32 results on '"Fawziya Al Khalaf"'
Search Results
2. Virtual training on advanced hybrid closed‐loop system MiniMed 780G in a teenager with type 1 diabetes previously treated with multiple daily injections: A case report
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Goran Petrovski, Judith Campbell, Douha Almajali, Fawziya Al Khalaf, and Khalid Hussain
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advanced hybrid closed‐loop system ,multiple daily injections ,type 1 diabetes ,virtual training ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Virtual pump training program for novel devices in people with type 1 diabetes on multiple daily injections can be an effective tool to initiate an advanced HCL system (MiniMed 780G) and to improve glycemic control in a safe manner without severe hypoglycemia and hyperglycemia.
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- 2021
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- View/download PDF
3. The effect of advanced hybrid closed loop system on glycated hemoglobin (HbA1c) in a young male with type 1 diabetes mellitus and growth hormone treatment: A case report
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Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Khalid Hussain, Emma Day, and Maheen Pasha
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advanced hybrid closed‐loop system ,growth hormone deficiency ,growth hormone treatment ,type 1 diabetes ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract The advanced hybrid closed loop system MiniMed 780G can be an effective tool to improve glycemic control and decrease the health burden in a young male with type 1 diabetes and short stature.
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- 2021
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4. Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar
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Arun Prasath Lakshmanan, Amira Kohil, Farah El Assadi, Sara Al Zaidan, Shaikha Al Abduljabbar, Dhinoth Kumar Bangarusamy, Fawziya Al Khalaf, Goran Petrovski, and Annalisa Terranegra
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Akkermansia ,T1DM ,Arabic diet ,ethnicity ,HbA1c ,CSII therapy ,Nutrition. Foods and food supply ,TX341-641 - Abstract
In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10.5 ± 3.53 years. The stool sample was used to measure microbial composition by 16s rDNA sequencing method. The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus Akkermansia was significantly enriched in the subjects without CSII therapy. Moreover, genus Akkermansia was higher in the subjects with poor glycemic control (HbA1c > 7.5%). When we classified the subjects based on dietary patterns and nationality, Akkermansia was significantly enriched in Qataris subjects without the CSII therapy consuming Arabic diet than expatriates living in Qatar and eating a Western/mixed diet. Thus, this pilot study showed that abundance of Akkermansia is dependent on the Arabic diet only in poorly controlled Qataris T1DM patients, opening new routes to personalized treatment for T1DM in Qataris pediatric subjects. Further comprehensive studies on the relation between the Arabic diet, ethnicity, and Akkermansia are warranted to confirm this preliminary finding.
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- 2021
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5. Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar
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Noor Hamed, Fawziya Al-Khalaf, Sara Al-Khawaga, Khalid Hussain, Tasneem Abdel-Karim, Goran Petrovski, Sabri Boughorbel, Reem Hasnah, Amira Saeed, Houda Afyouni, Shihab Mundekkadan, Ahmed Elawwa, Basma Haris, Maryam Al-Maadheed, Amel Khalifa, Saras Saraswathi, Mahmoud Alzyoud, Shayma Mohammed, and Ahmed Shamekh
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Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,endocrine system diseases ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Maturity onset diabetes of the young ,Diseases of the endocrine glands. Clinical endocrinology ,Neonatal diabetes mellitus ,Diabetes mellitus ,Prevalence ,Internal Medicine ,medicine ,Humans ,Childhood Diabetes Mellitus ,Prospective Studies ,Child ,Qatar ,Type 1 diabetes ,business.industry ,Incidence ,Incidence (epidemiology) ,Infant, Newborn ,Infant ,Articles ,General Medicine ,medicine.disease ,RC648-665 ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Child, Preschool ,Original Article ,Female ,business ,Pediatric diabetes - Abstract
Aims/Introduction To study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. Materials and methods All patients (aged 0–18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association guidelines were used to classify types of diabetes mellitus. The incidence and prevalence of all the different types of diabetes mellitus were calculated. Results Total number of children with diabetes mellitus was 1,325 (type 1 n = 1,096, ≥1 antibody; type 2 n = 104, type 1B n = 53; maturity onset diabetes of the young n = 20; monogenic autoimmune n = 4; neonatal diabetes mellitus n = 10;, syndromic diabetes mellitus n = 23; and double diabetes mellitus n = 15). The incidence and prevalence of type 1 diabetes were 38.05 and 249.73 per 100,000, respectively, and for type 2 were 2.51 and 23.7 per 100,000, respectively. The incidence of neonatal diabetes mellitus was 34.4 per 1,000,000 live births, and in indigenous Qataris the incidence was 43.6 per 1,000,000 live births. The prevalence of type 1 diabetes and type 2 diabetes in Qatari children was double compared with other nationalities. The prevalence of maturity onset diabetes of the young in Qatar was 4.56 per 100,000. Conclusions This is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type 1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non‐Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world. GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type 1B diabetes mellitus., This is the first comprehensive, prospective study from the Middle East North Africa region to systematically study the causes of diabetes in every child in the State of Qatar. The State of Qatar has the fourth highest incidence of type 1 diabetes in the world. The incidence of type 2 diabetes is much higher in Qatar than in Western countries. Both type 1 and type 2 diabetes are more common in the Qatari population than the non‐Qatari population. Mutations in GCK were the most common cause of maturity onset diabetes of the young, and mutations in the PTF1A and INS genes were the most common cause of neonatal diabetes in this population.
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- 2021
6. The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar
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Ahmed Elawwa, Maryam Al-Maadheed, Tasneem Abdel-Karim, Basma Haris, Ahmed Abdellatief, Goran Petrovski, Shayma Mohammed, Mahmoud Al Zyoud, Amel Khalifa, Khalid Hussain, Fawziya Al-Khalaf, and Houda Afyouni
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Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Population ,Disease ,Human leukocyte antigen ,Asymptomatic ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Prevalence ,medicine ,Humans ,Family history ,Child ,education ,Qatar ,Autoantibodies ,education.field_of_study ,Type 1 diabetes ,Glutamate Decarboxylase ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Celiac Disease ,Diabetes Mellitus, Type 1 ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,Age of onset ,business - Abstract
Objectives Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar. Methods All children (aged 0–18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected. Results Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6–10 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening. Conclusions The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.
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- 2021
7. Successful transitioning children and adolescents with type 1 diabetes from multiple daily injections to advanced hybrid closed-loop system in 10 days: a prospective intervention study on MiniMed 780G system
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Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Emma Day, Douha Almajaly, Khalid Hussain, Maheen Pasha, Fareeda Umer, Manar Hamdan, and Amel Khalifa
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Blood Glucose ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Blood Glucose Self-Monitoring ,General Medicine ,Endocrinology ,Diabetes Mellitus, Type 1 ,Insulin Infusion Systems ,Internal Medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Prospective Studies ,Child - Published
- 2021
8. Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar
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Khalid Hussain, Fawziya Al-Khalaf, Idris Mohammed, Ikhlak Ahmed, Maryam Al-Maadheed, Goran Petrovski, Sara Al-Khawaga, Shayma Mohammed, Ahmed Shamekh, Najeeb Syed, Hakeem Almabrazi, Zohreh Tatari-Calderone, Saras Saraswathi, Iman Hawari, Amira Saeed, Noor Hamed, Shihab Mundekkadan, Houda Afyouni, Mohammed Yousuf Karim, Amel Khalifa, Basma Haris, Ahmed Elawwa, Sanaa Sharari, Mahmoud Zyoud, and Tasneem Abdel-Karim
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Male ,medicine.medical_specialty ,endocrine system diseases ,Adolescent ,Science ,Human leukocyte antigen ,Article ,Histocompatibility Antigens ,Epidemiology ,medicine ,Prevalence ,Humans ,Genetic Predisposition to Disease ,Allele ,Risk factor ,Child ,Qatar ,Alleles ,Autoantibodies ,Type 1 diabetes ,Multidisciplinary ,business.industry ,Incidence (epidemiology) ,Incidence ,Haplotype ,Autoantibody ,Infant, Newborn ,nutritional and metabolic diseases ,Infant ,medicine.disease ,Diabetes Mellitus, Type 1 ,Haplotypes ,Child, Preschool ,Immunology ,Medicine ,Female ,business - Abstract
To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. The incidence of T1DM in Qatar is the fourth highest in the world, IA2 autoantibody was the most specific with some patients only having ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 autoantibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.
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- 2021
9. The Epidemiology and Genetic Analysis of Children With Idiopathic Type 1 Diabetes in the State of Qatar
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Maryam Al-Maadheed, Goran Petrovski, Basma Haris, Ahmed Elawwa, Amel Khalifa, Tasneem Abdel-Karim, Fawziya Al-Khalaf, Khalid Hussain, Shayma Mohammed, Houda Afyouni, and Mahmoud Al Zyoud
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insulin ,Type 1 diabetes ,Pediatrics ,medicine.medical_specialty ,diabetes ,medicine.diagnostic_test ,Diabetic ketoacidosis ,autoantibodies ,business.industry ,Wolfram syndrome ,Endocrinology, Diabetes and Metabolism ,Autoantibody ,Context (language use) ,medicine.disease ,Maturity onset diabetes of the young ,pediatric ,Diabetes mellitus ,medicine ,pancreas ,glucose ,business ,Clinical Research Articles ,AcademicSubjects/MED00250 ,Genetic testing - Abstract
Context Idiopathic type 1 diabetes is characterized by the absence of autoantibodies and the underlying mechanisms are not clear. Objective We aimed to study the epidemiology, describe the clinical characteristics, and report results of genetic studies in pediatric patients with idiopathic type 1 diabetes. Methods This was a prospective study of type 1 diabetes patients attending Sidra Medicine from 2018 to 2020. Autoantibodies (GAD65, IAA, IA-2A, and ZnT8) were measured and genetic testing was undertaken in patients negative for autoantibodies to rule out monogenic diabetes. Demographic and clinical data of patients with idiopathic type 1 diabetes were compared with patients with autoimmune type 1 diabetes. Results Of 1157 patients with type 1 diabetes, 63 were antibody-negative. Upon genome sequencing, 4 had maturity onset diabetes of the young (MODY), 2 had Wolfram syndrome, 1 had H syndrome, and 3 had variants of uncertain significance in MODY genes; 53 patients had idiopathic type 1 diabetes. The most common age of diagnosis was 10 to 14 years. C-peptide level was low but detectable in 30 patients (56.6%) and normal in 23 patients (43.4%) The average body mass index was in the normal range and 33% of the patients had a history of diabetic ketoacidosis (DKA). Conclusion Four percent of the children had idiopathic type 1 diabetes. There were statistically significant differences in the C-peptide level and insulin requirement between the 2 groups. DKA was less common in the idiopathic group. Mutations in MODY genes suggest the importance of autoantibody testing and genetic screening for known causes of monogenic diabetes in idiopathic type 1 diabetes. The mechanism of idiopathic type 1 diabetes is unknown but could be due to defects in antibody production or due to autoantibodies that are not yet detectable or discovered.
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- 2021
10. Sib-pair subgroup familial type 1 diabetes mellitus in children in the state of Qatar
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Houda, Afyouni, Basma, Haris, Najeeb, Syed, Ikhlak, Ahmed, Noor, Hamed, Tasneem, Abdel-Karim, Shayma, Mohammed, Amel, Khalifa, Maryam, Al-Maadheed, Mahmoud, Zyoud, Ahmed, Elawwa, Fawziya, Al-Khalaf, Goran, Petrovski, and Khalid, Hussain
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Diabetes Mellitus, Type 1 ,Multidisciplinary ,Adolescent ,Child, Preschool ,Siblings ,Humans ,Child ,HLA-DRB3 Chains ,Qatar ,Autoantibodies - Abstract
Background Type 1 diabetes is the most common type of diabetes mellitus (DM) in children. It can be sporadic in onset or cluster in families, which comprises parent-offspring and sib-pair subgroups. The risk of developing DM in first-degree relatives of affected individuals is 8–15 fold higher. There is limited data about familial DM from the Gulf region. This study aims to describe the clinical, biochemical and genetic characteristics of sib-pair familial type 1 diabetes in Qatar. Methods Every child with DM following up at Sidra Medicine was recruited. Data was collected regarding clinical features, family history, type 1 diabetes autoantibodies and whole genome sequencing was performed. Genetic analysis for MODY genes and HLA association analysis was conducted. Results 44 families with sib-pair familial diabetes were identified. Of these, 2 families had 4 affected siblings and 5 families had 3 affected siblings. The majority are of Qatari ethnicity and the most common autoantibody was GAD65. The most common age of onset in the proband was 5–9 years while it was 10–14 years in subsequent siblings. The occurrence of DKA & HbA1c levels were lower in the second affected sibling. No relevant MODY gene variants were found. HLA analysis found 15 variants in at least 50% of the subjects. Most common were HLA-F*01*01*01G, HLA- DPA1*01*03*01G, HLA- DRB3*02*02*01G, HLA- E*01*01*01G & DRB4*03*01N. Conclusions The prevalence of sib-pair diabetes is 3.64%. The second affected siblings were older. MODY is unlikely and Class I and II HLA genes was present in sib-pair diabetes.
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- 2022
11. Clinical features, Epidemiology, Autoantibody status, HLA Haplotypes and Genetic Mechanisms of Type 1 diabetes mellitus among Children in Qatar
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Basma Haris, Ikhlak Ahmed, Najeeb Syed, Hakeem Almabrazi, Saras Saraswathi, Sara Al-Khawaga, Amira Saeed, Shihab Mundekkadan, Idris Mohamed, Sanaa Sharari, Iman Hawari, Noor Hamed, Houda Afyouni, Tasneem Abdel-Karim, Shayma Mohammed, Amel Khalifa, Maryam Al-Maadheed, Mahmoud Zyoud, Ahmed Shamekh, Ahmed Elawwa, Fawziya Al-Khalaf, Zohreh Tatari-Calderone, Goran Petrovski, and Khalid Hussain
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endocrine system diseases - Abstract
Aims - To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Methods - Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. Results - 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GAD65 was the most common autoantibody and IA2 was most specific. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, pvalue = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. Conclusions - In this first prospective study, IA2 autoantibody was the most specific, some patients only have ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 antibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.
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- 2021
12. Outpatient clinic-wide psychological screening for children and adolescents with type 1 diabetes in Qatar: An initiative for integrative healthcare in the Gulf region
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Fawziya Al Khalaf, Mona Korayem, Christina H. Vlahou, Ahmed El Awwa, Omar M. Mahmood, Muhammed Waqar Azeem, and Goran Petrovski
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Male ,Adolescent ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Anxiety ,Ambulatory Care Facilities ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Surveys and Questionnaires ,Internal Medicine ,medicine ,Outpatient clinic ,Humans ,Mass Screening ,030212 general & internal medicine ,Child ,Qatar ,Depression (differential diagnoses) ,Glycated Hemoglobin ,Type 1 diabetes ,business.industry ,Depression ,Psychiatric assessment ,medicine.disease ,Mental health ,Mood ,Diabetes Mellitus, Type 1 ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Female ,medicine.symptom ,business ,Clinical psychology - Abstract
Objective To identify culturally appropriate psychological screening measures for children and adolescents with type 1 diabetes in Qatar, determine rates of depressive and anxiety symptoms in a clinical sample, and examine associations between screening measures, demographic variables, medical characteristics, and diabetes treatment outcomes, specifically HbA1c. Methods A total of 150 participants with type 1 diabetes aged 10-17 were recruited. Participants were Arabic or English speaking and of Qatari and non-Qatari nationality. Participants completed the Mood and Feelings Questionnaire (child and parent proxy form), the Spence Children's Anxiety Scale, and the Pediatric Quality of Life, Diabetes version (child and parent proxy form). Glycosylated hemoglobin (HbA1c) on the date of the testing was recorded. Results Approximately ten percent (10.2%) of children and adolescents scored above the cutoff score of 27 indicating clinically significant depressive symptoms, and 12.8% of parents rated their child above the respective cutoff score of 21 for the parent proxy form. Further, 36% of the sample reported clinically significant anxiety symptoms, scoring above the cutoff score of 50. Parent report on their child's quality of life predicted HbA1c (F[6, 140] = 5.42, p = 0.000); B = -0.05, p = 0.002). Conclusions Rates of depressive and anxiety symptoms are comparable to those observed in western countries. Thus, systematic screening for depression and anxiety in children and adolescents with type 1 diabetes should be implemented in Qatar. This will help inform decisions to refer to mental health services and thus provide more integrated care, possibly improving treatment outcomes.
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- 2021
13. Comment on 'One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology' by Breton M and Kovatchev B
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Judith Campbell, Goran Petrovski, Fawziya Al Khalaf, and Khalid Hussain
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Medical Laboratory Technology ,Endocrinology ,business.industry ,Endocrinology, Diabetes and Metabolism ,MEDLINE ,Medicine ,Artificial intelligence ,business ,Control (linguistics) ,computer.software_genre ,computer ,Closed loop ,Natural language processing - Published
- 2021
14. Successful Transitioning Children and Adolescents with Type 1 Diabetes from Multiple Daily Injections to Advanced Hybrid Closed Loop System in 10 Days: A Prospective Intervention Study on MiniMed 780G System
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Amel Khalifa, Manar Hamdan, Judith Campbell, Goran Petrovski, Fareeda Umer, Fawziya Al Khalaf, Khalid Hussain, Douha Almajaly, Emma Day, and Maheen Pasha
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Study phase ,Type 1 diabetes ,medicine.medical_specialty ,business.industry ,Continuous glucose monitoring ,Ethics committee ,medicine.disease ,Intervention studies ,Clinical trial ,Physical therapy ,Medicine ,business ,Closed loop ,Glycemic - Abstract
Background: Advanced Hybrid Closed Loop (AHCL) systems provide superior glycemic control in children and adolescents with Type 1 Diabetes (T1D). Current studies included participants with previous pump and Continuous Glucose Monitoring (CGM) experience. We aimed to study transitioning these patients on Multiple Daily Injections (MDI) without prior pump experience to AHCL systems within a short period, utilizing a structured initiation protocol and the glycemic control they achieved with the MiniMed 780G system. Methods: In this prospective open label single-arm, single-center, clinical investigation, we recruited children and adolescents (aged 7-17 years) with T1D on MDI therapy and HbA1c below 12.5% from Sidra Medicine (Doha, Qatar). All participants followed a structured initiation protocol including 4 steps: step 1: AHCL system assessment (1 hour discussion with educator); step 2: AHCL system training (2-hours sessions in 4 consecutive days with groups of 2 to 3 participants and caregivers); step 3: SAP use for 3 days; step 4: AHCL system use for 12 weeks, cumulating in 10 days from MDI to AHCL initiation. The primary outcome of the study was the change in the time spent in the target in range (TIR) of 70-180 mg/dl and HbA1c from baseline (MDI + CGM, 1 week) to study phase (AHCL, 12 weeks). This study is registered with ClinicalTrials.gov, number NCT04308291, and is completed. Findings: Between October 25, 2020, and February 5, 2021, 34 participants were recruited and all of them completed the 12 weeks study. TIR increased from 42.1±18.7% at baseline to 78.8±6.1% in the study phase ( p 70% and a HbA1c of
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- 2021
15. Author response for 'Outpatient clinic‐wide psychological screening for children and adolescents with type 1 diabetes in Qatar: An initiative for integrative healthcare in the Gulf region'
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Fawziya Al Khalaf, Omar M. Mahmood, Muhammed Waqar Azeem, Christina H. Vlahou, Goran Petrovski, Ahmed El Awwa, and Mona Korayem
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Type 1 diabetes ,medicine.medical_specialty ,business.industry ,Family medicine ,Psychiatric assessment ,Health care ,medicine ,Outpatient clinic ,medicine.disease ,business - Published
- 2020
16. The clinical and genetic characteristics of permanent neonatal diabetes (PNDM) in the State of Qatar
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Amel Khalifa, Hakeem Almabrazi, Reem Hasnah, Saras Saraswathi, Essam M. Abdelalim, Basma Haris, Puthen V. Jithesh, Goran Petrovski, Idris Mohammed, Najeeb Syed, Fawziya Al-Khalaf, El Awwa A, Amira Saeed, Khalid Hussain, and Sara Al-Khawaga
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Blood Glucose ,Male ,HNF1B ,INS ,Pediatrics ,medicine.medical_specialty ,lcsh:QH426-470 ,Neonatal diabetes ,Fanconi–Bickel Syndrome (FBS) ,pancreatic agenesis ,Permanent neonatal diabetes (PNDM) ,Osteochondrodysplasias ,Germinal Center Kinases ,Diabetes Mellitus ,medicine ,Humans ,Qatar ,Glucose Transporter Type 2 ,GCK ,Whole Genome Sequencing ,business.industry ,Incidence ,Infant, Newborn ,Infant ,Original Articles ,Fanconi Syndrome ,Pedigree ,lcsh:Genetics ,Diabetes Mellitus, Type 1 ,Enhancer Elements, Genetic ,Phenotype ,PTF1A ,Female ,Original Article ,Wolcott–Rallison Syndrome (WRS) ,business ,Epiphyses ,Gene Deletion ,Transcription Factors ,Whole Genome Sequencing (WGS) - Abstract
Background Neonatal diabetes mellitus (NDM) is a rare condition that occurs within the first six months of life. Permanent NDM (PNDM) is caused by mutations in specific genes that are known for their expression at early and/or late stages of pancreatic beta‐ cell development, and are either involved in beta‐cell survival, insulin processing, regulation, and release. The native population in Qatar continues to practice consanguineous marriages that lead to a high level of homozygosity. To our knowledge, there is no previous report on the genomics of NDM among the Qatari population. The aims of the current study are to identify patients with NDM diagnosed between 2001 and 2016, and examine their clinical and genetic characteristics. Methods To calculate the incidence of PNDM, all patients with PNDM diagnosed between 2001 and 2016 were compared to the total number of live births over the 16‐year‐period. Whole Genome Sequencing (WGS) was used to investigate the genetic etiology in the PNDM cohort. Results PNDM was diagnosed in nine (n = 9) patients with an estimated incidence rate of 1:22,938 live births among the indigenous Qatari. Seven different mutations in six genes (PTF1A, GCK, SLC2A2, EIF2AK3, INS, and HNF1B) were identified. In the majority of cases, the genetic etiology was part of a previously identified autosomal recessive disorder. Two novel de novo mutations were identified in INS and HNF1B. Conclusion Qatar has the second highest reported incidence of PNDM worldwide. A majority of PNDM cases present as rare familial autosomal recessive disorders. Pancreas associated transcription factor 1a (PTF1A) enhancer deletions are the most common cause of PNDM in Qatar, with only a few previous cases reported in the literature.
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- 2020
17. Successful Initiation of Hybrid Closed-Loop System Using Virtual Pump Training Program in a Teenager With Type 1 Diabetes Previously Treated with Multiple Daily Injections
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Khalid Hussain, Fawziya Al Khalaf, Goran Petrovski, Douha Almajali, and Judith Campbell
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Blood Glucose ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,type 1 diabetes ,Endocrinology, Diabetes and Metabolism ,Biomedical Engineering ,Bioengineering ,chemistry.chemical_compound ,Insulin Infusion Systems ,Diabetes mellitus ,Commentaries ,Internal Medicine ,medicine ,Virtual training ,Humans ,Hypoglycemic Agents ,Insulin ,Glycemic ,Glycated Hemoglobin ,Type 1 diabetes ,business.industry ,SARS-CoV-2 ,Blood Glucose Self-Monitoring ,diabetes education ,COVID-19 ,medicine.disease ,Diabetes Mellitus, Type 1 ,chemistry ,closed-loop systems ,Anesthesia ,Female ,Glycated hemoglobin ,Training program ,business ,Closed loop ,virtual training - Abstract
Due to the coronavirus disease 2019 restrictions in providing diabetes services, we have developed an innovative pump training program, which consisted of technical session, pump training, one in-person practical session, and four consecutive online sessions (Skype Meet Now). A 13-year-old female patient with a 4-year history of type 1 diabetes (T1D) on multiple daily injections (MDI) with glycated hemoglobin 8.9%; 74 mmol/mol) initiated Minimed 670G system using the program. Time in range (70-180 mg/dL) of 39% and sensor glucose (SG) of 214±91 mg/dL (MDI with continuous glucose monitoring) increased to 69% in the first 2 weeks and reached 86% and SG of 140±40 mg/dL in the first month of auto mode initiation, without severe hypoglycemia or hyperglycemia. Virtual pump training program can be an effective tool to initiate a hybrid closed-loop system and to improve glycemic control in people with T1D on MDI.
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- 2020
18. One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes
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Goran, Petrovski, Fawziya, Al Khalaf, Judith, Campbell, Fareeda, Umer, Douha, Almajaly, Manar, Hamdan, and Khalid, Hussain
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Blood Glucose ,Male ,Diabetes education ,Adolescent ,Blood Glucose Self-Monitoring ,Continuous subcutaneous insulin infusion ,Closed-loop systems ,Glycemic Control ,Drug Administration Schedule ,Injections ,Diabetes Mellitus, Type 1 ,Insulin Infusion Systems ,Treatment Outcome ,Type 1 diabetes ,Patient Education as Topic ,Humans ,Hypoglycemic Agents ,Insulin ,Female ,Original Article ,Prospective Studies ,Child ,Continuous glucose monitoring - Abstract
Objective To evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI). Methods This was a 1-year observational study, as a continuation of the previous 3 months prospective study of pediatric patients with T1D conducted at Sidra Medicine in Qatar. The study enrolled individuals aged 7–18 years with T1D > 1 year, on MDI with self-monitoring of blood glucose or continuous glucose monitoring, with no prior pump experience, and with an HbA1c level
- Published
- 2020
19. Review for 'Effect of fully automated closed‐loop insulin delivery using faster aspart versus standard aspart on gluco‐regulatory hormones in type 2 diabetes'
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Fawziya Al Khalaf
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Fully automated ,business.industry ,medicine ,Insulin delivery ,Type 2 diabetes ,Pharmacology ,medicine.disease ,business ,Closed loop ,Hormone - Published
- 2020
20. 197-OR: Six Months Experience on Hybrid Closed-Loop System in Children and Adolescents Previously Treated with Multiple Daily Injections
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Fawziya Al-Khalaf, Khalid Hussain, Fareeda Umer, Judith Campbell, and Goran Petrovski
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Type 1 diabetes ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.disease ,Severe hypoglycemia ,Regimen ,Anesthesia ,Internal Medicine ,medicine ,In patient ,Previously treated ,business ,Closed loop ,Glycemic - Abstract
Aim: Evaluation of six months experience on MiniMed 670G Hybrid Closed Loop (HCL) system in patients with type 1 diabetes (T1D), previously treated with Multiple Daily Injections (MDI). Methods: This is a 6-months prospective observational study of patients (7 to 18 years) with T1D on MDI, starting the MiniMed 670G system, using a 10-day initiation protocol: 2-days, HCL system assessment; 5-days, HCL system training (2-hours sessions in 5 consecutive days); 3-days, Manual Mode use of HCL system and 6 months, Auto Mode use of the HCL system. Results: MiniMed 670G was initiated in 47 patients (age 12.2±3.2 years). All patients used the system for six months period. Auto Mode usage was 87.2% at the first month and 89.6% at the 6-months of Auto Mode initiation. The mean HbA1c decreased from 8.4±1.5% (68±16.4 mmol/mol) at baseline, 6.7±0.8% (50±8.7 mmol/mol) at 3-months (p=0.021), to 6.9±0.7% (52±7.7 mmol/mol) at 6-months of MiniMed 670G initiation (p=0.024). Time in Range (70-180mg/dL) significantly increased over the time (Figure 1). No severe hypoglycemia nor DKA were found. Conclusion: Children and adolescents with T1D can successfully initiate the HCL system, achieve and maintain better glycemic control than previous MDI regimen. Low attrition rate and the sustainability of the results are likely due to patients’ selection, structured educational program and HCL system by itself. Disclosure G. Petrovski: None. J. Campbell: None. F. AlKhalaf: None. F. Umer: None. K. Hussain: None.
- Published
- 2020
21. Corneal nerve loss in children with type 1 diabetes mellitus without retinopathy or microalbuminuria
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Souhaila Al Khodor, Ahmed Shamekh, Adnan Khan, Parul Singh, Fawziya Al-Khalaf, Hatim Abdelrahman, Rayaz A. Malik, Ioannis N. Petropoulos, Georgios Ponirakis, Khalid Hussain, Mamoun Elawad, Wesam Almasri, Anthony K Akobeng, Saras Saraswathi, Goran Petrovski, Bara Al-Jarrah, Mohamed A Hendaus, Mahmoud Al Zyoud, Amel Khalifa, Hoda Gad, Maryam Al Maadheed, and Ahmed Elawwa
- Subjects
Blood Glucose ,Male ,genetic structures ,Endocrinology, Diabetes and Metabolism ,law.invention ,Corneal Diseases ,Cornea ,chemistry.chemical_compound ,0302 clinical medicine ,Diabetic Neuropathies ,law ,Outpatient clinic ,030212 general & internal medicine ,Child ,Subclinical infection ,General Medicine ,Articles ,Prognosis ,Clinical Science and Care ,Female ,Original Article ,Small fiber neuropathy ,Retinopathy ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,Confocal microscopy ,Type 1 diabetes mellitus ,Diabetes mellitus ,Ophthalmology ,Internal Medicine ,medicine ,Albuminuria ,Humans ,Glycated Hemoglobin ,Type 1 diabetes ,Diabetic Retinopathy ,business.industry ,RC648-665 ,medicine.disease ,eye diseases ,United Kingdom ,Cross-Sectional Studies ,Diabetes Mellitus, Type 1 ,chemistry ,Case-Control Studies ,Microalbuminuria ,Glycated hemoglobin ,sense organs ,business ,Biomarkers ,Follow-Up Studies - Abstract
Aims/Introduction Corneal confocal microscopy is a rapid, non‐invasive ophthalmic technique to identify subclinical neuropathy. The aim of this study was to quantify corneal nerve morphology in children with type 1 diabetes mellitus compared with age‐matched healthy controls using corneal confocal microscopy. Materials and Methods A total of 20 participants with type 1 diabetes mellitus (age 14 ± 2 years, diabetes duration 4.08 ± 2.91 years, glycated hemoglobin 9.3 ± 2.1%) without retinopathy or microalbuminuria and 20 healthy controls were recruited from outpatient clinics. Corneal confocal microscopy was undertaken, and corneal nerve fiber density (n/mm2), corneal nerve branch density (n/mm2), corneal nerve fiber length (mm/mm2), corneal nerve fiber tortuosity and inferior whorl length (mm/mm2) were quantified manually. Results Corneal nerve fiber density (22.73 ± 8.84 vs 32.92 ± 8.59; P, This is the first study showing significant corneal nerve loss in the central cornea and inferior whorl, indicative of early subclinical neuropathy in children with type 1 diabetes mellitus without microalbuminuria or retinopathy.
- Published
- 2020
22. Supplementary_-_Program – Supplemental material for Successful Initiation of Hybrid Closed-Loop System Using Virtual Pump Training Program in a Teenager With Type 1 Diabetes Previously Treated with Multiple Daily Injections
- Author
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Petrovski, Goran, Campbell, Judith, Douha Almajali, Fawziya Al Khalaf, and Hussain, Khalid
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111708 Health and Community Services ,FOS: Clinical medicine ,111199 Nutrition and Dietetics not elsewhere classified ,Medicine ,FOS: Health sciences ,110306 Endocrinology - Abstract
Supplemental material, Supplementary_-_Program for Successful Initiation of Hybrid Closed-Loop System Using Virtual Pump Training Program in a Teenager With Type 1 Diabetes Previously Treated with Multiple Daily Injections by Goran Petrovski, Judith Campbell, Douha Almajali, Fawziya Al Khalaf and Khalid Hussain in Journal of Diabetes Science and Technology
- Published
- 2020
- Full Text
- View/download PDF
23. Continuous Subcutaneous Insulin Infusion Characteristics in Type 1 Diabetes Children and Adolescents in Qatar
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Ahmed El Awwa, Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, and Khalid Hussain
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Male ,Diabetes duration ,Insulin pump ,medicine.medical_specialty ,Adolescent ,Glucose control ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Biomedical Engineering ,Bioengineering ,030209 endocrinology & metabolism ,03 medical and health sciences ,chemistry.chemical_compound ,Insulin Infusion Systems ,0302 clinical medicine ,Bolus (medicine) ,Predictive Value of Tests ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,030212 general & internal medicine ,Child ,Letters to the Editor ,Qatar ,Retrospective Studies ,Original Research ,Glycated Hemoglobin ,Type 1 diabetes ,business.industry ,Health Policy ,CSII ,Health Care Costs ,medicine.disease ,Subcutaneous insulin ,Cross-Sectional Studies ,Diabetes Mellitus, Type 1 ,chemistry ,Female ,Glycated hemoglobin ,business ,Follow-Up Studies - Abstract
Aim To describe continuous subcutaneous insulin infusion (CSII) characteristics in type 1 diabetes mellitus (T1DM) children and adolescents using a standardized protocol in routine clinical settings in Qatar. Methods A total of 138 T1DM patients (62 males; 76 females; mean age 9.8 ± 3.4 years) with a mean diabetes duration of 2.4 ± 1.9 years initiated CSII (MiniMed® Veo®™ and MiniMed® 640 G insulin pumps; Medtronic, Northridge, CA, USA) in 2016 and 2017. CSII characteristics and glycated hemoglobin (HbA1c) were evaluated 1 year after treatment initiation. Results At 1 year after treatment initiation, the insulin dose had significantly increased (from 0.59 ± 0.23 to 0.74 ± 0.26 U/kg body weight per 24; P
- Published
- 2018
24. From Multiple Daily Injections to Hybrid Closed-Loop System in Ten Days, Utilizing a Structured Initiation Protocol
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Hannah Fisher, Goran Petrovski, Khalid Hussain, Judith Campbell, Fareeda Umer, and Fawziya Al Khalaf
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Blood Glucose ,Male ,Health Knowledge, Attitudes, Practice ,Time Factors ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Biomedical Engineering ,Bioengineering ,Glycemic Control ,Letter to the Editors ,Insulin Infusion Systems ,Patient Education as Topic ,Control theory ,Internal Medicine ,Medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Child ,Protocol (object-oriented programming) ,Glycated Hemoglobin ,business.industry ,Blood Glucose Self-Monitoring ,Diabetes Mellitus, Type 1 ,Treatment Outcome ,Female ,business ,Closed loop ,Biomarkers - Published
- 2019
25. 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
- Author
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Goran, Petrovski, Fawziya, Al Khalaf, Judith, Campbell, Hannah, Fisher, Fareeda, Umer, and Khalid, Hussain
- Subjects
Blood Glucose ,Glycated Hemoglobin ,Male ,Time Factors ,Adolescent ,Blood Glucose Self-Monitoring ,Drug Administration Schedule ,Hypoglycemia ,Injections ,Diabetes Mellitus, Type 1 ,Insulin Infusion Systems ,Type 1 diabetes ,Hybrid closed-loop system ,Protocol ,Humans ,Hypoglycemic Agents ,Insulin ,Female ,Original Article ,Child ,Multiple daily injection - Abstract
Aim The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control. Methods An open-label single-arm, single-center, clinical investigation in children aged 7–18 years on MDI following a structured protocol: 2 days, HCL system assessment; 5 days, HCL system training (2-h sessions on 5 consecutive days with groups of 3–5 participants and families); 3 days, Manual Mode use of HCL system; 84 days, Auto Mode use of the HCL system, cumulating in 10 days from MDI to Auto Mode activation. Results A total of 30 children (age 10.24 ± 2.6 years) were enrolled in the study, and all completed the planned 84 days on Auto Mode. The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). Time in range (70–180 mg/dL) increased from 46.9 ± 18.5% at baseline to 75.6 ± 6.9% in Auto Mode (p
- Published
- 2019
26. Optimizing a Hybrid Closed Loop System in Type 1 Diabetes: A Case Report
- Author
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Goran Petrovski, Khalid Hussain, Judith Campbell, and Fawziya Al Khalaf
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Optimization ,Insulin pump ,medicine.medical_specialty ,Glucose control ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Case Report ,030209 endocrinology & metabolism ,03 medical and health sciences ,0302 clinical medicine ,Bolus (medicine) ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,030212 general & internal medicine ,Morning ,Type 1 diabetes ,business.industry ,Insulin ,medicine.disease ,Cardiology ,business ,Closed loop ,Hybrid closed loop - Abstract
We present the optimization of a hybrid closed-loop (HCL) insulin pump system in a type 1 diabetes (T1D) patient in the first 3 months of using the Minimed 670G. An 11-year-old female with 7 years of T1D history started using the Minimed 670G HCL system at our center. The patient had been using the Medtronic Veo insulin pump without a sensor for almost 4 years with HbA1c levels between 7.8% and 10.2%. We introduced the Minimed 670G to improve overall glucose control, improve quality of life and lessen the diabetes burden. Insulin pump characteristics of the Minimed Veo pump were used as the initial setting in the HCL system. The optimization of the Minimed 670G in the next 3 months led to the following changes: an insulin-to-carbohydrate ratio (ICHR) from 1 to 10 g in the morning period (6 a.m. to 12 a.m.) and 15-12 g for the rest of the day (12 p.m. to 6 a.m.); an active insulin time from 4 to 3 h and insulin sensitivity factor (ISF) from 120 to 90 mg/dl with no change in target range. The HbA1c level decreased by - 1.3%, and the time in range significantly increased to 77% with SG values of 139 ± 60 mg/dl, sensor wear of 82% and an auto mode period of 84% per week. Health providers should consider immediate adjustment of the bolus wizard settings such as the ICHR, ISF and active insulin time. The HCL system can improve overall glucose control with increased time in the range of sensor glucose values and reduction of HbA1c levels.
- Published
- 2018
27. Glucose control during Ramadan fasting in a teenager with type 1 diabetes on MiniMed 670G hybrid closed-loop system
- Author
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Goran, Petrovski, Fawziya, Al Khalaf, Judith, Campbell, Khalid, Hussain, Hannah, Fisher, and Fareeda, Umer
- Subjects
Blood Glucose ,Male ,Religion ,Diabetes Mellitus, Type 1 ,Insulin Infusion Systems ,Adolescent ,Blood Glucose Self-Monitoring ,Humans ,Hypoglycemic Agents ,Insulin ,Case Report ,Fasting - Published
- 2019
28. Needle in a Haystack—Parathyroid Gland in a 10-Day Old Infant: A Case Report and Literature Review
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Adel Ismail, Tariq O. Abbas, and Fawziya Al-Khalaf
- Subjects
Calcium metabolism ,Pathology ,medicine.medical_specialty ,Hyperparathyroidism ,Bone disease ,endocrine system diseases ,business.industry ,Thyroid ,Case Report ,Parathyroid chief cell ,medicine.disease ,medicine.anatomical_structure ,Respiratory failure ,medicine ,Parathyroid gland ,business ,hormones, hormone substitutes, and hormone antagonists ,Neonatal severe primary hyperparathyroidism - Abstract
Neonatal severe primary hyperparathyroidism (NSPHT) is a rare autosomal recessive disorder of calcium homeostasis. It presents shortly after birth and is characterized by striking hyperparathyroidism, marked hypercalcemia, and hyperparathyroid bone disease. It is caused by mutations of the calcium-sensing receptor (CASR), the ionized calcium sensor for the parathyroid cells, the parafollicular thyroid C cells, and the kidney epithelium, as well as cells in bone and intestine. Without early intervention, which frequently requires surgical removal of the hyperplastic parathyroids, the patients often succumb to complications of hypercalcemia and respiratory failure. Finding the parathyroid gland in small neonates is not an easy task. Here we report on a patient with neonatal hyperparathyroidism who was treated by total parathyroidectomy and discuss the various ways of helping to find the parathyroid glands during surgery at this young age.
- Published
- 2011
29. Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar
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Basma Haris, Saras Saraswathi, Sara Al‐Khawaga, Reem Hasnah, Amira Saeed, Shihab Mundekkadan, Noor Hamed, Houda Afyouni, Tasneem Abdel‐Karim, Shayma Mohammed, Amel Khalifa, Maryam Al‐Maadheed, Mahmoud Al‐Zyoud, Ahmed Shamekh, Ahmed Elawwa, Fawziya Al‐Khalaf, Sabri Boughorbel, Goran Petrovski, and Khalid Hussain
- Subjects
Epidemiology ,Pediatric diabetes ,Type 1 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction To study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. Materials and methods All patients (aged 0–18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association guidelines were used to classify types of diabetes mellitus. The incidence and prevalence of all the different types of diabetes mellitus were calculated. Results Total number of children with diabetes mellitus was 1,325 (type 1 n = 1,096, ≥1 antibody; type 2 n = 104, type 1B n = 53; maturity onset diabetes of the young n = 20; monogenic autoimmune n = 4; neonatal diabetes mellitus n = 10;, syndromic diabetes mellitus n = 23; and double diabetes mellitus n = 15). The incidence and prevalence of type 1 diabetes were 38.05 and 249.73 per 100,000, respectively, and for type 2 were 2.51 and 23.7 per 100,000, respectively. The incidence of neonatal diabetes mellitus was 34.4 per 1,000,000 live births, and in indigenous Qataris the incidence was 43.6 per 1,000,000 live births. The prevalence of type 1 diabetes and type 2 diabetes in Qatari children was double compared with other nationalities. The prevalence of maturity onset diabetes of the young in Qatar was 4.56 per 100,000. Conclusions This is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type 1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non‐Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world. GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type 1B diabetes mellitus.
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- 2021
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30. Corneal nerve loss in children with type 1 diabetes mellitus without retinopathy or microalbuminuria
- Author
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Hoda Gad, Bara Al‐Jarrah, Saras Saraswathi, Ioannis N Petropoulos, Georgios Ponirakis, Adnan Khan, Parul Singh, Souhaila Al Khodor, Mamoun Elawad, Wesam Almasri, Hatim Abdelrahman, Ahmed Elawwa, Amel Khalifa, Ahmed Shamekh, Fawziya Al‐Khalaf, Goran Petrovski, Mahmoud Al Zyoud, Maryam Al Maadheed, Mohamed A Hendaus, Khalid Hussain, Anthony K Akobeng, and Rayaz A Malik
- Subjects
Child ,Small fiber neuropathy ,Type 1 diabetes mellitus ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction Corneal confocal microscopy is a rapid, non‐invasive ophthalmic technique to identify subclinical neuropathy. The aim of this study was to quantify corneal nerve morphology in children with type 1 diabetes mellitus compared with age‐matched healthy controls using corneal confocal microscopy. Materials and Methods A total of 20 participants with type 1 diabetes mellitus (age 14 ± 2 years, diabetes duration 4.08 ± 2.91 years, glycated hemoglobin 9.3 ± 2.1%) without retinopathy or microalbuminuria and 20 healthy controls were recruited from outpatient clinics. Corneal confocal microscopy was undertaken, and corneal nerve fiber density (n/mm2), corneal nerve branch density (n/mm2), corneal nerve fiber length (mm/mm2), corneal nerve fiber tortuosity and inferior whorl length (mm/mm2) were quantified manually. Results Corneal nerve fiber density (22.73 ± 8.84 vs 32.92 ± 8.59; P
- Published
- 2020
- Full Text
- View/download PDF
31. Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus
- Author
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Arun Prasath Lakshmanan, Ibrahim F. Shatat, Sara Zaidan, Shana Jacob, Dhinoth Kumar Bangarusamy, Shaikha Al-Abduljabbar, Fawziya Al-Khalaf, Goran Petroviski, and Annalisa Terranegra
- Subjects
Microbiota ,Pediatric ,Diabetes ,Hypertension ,Blood pressure ,Dysbiosis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Children with Type 1 diabetes mellitus (T1DM) have an elevated risk of abnormal blood pressure (BP) measurements and patterns. Both hypertension and T1DM are well-known risk factors for cardiovascular disease and kidney failure. The human microbiome has been linked to both diabetes and hypertension, but the relationship between the gut microbiome and BP in children with T1DM is not well-understood. In this cross-sectional study, we examined the relationship between resting office BP and gut microbiota composition, diversity, and richness in children with T1DM and healthy controls. We recruited 29 pediatric subjects and divided them into three groups: healthy controls (HC, n = 5), T1DM with normal BP (T1DM-Normo, n = 17), and T1DM with elevated BP (T1DM-HBP, n = 7). We measured the BP, dietary and clinical parameters for each subject. We collected fecal samples to perform the 16s rDNA sequencing and to measure the short-chain fatty acids (SCFAs) level. The microbiome downstream analysis included the relative abundance of microbiota, alpha and beta diversity, microbial markers using Linear Discriminant effect size analysis (LEfSe), potential gut microbial metabolic pathways using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) and metabolic pathways validation using Statistical Inference of Associations between Microbial Communities And host phenotype (SIAMCAT) machine learning toolbox. Our study results showed that T1DM-HBP group had distinct gut microbial composition (at multiple taxonomic levels) and reduced diversity (richness and abundance) compared with T1DM-Normo and HC groups. Children with T1DM-HBP showed a significant reduction of Bifidobacterium levels (especially B. adolescentis, B. bifidum, and B. longum) compared to the T1DM-Normo group. We also observed unique gut-microbial metabolic pathways, such as elevated lipopolysaccharide synthesis and glutathione metabolism in children with T1DM-HBP compared to T1DM-Normo children. We can conclude that the reduction in the abundance of genus Bifidobacterium could play a significant role in elevating the BP in pediatric T1DM subjects. More studies are needed to corroborate our findings and further explore the potential contributing mechanisms we describe.
- Published
- 2021
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32. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency
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Atqah Abdul Wahab, M. Hammoudeh, Mona Allangawi, Fawziya Al-Khalaf, and Prem Chandra
- Subjects
Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objectives. To study bone mineral density (BMD) in cystic fibrosis (CF) children and adults with the CFTR I1234V mutation associated with pancreatic sufficiency. Methods. Lumbar spine, total hip, and whole-body mineral density were measured by dual-energy radiographic absorptiometry (DEXA) scan. Z score was used for those less than 21 years and T score was used for those 21 years or older. Results. Twenty-one CF patients were younger than 21 years and 5 CF patients were 21 years or older. Mean age was 17.29 ± 4.95 years, ranging from 10 to 33 years. The mean BMD Z scores for patients younger than 21 years were −0.69 ± 0.96 (lumbar spine = L1–L4), −0.48 ± 0.92 (total hip), and −0.38 ± 0.86 (total body). The mean T scores for patients 21 years or older were 0.14 ± 0.7 (L1–L4), 0.38 ± 1 (total hip), and 0.52 ± 1.03 (total body). BMD reduction less than −1 was found in 7 (26.9%) CF patients. Vitamin D deficiency in 20 CF patients (76.9%) tended to be lower in CF patients with low BMD. BMD was significantly correlated with FEV1; however, no significant association was observed with P. aeruginosa colonization. Conclusion. BMD reduction does occur in patients with mild CFTR mutation associated with pancreatic sufficiency.
- Published
- 2014
- Full Text
- View/download PDF
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