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22 results on '"Favero, Elisabetta"'

1. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life

Author

Nettis, Eustachio, Brussino, Luisa, Patella, Vincenzo, Bonzano, Laura, Detoraki, Aikaterini, Di Leo, Elisabetta, Sirufo, Maria Maddalena, Caruso, Cristiano, Lodi Rizzini, Fabio, Conte, Mariaelisabetta, Yacoub, Mona-Rita, Triggiani, Massimo, Ridolo, Erminia, Macchia, Luigi, Rolla, Giovanni, Brancaccio, Raffaele, De Paulis, Amato, Spadaro, Giuseppe, Di Bona, Danilo, D’Uggento, Angela Maria, Ginaldi, Lia, Gaeta, Francesco, Nucera, Eleonora, Jaubashi, Kliljeda, Villalta, Danilo, Dagna, Lorenzo, Ciotta, Domenico, Pucciarini, Francesco, Bagnasco, Diego, Celi, Giorgio, Chieco Bianchi, Fulvia, Cosmi, Lorenzo, Costantino, Maria Teresa, Crivellaro, Maria Angiola, D’Alò, Simona, del Biondo, Pietro, Del Giacco, Stefano, Di Gioacchino, Mario, Di Pietro, Linda, Favero, Elisabetta, Gangemi, Sebastiano, Guarnieri, Gabriella, Heffler, Enrico, Leto Barone, Maria Stefania, Lombardo, Carla, Losa, Francesca, Matucci, Andrea, Minciullo, Paola Lucia, Parronchi, Paola, Passalacqua, Giovanni, Pucci, Stefano, Rossi, Oliviero, Salvati, Lorenzo, Schiappoli, Michele, Senna, Gianenrico, Vianello, Andrea, Vultaggio, Alessandra, Baoran, Yang, Incorvaia, Cristoforo, and Canonica, Giorgio Walter

Published
2022
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2. COVID-19 Clinical Features and Outcome in Italian Patients Treated with Biological Drugs Targeting Type 2 Inflammation

Author

Sambugaro, Giada, primary, Brambilla, Elena, additional, Costanzo, Giulia, additional, Bonato, Vera, additional, Ledda, Andrea Giovanni, additional, Del Giacco, Stefano, additional, Scarpa, Riccardo, additional, Rattazzi, Marcello, additional, Favero, Elisabetta, additional, Cinetto, Francesco, additional, and Firinu, Davide, additional

Published
2024
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3. Severe asthma: One disease and multiple definitions

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Published
2021
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4. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni

Published
2021
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5. Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Author

Canonica, Giorgio Walter, Blasi, Francesco, Paggiaro, Pierluigi, Senna, Gianenrico, Passalacqua, Giovanni, Spanevello, Antonio, Aliberti, Stefano, Bagnasco, Diego, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Bucca, Caterina, Caiaffa, Maria F., Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Carpagnano, Giovanna E., Caruso, Cristiano, Centanni, Stefano, Conte, Maria E., Corsico, Angelo G., Cosmi, Lorenzo, Costantino, Maria T., Crimi, Nunzio, D’Alò, Simona, D'Amato, Maria, Del Giacco, Stefano, Farsi, Alessandro, Favero, Elisabetta, Foschino Barbaro, Maria P., Guarnieri, Gabriella, Guida, Giuseppe, Latorre, Manuela, Lo Cicero, Salvatore, Lombardi, Carlo, Macchia, Luigi, Mazza, Francesco, Menzella, Francesco, Milanese, Manlio, Montagni, Marcello, Montuschi, Paolo, Nucera, Eleonora, Parente, Roberta, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ricciardolo, Fabio L.M., Richeldi, Luca, Ridolo, Erminia, Rolla, Giovanni, Santus, Pierachille, Scichilone, Nicola, Spadaro, Giuseppe, Vianello, Andrea, Viviano, Vittorio, Yacoub, Mona R., Zappa, Maria C., and Heffler, Enrico

Published
2020
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6. The Severe Asthma Network in Italy: Findings and Perspectives

Author

Barbuto, Sarah, Bradicich, Matteo, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino, Maria Teresa, Crimi, Nunzio, Crivellaro, Mariangiola, D’Adda, Alice, D’Amato, Mariella, Favero, Elisabetta, Foschino, Maria Pia, Galeone, Carla, Guarnieri, Gabriella, Lombardi, Carlo, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, Heffler, Enrico, Blasi, Francesco, Latorre, Manuela, Menzella, Francesco, Paggiaro, Pierluigi, Pelaia, Girolamo, Senna, Gianenrico, and Canonica, Giorgio Walter

Published
2019
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7. Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry

Author

Aliberti, Stefano, Bagnasco, Diego, Barbuto, Sarah, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino Maria, Teresa, Crimi, Claudia, Crivellaro, Mariangiola, D'Amato, Mariella, Favero, Elisabetta, Foschino Maria, Pia, Guarnieri, Gabriella, Latorre, Manuela, Lombardi, Carlo, Menzella, Francesco, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, Triggiani, Massimo, Canonica, Giorgio Walter, Colombo, Giorgio Lorenzo, Bruno, Giacomo Matteo, Di Matteo, Sergio, Martinotti, Chiara, Blasi, Francesco, Bucca, Caterina, Crimi, Nunzio, Paggiaro, Pierluigi, Pelaia, Girolamo, Passalaqua, Giovanni, Senna, Gianenrico, and Heffler, Enrico

Published
2019
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8. Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry

Author

Giorgio Walter Canonica, Giorgio Lorenzo Colombo, Giacomo Matteo Bruno, Sergio Di Matteo, Chiara Martinotti, Francesco Blasi, Caterina Bucca, Nunzio Crimi, Pierluigi Paggiaro, Girolamo Pelaia, Giovanni Passalaqua, Gianenrico Senna, Enrico Heffler, Aliberti Stefano, Bagnasco Diego, Barbuto Sarah, Camiciottoli Gianna, Caminati Marco, Colombo Giselda, Costantino Maria Teresa, Crimi Claudia, Crivellaro Mariangiola, D'Amato Mariella, Favero Elisabetta, Foschino Maria Pia, Guarnieri Gabriella, Latorre Manuela, Lombardi Carlo, Francesco Menzella, Patella Vincenzo, Puggioni Francesca, Ridolo Erminia, Rolla Giovanni, Savi Eleonora, Scichilone Nicola, Solidoro Paolo, Spadaro Giuseppe, and Triggiani Massimo

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Background: Asthma is one of the most common non-communicable respiratory diseases, affecting about 6% of the general population. Severe asthma, even if afflicts a minority of asthmatics, drives the majority of costs of the disease. The aim of this study is to create a pharmacoeconomic model to predict the costs of corticosteroid-related adverse events in severe asthmatics and applying it to the first published epidemiologic data from the Severe Asthma Network in Italy (SANI) registry. Methods: The analysis was conducted from the perspective of the Italian National Healthcare System (INHS). Model inputs, derived from literature, included: asthma epidemiology data, frequency of adverse events, percentage of severe asthma treated with OCS and adverse event cost (Diagnosis-Related Group (DRG) national tariffs). We estimated costs per different patient groups: non-asthma controls, mild/moderate and severe asthmatics. Final results report estimated direct cost per patient and total direct cost for overall target population, showing economic impact related to corticosteroid complication. Results: Based on epidemiological data input, in Italy, asthmatic subjects resulted about 3,999,600, of which 199,980 with severe asthma. The number of patients with severe asthma OCS-treated was estimated at 123,988. Compared to the non-asthma control cohort and to that with moderate asthma annual cost per severe asthmatic patient resulted respectively about €892 and €606 higher, showing a corticosteroids shadow cost ranging from 45% to 30%.Applying the cost per patient to the target population identified for Italy, the budget impact model estimated a total annual cost related to OCS-related adverse events of €242.7 million for severe asthmatics. In respect with non-asthmatic and moderate population, an incremental expenditure of about € 110.6 million and €75.2, respectively, were shown. Conclusions: Our study provides the first estimates of additional healthcare costs related to corticosteroid induced adverse events in severe asthma patient. Budget impact model results highlighted the relevant economic impact of OCS-related adverse events in severe asthma patients. The future extrapolation of additional data from SANI registry will support the development of a model to investigate the role of corticosteroids sparing drugs. Keywords: Severe asthma, Oral corticosteroids, Adverse events, Pharmacoeconomy, Costs, Diabetes, Glaucoma, Obesity, Bone fracture, Chronic kidney disease

Published
2019
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10. Severe asthma: One disease and multiple definitions

Author

Bagnasco, Diego, primary, Paggiaro, Pierluigi, additional, Latorre, Manuela, additional, Folli, Chiara, additional, Testino, Elisa, additional, Bassi, Arianna, additional, Milanese, Manlio, additional, Heffler, Enrico, additional, Manfredi, Andrea, additional, Riccio, Anna Maria, additional, De Ferrari, Laura, additional, Blasi, Francesco, additional, Canevari, Rikki Frank, additional, Canonica, Giorgio Walter, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Giovanna Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Lombardi, Carlo, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Menzella, Francesco, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, D’Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D’Amato, additional, Verrillo, Maria Vittoria, additional, Rolla, Giovanni, additional, Brussino, Luisa, additional, Frazzetto, Agata Valentina, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Senna, Gianenrico, additional, Caminati, Marco, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D’Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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12. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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13. Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC)

Author

Heffler, Enrico, primary, Carpagnano, Giovanna Elisiana, additional, Favero, Elisabetta, additional, Guida, Giuseppe, additional, Maniscalco, Mauro, additional, Motta, Andrea, additional, Paoletti, Giovanni, additional, Rolla, Giovanni, additional, Baraldi, Eugenio, additional, Pezzella, Vincenza, additional, Piacentini, Giorgio, additional, and Nardini, Stefano G., additional

Published
2020
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16. The Severe Asthma Network in Italy: Findings and Perspectives

Author

Heffler, Enrico, primary, Blasi, Francesco, additional, Latorre, Manuela, additional, Menzella, Francesco, additional, Paggiaro, Pierluigi, additional, Pelaia, Girolamo, additional, Senna, Gianenrico, additional, Canonica, Giorgio Walter, additional, Barbuto, Sarah, additional, Bradicich, Matteo, additional, Camiciottoli, Gianna, additional, Caminati, Marco, additional, Colombo, Giselda, additional, Costantino, Maria Teresa, additional, Crimi, Nunzio, additional, Crivellaro, Mariangiola, additional, D’Adda, Alice, additional, D’Amato, Mariella, additional, Favero, Elisabetta, additional, Foschino, Maria Pia, additional, Galeone, Carla, additional, Guarnieri, Gabriella, additional, Lombardi, Carlo, additional, Parente, Roberta, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Puggioni, Francesca, additional, Ridolo, Erminia, additional, Rolla, Giovanni, additional, Savi, Eleonora, additional, Scichilone, Nicola, additional, Solidoro, Paolo, additional, and Spadaro, Giuseppe, additional

Published
2019
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17. Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry

Author

Canonica, Giorgio Walter, primary, Colombo, Giorgio Lorenzo, additional, Bruno, Giacomo Matteo, additional, Di Matteo, Sergio, additional, Martinotti, Chiara, additional, Blasi, Francesco, additional, Bucca, Caterina, additional, Crimi, Nunzio, additional, Paggiaro, Pierluigi, additional, Pelaia, Girolamo, additional, Passalaqua, Giovanni, additional, Senna, Gianenrico, additional, Heffler, Enrico, additional, Aliberti, Stefano, additional, Bagnasco, Diego, additional, Barbuto, Sarah, additional, Camiciottoli, Gianna, additional, Caminati, Marco, additional, Colombo, Giselda, additional, Costantino Maria, Teresa, additional, Crimi, Claudia, additional, Crivellaro, Mariangiola, additional, D'Amato, Mariella, additional, Favero, Elisabetta, additional, Foschino Maria, Pia, additional, Guarnieri, Gabriella, additional, Latorre, Manuela, additional, Lombardi, Carlo, additional, Menzella, Francesco, additional, Patella, Vincenzo, additional, Puggioni, Francesca, additional, Ridolo, Erminia, additional, Rolla, Giovanni, additional, Savi, Eleonora, additional, Scichilone, Nicola, additional, Solidoro, Paolo, additional, Spadaro, Giuseppe, additional, and Triggiani, Massimo, additional

Published
2019
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18. A survey of clinical features of allergic rhinitis in adults

Author

Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Bonini, Sergio, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, ANTONIO IGNAZIO, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio Della, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, Zanoni, Giovanna, Frati, F, Dell’Albani, I, Passalacqua, G, Bonini, Sergio, Rossi, O, Senna, G, Incorvaia, C, Adult SURF Study, Group, DE PALMA, Raffaele, Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, Antonio, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi-Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, and Zanoni, Giovanna

Subjects
Adult, Male, medicine.medical_specialty, Allergen immunotherapy, Sublingual, Adolescent, medicine.medical_treatment, ARIA guidelines, Desensitization, allergic rhinitis, survey data, Drug treatment, Young Adult, Patient satisfaction, Allergic, Immunologic, Allergic Rhinitis, Internal medicine, Administration, Patient compliance, Rhinitis, Seasonal, Female, Humans, Italy, Middle Aged, Patient Satisfaction, Rhinitis, Allergic, Skin Tests, Treatment Outcome, Data Collection, Medicine (all), medicine, In patient, Young adult, Rhiniti, Desensitization (medicine), High prevalence, Skin Test, Adult patients, business.industry, Settore MED/09 - MEDICINA INTERNA, General Medicine, Surgery, Public Health, business, Human
Abstract

Background: Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden.Material/Methods: The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18-45 years). For each patient, the attending physician had to fill in a standardized questionnaire, covering, in particular, some issues such as the ARIA classification of allergic rhinitis (AR), the results of skin prick test (SPT), the kind of treatment, the response to treatment, and the satisfaction with treatment.Results: Out of the 3383 patients with rhinitis, 2788 (82.4%) had AR: 311 (11.5%) had a mild intermittent, 229 (8.8%) a mild persistent, 636 (23.5%) a moderate-severe intermittent, and 1518 (56.1%) a moderate-severe persistent form. The most frequently used drugs were oral antihistamines (77.1%) and topical corticosteroids (60.8%). The response to treatment was judged as excellent in 12.2%, good in 41.3%, fair in 31.2%, poor in 14.5%, and very bad in 0.8% of subjects. The rate of treatment dissatisfaction was significantly higher in patients with moderate-to-severe AR than in patients with mild AR (p

Published
2014

19. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life

Author

Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio, Amato De Paulis, Giuseppe Spadaro, Danilo Di Bona, Angela Maria D’Uggento, Lia Ginaldi, Francesco Gaeta, Eleonora Nucera, Kliljeda Jaubashi, Danilo Villalta, Lorenzo Dagna, Domenico Ciotta, Francesco Pucciarini, Diego Bagnasco, Giorgio Celi, Fulvia Chieco Bianchi, Lorenzo Cosmi, Maria Teresa Costantino, Maria Angiola Crivellaro, Simona D’Alò, Pietro del Biondo, Stefano Del Giacco, Mario Di Gioacchino, Linda Di Pietro, Elisabetta Favero, Sebastiano Gangemi, Gabriella Guarnieri, Enrico Heffler, Maria Stefania Leto Barone, Carla Lombardo, Francesca Losa, Andrea Matucci, Paola Lucia Minciullo, Paola Parronchi, Giovanni Passalacqua, Stefano Pucci, Oliviero Rossi, Lorenzo Salvati, Michele Schiappoli, Gianenrico Senna, Andrea Vianello, Alessandra Vultaggio, Yang Baoran, Cristoforo Incorvaia, Giorgio Walter Canonica, Nettis, Eustachio, Brussino, Luisa, Patella, Vincenzo, Bonzano, Laura, Detoraki, Aikaterini, Di Leo, Elisabetta, Sirufo, Maria Maddalena, Caruso, Cristiano, Lodi Rizzini, Fabio, Conte, Mariaelisabetta, Yacoub, Mona-Rita, Triggiani, Massimo, Ridolo, Erminia, Macchia, Luigi, Rolla, Giovanni, Brancaccio, Raffaele, De Paulis, Amato, Spadaro, Giuseppe, Di Bona, Danilo, D'Uggento, Angela Maria, Ginaldi, Lia, Gaeta, Francesco, Nucera, Eleonora, Jaubashi, Kliljeda, Villalta, Danilo, Dagna, Lorenzo, Ciotta, Domenico, Pucciarini, Francesco, Bagnasco, Diego, Celi, Giorgio, Chieco Bianchi, Fulvia, Cosmi, Lorenzo, Costantino, Maria Teresa, Crivellaro, Maria Angiola, D'Alò, Simona, Del Biondo, Pietro, Del Giacco, Stefano, Di Gioacchino, Mario, Di Pietro, Linda, Favero, Elisabetta, Gangemi, Sebastiano, Guarnieri, Gabriella, Heffler, Enrico, Leto Barone, Maria Stefania, Lombardo, Carla, Losa, Francesca, Matucci, Andrea, Minciullo, Paola Lucia, Parronchi, Paola, Passalacqua, Giovanni, Pucci, Stefano, Rossi, Oliviero, Salvati, Lorenzo, Schiappoli, Michele, Senna, Gianenrico, Vianello, Andrea, Vultaggio, Alessandra, Baoran, Yang, Incorvaia, Cristoforo, and Canonica, Giorgio Walter

Subjects
POLYPS, Immunology, Settore MED/09 - MEDICINA INTERNA, Immunology and Allergy, Molecular Biology, DUPILUMAB
Abstract

Background Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Aim of the study was to evaluate the efficacy and safety of dupilumab in adult patients with CRSwNP stratified by common overlapping comorbid conditions. Methods We performed a multicenter, observational, prospective study enrolling adult patients with severe CRSwNP who had started dupilumab treatment in the context of standard care from January 2021 to October 2021. Data were collected from twentynine Italian secondary care centers for allergy and clinical immunology, all of which were part of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). A number of efficacy parameters were used. Patient data were compared using the Wilcoxon test for paired data. All statistical analyses were performed with SPSS version 20 (IBM, Armonk, NY, USA). Results In total, 82 patients with nasal polyposis were identified. A significant improvement was detected for all the applied efficacy parameters, i.e. 22-item Sino-Nasal Outcome Test (SNOT-22) and bilateral endoscopic nasal polyp score (NPS) scores for CRSwNP, Rhinitis Control Scoring System (RCSS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores for allergic perennial rhinitis, Forced Expiratory Volume in the 1st second (FEV1) and Asthma Quality of Life Questionnaire (AQLQ) scores for asthma, Eczema Area and Severity Index (EASI) and Dermatology Life Quality Index (DLQI) scores for AD. A non-significant improvement was also obtained in the Urticaria Activity Score over 7 days (UAS7) for chronic spontaneous urticaria. Treatment with dupilumab was well tolerated. Conclusions These data suggest that dupilumab treatment in patients suffering from CRSwNP and associated comorbidities may be suitable. Such outcome, although confirmation by trials is warranted, suggests the possibility to treat different disorders with a single therapy, with favorable effects especially under the cost-effectiveness aspect.

Published
2022

20. Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry

Author

Giovanni Rolla, Pierluigi Paggiaro, Marco Caminati, Girolamo Pelaia, Claudia Crimi, Pia Foschino Maria, Vincenzo Patella, Sarah Barbuto, Gianenrico Senna, Stefano Aliberti, Nunzio Crimi, Manuela Latorre, Giselda Colombo, Giorgio L Colombo, Giuseppe Spadaro, Teresa Costantino Maria, Nicola Scichilone, Giovanni Passalaqua, Mariangiola Crivellaro, Massimo Triggiani, Enrico Heffler, Caterina Bucca, Francesco Menzella, Sergio Di Matteo, Eleonora Savi, Elisabetta Favero, Chiara Martinotti, Diego Bagnasco, Gabriella Guarnieri, Gianna Camiciottoli, Francesco Blasi, M D'Amato, GM Bruno, Francesca Puggioni, Paolo Solidoro, Carlo Lombardi, Giorgio Walter Canonica, Erminia Ridolo, Giorgio Walter, Canonica, Giorgio Lorenzo, Colombo, Giacomo Matteo, Bruno, Sergio Di, Matteo, Chiara, Martinotti, Francesco, Blasi, Caterina, Bucca, Nunzio, Crimi, Pierluigi, Paggiaro, Girolamo, Pelaia, Giovanni, Passalaqua, Gianenrico, Senna, Enrico, Heffler, Aliberti, Stefano, Bagnasco, Diego, Barbuto, Sarah, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino Maria, Teresa, Crimi, Claudia, Crivellaro, Mariangiola, D'Amato, Mariella, Favero, Elisabetta, Foschino Maria, Pia, Guarnieri, Gabriella, Latorre, Manuela, Lombardi, Carlo, Menzella, Francesco, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, and Triggiani, Massimo

Subjects
Pulmonary and Respiratory Medicine, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Severe asthma, Immunology, Population, Disease, Article, Pharmacoeconomy, Chronic kidney disease, Health care, Epidemiology, Oral corticosteroids, medicine, Immunology and Allergy, Obesity, Adverse effect, education, Asthma, education.field_of_study, business.industry, Diabetes, Adverse events, Bone fracture, Costs, Glaucoma, medicine.disease, Emergency medicine, Cohort, business, Complication, lcsh:RC581-607
Abstract

Background: Asthma is one of the most common non-communicable respiratory diseases, affecting about 6% of the general population. Severe asthma, even if afflicts a minority of asthmatics, drives the majority of costs of the disease. The aim of this study is to create a pharmacoeconomic model to predict the costs of corticosteroid-related adverse events in severe asthmatics and applying it to the first published epidemiologic data from the Severe Asthma Network in Italy (SANI) registry. Methods: The analysis was conducted from the perspective of the Italian National Healthcare System (INHS). Model inputs, derived from literature, included: asthma epidemiology data, frequency of adverse events, percentage of severe asthma treated with OCS and adverse event cost (Diagnosis-Related Group (DRG) national tariffs). We estimated costs per different patient groups: non-asthma controls, mild/moderate and severe asthmatics. Final results report estimated direct cost per patient and total direct cost for overall target population, showing economic impact related to corticosteroid complication. Results: Based on epidemiological data input, in Italy, asthmatic subjects resulted about 3,999,600, of which 199,980 with severe asthma. The number of patients with severe asthma OCS-treated was estimated at 123,988. Compared to the non-asthma control cohort and to that with moderate asthma annual cost per severe asthmatic patient resulted respectively about €892 and €606 higher, showing a corticosteroids shadow cost ranging from 45% to 30%.Applying the cost per patient to the target population identified for Italy, the budget impact model estimated a total annual cost related to OCS-related adverse events of €242.7 million for severe asthmatics. In respect with non-asthmatic and moderate population, an incremental expenditure of about € 110.6 million and €75.2, respectively, were shown. Conclusions: Our study provides the first estimates of additional healthcare costs related to corticosteroid induced adverse events in severe asthma patient. Budget impact model results highlighted the relevant economic impact of OCS-related adverse events in severe asthma patients. The future extrapolation of additional data from SANI registry will support the development of a model to investigate the role of corticosteroids sparing drugs. Keywords: Severe asthma, Oral corticosteroids, Adverse events, Pharmacoeconomy, Costs, Diabetes, Glaucoma, Obesity, Bone fracture, Chronic kidney disease

Published
2019

21. The Severe Asthma Network in Italy: Findings and Perspectives

Author

Giovanni Rolla, Girolamo Pelaia, Mariangiola Crivellaro, Maria Teresa Costantino, Maria Pia Foschino, Enrico Heffler, Alice D'Adda, Carlo Lombardi, Gabriella Guarnieri, Pierluigi Paggiaro, Nunzio Crimi, Francesco Blasi, Eleonora Savi, Manuela Latorre, Carla Galeone, Nicola Scichilone, Giselda Colombo, Giorgio Walter Canonica, Giovanni Passalacqua, M D'Amato, Francesco Menzella, Vincenzo Patella, Francesca Puggioni, Roberta Parente, Paolo Solidoro, Giuseppe Spadaro, Sarah Barbuto, Erminia Ridolo, Elisabetta Favero, Matteo Bradicich, Marco Caminati, Gianna Camiciottoli, Gianenrico Senna, Heffler, Enrico, Blasi, Francesco, Latorre, Manuela, Menzella, Francesco, Paggiaro, Pierluigi, Pelaia, Girolamo, Senna, Gianenrico, Canonica, Giorgio Walter, Barbuto, Sarah, Bradicich, Matteo, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino, Maria Teresa, Crimi, Nunzio, Crivellaro, Mariangiola, D'Adda, Alice, D'Amato, Mariella, Favero, Elisabetta, Foschino, Maria Pia, Galeone, Carla, Guarnieri, Gabriella, Lombardi, Carlo, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, Heffler E., Blasi F., Latorre M., Menzella F., Paggiaro P., Pelaia G., Senna G., Canonica G.W., Barbuto S., Bradicich M., Camiciottoli G., Caminati M., Colombo G., Costantino M.T., Crimi N., Crivellaro M., D'Adda A., D'Amato M., Favero E., Foschino M.P., Galeone C., Guarnieri G., Lombardi C., Parente R., Passalacqua G., Patella V., Puggioni F., Ridolo E., Rolla G., Savi E., Scichilone N., Solidoro P., and Spadaro G.

Subjects
Adult, Male, medicine.medical_specialty, Registry, Severe asthma, Exacerbation, Bronchiectasis, Comorbidities, Late-onset asthma, Nasal polyps, SANI, Immunology and Allergy, Omalizumab, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Atopy, 03 medical and health sciences, Bronchiectasi, 0302 clinical medicine, Food allergy, Internal medicine, Aged, Asthma, Eosinophils, Female, Humans, Immunoglobulin E, Italy, Middle Aged, Nasal Polyps, Registries, Rhinitis, Medicine, Bronchiectasis, Comorbidities, Late-onset asthma, Nasal polyps, Registry, SANI, Severe asthma, Immunology and Allergy, 030212 general & internal medicine, business.industry, Nasal polyp, medicine.disease, 030228 respiratory system, Asthma Control Questionnaire, Comorbiditie, business, Mepolizumab, medicine.drug
Abstract

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by accredited centers on severe asthma. Objective To analyze epidemiological, clinical, inflammatory, functional, and treatment characteristics of severe asthmatics from the SANI registry. Methods All consecutive patients with severe asthma were included into the registry, without exclusion criteria to have real-life data on demographics, asthma control, treatments (including biologics), inflammatory biomarkers, and comorbidities. Results A total of 437 patients (mean age: 54.1 years, 57.2% females, 70.7% atopics, 94.5% in Global Initiative for Asthma severity step V) were enrolled into the study. The mean annual exacerbation rate was 3.75. The mean blood eosinophil level was 536.7 cells/mcL, and the average serum total IgE was 470.3 kU/L. Approximately 64% of patients were on regular oral corticosteroid treatment, 57% with omalizumab and 11.2% with mepolizumab. Most common comorbidities were rhinitis, nasal polyposis, and bronchiectasis. Patients with nasal polyposis had higher age of disease onset, higher blood eosinophil count, and lower frequency of atopy and atopic eczema. Bronchiectasis was associated with more frequent severe exacerbations, higher blood eosinophils, and total IgE. Stratifying patients, those with late-onset asthma were less frequently atopic (with less frequent allergic rhinitis and food allergy), and more frequently with nasal polyposis and higher serum total IgE levels. Conclusions This study revealed a high frequency of relevant comorbidities and that a substantial proportion of patients have late-onset asthma; all these features define specific different disease phenotypes. Severe asthma complexity and comorbidities require multidisciplinary approaches, led by specifically trained pulmonologists and allergists.

Published
2018

22. Venom immunotherapy during COVID-19 pandemic: Experience from a University Allergy Center in Northern Italy.

Author

Dell'Edera A, Borghesan F, Favero E, Rattazzi M, Scarpa R, Tartaglia L, Agostini C, and Cinetto F

Abstract

During the ongoing pandemic of Coronavirus Disease 2019 (COVID-19) allergic patients need to continue their constant and proper treatment, including allergen-specific immunotherapy. These patients are expected to be at a higher risk for exacerbation of lung inflammation during viral infection. We investigated the putative interplay existing between allergen-specific immunotherapy and COVID-19 infection in a Hymenoptera venom-allergic population. We evaluated the frequency and severity of COVID-19 infection in a cohort of 211 subjects referring to our center for the regular administration of venom immunotherapy (VIT). Our result showed that the median age of our cohort is similar to the one that in our region has been associated with a high incidence of COVID-19 infection, increased hospitalization, and mortality rates. We reported only an isolated positivity of COVID-19 in the overall group; whereas none suffered from upper airway symptoms associated with COVID-19 (fever, cough, dyspnoea, sore throat, anosmia, and/or ageusia). Even though the demographic characteristics pose a substantial risk for such a population, we suggest that a regular administration of VIT may help in the development of an immunological milieu able to down modulate the Th1/Th17 environment that has been linked to inflammatory manifestations of COVID-19. To the best of our knowledge, this is the first description of the incidence of COVID-19 infection in Hymenoptera venom allergic patients treated with VIT, suggesting indirectly that venom immune tolerance-inducing treatment may be capable of reducing the aberrant inflammatory response induced by the virus in this specific population., (© 2020 The Authors.)

Published
2020
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