Search

Your search keyword '"Faust, Christina"' showing total 170 results
Start Over Author "Faust, Christina"
170 results on '"Faust, Christina"'

1. Anthropogenic land consolidation intensifies zoonotic host diversity loss and disease transmission in human habitats

Author

Pei, Shan, Yu, Pengbo, Raghwani, Jayna, Wang, Yuxin, Liu, Ziyan, Li, Yidan, Cheng, Yanchao, Lin, Qiushi, Song, Chuliang, Dharmarajan, Guha, Faust, Christina L., Tian, Yunyu, Xu, Yiting, Liang, Yilin, Qu, Jianhui, Wei, Jing, Li, Shen, Zhang, Tongjun, Ma, Chaofeng, Bharti, Nita, Cazelles, Bernard, Yang, Ruifu, Pybus, Oliver G., Dobson, Andrew P., Stenseth, Nils Chr., and Tian, Huaiyu

Published
2024
Full Text
View/download PDF

2. Ecological countermeasures to prevent pathogen spillover and subsequent pandemics.

Author

Plowright, Raina, Ahmed, Aliyu, Coulson, Tim, Crowther, Thomas, Ejotre, Imran, Faust, Christina, Frick, Winifred, Hudson, Peter, Kingston, Tigga, Nameer, P, OMara, M, Peel, Alison, Possingham, Hugh, Razgour, Orly, Reeder, DeeAnn, Ruiz-Aravena, Manuel, Simmons, Nancy, Srinivas, Prashanth, Tabor, Gary, Tanshi, Iroro, Thompson, Ian, Vanak, Abi, Vora, Neil, Willison, Charley, and Keeley, Annika

Subjects
Animals, Pandemics, Zoonoses, Viruses, Ecosystem
Abstract

Substantial global attention is focused on how to reduce the risk of future pandemics. Reducing this risk requires investment in prevention, preparedness, and response. Although preparedness and response have received significant focus, prevention, especially the prevention of zoonotic spillover, remains largely absent from global conversations. This oversight is due in part to the lack of a clear definition of prevention and lack of guidance on how to achieve it. To address this gap, we elucidate the mechanisms linking environmental change and zoonotic spillover using spillover of viruses from bats as a case study. We identify ecological interventions that can disrupt these spillover mechanisms and propose policy frameworks for their implementation. Recognizing that pandemics originate in ecological systems, we advocate for integrating ecological approaches alongside biomedical approaches in a comprehensive and balanced pandemic prevention strategy.

Published
2024

4. CONTRIBUTORS

Author

Abahuje, Egide, primary, Abrahim, Orit, additional, Adetifa, Ifedayo M.O., additional, Ajjampur, Sitara S.R., additional, Alexander, Suceena, additional, PhD, Chiara Altare,, additional, Alves, Fabiana, additional, Andrianaivoarimanana, Voahangy, additional, Angelakis, Emmanouil, additional, Aronson, Jeffrey K., additional, Atukorala, Inoshi G., additional, Baily, Guy, additional, Baker, Stephen, additional, Barrett, Alan D.T., additional, Basnyat, Buddha, additional, Bastawrous, Andrew, additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Baxter, Cheryl, additional, Beare, Nicholas A.V., additional, Beeching, Nick J., additional, Bekker, Linda-Gail, additional, Berlin, Anita, additional, FRS, Zulfiqar A. Bhutta, additional, Bloom, David E., additional, Blumberg, Lucille, additional, Boelaert, Marleen, additional, Brett-Major, David, additional, Brooker, Simon J., additional, Brouwer, Matthijs C., additional, Brunetti, Enrico, additional, Bull, Susan, additional, Bundy, Donald A.P., additional, Burri, Christian, additional, Bustinduy, Amaya L., additional, Caillet, Céline, additional, Chai, Jong Yil, additional, Chang, Thashi, additional, Chappuis, François, additional, Chibi, Buyisile, additional, Chiodini, Peter L., additional, Chowdhury, Rajiv, additional, Chowdhury, Sudipta Dhar, additional, Clemens, John D., additional, Cooke, Graham S., additional, Cotton, Mark F., additional, Currie, Bart J., additional, Cusack, Tomas-Paul, additional, Dance, David A.B., additional, Davis, Emily H., additional, Day, Nicholas P.J., additional, Deen, Jacqueline, additional, Dondorp, Arjen M., additional, Dünser, Martin W., additional, Eitzen, Edward, additional, Chebib, Hassan El, additional, Enria, Delia, additional, Faust, Christina, additional, Fekadu, Abebaw, additional, Fink, Günther, additional, Fischer, Peter U., additional, Fletcher, Tom, additional, Franco-Paredes, Carlos, additional, French, Neil, additional, Frumkin, Howard, additional, Garcia, Hector H., additional, Gerada, Alessandro, additional, Glass, Roger I., additional, Gordon, Stephen B., additional, Gottstein, Bruno, additional, Goyal, Alpesh, additional, Grey, Jonathan, additional, Gupta, Yashdeep, additional, Haines, Andy, additional, Hampson, Katie, additional, Hanlon, Charlotte, additional, Harrison, Mark, additional, Haswell, Melissa R., additional, Hawkesworth, Sophie, additional, Hay, Roderick J., additional, Heckmann, Jeannine M., additional, Heimesaat, Markus M., additional, Henao-Martínez, Andrés F., additional, Hien, Tran Tinh, additional, Hoerauf, Achim, additional, Irfan, Omar, additional, PhD, Euzebiusz Jamrozik, additional, Jobe, Modou, additional, John, George T., additional, Jones, Nick K., additional, Jones, Malcolm K., additional, Junghanss, Thomas, additional, Kaewkes, Sasithorn, additional, Karim, Quarraisha Abdool, additional, Keiser, Jennifer, additional, Kelly, Paul, additional, Khan, Amira M., additional, King, Charles H., additional, Kishore, Sandeep P., additional, Lang, Trudie, additional, Le, Thuy, additional, Liesenfeld, Oliver, additional, Lockwood, Diana N.J., additional, Mabey, David C.W., additional, Madkour, M. Monir, additional, Manesh, Abi, additional, Masekela, Refiloe, additional, Mäser, Pascal, additional, Mayaud, Philippe, additional, Mbanya, Dora, additional, McCarthy, James S., additional, McCartney, Daniel J., additional, McGready, Rose, additional, McKee, Martin, additional, Mc, Namara, Paul S., additional, Meara, John G., additional, Meintjes, Graeme, additional, Merson, Laura, additional, Mola, Glen, additional, Morassutti, Alessandra L., additional, Morris-Jones, Rachael, additional, Mortimer, Kevin J., additional, Muliyil, Divya Elizabeth, additional, Mumcuoglu, Kosta Y., additional, Munoz, Flor M., additional, Murphy, Adrianna, additional, Mutabingwa, Theonest, additional, Nawa, Yukifumi, additional, Newton, Paul N., additional, Nightingale, Sam, additional, Nokes, D. James, additional, Nosten, François H., additional, O’Hea, Jennifer, additional, Olliaro, Piero, additional, Ong, Jason J., additional, Oommen, Anu Mary, additional, Parashar, Umesh D., additional, Paris, Daniel H., additional, Parker, Michael, additional, Pluschke, Gerd, additional, Preidis, Geoffrey A., additional, Prentice, Andrew M., additional, Quail, Geoffrey, additional, Quinn, Thomas C., additional, Rabie, Helena, additional, Rajashekharaiah, Harsha, additional, Rajerison, Minoarisoa, additional, Ranganathan, Kannan, additional, Raoult, Didier, additional, Rassi,, Anis, additional, Ravi, Vasanthapuram, additional, Reddy, K. Srinath, additional, Rees, Claire, additional, Reynolds, Steven J., additional, Richter, Joachim, additional, Rijken, Marcus J., additional, Riviello, Robert, additional, Robinson, Janet, additional, Salazar, Juan C., additional, Schultz, Marcus J., additional, Schwarz, Dan, additional, Sendagire, Ibrahim, additional, Sharma, Savitri, additional, Shawon, Shajedur Rahman, additional, Singh, Bhagteshwar, additional, Sithithaworn, Paiboon, additional, Siwila, Joyce, additional, Solomon, Tom, additional, Spiegel, Paul, additional, Sridhar, Devi, additional, Sripa, Banchob, additional, Srour, M. Leila, additional, Stojković, Marija, additional, Strader, Christopher, additional, Suárez, Jose A., additional, Sundar, Shyam, additional, Tamarozzi, Francesca, additional, Tandon, Nikhil, additional, Tate, Jacqueline E., additional, Thachil, Jecko, additional, Thomson, Madeleine C., additional, Thwaites, Guy, additional, Thwaites, C. Louise, additional, van Daalen, Kim R., additional, Beek, Diederik van de, additional, van Doorn, H. Rogier, additional, Vega-Lopez, Francisco, additional, von Seidlein, MD, PhD, Lorenz, additional, Wakeham, Katie, additional, Walker, Stephen L., additional, Wallace, Ryan M., additional, Ward, Honorine, additional, Warrell, David A., additional, Weber, Tim Frederik, additional, Weil, Gary J., additional, White, Nicholas J., additional, White, MB Ch, B, Graham B., additional, Wong, Vanessa, additional, Wood, Robin, additional, Wood, Georgina, additional, Wyllie, Sarah, additional, Yacoub, Sophie, additional, Yen, Lam Minh, additional, Young, Paul R., additional, and Zafren, Ken, additional

Published
2024
Full Text
View/download PDF

6. Ecology, evolution and spillover of coronaviruses from bats.

Author

Ruiz-Aravena, Manuel, McKee, Clifton, Gamble, Amandine, Lunn, Tamika, Morris, Aaron, Snedden, Celine, Yinda, Claude, Port, Julia, Buchholz, David, Yeo, Yao, Faust, Christina, Jax, Elinor, Dee, Lauren, Jones, Devin, Kessler, Maureen, Falvo, Caylee, Crowley, Daniel, Bharti, Nita, Brook, Cara, Aguilar, Hector, Peel, Alison, Restif, Olivier, Schountz, Tony, Parrish, Colin, Gurley, Emily, Hudson, Peter, Munster, Vincent, Plowright, Raina, and Lloyd-Smith, James

Subjects
Animals, COVID-19, Chiroptera, Evolution, Molecular, Humans, Phylogeny, SARS-CoV-2
Abstract

In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS epidemic in 2002-2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly. More than 4,000 coronavirus sequences from 14 bat families have been identified, yet the true diversity of bat coronaviruses is probably much greater. Given that bats are the likely evolutionary source for several human coronaviruses, including strains that cause mild upper respiratory tract disease, their role in historic and future pandemics requires ongoing investigation. We review and integrate information on bat-coronavirus interactions at the molecular, tissue, host and population levels. We identify critical gaps in knowledge of bat coronaviruses, which relate to spillover and pandemic risk, including the pathways to zoonotic spillover, the infection dynamics within bat reservoir hosts, the role of prior adaptation in intermediate hosts for zoonotic transmission and the viral genotypes or traits that predict zoonotic capacity and pandemic potential. Filling these knowledge gaps may help prevent the next pandemic.

Published
2022

8. Cross-species pathogen spillover across ecosystem boundaries: mechanisms and theory.

Author

Borremans, Benny, Faust, Christina, Manlove, Kezia, Sokolow, Susanne, and Lloyd-Smith, James

Subjects
cross-boundary spillover, disease ecology, edge effects, emerging infectious disease, fragmentation, spillover theory, Animals, Animals, Wild, Disease Outbreaks, Disease Reservoirs, Ecosystem, Humans, Zoonoses
Abstract

Pathogen spillover between different host species is the trigger for many infectious disease outbreaks and emergence events, and ecosystem boundary areas have been suggested as spatial hotspots of spillover. This hypothesis is largely based on suspected higher rates of zoonotic disease spillover and emergence in fragmented landscapes and other areas where humans live in close vicinity to wildlife. For example, Ebola virus outbreaks have been linked to contacts between humans and infected wildlife at the rural-forest border, and spillover of yellow fever via mosquito vectors happens at the interface between forest and human settlements. Because spillover involves complex interactions between multiple species and is difficult to observe directly, empirical studies are scarce, particularly those that quantify underlying mechanisms. In this review, we identify and explore potential ecological mechanisms affecting spillover of pathogens (and parasites in general) at ecosystem boundaries. We borrow the concept of permeability from animal movement ecology as a measure of the likelihood that hosts and parasites are present in an ecosystem boundary region. We then discuss how different mechanisms operating at the levels of organisms and ecosystems might affect permeability and spillover. This review is a step towards developing a general theory of cross-species parasite spillover across ecosystem boundaries with the eventual aim of improving predictions of spillover risk in heterogeneous landscapes. This article is part of the theme issue Dynamic and integrative approaches to understanding pathogen spillover.

Published
2019

16. Author Correction: Ecology, evolution and spillover of coronaviruses from bats

Author

Ruiz-Aravena, Manuel, McKee, Clifton, Gamble, Amandine, Lunn, Tamika, Morris, Aaron, Snedden, Celine E., Yinda, Claude Kwe, Port, Julia R., Buchholz, David W., Yeo, Yao Yu, Faust, Christina, Jax, Elinor, Dee, Lauren, Jones, Devin N., Kessler, Maureen K., Falvo, Caylee, Crowley, Daniel, Bharti, Nita, Brook, Cara E., Aguilar, Hector C., Peel, Alison J., Restif, Olivier, Schountz, Tony, Parrish, Colin R., Gurley, Emily S., Lloyd-Smith, James O., Hudson, Peter J., Munster, Vincent J., and Plowright, Raina K.

Published
2022
Full Text
View/download PDF

22. Seasonal dynamics of the wild rodent faecal virome

Author

Raghwani, Jayna, primary, Faust, Christina L., additional, François, Sarah, additional, Nguyen, Dung, additional, Marsh, Kirsty, additional, Raulo, Aura, additional, Hill, Sarah C., additional, Parag, Kris V., additional, Simmonds, Peter, additional, Knowles, Sarah C. L., additional, and Pybus, Oliver G., additional

Published
2022
Full Text
View/download PDF

23. Seasonal dynamics of the wild rodent faecal virome.

Author

Raghwani, Jayna, Faust, Christina L., François, Sarah, Nguyen, Dung, Marsh, Kirsty, Raulo, Aura, Hill, Sarah C., Parag, Kris V., Simmonds, Peter, Knowles, Sarah C. L., and Pybus, Oliver G.

Subjects
*TEMPERATE forests, *SEASONS, *RODENTS, *VIRAL shedding, *INFECTIOUS disease transmission
Abstract

Viral discovery studies in wild animals often rely on cross‐sectional surveys at a single time point. As a result, our understanding of the temporal stability of wild animal viromes remains poorly resolved. While studies of single host–virus systems indicate that host and environmental factors influence seasonal virus transmission dynamics, comparable insights for whole viral communities in multiple hosts are lacking. Utilizing noninvasive faecal samples from a long‐term wild rodent study, we characterized viral communities of three common European rodent species (Apodemus sylvaticus, A. flavicollis and Myodes glareolus) living in temperate woodland over a single year. Our findings indicate that a substantial fraction of the rodent virome is seasonally transient and associated with vertebrate or bacteria hosts. Further analyses of one of the most common virus families, Picornaviridae, show pronounced temporal changes in viral richness and evenness, which were associated with concurrent and up to ~3‐month lags in host density, ambient temperature, rainfall and humidity, suggesting complex feedbacks from the host and environmental factors on virus transmission and shedding in seasonal habitats. Overall, this study emphasizes the importance of understanding the seasonal dynamics of wild animal viromes in order to better predict and mitigate zoonotic risks. see also the Perspective by Wei‐shan Chang and Michelle Wille [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

24. Translating from egg-to antigen-based indicators for Schistosoma mansoni elimination targets: a Bayesian latent class analysis study

Author

Clark, Jessica, Moses, Arinaitwe, Nankasi, Andrina, Faust, Christina L., Adriko, Moses, Ajambo, Diana, Besigye, Fred, Atuhaire, Arron, Wamboko, Aidah, Rowel, Candia, Carruthers, Lauren V., Francoeur, Rachel, Tukahebwa, Edridah M., Lamberton, Poppy H.L., and Prada, Joaquin M.

Abstract

Schistosomiasis is a parasitic disease affecting over 240-million people. World Health Organization (WHO) targets for Schistosoma mansoni elimination are based on Kato-Katz egg counts, without translation to the widely used, urine-based, point-of-care circulating cathodic antigen diagnostic (POC-CCA). We aimed to standardize POC-CCA score interpretation and translate them to Kato-Katz-based standards, broadening diagnostic utility in progress towards elimination. A Bayesian latent-class model was fit to data from 210 school-aged-children over four timepoints pre- to six-months-post-treatment. We used 1) Kato-Katz and established POC-CCA scoring (Negative, Trace, +, ++ and +++), and 2) Kato-Katz and G-Scores (a new, alternative POC-CCA scoring (G1 to G10)). We established the functional relationship between Kato-Katz counts and POC-CCA scores, and the score-associated probability of true infection. This was combined with measures of sensitivity, specificity, and the area under the curve to determine the optimal POC-CCA scoring system and positivity threshold. A simulation parametrized with model estimates established antigen-based elimination targets. True infection was associated with POC-CCA scores of ≥ + or ≥G3. POC-CCA scores cannot predict Kato-Katz counts because low infection intensities saturate the POC-CCA cassettes. Post-treatment POC-CCA sensitivity/specificity fluctuations indicate a changing relationship between egg excretion and antigen levels (living worms). Elimination targets can be identified by the POC-CCA score distribution in a population. A population with ≤2% ++/+++, or ≤0.5% G7 and above, indicates achieving current WHO Kato-Katz-based elimination targets. Population-level POC-CCA scores can be used to access WHO elimination targets prior to treatment. Caution should be exercised on an individual level and following treatment, as POC-CCAs lack resolution to discern between WHO Kato-Katz-based moderate- and high-intensity-infection categories, with limited use in certain settings and evaluations.

Published
2022

25. Additional file 2 of Variation in water contact behaviour and risk of Schistosoma mansoni (re)infection among Ugandan school-aged children in an area with persistent high endemicity

Author

Trienekens, Suzan C. M., Faust, Christina L., Besigye, Fred, Pickering, Lucy, Tukahebwa, Edridah M., Seeley, Janet, and Lamberton, Poppy H. L.

Abstract

Additional file 2: Table S2. Number of collected Biomphalaria snails by data collection time point, water contact site (A���J) and species. Abbreviations: Bs, Biomphalaria sudanica; Bp, Biomphalaria pfeifferi; Bc, Biomphalaria choanomphala).

Published
2022
Full Text
View/download PDF

27. Additional file 4 of Variation in water contact behaviour and risk of Schistosoma mansoni (re)infection among Ugandan school-aged children in an area with persistent high endemicity

Author

Trienekens, Suzan C. M., Faust, Christina L., Besigye, Fred, Pickering, Lucy, Tukahebwa, Edridah M., Seeley, Janet, and Lamberton, Poppy H. L.

Subjects
parasitic diseases
Abstract

Additional file 4: Table S4 Temperature, pH, total dissolved solids and conductivity by type of water contact site. Temperature was not found to be different between lake and non-lake sites, but pH was significantly higher for the lake sites. Total dissolved solids and conductivity were significantly higher in the non-lake sites.

Published
2022
Full Text
View/download PDF

28. Additional file 1 of Variation in water contact behaviour and risk of Schistosoma mansoni (re)infection among Ugandan school-aged children in an area with persistent high endemicity

Author

Trienekens, Suzan C. M., Faust, Christina L., Besigye, Fred, Pickering, Lucy, Tukahebwa, Edridah M., Seeley, Janet, and Lamberton, Poppy H. L.

Subjects
fluids and secretions, parasitic diseases
Abstract

Additional file 1: Table S1. Schistosoma mansoni infection status and intensity (mean number of eggs per gram of stool from 1���3 days of duplicate kato-katz thick smears) per timepoint for CLI and CRI. Week 0 occurred in March 2017.

Published
2022
Full Text
View/download PDF

32. Ecology, evolution and spillover of coronaviruses from bats

Author

Ruiz-Aravena, Manuel, primary, McKee, Clifton, additional, Gamble, Amandine, additional, Lunn, Tamika, additional, Morris, Aaron, additional, Snedden, Celine E., additional, Yinda, Claude Kwe, additional, Port, Julia R., additional, Buchholz, David W., additional, Yeo, Yao Yu, additional, Faust, Christina, additional, Jax, Elinor, additional, Dee, Lauren, additional, Jones, Devin N., additional, Kessler, Maureen K., additional, Falvo, Caylee, additional, Crowley, Daniel, additional, Bharti, Nita, additional, Brook, Cara E., additional, Aguilar, Hector C., additional, Peel, Alison J., additional, Restif, Olivier, additional, Schountz, Tony, additional, Parrish, Colin R., additional, Gurley, Emily S., additional, Lloyd-Smith, James O., additional, Hudson, Peter J., additional, Munster, Vincent J., additional, and Plowright, Raina K., additional

Published
2021
Full Text
View/download PDF

33. Contributors

Author

Abrams, Steven, primary, Adesina, Adekunle M., additional, Adu, Dwomoa, additional, Ajjampur, Sitara S.R., additional, Andrianaivoarimanana, Voahangy, additional, Emmanouil, Angelakis, additional, Aronson, Jeffrey K., additional, Atukorala, Inoshi, additional, Baily, Guy, additional, Bärnighausen, Till, additional, Basnyat, Buddha, additional, Bastawrous, Andrew, additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Beare, Nicholas A.V., additional, Bedi, Raman, additional, Beeching, Nick J., additional, Bennett, Nicholas J., additional, Berlin, Anita, additional, Bhigjee, Ahmed I., additional, Bhutta, Zulfiqar A., additional, Bloom, David E., additional, Blumberg, Lucille Hellen, additional, Boelaert, Marleen, additional, Bowden, Francis J., additional, Brabin, Bernard J., additional, Bray, Freddie, additional, Bray, Rodney A., additional, Brooker, Simon J., additional, Brouwer, Matthijs C., additional, Brun, Reto, additional, Brunetti, Enrico, additional, Bull, Susan, additional, Bundy, Donald A.P., additional, Burri, Christian, additional, Bustinduy, Amaya, additional, Chang, Thashi, additional, Chappuis, François, additional, Chierakul, Wirongrong, additional, Chiodini, Peter L., additional, Clemens, John D., additional, Cook, Gordon C., additional, Cotton, Mark F., additional, Coulter, John B.S., additional, Cunliffe, Nigel A., additional, Currie, Bart J., additional, Currie, Marian J., additional, Dance, David A.B., additional, Day, Nicholas P.J., additional, DeCock, Kevin, additional, Deen, Jacqueline, additional, Doffman, Sarah R, additional, Dondorp, Arjen, additional, van Doorn, H. Rogier, additional, Dünser, Martin W., additional, Eitzen, Edward M., additional, Enria, Delia A., additional, Farrar, Jeremy, additional, Faust, Christina, additional, Feasey, Nicholas A., additional, Fekadu, Abebaw, additional, Fink, Günther, additional, Fischer, Peter U., additional, Franco-Paredes, Carlos, additional, French, Neil, additional, Garcia, Hector H., additional, Glass, Roger I., additional, Gordon, Melita A., additional, Gordon, Stephen B., additional, Gottstein, Bruno, additional, Graham, Stephen M., additional, Haines, Andy, additional, Hall, Roy A., additional, Hanlon, Charlotte, additional, Hart, The late C. Anthony, additional, Haswell, Melissa R., additional, Hawkesworth, Sophie, additional, Hay, Roderick J., additional, Heckmann, Jeannine M., additional, Heimesaat, Markus M., additional, Hennis, Anselm J.M., additional, Hien, Tran Tinh, additional, Hoerauf, Achim, additional, Hotez, Peter J., additional, Humair, Salal, additional, Johansen, Cheryl A., additional, Johnson, Roch Christian, additional, Jones, Malcolm K., additional, Junghanss, Thomas, additional, Kaewkes, Sasithorn, additional, Kang, Gagandeep, additional, Kelly, Paul, additional, King, Charles H., additional, Kishore, Sandeep P., additional, Kissinger, Patricia, additional, Lalloo, David, additional, Lang, Trudie, additional, Liesenfeld, Oliver, additional, Lockwood, Diana N.J., additional, Mabey, David C.W., additional, Madkour, The late M. Monir, additional, Marston, Barbara J., additional, Masekela, Refiloe, additional, Mayaud, Philippe, additional, McCarthy, James S., additional, McGready, Rose, additional, McNamara, Paul S., additional, Merson, Laura, additional, Miller, Robert F., additional, Liddell, Glen D., additional, Mortimer, Kevin, additional, Motala, Ayesha A., additional, Mumcuoglu, Kosta Y., additional, Munoz, Flor M., additional, Munoz Roldan, Melba, additional, Mutabingwa, Theonest, additional, Nakagomi, Osamu, additional, Nawa, Yukifumi, additional, Newton, Robert, additional, Ng, Lisa F.P., additional, Nosten, François H., additional, O’Hea, Jennifer, additional, Owusu-Ofori, Shirley, additional, Paris, Daniel H., additional, Parker, Michael, additional, Peters, Philip J., additional, Pirie, Fraser J., additional, Pluschke, Gerd, additional, Prentice, Andrew M., additional, Quinn, Thomas C., additional, Rajerison, Minoarisoa Esther, additional, Raoult, Didier, additional, Ratsitorahina, Maherisoa, additional, Reddy, K. Srinath, additional, Reynolds, Steven J., additional, Richens, John, additional, Rijken, Marcus J., additional, Ritchie, Sara, additional, Robinson, Janet, additional, Rose, Angela M.C., additional, Salazar, Juan C., additional, Samuels, T. Alafia, additional, Schultz, Marcus J., additional, Scully, Crispian, additional, Shears, Paul, additional, Simonsen, Paul E., additional, Sithithaworn, Paiboon, additional, Smith, David W., additional, Solomon, Tom, additional, Southgate, Vaughan R., additional, Sripa, Banchob, additional, Srour, M. Leila, additional, Stojkovic, Marija, additional, Sundar, Shyam, additional, Thachil, Jecko, additional, Thuraisingham, Raj, additional, Thwaites, C. Louise, additional, Thwaites, Guy, additional, Török, M. Estée, additional, Unwin, Nigel, additional, van de Beek, Diederik, additional, Vega-Lopez, Francisco, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wakeham, Katie, additional, Walker, Stephen L., additional, Ward, Honorine, additional, Warrell, Mary J., additional, Warrell, David A., additional, Weil, Gary J., additional, White, Graham B., additional, White, Nicholas J., additional, Withington, Stephen G., additional, Wong, Vanessa, additional, Wood, Robin, additional, Wyllie, Sarah, additional, Yen, Lam Minh, additional, Young, Paul R., additional, Yacoub, Sophie, additional, and Zafren, Ken, additional

Published
2014
Full Text
View/download PDF

36. Reconciling Egg- and Antigen-Based Estimates of Schistosoma mansoni Clearance and Reinfection: A Modeling Study

Author

Clark, Jessica, primary, Moses, Arinaitwe, additional, Nankasi, Andrina, additional, Faust, Christina L, additional, Moses, Adriko, additional, Ajambo, Diana, additional, Besigye, Fred, additional, Atuhaire, Aaron, additional, Wamboko, Aidah, additional, Carruthers, Lauren V, additional, Francoeur, Rachel, additional, Tukahebwa, Edridah M, additional, Prada, Joaquin M, additional, and Lamberton, Poppy H L, additional

Published
2021
Full Text
View/download PDF

38. Evolutionary consequences of feedbacks between within-host competition and and disease control

Author

Greischar, Megan A., Alexander, Helen K., Bashey, Farrah, Bento, Ana, I., Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M., Daversa, David, Day, Troy, Faust, Christina L., Gallagher, Molly E., Gandon, Sylvain, Glidden, Caroline, Halliday, Fletcher, Hanley, Kathryn A., Kamiya, Tsukushi, Read, Andrew F., Schwabl, Philipp, Sweeny, Amy R., Tate, Ann T., Thompson, Robin N., Wale, Nina, Wearing, Helen J., Yeh, Pamela J., Mideo, Nicole, Greischar, Megan A., Alexander, Helen K., Bashey, Farrah, Bento, Ana, I., Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M., Daversa, David, Day, Troy, Faust, Christina L., Gallagher, Molly E., Gandon, Sylvain, Glidden, Caroline, Halliday, Fletcher, Hanley, Kathryn A., Kamiya, Tsukushi, Read, Andrew F., Schwabl, Philipp, Sweeny, Amy R., Tate, Ann T., Thompson, Robin N., Wale, Nina, Wearing, Helen J., Yeh, Pamela J., and Mideo, Nicole

Published
2020
Full Text
View/download PDF

39. Evolutionary consequences of feedbacks between within-host competition and and disease control

Author

Mathematics, Greischar, Megan A., Alexander, Helen K., Bashey, Farrah, Bento, Ana, I., Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M., Daversa, David, Day, Troy, Faust, Christina L., Gallagher, Molly E., Gandon, Sylvain, Glidden, Caroline, Halliday, Fletcher, Hanley, Kathryn A., Kamiya, Tsukushi, Read, Andrew F., Schwabl, Philipp, Sweeny, Amy R., Tate, Ann T., Thompson, Robin N., Wale, Nina, Wearing, Helen J., Yeh, Pamela J., Mideo, Nicole, Mathematics, Greischar, Megan A., Alexander, Helen K., Bashey, Farrah, Bento, Ana, I., Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M., Daversa, David, Day, Troy, Faust, Christina L., Gallagher, Molly E., Gandon, Sylvain, Glidden, Caroline, Halliday, Fletcher, Hanley, Kathryn A., Kamiya, Tsukushi, Read, Andrew F., Schwabl, Philipp, Sweeny, Amy R., Tate, Ann T., Thompson, Robin N., Wale, Nina, Wearing, Helen J., Yeh, Pamela J., and Mideo, Nicole

Published
2020

40. Evolutionary consequences of feedbacks between within-host competition and disease control

Author

Greischar, Megan A; https://orcid.org/0000-0002-7521-9344, Alexander, Helen K, Bashey, Farrah, Bento, Ana I, Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M, Daversa, David R, Day, Troy, Faust, Christina L, Gallagher, Molly E, Gandon, Sylvain, Glidden, Caroline K, Halliday, Fletcher W, Hanley, Kathryn A, Kamiya, Tsukushi, Read, Andrew F, Schwabl, Philipp, Sweeny, Amy R, Tate, Ann T, Thompson, Robin N, Wale, Nina, Wearing, Helen J, Yeh, Pamela J, Mideo, Nicole, Greischar, Megan A; https://orcid.org/0000-0002-7521-9344, Alexander, Helen K, Bashey, Farrah, Bento, Ana I, Bhattacharya, Amrita, Bushman, Mary, Childs, Lauren M, Daversa, David R, Day, Troy, Faust, Christina L, Gallagher, Molly E, Gandon, Sylvain, Glidden, Caroline K, Halliday, Fletcher W, Hanley, Kathryn A, Kamiya, Tsukushi, Read, Andrew F, Schwabl, Philipp, Sweeny, Amy R, Tate, Ann T, Thompson, Robin N, Wale, Nina, Wearing, Helen J, Yeh, Pamela J, and Mideo, Nicole

Abstract

Lay Summary: Competition often occurs among diverse parasites within a single host, but control efforts could change its strength. We examined how the interplay between competition and control could shape the evolution of parasite traits like drug resistance and disease severity.

Published
2020

41. Translating from Egg- to Antigen-Based Indicators for Schistosoma Mansoni Elimination Targets: A Bayesian Latent Class Analysis Study

Author

Clark, Jessica, primary, Moses, Arinaitwe, additional, Nankasi, Andrina, additional, Faust, Christina L., additional, Adriko, Moses, additional, Ajambo, Diana, additional, Besigye, Fred, additional, Atuhire, Arron, additional, Wamboko, Aidah, additional, Rowell, Candia, additional, Carruthers, Lauren V., additional, Francoeur, Rachel, additional, Tukahebwa, Edridah M., additional, Lamberton, Poppy H. L., additional, and Prada, Joaquin M., additional

Published
2021
Full Text
View/download PDF

42. Reconciling Egg- and Antigen-Based Estimates of Schistosoma mansoni Clearance and Reinfection: A Modeling Study.

Author

Clark, Jessica, Moses, Arinaitwe, Nankasi, Andrina, Faust, Christina L, Moses, Adriko, Ajambo, Diana, Besigye, Fred, Atuhaire, Aaron, Wamboko, Aidah, Carruthers, Lauren V, Francoeur, Rachel, Tukahebwa, Edridah M, Prada, Joaquin M, and Lamberton, Poppy H L

Subjects
HELMINTHIASIS, TREMATODA, CONFIDENCE intervals, REINFECTION, MOLECULAR pathology, DESCRIPTIVE statistics
Abstract

Background Despite decades of interventions, 240 million people have schistosomiasis. Infections cannot be directly observed, and egg-based Kato-Katz thick smears lack sensitivity, affected treatment efficacy and reinfection rate estimates. The point-of-care circulating cathodic antigen (referred to from here as POC-CCA+) test is advocated as an improvement on the Kato-Katz method, but improved estimates are limited by ambiguities in the interpretation of trace results. Method We collected repeated Kato-Katz egg counts from 210 school-aged children and scored POC-CCA tests according to the manufacturer's guidelines (referred to from here as POC-CCA+) and the externally developed G score. We used hidden Markov models parameterized with Kato-Katz; Kato-Katz and POC-CCA+; and Kato-Katz and G-Scores, inferring latent clearance and reinfection probabilities at four timepoints over six-months through a more formal statistical reconciliation of these diagnostics than previously conducted. Our approach required minimal but robust assumptions regarding trace interpretations. Results Antigen-based models estimated higher infection prevalence across all timepoints compared with the Kato-Katz model, corresponding to lower clearance and higher reinfection estimates. Specifically, pre-treatment prevalence estimates were 85% (Kato-Katz; 95% CI: 79%–92%), 99% (POC-CCA+; 97%–100%) and 98% (G-Score; 95%–100%). Post-treatment, 93% (Kato-Katz; 88%–96%), 72% (POC-CCA+; 64%–79%) and 65% (G-Score; 57%–73%) of those infected were estimated to clear infection. Of those who cleared infection, 35% (Kato-Katz; 27%–42%), 51% (POC-CCA+; 41%–62%) and 44% (G-Score; 33%–55%) were estimated to have been reinfected by 9-weeks. Conclusions Treatment impact was shorter-lived than Kato-Katz–based estimates alone suggested, with lower clearance and rapid reinfection. At 3 weeks after treatment, longer-term clearance dynamics are captured. At 9 weeks after treatment, reinfection was captured, but failed clearance could not be distinguished from rapid reinfection. Therefore, frequent sampling is required to understand these important epidemiological dynamics. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

43. Harnessing technology and portability to conduct molecular epidemiology of endemic pathogens in resource-limited settings

Author

Faust, Christina L, primary, Brunker, Kirstyn, additional, Ajambo, Diana, additional, Ryan, Mary, additional, Moses, Arinaitwe, additional, Rowel, Candia, additional, Wangoola, Robert Mandela, additional, Wampande, Eddie M, additional, Guma, Andrew, additional, Adriko, Moses, additional, Lamberton, Poppy H L, additional, Tukahebwa, Edridah M, additional, Mugenyi, Albert, additional, and Waiswa, Charles, additional

Published
2020
Full Text
View/download PDF

48. Evolutionary consequences of feedbacks between within-host competition and disease control

Author

Greischar, Megan A, primary, Alexander, Helen K, primary, Bashey, Farrah, primary, Bento, Ana I, primary, Bhattacharya, Amrita, primary, Bushman, Mary, primary, Childs, Lauren M, primary, Daversa, David R, primary, Day, Troy, primary, Faust, Christina L, primary, Gallagher, Molly E, primary, Gandon, Sylvain, primary, Glidden, Caroline K, primary, Halliday, Fletcher W, primary, Hanley, Kathryn A, primary, Kamiya, Tsukushi, primary, Read, Andrew F, primary, Schwabl, Philipp, primary, Sweeny, Amy R, primary, Tate, Ann T, primary, Thompson, Robin N, primary, Wale, Nina, primary, Wearing, Helen J, primary, Yeh, Pamela J, primary, and Mideo, Nicole, primary

Published
2020
Full Text
View/download PDF

49. MOESM1 of Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda

Author

Faust, Christina, Crotti, Marco, Arinaitwe Moses, Oguttu, David, Aidah Wamboko, Adriko, Moses, Adekanle, Elizabeth, Kabatereine, Narcis, Edridah Tukahebwa, Norton, Alice, Gower, Charlotte, Webster, Joanne, and Lamberton, Poppy

Subjects
Pharmacology, Evolutionary Biology, Ecology, Science Policy, 60506 Virology, Computational Biology, FOS: Earth and related environmental sciences, FOS: Health sciences, 59999 Environmental Sciences not elsewhere classified, Inorganic Chemistry, Space Science, FOS: Chemical sciences, FOS: Biological sciences, Medicine, 110309 Infectious Diseases, 69999 Biological Sciences not elsewhere classified
Abstract

Additional file 1: Text S1. Additional methods. Table S1. Travel distances between schools. Table S2. Summary of infrapopulations (individuals) sampled at each timepoint (listed as weeks since start of study). Table S3. Microsatellite loci utilized in this study. Text S2. Additional results. Table S4. Comparison of genetic diversity at the seven microsatellite loci used in the study. Table S5. Proportion infected at pre- and post-treatment. Table S6. Infection intensity between pre- and post-treatment timepoints. Table S7. Summary of infrapopulation phenotyped. Table S8. Frequency of miracidia isolated per individual from relative timepoints. Table S9. Frequency of full-sibling miracidia belonging to a family structure (including singletons) per individual. Table S10. Analysis of molecular variance (AMOVA) for Schistosoma mansoni. Figure S1. Parasite structure through time. Figure S2. Trees of phenotype data. Figure S3. Phylogenies of infrapopulations from individual children sampled over time (continued from Fig. 5). Figure S4. Pairwise FST between each school and timepoint. Figure S5. Population differentiation by village. Figure S6. Clustering by discriminant analysis of principal components (DAPC).

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results