ABOTT i-STAT) (ClinicalTrials.gov: NCT01655134). Among the 15 home-monitored patients, two patients died (one suddenly), and one was readmitted for ischaemic acute pulmonary oedema, with a subsequent acute coronary syndrome, and did not have a complete 2-month follow-up. The 5-day-a-week biological home monitoring revealed an ePV >5.5 mL/g Hb, suggestive of undiagnosed residual congestion at discharge in 3 out the 15 patients. It was possible to document a number of episodes of hyperkalaemia (>5: mean ± standard deviation: 2.2 ± 2.2 or 5.5: 1.7 ± 1.6 mmol/L), hypokalaemia ( 20%: 1.3 ± 1.8 or 30%: 0.7 ± 1.2) and recongestion (ePV rise above 10%: 1.4 ± 1.5, 15%: 2.3 ± 2.4, 5.5 mL/g Hb: 1.8 ± 2.6) episodes indicative of clinically relevant and potentially actionable cardiorenal and electrolytic patterns.Conclusions: Our findings demonstrate that a 5-day-a-week home monitoring combining haemoglobin/haematocrit, potassium, and creatinine measurements was able to capture a substantial number of clinically relevant cardiorenal and electrolyte events which are frequently overlooked and potentially actionable. Whether acting on these events may help optimizing renin angiotensin aldosterone system inhibitors and diuretic therapy warrants further dedicated testing. The ongoing HERMES HF study (NCT04050904) is assessing the short-term feasibility and safety of such a monitoring strategy, complemented by a decision support system, and generating recommendations based on ESC clinical guidelines in patients discharged after an episode of worsening heart failure with reduced ejection fraction.

Published
2020

30. Response to Letter by Hnid

Author

Kearney-Schwartz, Anna, Rossignol, Patrick, Bracard, Serge, Felblinger, Jacques, Fay, Renaud, Boivin, Jean-Marc, Lecompte, Thomas, Lacolley, Patrick, Benetos, Athanase, and Zannad, Faiez

Published
2009
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36. Echocardiographic diastolic function evolution in patients with an anterior Q-wave myocardial infarction: insights from the REVE-2 study

Author

Ferreira, Joao Pedro, Bauters, Christophe, Eschalier, Romain, Lamiral, Zohra, Fay, Renaud, Huttin, Olivier, Girerd, Nicolas, Zannad, Faiez, Pinet, Florence, Rossignol, Patrick, Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Service de Médecine Nucléaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Service de Médecine Nucléaire [Nancy]

Subjects
Adult, Male, Time Factors, Galectin 3, Galectins, Ventricular Function, Left, Electrocardiography, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diastole, Original Research Articles, Galectin‐3, Natriuretic Peptide, Brain, Cardiac remodelling, Humans, Original Research Article, Prospective Studies, Anterior Wall Myocardial Infarction, Aged, Ventricular Remodeling, Stroke Volume, Blood Proteins, Middle Aged, Myocardial infarction, Echocardiography, Diastolic dysfunction, Collagen peptides, Female, Follow-Up Studies
Abstract

Aims Myocardial fibrosis plays a key role in the development of adverse left ventricular remodelling after myocardial infarction (MI). This study aimed to determine whether the circulating levels of BNP, collagen peptides, and galectin‐3 are associated with diastolic function evolution (both deterioration and improvement) at 1 year after an anterior MI. Methods and results The REVE‐2 is a prospective multicentre study including 246 patients with a first anterior Q‐wave MI. Echocardiographic assessment was performed at hospital discharge and ±1 year after MI. BNP, galectin‐3, and collagen peptides were measured ±1 month after MI. Left ventricular diastolic dysfunction (DD) was defined according to the presence of at least two criteria of echocardiographic parameters: septal e′ 6 mg/L [odds ratio (OR) = 5.29; 95% confidence interval (CI) = 1.05–26.66; P = 0.044], galectin‐3 > 13 μg/L (OR = 5.99; 95% CI = 1.18–30.45; P = 0.031), and BNP > 82 ng/L (OR = 10.25; 95% CI = 2.36–44.50; P = 0.002) quantified at 1 month post‐MI were independently associated with 1 year DD. Follow‐up of the 137 patients with DD at baseline among the 159 patients showed that 36 patients (26%) had a normalized diastolic function at 1 year post‐MI. Patients with a BNP > 82 ng/L were less likely to improve diastolic function (OR = 0.06; 95% CI = 0.01–0.28; P = 0.0003). Conclusions The present study suggests that circulating levels of amino‐terminal propeptide of type III procollagen, galectin‐3, and BNP may be independently associated with new‐onset DD in post‐MI patients.

Published
2018

39. Impact of eplerenone on cardiovascular outcomes in heart failure patients with hypokalaemia

Author

Rossignol, Patrick, Girerd, Nicolas, Bakris, George, Vardeny, Orly, Claggett, Brian, McMurray, John J. V., Swedberg, Karl, Krum, Henry, van Veldhuisen, Dirk J., Shi, Harry, Spanyers, Sean, Vincent, John, Fay, Renaud, Lamiral, Zohra, Solomon, Scott D., Zannad, Faiez, Pitt, Bertram, and Cardiovascular Centre (CVC)

Subjects
CHRONIC KIDNEY-DISEASE, MORTALITY, nutritional and metabolic diseases, Heart failure, Prognosis, WORSENING RENAL-FUNCTION, LOW SERUM POTASSIUM, EMPHASIS-HF, HYPERKALEMIA, Eplerenone, MILD PATIENTS HOSPITALIZATION, BENEFITS, Potassium, SURVIVAL, MINERALOCORTICOID RECEPTOR ANTAGONIST, hormones, hormone substitutes, and hormone antagonists
Abstract

AimsAlthough hypokalaemia is common among patients with heart failure (HF), the prognostic significance of baseline hypokalaemia and hypokalaemia during follow-up in HF patients receiving a mineralocorticoid receptor antagonist (MRA) remains uncertain. Methods and resultsResults of the EMPHASIS-HF trial in patients (n = 2737) with HF and reduced EF with mild symptoms, randomized to eplerenone or placebo, were analysed with regard to the presence or occurrence of hypokalaemia (serum K+ 4.0 mmol/L at 1 month after randomization mediated 26.0% (0.6-51.4%) of the eplerenone treatment effect (P = 0.04). ConclusionIn HF patients receiving optimal therapy but not treated with eplerenone, baseline hypokalaemia was associated with worse outcomes. Conversely, hypokalaemia amplified the treatment effect of eplerenone.

Published
2017

40. Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage

Author

Ibarrola, Jaime, primary, Arrieta, Vanessa, additional, Sádaba, Rafael, additional, Martinez-Martinez, Ernesto, additional, Garcia-Peña, Amaia, additional, Alvarez, Virginia, additional, Fernández-Celis, Amaya, additional, Gainza, Alicia, additional, Santamaría, Enrique, additional, Fernández-Irigoyen, Joaquin, additional, Cachofeiro, Victoria, additional, Zalba, Guillermo, additional, Fay, Renaud, additional, Rossignol, Patrick, additional, and López-Andrés, Natalia, additional

Published
2018
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41. Cardiac remodeling following reperfused acute myocardial infarction is linked to the concomitant evolution of vascular function as assessed by cardiovascular magnetic resonance

Author

Huttin, Olivier, primary, Mandry, Damien, additional, Eschalier, Romain, additional, Zhang, Lin, additional, Micard, Emilien, additional, Odille, Freddy, additional, Beaumont, Marine, additional, Fay, Renaud, additional, Felblinger, Jacques, additional, Camenzind, Edoardo, additional, Zannad, Faïez, additional, Girerd, Nicolas, additional, and Marie, Pierre Y., additional

Published
2017
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42. Impact of eplerenone on cardiovascular outcomes in heart failure patients with hypokalaemia

Author

Rossignol, Patrick, primary, Girerd, Nicolas, additional, Bakris, George, additional, Vardeny, Orly, additional, Claggett, Brian, additional, McMurray, John J.V., additional, Swedberg, Karl, additional, Krum, Henry, additional, van Veldhuisen, Dirk J., additional, Shi, Harry, additional, Spanyers, Sean, additional, Vincent, John, additional, Fay, Renaud, additional, Lamiral, Zohra, additional, Solomon, Scott D., additional, Zannad, Faiez, additional, and Pitt, Bertram, additional

Published
2016
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43. Central pulse pressure is a determinant of heart and brain remodeling in the elderly

Author

Verger, Antoine, van Der Gucht, Axel, Guedj, Eric, Marie, Pierre-Yves, Hossu, Gabriela, Mandry, Damien, Morel, Olivier, Perrin, Mathieu, Fay, Renaud, Benetos, Athanase, Joly, Laure, Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'Investigation Clinique - Innovation Technologique [Nancy] (CIC-IT), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Radiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Service de médecine gériatrique, and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; OBJECTIVE:The sustained elevation of blood pressure (BP) and especially of central pulse pressure (cPP) leads to heart and brain damage. This pilot study was aimed to precise the relationships between peripheral and central BP levels, and the remodeling of heart and brain as objectively quantified by cardiac MRI and brain F-fluorodeoxyglucose (FDG)-PET imaging in the elderly.METHODS:Twenty-eight apparently healthy elderly individuals (66-85 years old, 14 women) were prospectively recruited and allocated into two half groups, one with and one without hypertension, and all were referred for the quantitative determinations of peripheral and central BP using applanation tonometry, indexed left ventricular mass (per m of body surface area) using cardiac MRI, and brain metabolism with a voxel-based analysis of FDG-PET images adjusted for age and sex.RESULTS:Indexed left ventricular mass, reflecting cardiac remodeling, was correlated with the overall pressure variables involving both peripheral and central levels of systolic and pulse pressure (all P ≤ 0.001). By contrast, brain metabolism was significantly correlated with only cPP (P

Published
2015

44. Echocardiographic diastolic function evolution in patients with an anterior Q‐wave myocardial infarction: insights from the REVE‐2 study.

Author

Ferreira, João Pedro, Bauters, Christophe, Eschalier, Romain, Lamiral, Zohra, Fay, Renaud, Huttin, Olivier, Girerd, Nicolas, Zannad, Faiez, Pinet, Florence, and Rossignol, Patrick

Subjects
ECHOCARDIOGRAPHY, MYOCARDIAL infarction, VENTRICULAR ejection fraction
Abstract

Aims: Myocardial fibrosis plays a key role in the development of adverse left ventricular remodelling after myocardial infarction (MI). This study aimed to determine whether the circulating levels of BNP, collagen peptides, and galectin‐3 are associated with diastolic function evolution (both deterioration and improvement) at 1 year after an anterior MI. Methods and results: The REVE‐2 is a prospective multicentre study including 246 patients with a first anterior Q‐wave MI. Echocardiographic assessment was performed at hospital discharge and ±1 year after MI. BNP, galectin‐3, and collagen peptides were measured ±1 month after MI. Left ventricular diastolic dysfunction (DD) was defined according to the presence of at least two criteria of echocardiographic parameters: septal e′ < 8 cm/s, lateral e′ < 10 cm/s, and left atrial volume ≥ 34 mL/m2. At baseline, 87 (35.4%) patients had normal diastolic function and 159 (64.6%) patients had DD. Follow‐up of 61 patients among the 87 patients with normal diastolic function at baseline showed that 22 patients (36%) developed DD at 1 year post‐MI. The circulating levels of amino‐terminal propeptide of type III procollagen > 6 mg/L [odds ratio (OR) = 5.29; 95% confidence interval (CI) = 1.05–26.66; P = 0.044], galectin‐3 > 13 μg/L (OR = 5.99; 95% CI = 1.18–30.45; P = 0.031), and BNP > 82 ng/L (OR = 10.25; 95% CI = 2.36–44.50; P = 0.002) quantified at 1 month post‐MI were independently associated with 1 year DD. Follow‐up of the 137 patients with DD at baseline among the 159 patients showed that 36 patients (26%) had a normalized diastolic function at 1 year post‐MI. Patients with a BNP > 82 ng/L were less likely to improve diastolic function (OR = 0.06; 95% CI = 0.01–0.28; P = 0.0003). Conclusions: The present study suggests that circulating levels of amino‐terminal propeptide of type III procollagen, galectin‐3, and BNP may be independently associated with new‐onset DD in post‐MI patients. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal ObesityNovelty and Significance

Author

Eschalier, Romain, Rossignol, Patrick, Kearney-Schwartz, Anna, Adamopoulos, Chris, Karatzidou, Kyparissi, Fay, Renaud, Mandry, Damien, Marie, Pierre-Yves, Zannad, Faiez, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Service de Cardiologie Maladies Vasculaires [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Radiologie adultes [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Service de Cardiologie [CHRU Nancy], UL, IADI, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Service de Médecine Nucléaire [CHRU Nancy]

Subjects
diastolic, obesity, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, abdominal, blood pressure, heart failure, procollagen, ventricular remodeling, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Incidence and prevalence of abdominal obesity (AO) are growing exponentially. Subjects with AO are at higher risk of developing heart failure. The purpose of the study was to investigate early changes in cardiac and arterial structure and function and extracellular matrix biomarkers in normotensive healthy subjects with AO. Subjects with AO and age- and sex-matched controls underwent echocardiography, MRI (cardiac remodeling index), carotid intima-media thickness, pulse wave velocity, and blood fibrosis biomarkers measurements. We enrolled 87 subjects with AO and 53 controls. Although normotensive, subjects with AO had higher systolic blood pressure (BP; 122±11 versus 116±11 mm Hg; P=0.003), left ventricular mass (94±24 versus 84±21 g; P=0.034), and cardiac remodeling index (0.67±0.16 versus 0.60±0.10 g/mL; P=0.026) but unchanged carotid intima-media thickness and pulse wave velocity. Diastolic dysfunction (E'

Published
2014

47. Normal Values of Bony, Cartilaginous, and Labral Coverage of the Infant Hip in MR Imaging

Author

Fay Renaud, Laurence Mainard-Simard, Meyer Jean-Baptiste, Pierre Journeau, Pierre Lascombes, Hanspeter Huber, Service de Chirurgie d’Orthopédie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Department of Surgery [University Children’s Hospital of Zürich], University Children’s Hospital Zurich, Division of Paediatrics Orthopaedic [Geneva], Geneva University Hospital (HUG), Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), and Université de Lorraine (UL)

Subjects
Cartilage, Articular, Male, musculoskeletal diseases, Adolescent, Normal values, 03 medical and health sciences, 0302 clinical medicine, Reference Values, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Child, Retrospective Studies, Hip dysplasia, 030222 orthopedics, ddc:618, medicine.diagnostic_test, business.industry, Cartilage, Infant, Magnetic resonance imaging, Acetabulum, General Medicine, Anatomy, medicine.disease, Mr imaging, Magnetic Resonance Imaging, medicine.anatomical_structure, Cross-Sectional Studies, ROC Curve, Reference values, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Hip Joint, business, Nuclear medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background: Magnetic resonance imaging (MRI) is becoming more popular in the evaluation of residual hip dysplasia. Normal values of the bony, cartilaginous, and labral coverage in MRI are not published. The aim of our study was to establish reference values for normal hips at different ages and to assess the interobserver variability of such measurements.Methods: MRIs of 115 normal hips in 73 children were analyzed. The bony, cartilaginous, and labral acetabular index (AI bone/cartilage/labrum) was measured in the coronal plane just posterior to the inferior branch of the triradiate cartilage. To determine interobserver variability, measurements were made by 3 different observers. Percentile graphs were established from the Student t distribution of the measurements grouped by 2 years of age.Results: Global interobserver variability for the measurement of the AI bone was excellent [intraclass correlation coefficient (ICC)=0.88]. For the AI cartilage and labrum the ICC was somewhat lower (ICC 0.78) but still rated as good. Age-dependent percentile graphs of the AI bone, cartilage, and labrum are presented. Although the AI bone decreased during childhood, the AI cartilage as well as the AI labrum stays relatively constant with the 50 percentile around 5 degrees for the AI cartilage and −5 degrees for the AI labrum. The 90 percentile is around 10 degrees for the AI cartilage and 0 degrees for the AI labrum.Conclusions: We present percentile graphs of age-related normal values. Although bony coverage increases during childhood, cartilaginous and labral coverage stay constant. We think that measuring an AI cartilage above 10 degrees or an AI cartilage above 0 degrees might be a good additional parameter to classify hips into the group of residual dysplasia.Clinical Relevance: The knowledge of normal values for cartilaginous and labral coverage is a valuable adjunct in decision-making for secondary surgery in residual dysplasia. This was a retrospective cross-sectional study.

Published
2014

48. Extracellular Matrix Turnover Biomarkers Predict Long-Term Left Ventricular Remodeling After Myocardial Infarction

Author

Eschalier, Romain, Fertin, Marie, Fay, Renaud, Bauters, Christophe, Zannad, Faiez, Pinet, Florence, Rossignol, Patrick, Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Médecine Nucléaire [CHRU Nancy], and Pinet, Florence

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience

Published
2013

49. Beneficial Effects of Norepinephrine Alone on Cardiovascular Function and Tissue Oxygenation in a Pig Model of Cardiogenic Shock

Author

Beurton, Alexandra, primary, Ducrocq, Nicolas, additional, Auchet, Thomas, additional, Joineau-Groubatch, Frédérique, additional, Falanga, Aude, additional, Kimmoun, Antoine, additional, Girerd, Nicolas, additional, Fay, Renaud, additional, Vanhuyse, Fabrice, additional, Tran, Nguyen, additional, and Levy, Bruno, additional

Published
2016
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50. Comprehensive monitoring of cardiac remodeling with aortic stroke volume values provided by a phase-contrast MRI sequence

Author

Marie, Pierre Y., primary, Mandry, Damien, additional, Huttin, Olivier, additional, Micard, Emilien, additional, Bonnemains, Laurent, additional, Girerd, Nicolas, additional, Beaumont, Marine, additional, Fay, Renaud, additional, Joly, Laure, additional, Rossignol, Patrick, additional, Benetos, Athanase, additional, Felblinger, Jacques, additional, and Zannad, Faïez, additional

Published
2016
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