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3 results on '"Fawn Qin"'

1. An STS-Based Radiation Hybrid Map of the Human Genome

Author

Tim Reif, Wei Lin Sun, Mark Piercy, Mark Harris, Susan Voyticky, Sid Cowles, Kyle O'Connor, Kathleen B. McKusick, Fawn Qin, Xiaohong She, Richard M. Myers, David R. Cox, Nicole Y. Fang, Amita Aggarwal, Jian Bing Fan, David Hadley, Shanti M. Perkins, Richard S. Lee, Annu Maratukulam, Sami Hussain, Christopher Mader, John Quackenbush, Ewa Bajorek, Poroshat Tabar, Elizabeth A. Stewart, Carla Sanders, Shannon T. Brady, and Angela Chu

Subjects
Genetic Markers, Male, Genome, Human, Chromosome Mapping, Radiation Hybrids, Computational biology, Hybrid Cells, Biology, Diploidy, Genome, Cell Line, genomic DNA, Genetic marker, Cricetinae, Genetics, Animals, Chromosomes, Human, Humans, Map Location, Human genome, Lymphocytes, Software, Genetics (clinical), Sequence Tagged Sites
Abstract

We have constructed a physical map of the human genome by using a panel of 83 whole genome radiation hybrids (the Stanford G3 panel) in conjunction with 10,478 sequence-tagged sites (STSs) derived from random genomic DNA sequences, previously mapped genetic markers, and expressed sequences. Of these STSs, 5049 are framework markers that fall into 1766 high-confidence bins. An additional 945 STSs are indistinguishable in their map location from one or more of the framework markers. These 5994 mapped STSs have an average spacing of 500 kb. An additional 4484 STSs are positioned with respect to the framework markers. Comparison of the orders of markers on this map with orders derived from independent meiotic and YAC STS-content maps indicates that the error rate in defining high-confidence bins is

Published
1997
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2. A Gene Map of the Human Genome

Author

Christopher Mader, B. B. Birren, Jean Morissette, C. Sanders, K. Swanson, Xiao-Yu Wu, Thomas J. Hudson, Mark S. Boguski, A. Maratukulam, Midori A. Harris, L. Green, S. Hussain, C. East, Robert E. White, Andrew A. Hicks, K. R. Iorio, Andrew B. Castle, W.-L. Sun, Paul Harrison, Simone Duprat, Kate Rice, Eric S. Lander, X. She, Shanti M. Perkins, Ammon B. Peck, Mina Sandusky, John Quackenbush, L. Hui, David Bentley, K. B. McKusick, Anindya Dehejia, Gregory D. Schuler, Gabor Gyapay, T. Dibling, C M Clee, Amita Aggarwal, James R. Hudson, R. Torres, Eva Bajorek, Peter N. Goodfellow, Mark Piercy, Mark Raymond Adams, Jun Fan, Cheryl Phillips, Elizabeth A. Stewart, Nicole Y. Fang, N. Drouot, Ian Dunham, Donna K. Slonim, Mihael H. Polymeropoulos, N. Nomura, Andrew J. Mungall, K. Ishikawa, E. Holloway, J. Ma, P. J. R. Day, N. Seki, S. Bentolila, Jean Weissenbach, P. Rodriguez-Tomé, Adam Butler, Sid Cowles, Angela M. Chu, Karin Schmitt, R. Houlgatte, Panos Deloukas, Tim Reif, Michael R. James, C. Louis-Dit-Sully, S. Voyticky, P. Tabar, David R. Cox, A. MacGilvery, David C. Page, Carol Soderlund, C A Edwards, S A Ranby, Nicole A.R. Walter, Douglas Vollrath, T. E. Wilmer, Lincoln Stein, H. C. Nusbaum, Takahiro Nagase, Tara C. Matise, T. Thangarajah, Susan E. Ide, Fawn Qin, Richard M. Myers, Steve Rozen, Jacques S. Beckmann, Richard Berry, James M. Sikela, Charles Auffray, Shannon T. Brady, Cécile Fizames, Christine Garrett, David Hadley, Delphine Muselet, Nathalie Vega-Czarny, Rhonda Brandon, Wha‐Young Lee, N. Chiannilkulchai, J. C. Venter, and James Silva

Subjects
Sequence-tagged site, Yeast artificial chromosome, Genetics, Expressed sequence tag, Multidisciplinary, Gene map, Gene mapping, Human genome, Computational biology, Genome project, Biology, Genome
Abstract

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.

Published
1996
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3. A high-resolution radiation hybrid map of the human genome draft sequence

Author

Amy J. Perou, Kelly Sheppard, Eva Bajorek, Nu T. Vo, Michael Olivier, Amita Aggarwal, Tonya J. Jeffrey, Joseph P. Marquis, Wei-Lin Sun, Xia Liu, Tisha R. Chung, Saskia C. Lewis, Valerie I. Bustos, Nguyet M. Tran, Ellen M. Beasley, Ravi Sachidanandam, Barbara J. Trask, Angela Chu, Robert W. Freudenberg, Robert A. Martinez, Nedda S. Misherghi, Mirian Denys, Margaret K. Matsuura, Frederick Lopez, David Hadley, Tim Reif, Michelle R. Levy, Shaying Zhao, Brent Louie, Fawn Qin, Richard M. Myers, Vida Shokoohi, Tejeda, Annalisa A. Almendras, Jannette M. Bushard, Elizabeth A. Stewart, J. Fernando, Nicole Y. Fang, Libby R. Hamilton, Deborah L. Zierten, Tonatiuh Trejo, Laura C. Lazzeroni, Christopher Piercy, Adam B. Olshen, Shanti M. Perkins, Mark Piercy, Shannon D. Brady, David R. Cox, Geoff A. Smick, Brian D. Foster, Rakly Dominguez, Jolanna A. Norton, Simon C. M. Yan, Jennifer Allen, Libusha Kelly, and Anniek de Witte

Subjects
Chromosomes, Artificial, Bacterial, Databases, Factual, Sequence analysis, Biology, Genome, Polymerase Chain Reaction, Contig Mapping, Sequence-tagged site, Human Genome Project, Humans, In Situ Hybridization, Fluorescence, Genomic organization, Sequence (medicine), Sequence Tagged Sites, Whole genome sequencing, Genetics, Radiation Hybrid Mapping, Multidisciplinary, Genome, Human, Computational Biology, Sequence Analysis, DNA, Physical Chromosome Mapping, Human genome, Algorithms, Software
Abstract

We have constructed a physical map of the human genome by using a panel of 90 whole-genome radiation hybrids (the TNG panel) in conjunction with 40,322 sequence-tagged sites (STSs) derived from random genomic sequences as well as expressed sequences. Of 36,678 STSs on the TNG radiation hybrid map, only 3604 (9.8%) were absent from the unassembled draft sequence of the human genome. Of 20,030 STSs ordered on the TNG map as well as the assembled human genome draft sequence and the Celera assembled human genome sequence, 36% of the STSs had a discrepant order between the working draft sequence and the Celera sequence. The TNG map order was identical to one of the two sequence orders in 60% of these discrepant cases.

Published
2001

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