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7. Antibiotic treatment of infections caused by carbapenem-resistant Gram-negative bacilli: an international ESCMID cross-sectional survey among infectious diseases specialists practicing in large hospitals

Author

Abbo, L., Abgueguen, P., Almirante, B., Azzini, A.M., Bani-Sadr, F., Bassetti, M., Ben-Ami, R., Beović, B., Béraud, G., Botelho-Nevers, E., Bou, G., Boutoille, D., Cabié, A., Cacopardo, B., Cascio, A., Cassir, N., Castelli, F., Cecala, M., Charmillon, A., Chirouze, C., Cisneros, J.M., Colmenero, J.D., Coppola, N., Corcione, S., Daikos, G.L., Dalla Gasperina, D., De la Calle Cabrera, C., Delobel, P., Di Caprio, D., Durante Mangoni, E., Dupon, M., Ettahar, N., Falagas, M.E., Falcone, M., Fariñas, M.C., Faure, E., Forestier, E., Foti, G., Gallagher, J., Gattuso, G., Gendrin, V., Gentile, I., Giacobbe, D.R., Gogos, C.A., Grandiere Perez, L., Hansmann, Y., Horcajada, J.P., Iacobello, C., Jacob, J.T., Justo, J.A., Kernéis, S., Komnos, A., Kotnik Kevorkijan, B., Lebeaux, D., Le Berre, R., Lechiche, C., Le Moxing, V., Lescure, F.X., Libanore, M., Martinot, M., Merino de Lucas, E., Mondain, V., Mondello, P., Montejo, M., Mootien, J., Muñoz, P., Nir-Paz, R., Pan, A., Paño-Pardo, J.R., Patel, G., Paul, M., Pérez Rodríguez, M.T., Piroth, L., Pogue, J., Potoski, B.A., Pourcher, V., Pyrpasopoulou, A., Rahav, G., Rizzi, M., Rodríguez-Baño, J., Salavert, M., Scheetz, M., Sims, M., Spahija, G., Stefani, S., Stefos, A., Tamma, P.D., Tattevin, P., Tedesco, A., Torre-Cisneros, J., Tripolitsioti, P., Tsiodras, S., Uomo, G., Verdon, R., Viale, P., Vitrat, V., Weinberger, M., Wiener-Well, Y., Papst, L., Pulcini, C., Durante-Mangoni, E., Kaye, K.S., and Raka, L.

Published
2018
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14. Rôle de l'infirmière dans la mise en place du parcours de soins des patients infectés par le MPox au sein d'un Centre Ambulatoire de Maladies Infectieuses en situation d'urgence émergente: retour d'expérience

Author

Duflos, S., primary, Broyez, M., additional, Paquet, O., additional, Faure, E., additional, Assaf, A., additional, Faure, K., additional, Moreau, F., additional, Diafi, F., additional, Kerjean, I., additional, and Vuotto, F., additional

Published
2023
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19. Testing the Effect of Relative Pollen Productivity on the REVEALS Model : A Validated Reconstruction of Europe-Wide Holocene Vegetation

Author

Serge, M. A., Mazier, F., Fyfe, R., Gaillard, Marie-José, Klein, T., Lagnoux, A., Galop, D., Githumbi, Esther, Mindrescu, M., Nielsen, A. B., Trondman, Anna-Kari, Poska, A., Sugita, S., Woodbridge, J., Abel-Schaad, D., Åkesson, C., Alenius, T., Ammann, B., Andersen, S. T., Scott Anderson, R., Andric, M., Balakauskas, L., Barnekow, L., Batalova, V., Bergman, J., Birks, H. John B., Björkman, L., Bjune, A. E., Borisova, O., Broothaerts, N., Carrion, J., Caseldine, C., Christiansen, J., Cui, Q., Curras, A., Czerwinski, S., David, R., Davies, A. L., De Jong, R., Di Rita, F., Dietre, B., Doerfler, W., Doyen, E., Edwards, K. J., Ejarque, A., Endtmann, E., Etienne, D., Faure, E., Feeser, I., Feurdean, A., Fischer, E., Fletcher, W., Franco-Mugica, F., Fredh, E. D., Froyd, C., Garces-Pastor, S., Garcia-Moreiras, I., Gauthier, E., Gil-Romera, G., Gonzalez-Samperiz, P., Grant, M. J., Grindean, R., Haas, J. N., Hannon, G., Heather, A. -J, Heikkilae, M., Hjelle, K., Jahns, S., Jasiunas, N., Jimenez-Moreno, G., Jouffroy-Bapicot, I., Kabailiene, M., Kamerling, I. M., Kangur, M., Karpinska-Kolaczek, M., Kasianova, A., Kolaczek, P., Lageras, P., Latalowa, M., Lechterbeck, J., Leroyer, C., Leydet, M., Lindbladh, M., Lisitsyna, O., Lopez-Saez, J. -A, Lowe, John, Luelmo-Lautenschlaeger, R., Lukanina, E., Macijauskaite, L., Magri, D., Marguerie, D., Marquer, L., Martinez-Cortizas, A., Mehl, I., Mesa-Fernandez, J. M., Mighall, T., Miola, A., Miras, Y., Morales-Molino, C., Mrotzek, A., Sobrino, C. Munoz, Odgaard, B., Ozola, I., Perez-Diaz, S., Perez-Obiol, R. P., Poggi, C., Rego, P. Ramil, Ramos-Roman, M. J., Rasmussen, P., Reille, M., Roesch, M., Ruffaldi, P., Goni, M. Sanchez, Savukyniene, N., Schroeder, T., Schult, M., Segerström, U., Seppae, H., Vives, G. Servera, Shumilovskikh, L., Smettan, H. W., Stancikaite, M., Stevenson, A. C., Stivrins, N., Tantau, I., Theuerkauf, M., Tonkov, S., van der Knaap, W. O., van Leeuwen, J. F. N., Vecmane, E., Verstraeten, G., Veski, S., Voigt, R., Von Stedingk, H., Waller, M. P., Wiethold, J., Willis, K. J., Wolters, S., Zernitskaya, V. P., Serge, M. A., Mazier, F., Fyfe, R., Gaillard, Marie-José, Klein, T., Lagnoux, A., Galop, D., Githumbi, Esther, Mindrescu, M., Nielsen, A. B., Trondman, Anna-Kari, Poska, A., Sugita, S., Woodbridge, J., Abel-Schaad, D., Åkesson, C., Alenius, T., Ammann, B., Andersen, S. T., Scott Anderson, R., Andric, M., Balakauskas, L., Barnekow, L., Batalova, V., Bergman, J., Birks, H. John B., Björkman, L., Bjune, A. E., Borisova, O., Broothaerts, N., Carrion, J., Caseldine, C., Christiansen, J., Cui, Q., Curras, A., Czerwinski, S., David, R., Davies, A. L., De Jong, R., Di Rita, F., Dietre, B., Doerfler, W., Doyen, E., Edwards, K. J., Ejarque, A., Endtmann, E., Etienne, D., Faure, E., Feeser, I., Feurdean, A., Fischer, E., Fletcher, W., Franco-Mugica, F., Fredh, E. D., Froyd, C., Garces-Pastor, S., Garcia-Moreiras, I., Gauthier, E., Gil-Romera, G., Gonzalez-Samperiz, P., Grant, M. J., Grindean, R., Haas, J. N., Hannon, G., Heather, A. -J, Heikkilae, M., Hjelle, K., Jahns, S., Jasiunas, N., Jimenez-Moreno, G., Jouffroy-Bapicot, I., Kabailiene, M., Kamerling, I. M., Kangur, M., Karpinska-Kolaczek, M., Kasianova, A., Kolaczek, P., Lageras, P., Latalowa, M., Lechterbeck, J., Leroyer, C., Leydet, M., Lindbladh, M., Lisitsyna, O., Lopez-Saez, J. -A, Lowe, John, Luelmo-Lautenschlaeger, R., Lukanina, E., Macijauskaite, L., Magri, D., Marguerie, D., Marquer, L., Martinez-Cortizas, A., Mehl, I., Mesa-Fernandez, J. M., Mighall, T., Miola, A., Miras, Y., Morales-Molino, C., Mrotzek, A., Sobrino, C. Munoz, Odgaard, B., Ozola, I., Perez-Diaz, S., Perez-Obiol, R. P., Poggi, C., Rego, P. Ramil, Ramos-Roman, M. J., Rasmussen, P., Reille, M., Roesch, M., Ruffaldi, P., Goni, M. Sanchez, Savukyniene, N., Schroeder, T., Schult, M., Segerström, U., Seppae, H., Vives, G. Servera, Shumilovskikh, L., Smettan, H. W., Stancikaite, M., Stevenson, A. C., Stivrins, N., Tantau, I., Theuerkauf, M., Tonkov, S., van der Knaap, W. O., van Leeuwen, J. F. N., Vecmane, E., Verstraeten, G., Veski, S., Voigt, R., Von Stedingk, H., Waller, M. P., Wiethold, J., Willis, K. J., Wolters, S., and Zernitskaya, V. P.

Abstract

Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based reconstructions of plant cover in Europe (at a spatial resolution of 1 degrees x 1 degrees) over the Holocene (last 11.7 ka BP) using the 'Regional Estimates of VEgetation Abundance from Large Sites' (REVEALS) model. This study has three main aims. First, to present the most accurate and reliable generation of REVEALS reconstructions across Europe so far. This has been achieved by including a larger number of pollen records compared to former analyses, in particular from the Mediterranean area. Second, to discuss methodological issues in the quantification of past land cover by using alternative datasets of relative pollen productivities (RPPs), one of the key input parameters of REVEALS, to test model sensitivity. Finally, to validate our reconstructions with the global forest change dataset. The results suggest that the RPPs.st1 (31 taxa) dataset is best suited to producing regional vegetation cover estimates for Europe. These reconstructions offer a long-term perspective providing unique possibilities to explore spatial-temporal changes in past land cover and biodiversity.

Published
2023
Full Text
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20. Testing the Effect of Relative Pollen Productivity on the REVEALS Model: A Validated Reconstruction of Europe-Wide Holocene Vegetation

Author

European Commission, Serge, M. A., Mazier, F., Fyfe, R., Gaillard, M. J., Klein, T., Lagnoux, A., Galop, D., Githumbi, E., Mindrescu, M., Nielsen, A. B., Trondman, A. K., Barnekow, L., Batalova, V., Bergman, J., Birks, H. John B., Björkman, L., Bjune, A. E., Borisova, O., Broothaerts, N., Carrion, J., Caseldine, C., Grindean, R., Christiansen, J., Cui, Q., Currás, Andrés, Czerwiński, S., David, R., Davies, A. L., De Jong, R., Di Rita, F., Dietre, B., Dörfler, W., Haas, J. N., Doyen, E., Edwards, K. J., Ejarque, A., Endtmann, E., Etienne, D., Faure, E., Feeser, I., Feurdean, A., Fischer, E., Fletcher, W., Hannon, G., Franco-Múgica, F., Fredh, E. D., Froyd, C., Garcés-Pastor, S., García-Moreiras, I., Gauthier, E., Gil-Romera, Graciela, González-Sampériz, Penélope, Grant, M. J., Heather, A. J., Heikkilä, M., Hjelle, K., Jahns, S., Jasiunas, N., Jiménez-Moreno, G., Jouffroy-Bapicot, I., Sobrino, C. Muñoz, Kabailienė, M., Kamerling, I. M., Kangur, M., Karpińska-Kołaczek, M., Kasianova, A., Kołaczek, P., Lagerås, P., Latalowa, M., Lechterbeck, J., Leroyer, C., Odgaard, B., Leydet, M., Lindbladh, M., Lisitsyna, O., López Sáez, José Antonio, Lowe, John, Luelmo Lautenschlaeger, Reyes, Lukanina, E., Macijauskaitė, L., Magri, D., Marguerie, D., Ozola, I., Marquer, L., Martínez Cortizas, Antonio, Mehl, I., Mesa-Fernández, J. M., Mighall, Tim, Miola, A., Miras, Y., Morales-Molino, C., Mrotzek, A., Pérez-Díaz, S., Pérez-Obiol, R. P., Poggi, C., Rego, P. Ramil, Ramos-Román, M. J., Rasmussen, P., Reille, M., Poska, A., Rösch, M., Ruffaldi, P., Goni, M. Sánchez, Savukynienė, N., Schröder, T., Schult, M., Segerström, U., Seppä, H., Vives, G. Servera, Shumilovskikh, L., Sugita, S., Smettan, H. W., Stancikaite, M., Stevenson, A. C., Stivrins, N., Tantau, I., Theuerkauf, M., Tonkov, S., van der Knaap, W. O., van Leeuwen, J. F. N., Vecmane, E., Woodbridge, J., Verstraeten, G., Veski, S., Voigt, R., Von Stedingk, H., Waller, M. P., Wiethold, J., Willis, K. J., Wolters, S., Zernitskaya, V. P., Abel-Schaad, D., Åkesson, C., Alenius, T., Ammann, B., Andersen, S. T., Anderson, R. Scott, Andrič, M., Balakauskas, L., European Commission, Serge, M. A., Mazier, F., Fyfe, R., Gaillard, M. J., Klein, T., Lagnoux, A., Galop, D., Githumbi, E., Mindrescu, M., Nielsen, A. B., Trondman, A. K., Barnekow, L., Batalova, V., Bergman, J., Birks, H. John B., Björkman, L., Bjune, A. E., Borisova, O., Broothaerts, N., Carrion, J., Caseldine, C., Grindean, R., Christiansen, J., Cui, Q., Currás, Andrés, Czerwiński, S., David, R., Davies, A. L., De Jong, R., Di Rita, F., Dietre, B., Dörfler, W., Haas, J. N., Doyen, E., Edwards, K. J., Ejarque, A., Endtmann, E., Etienne, D., Faure, E., Feeser, I., Feurdean, A., Fischer, E., Fletcher, W., Hannon, G., Franco-Múgica, F., Fredh, E. D., Froyd, C., Garcés-Pastor, S., García-Moreiras, I., Gauthier, E., Gil-Romera, Graciela, González-Sampériz, Penélope, Grant, M. J., Heather, A. J., Heikkilä, M., Hjelle, K., Jahns, S., Jasiunas, N., Jiménez-Moreno, G., Jouffroy-Bapicot, I., Sobrino, C. Muñoz, Kabailienė, M., Kamerling, I. M., Kangur, M., Karpińska-Kołaczek, M., Kasianova, A., Kołaczek, P., Lagerås, P., Latalowa, M., Lechterbeck, J., Leroyer, C., Odgaard, B., Leydet, M., Lindbladh, M., Lisitsyna, O., López Sáez, José Antonio, Lowe, John, Luelmo Lautenschlaeger, Reyes, Lukanina, E., Macijauskaitė, L., Magri, D., Marguerie, D., Ozola, I., Marquer, L., Martínez Cortizas, Antonio, Mehl, I., Mesa-Fernández, J. M., Mighall, Tim, Miola, A., Miras, Y., Morales-Molino, C., Mrotzek, A., Pérez-Díaz, S., Pérez-Obiol, R. P., Poggi, C., Rego, P. Ramil, Ramos-Román, M. J., Rasmussen, P., Reille, M., Poska, A., Rösch, M., Ruffaldi, P., Goni, M. Sánchez, Savukynienė, N., Schröder, T., Schult, M., Segerström, U., Seppä, H., Vives, G. Servera, Shumilovskikh, L., Sugita, S., Smettan, H. W., Stancikaite, M., Stevenson, A. C., Stivrins, N., Tantau, I., Theuerkauf, M., Tonkov, S., van der Knaap, W. O., van Leeuwen, J. F. N., Vecmane, E., Woodbridge, J., Verstraeten, G., Veski, S., Voigt, R., Von Stedingk, H., Waller, M. P., Wiethold, J., Willis, K. J., Wolters, S., Zernitskaya, V. P., Abel-Schaad, D., Åkesson, C., Alenius, T., Ammann, B., Andersen, S. T., Anderson, R. Scott, Andrič, M., and Balakauskas, L.

Abstract

Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based reconstructions of plant cover in Europe (at a spatial resolution of 1° × 1°) over the Holocene (last 11.7 ka BP) using the ‘Regional Estimates of VEgetation Abundance from Large Sites’ (REVEALS) model. This study has three main aims. First, to present the most accurate and reliable generation of REVEALS reconstructions across Europe so far. This has been achieved by including a larger number of pollen records compared to former analyses, in particular from the Mediterranean area. Second, to discuss methodological issues in the quantification of past land cover by using alternative datasets of relative pollen productivities (RPPs), one of the key input parameters of REVEALS, to test model sensitivity. Finally, to validate our reconstructions with the global forest change dataset. The results suggest that the RPPs.st1 (31 taxa) dataset is best suited to producing regional vegetation cover estimates for Europe. These reconstructions offer a long-term perspective providing unique possibilities to explore spatial-temporal changes in past land cover and biodiversity.

Published
2023

21. Testing the Effect of Relative Pollen Productivity on the REVEALS Model: A Validated Reconstruction of Europe-Wide Holocene Vegetation

Author

Serge, M., primary, Mazier, F., additional, Fyfe, R., additional, Gaillard, M.-J., additional, Klein, T., additional, Lagnoux, A., additional, Galop, D., additional, Githumbi, E., additional, Mindrescu, M., additional, Nielsen, A., additional, Trondman, A.-K., additional, Poska, A., additional, Sugita, S., additional, Woodbridge, J., additional, Abel-Schaad, D., additional, Åkesson, C., additional, Alenius, T., additional, Ammann, B., additional, Andersen, S., additional, Anderson, R., additional, Andrič, M., additional, Balakauskas, L., additional, Barnekow, L., additional, Batalova, V., additional, Bergman, J., additional, Birks, H., additional, Björkman, L., additional, Bjune, A., additional, Borisova, O., additional, Broothaerts, N., additional, Carrion, J., additional, Caseldine, C., additional, Christiansen, J., additional, Cui, Q., additional, Currás, A., additional, Czerwiński, S., additional, David, R., additional, Davies, A., additional, De Jong, R., additional, Di Rita, F., additional, Dietre, B., additional, Dörfler, W., additional, Doyen, E., additional, Edwards, K., additional, Ejarque, A., additional, Endtmann, E., additional, Etienne, D., additional, Faure, E., additional, Feeser, I., additional, Feurdean, A., additional, Fischer, E., additional, Fletcher, W., additional, Franco-Múgica, F., additional, Fredh, E., additional, Froyd, C., additional, Garcés-Pastor, S., additional, García-Moreiras, I., additional, Gauthier, E., additional, Gil-Romera, G., additional, González-Sampériz, P., additional, Grant, M., additional, Grindean, R., additional, Haas, J., additional, Hannon, G., additional, Heather, A.-J., additional, Heikkilä, M., additional, Hjelle, K., additional, Jahns, S., additional, Jasiunas, N., additional, Jiménez-Moreno, G., additional, Jouffroy-Bapicot, I., additional, Kabailienė, M., additional, Kamerling, I., additional, Kangur, M., additional, Karpińska-Kołaczek, M., additional, Kasianova, A., additional, Kołaczek, P., additional, Lagerås, P., additional, Latalowa, M., additional, Lechterbeck, J., additional, Leroyer, C., additional, Leydet, M., additional, Lindbladh, M., additional, Lisitsyna, O., additional, López-Sáez, J.-A., additional, Lowe, John, additional, Luelmo-Lautenschlaeger, R., additional, Lukanina, E., additional, Macijauskaitė, L., additional, Magri, D., additional, Marguerie, D., additional, Marquer, L., additional, Martinez-Cortizas, A., additional, Mehl, I., additional, Mesa-Fernández, J., additional, Mighall, T., additional, Miola, A., additional, Miras, Y., additional, Morales-Molino, C., additional, Mrotzek, A., additional, Sobrino, C., additional, Odgaard, B., additional, Ozola, I., additional, Pérez-Díaz, S., additional, Pérez-Obiol, R., additional, Poggi, C., additional, Rego, P., additional, Ramos-Román, M., additional, Rasmussen, P., additional, Reille, M., additional, Rösch, M., additional, Ruffaldi, P., additional, Goni, M., additional, Savukynienė, N., additional, Schröder, T., additional, Schult, M., additional, Segerström, U., additional, Seppä, H., additional, Vives, G., additional, Shumilovskikh, L., additional, Smettan, H., additional, Stancikaite, M., additional, Stevenson, A., additional, Stivrins, N., additional, Tantau, I., additional, Theuerkauf, M., additional, Tonkov, S., additional, van der Knaap, W., additional, van Leeuwen, J., additional, Vecmane, E., additional, Verstraeten, G., additional, Veski, S., additional, Voigt, R., additional, Von Stedingk, H., additional, Waller, M., additional, Wiethold, J., additional, Willis, K., additional, Wolters, S., additional, and Zernitskaya, V., additional

Published
2023
Full Text
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23. Testing the Effect of Relative Pollen Productivity on the REVEALS Model: A Validated Reconstruction of Europe-Wide Holocene Vegetation

Author

Serge, MA, Mazier, F, Fyfe, R, Gaillard, MJ, Klein, T, Lagnoux, A, Galop, D, Githumbi, E, Mindrescu, M, Nielsen, AB, Trondman, AK, Poska, A, Sugita, S, Woodbridge, J, Abel-Schaad, D, Åkesson, C, Alenius, T, Ammann, B, Andersen, ST, Anderson, RS, Andrič, M, Balakauskas, L, Barnekow, L, Batalova, V, Bergman, J, Birks, HJB, Björkman, L, Bjune, AE, Borisova, O, Broothaerts, N, Carrion, J, Caseldine, C, Christiansen, J, Cui, Q, Currás, A, Czerwiński, S, David, R, Davies, AL, De Jong, R, Di Rita, F, Dietre, B, Dörfler, W, Doyen, E, Edwards, KJ, Ejarque, A, Endtmann, E, Etienne, D, Faure, E, Feeser, I, Feurdean, A, Fischer, E, Fletcher, W, Franco-Múgica, F, Fredh, ED, Froyd, C, Garcés-Pastor, S, García-Moreiras, I, Gauthier, E, Gil-Romera, G, González-Sampériz, P, Grant, MJ, Grindean, R, Haas, JN, Hannon, G, Heather, AJ, Heikkilä, M, Hjelle, K, Jahns, S, Jasiunas, N, Jiménez-Moreno, G, Jouffroy-Bapicot, I, Kabailienė, M, Kamerling, IM, Kangur, M, Karpińska-Kołaczek, M, Kasianova, A, Kołaczek, P, Lagerås, P, Latalowa, M, Lechterbeck, J, Leroyer, C, Leydet, M, Lindbladh, M, Lisitsyna, O, López-Sáez, JA, Lowe, J, Luelmo-Lautenschlaeger, R, Lukanina, E, Macijauskaitė, L, Magri, D, Marguerie, D, Marquer, L, Martinez-Cortizas, A, Mehl, I, Mesa-Fernández, JM, Mighall, T, Miola, A, Miras, Y, Morales-Molino, C, Mrotzek, A, Serge, MA [0000-0001-5506-9732], Mazier, F [0000-0003-2643-0925], Fyfe, R [0000-0002-5676-008X], Gaillard, MJ [0000-0002-2025-410X], Klein, T [0000-0002-1276-3078], Lagnoux, A [0000-0002-6841-5814], Galop, D [0000-0003-1746-4760], Githumbi, E [0000-0002-6470-8986], Mindrescu, M [0000-0003-2291-4877], Nielsen, AB [0000-0001-7854-353X], Trondman, AK [0000-0003-3865-8548], Poska, A [0000-0002-8778-1430], Sugita, S [0000-0002-3634-7095], Woodbridge, J [0000-0003-0756-3538], Abel-Schaad, D [0000-0003-3915-8342], Alenius, T [0000-0003-2965-5177], Ammann, B [0000-0001-6123-6357], Andrič, M [0000-0003-1211-7081], Balakauskas, L [0000-0002-8941-989X], Batalova, V [0000-0002-8375-2835], Bergman, J [0000-0002-6753-917X], Birks, HJB [0000-0002-5891-9859], Bjune, AE [0000-0002-4509-0148], Borisova, O [0000-0003-1728-7610], Broothaerts, N [0000-0002-8605-9657], Carrion, J [0000-0002-6949-4382], Christiansen, J [0000-0003-2693-9887], Cui, Q [0000-0001-9824-3315], Currás, A [0000-0002-1828-7455], Czerwiński, S [0000-0003-3422-040X], Di Rita, F [0000-0002-3065-8474], Dietre, B [0000-0002-9959-3613], Dörfler, W [0000-0001-6251-7185], Ejarque, A [0000-0001-9101-5299], Feeser, I [0000-0002-9618-5139], Feurdean, A [0000-0002-2497-3005], Fletcher, W [0000-0001-8918-0690], Franco-Múgica, F [0000-0002-9372-8863], Fredh, ED [0000-0003-1787-6976], Froyd, C [0000-0001-5291-9156], Garcés-Pastor, S [0000-0001-5652-7264], García-Moreiras, I [0000-0001-8713-0374], Gauthier, E [0000-0002-9238-8190], Gil-Romera, G [0000-0001-5726-2536], González-Sampériz, P [0000-0002-5097-1468], Grant, MJ [0000-0002-4766-6913], Grindean, R [0000-0002-0518-8490], Hannon, G [0000-0002-5536-7884], Heikkilä, M [0000-0003-3885-8670], Hjelle, K [0000-0001-5777-0362], Jiménez-Moreno, G [0000-0001-7185-8686], Jouffroy-Bapicot, I [0000-0001-5920-7565], Kamerling, IM [0000-0003-3321-8631], Karpińska-Kołaczek, M [0000-0002-3249-7408], Kołaczek, P [0000-0003-2552-8269], Lagerås, P [0000-0002-2804-8028], Latalowa, M [0000-0001-7594-5146], Lechterbeck, J [0000-0003-3582-2605], Leroyer, C [0000-0002-2370-7303], Leydet, M [0000-0003-1123-3427], Lindbladh, M [0000-0002-0577-0050], Lisitsyna, O [0000-0003-1415-7650], López-Sáez, JA [0000-0002-3122-2744], Lukanina, E [0000-0001-7573-797X], Macijauskaitė, L [0000-0002-0623-871X], Magri, D [0000-0001-7254-593X], Marguerie, D [0000-0001-8672-2570], Marquer, L [0000-0002-5772-3782], Martinez-Cortizas, A [0000-0003-0430-5760], Mesa-Fernández, JM [0000-0003-1778-8351], Mighall, T [0000-0002-8365-7694], Miola, A [0000-0002-3441-4880], Miras, Y [0000-0002-4055-4134], Morales-Molino, C [0000-0002-9464-862X], and Apollo - University of Cambridge Repository

Subjects
15 Life on Land, 4104 Environmental Management, 3304 Urban and Regional Planning, 41 Environmental Sciences, 33 Built Environment and Design, 3301 Architecture
Abstract

Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based reconstructions of plant cover in Europe (at a spatial resolution of 1° × 1°) over the Holocene (last 11.7 ka BP) using the ‘Regional Estimates of VEgetation Abundance from Large Sites’ (REVEALS) model. This study has three main aims. First, to present the most accurate and reliable generation of REVEALS reconstructions across Europe so far. This has been achieved by including a larger number of pollen records compared to former analyses, in particular from the Mediterranean area. Second, to discuss methodological issues in the quantification of past land cover by using alternative datasets of relative pollen productivities (RPPs), one of the key input parameters of REVEALS, to test model sensitivity. Finally, to validate our reconstructions with the global forest change dataset. The results suggest that the RPPs.st1 (31 taxa) dataset is best suited to producing regional vegetation cover estimates for Europe. These reconstructions offer a long-term perspective providing unique possibilities to explore spatial-temporal changes in past land cover and biodiversity.

Published
2023

25. Математичне моделювання дискових п’єзоелектричних перетворювачiв для акустоелектронних пристроїв

Author

Bazilo, C. V., Bondarenko, M. O., Usyk, L. M., Faure, E. V., and Kovalenko, Yu. I.

Subjects
акустоелектронiка, дисковий елемент, п’єзоелектричний перетворювач, математична модель, 534.232.082.73, impedance, mathematical mode, disk element, iмпеданс, piezoelectric transducer, acoustoelectronics
Abstract

This study has presented an algorithm for assembling, solving, and analyzing the results obtained by mathematical modeling of the disc piezoelectric transducers, which are widely used in hydroacoustics, microelectronics, microcircuit engineering (for example, as components of receiving antennas of hydroacoustic communication devices). The models developed in this study enable us to establish dependencies, which represent a mathematical description of the electroacoustic connection between the wave fields in different sections of the disc piezoelectric transducers. Analytical dependences obtained by mathematical modelling make it possible to establish the electrical impedance and quality factor together with the amplitude values of the electric charge and current on the electroded surfaces of the piezoelectric disk, subject to the inverse piezoelectric effect conditions. A complete calculation of the problem of harmonic radial oscillations of disc piezoelectric transducers allowed the authors to significantly expand the list of physical and mechanical parameters of the piezoelectric material, which had been previously determined experimentally. The research has revealed the dependence of the change in electrical impedance on the values of the electromechanical coupling coefficient, the wave number of elastic oscillations, and the Voigt indices. The study has also determined a high agreement between the electric impedance modules of discs made of lead zirconate titanate PZT piezoelectric ceramics with and without the piezoelectric effect (the difference between the impedance values in these cases did not exceed 18%). В матерiалах статтi представлено алгоритм побудови та дослiдження математичних моделей дискових п’єзоелектричних перетворювачiв, що знаходять широке застосування в гiдроакустицi, мiкроелектронiцi, мiкросхемотехнiцi (наприклад, як компоненти приймальних антен приладiв гiдроакустичного зв’язку). Переваги розроблених в статтi моделей полягають у можливостi встановлення за їх допомогою залежностей, якi є математичним описом електроакустичного зв’язку мiж хвильовими полями на рiзних дiлянках п’єзоелектричного перетворювача дискової форми. Отриманi шляхом математичного моделювання аналiтичнi залежностi дозволяють розрахувати значення електричного iмпедансу та добротностi разом з амплiтудними значеннями електричного заряду та струму на електродованих поверхнях п’єзоелектричного диску за умов зворотного п’єзоелектричного ефекту. Проведений повний розрахунок задачi щодо гармонiйних радiальних коливань дискових п’єзоелектричних перетворювачiв дозволив суттєво розширити перелiк фiзико-механiчних параметрiв п’єзоматерiалу, якi ранiше визначалися експериментально. Показана залежнiсть змiни електричного iмпедансу вiд значень коефiцiєнту електромеханiчного зв’язку, хвильового числа пружних коливань та iндексiв Фойгта. Також встановлена висока збiжнiсть мiж модулями електричного iмпедансу дискiв з п’єзоелектричної керамiки сорту ЦТС (цирконат-титанат свинцю), як з урахуванням, так i без урахування п’єзоелектричного ефекту (розбiжнiсть мiж значеннями iмпедансу в цих випадках не перевищувала 18%).

Published
2023
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31. Methodology for the design of digital brain atlases

Author

Gibaud, B., Garlatti, S., Barillot, C., Faure, E., Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Keravnou, Elpida, editor, Garbay, Catherine, editor, Baud, Robert, editor, and Wyatt, Jeremy, editor

Published
1997
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32. The Hyalomma marginatum holobiont as a part of the Holis-Tiques project aiming at establishing the invasion history, the spread and associated risks

Author

Joly Kukla, Charlotte, Stachurski, Frédéric, Vial, Laurence, Jourdan-Pineau, Hélène, Huber, Karine, Verheyden, Hélène, Bernard, Célia, Duhayon, Maxime, Faure, E., Holzmuller, Philippe, Malandrin, Laurence, Marano, I., Moutailler, Sara, Pollet, Thomas, Joly Kukla, Charlotte, Stachurski, Frédéric, Vial, Laurence, Jourdan-Pineau, Hélène, Huber, Karine, Verheyden, Hélène, Bernard, Célia, Duhayon, Maxime, Faure, E., Holzmuller, Philippe, Malandrin, Laurence, Marano, I., Moutailler, Sara, and Pollet, Thomas

Abstract

Hyalomma marginatum is an endemic tick species in Mediterranean countries. Its area of distribution keeps expanding and has reached the South of France (region Occitanie) in 2015. H. marginatum is known as a vector of pathogens of interest in veterinary and human health, the most concerning H. marginatum-borne pathogen being the Crimean-Congo fever virus. Bacteria from genera Rickettsia and Anaplasma as well as the Theileria equi parasites are other pathogens H. marginatum is known to carry. It is within this context that reconstructing H. marginatum invasion history and assess associated risks has become a necessity for the tick control. The Holis-Tiques project founded by “Défi clé RIVOC région Occitanie” was built to handle this challenge. The scientific questions are spread into four work packages managed by several partner experts. Massive ticks sampling campaigns following different conditions are planned in order to provide the biological material necessary to cover the entire project. To get into the bottom of the subject, H. marginatum spread in Occitanie will be evaluated and mapped in time (2016-2022), and space. Key factors such as development and survival determinants -potentially explaining its invasion capacity- will be investigated according to experimental cages on the field assigned to different conditions (light, shadow, temperature, hygrometry) and will allow to feed distribution models. Moreover, potential genetic signatures associated to H. marginatum expansion will be highlighted by population phylogeographic and genetic studies. Since the tick is expanding, pathogen dissemination issues also raise a concern. About 40 pathogens (bacteria, virus, parasites) will be screened by the Fluidigm® technology in order to monitor pathogens distribution in space and time. On the other hand, H. marginatum microbiota have rarely been examined. The Holis-Tiques project will therefore assess the spatio-temporal dynamics of the H. marginatum microbiota. Combi

Published
2022

34. Association between transportation noise exposure ans hypertension risk in the french E3N cohort

Author

Faure, E., primary, Houeto, A., additional, Boileau, A., additional, Perrin, C., additional, Gelot, A., additional, Correia, E., additional, Artaud, F., additional, Jamard, P., additional, Perez Munoz, A., additional, Mietlicki, F., additional, Quenez, M., additional, Gissinger, V., additional, Domergue, C., additional, Janillon, V., additional, Vincent, B., additional, Mohamed, F., additional, Godet, K., additional, Giorgis-Allemand, L., additional, Leduc, J., additional, Evrard, A.-S., additional, and Severi, G., additional

Published
2022
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39. Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort

Author

Néant, N. (Nadège), Lingas, G. (Guillaume), Le Hingrat, Q. (Quentin), Ghosn, J. (Jade), Engelmann, I. (Ilka), Lepiller, Q. (Quentin), Gaymard, A. (Alexandre), Ferré, V. (Virginie), Hartard, C. (Cédric), Plantier, J-C. (Jean-Christophe), Thibault, V. (V.), Marlet, J. (Julien), Montes, B. (Brigitte), Bouiller, K. (Kevin), Lescure, F-X. (François-Xavier), Timsit, J-F. (Jean-François), Faure, E. (Emmanuel), Poissy, J. (Julien), Chidiac, C. (Christian), Raffi, F. (François), Kimmoun, A. (Antoine), Etienne, M. (Manuel), Richard, J-C. (Jean-Christophe), Tattevin, P. (Pierre), Garot, D. (Denis), Le Moing, V. (Vincent), Bachelet, D. (Delphine), Tardivon, C. (Coralie), Duval, X. (Xavier), Yazdanpanah, Y. (Yazdan), Mentré, F. (France), Laouénan, C. (Cédric), Visseaux, B. (Benoit), Guedj, J. (Jérémie), plantier, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Services de Maladies Infectieuses et Tropicales [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Microbiologie [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hospices Civils de Lyon (HCL), Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de virologie [Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Pontchaillou [Rennes], Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Service d'anesthésie - réanimation chirurgicale [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses et tropicales [CHU Lyon] (hôpital de la Croix-Rousse), Hôpital de la Croix-Rousse [CHU Lyon], Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Service de Réanimation Médicale [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service des Maladies Infectieuses et Tropicales [Hôpital Charles Nicolle, Rouen], Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Médecine Intensive et Réanimation [Tours], Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France, Département d’Epidémiologie, de Biostatistique et de Recherche Clinique [AP-HP Hôpital Bichat - Claude Bernard] (DEBRC), Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), The study has received financial support from the National Research Agency (ANR) through the ANR-Flash call for COVID-19 (Grant ANR-20-COVI-0018) and the Bill and Melinda Gates Foundation under Grant Agreement INV-017335. The French cohort was supported by the REACTing consortium and by a grant from the French Ministry of Health (Grant PHRC 20-0424). The funders had no role in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the article for publication., ANR-20-COVI-0018,TheraCoV,Dynamique virale au niveau individuel et populationnel : implications pour l'optimisation des stratégies antivirales(2020), Normandie Université (NU)-Département de microbiologie : Bactério, Virologie, Parasito, Hygiène, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), HAL UR1, Admin, Dynamique virale au niveau individuel et populationnel : implications pour l'optimisation des stratégies antivirales - - TheraCoV2020 - ANR-20-COVI-0018 - COVID-19 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Lille, CNRS, Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)], Pathogenèse virale du diabète de type 1 - ULR 3610, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) [CEF2P / CARCINO], Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon], Centre hospitalier universitaire de Nantes [CHU Nantes], Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement [LCPME], Morphogénèse et antigénicité du VIH et du virus des Hépatites [MAVIVH - U1259 Inserm - CHRU Tours ], CHU Montpellier, Laboratoire Chrono-environnement (UMR 6249) [LCE], Service des maladies infectieuses et tropicales, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Centre d’Investigation Clinique de Nantes [CIC Nantes], Défaillance Cardiovasculaire Aiguë et Chronique [DCAC], Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT], French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ], Service des maladies infectieuses et tropicales [Rouen], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé [CREATIS], ARN régulateurs bactériens et médecine [BRM], Centre Hospitalier Régional Universitaire de Tours [CHRU Tours], Département d'épidémiologie, biostatistique et recherche clinique, and Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique [CIC 1425]

Subjects
Male, 0301 basic medicine, Medical Sciences, viruses, MESH: Hospitalization, Antibodies, Viral, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Nasopharynx, Epidemiology, MESH: COVID-19, Prospective Studies, 030212 general & internal medicine, MESH: Models, Theoretical, Prospective cohort study, MESH: Aged, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, MESH: Kinetics, Mortality rate, Biological Sciences, Viral Load, Prognosis, viral dynamics, 3. Good health, Hospitalization, Survival Rate, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: RNA, Viral, Cohort, RNA, Viral, Female, France, MESH: Viral Load, Viral load, medicine.medical_specialty, MESH: Survival Rate, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, MESH: Prognosis, 03 medical and health sciences, Internal medicine, medicine, Humans, MESH: SARS-CoV-2, education, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Survival rate, Aged, MESH: Humans, SARS-CoV-2, business.industry, COVID-19, Models, Theoretical, mortality, MESH: Male, MESH: Nasopharynx, MESH: Prospective Studies, MESH: France, Kinetics, 030104 developmental biology, business, MESH: Female, MESH: Antibodies, Viral, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Significance A detailed characterization of viral load kinetics and its association with disease evolution is key to understand the virus pathogenesis, identify high-risk patients, and design better treatment strategies. We here analyze the mortality and the virological information collected in 655 hospitalized patients, including 284 with longitudinal measurements, and we build a mathematical model of virus dynamics and survival. We predict that peak viral load occurs 1 d before symptom onset, on average, and that dynamics of decline after peak is slower in older patients. Viral load dynamics after hospital admission is an independent predictor of the risk of death, suggesting that prolonged viral shedding of high quantities of virus is associated with poor outcome in this population., The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral kinetics in hospitalized patients and its association with mortality is unknown. We analyzed death and nasopharyngeal viral kinetics in 655 hospitalized patients from the prospective French COVID cohort. The model predicted a median peak viral load that coincided with symptom onset. Patients with age ≥65 y had a smaller loss rate of infected cells, leading to a delayed median time to viral clearance occurring 16 d after symptom onset as compared to 13 d in younger patients (P < 10−4). In multivariate analysis, the risk factors associated with mortality were age ≥65 y, male gender, and presence of chronic pulmonary disease (hazard ratio [HR] > 2.0). Using a joint model, viral dynamics after hospital admission was an independent predictor of mortality (HR = 1.31, P < 10−3). Finally, we used our model to simulate the effects of effective pharmacological interventions on time to viral clearance and mortality. A treatment able to reduce viral production by 90% upon hospital admission would shorten the time to viral clearance by 2.0 and 2.9 d in patients of age

Published
2021
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42. Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study.

Author

Amadou, A, Praud, D, Coudon, T, Deygas, F, Grassot, L, Faure, E, Couvidat, F, Caudeville, J, Bessagnet, B, Salizzoni, P, Gulliver, J, Leffondré, K, Severi, G, Mancini, FR, Fervers, B, Amadou, A, Praud, D, Coudon, T, Deygas, F, Grassot, L, Faure, E, Couvidat, F, Caudeville, J, Bessagnet, B, Salizzoni, P, Gulliver, J, Leffondré, K, Severi, G, Mancini, FR, and Fervers, B

Abstract

BACKGROUND: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study. METHODS: Within a nested case-control study of 5222 incident BC cases and 5222 matched controls, annual BaP exposure was estimated using a chemistry-transport model (CHIMERE) and was assigned to the geocoded residential addresses of participants for each year during the 1990-2011 follow-up period. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Overall, cumulative airborne BaP exposure was significantly associated with the overall risk of BC, for each 1 interquartile range (IQR) increase in the concentration levels of BaP (1.42 ng/m3), the OR = 1.15 (95% CI: 1.04-1.27). However, by menopausal status, the significant positive association remained only in women who underwent menopausal transition (i.e. premenopausal women at inclusion who became postmenopausal at diagnosis), OR per 1 IQR = 1.20 (95% CI: 1.03-1.40). By hormone receptor status, positive associations were observed for ER+, PR + and ER + PR + BC, with ORs = 1.17 (95% CI: 1.04-1.32), 1.16 (95% CI: 1.01-1.33), and 1.17 (95% CI: 1.01-1.36) per 1 IQR, respectively. There was also a borderline positive association between BaP and grade 3 BC (OR per 1 IQR = 1.15 (95% CI: 0.99-1.34). CONCLUSIONS: We provide evidence of increased risk of BC associated with cumulative BaP exposure, which varied according to m

Published
2021

43. Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study.

Author

Amadou, A, Praud, D, Coudon, T, Danjou, AMN, Faure, E, Deygas, F, Grassot, L, Leffondré, K, Severi, G, Salizzoni, P, Mancini, FR, Fervers, B, Amadou, A, Praud, D, Coudon, T, Danjou, AMN, Faure, E, Deygas, F, Grassot, L, Leffondré, K, Severi, G, Salizzoni, P, Mancini, FR, and Fervers, B

Abstract

Molecular studies suggest that cadmium due to its estrogenic properties, might play a role in breast cancer (BC) progression. However epidemiological evidence is limited. This study explored the association between long-term exposure to airborne cadmium and risk of BC by stage, grade of differentiation, and histological types at diagnosis. A nested case-control study of 4401 cases and 4401 matched controls was conducted within the French E3N cohort. A Geographic Information System (GIS)-based metric demonstrated to reliably characterize long-term environmental exposures was employed to evaluate airborne exposure to cadmium. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. There was no relationship between cadmium exposure and stage of BC. Also, no association between cadmium exposure and grade of differentiation of BC was observed. However, further analyses by histological type suggested a positive association between cadmium and risk of invasive tubular carcinoma (ITC) BC [ORQ5 vs Q1 = 3.4 (95% CI 1.1-10.7)]. The restricted cubic spline assessment suggested a dose-response relationship between cadmium and ITC BC subtype. Our results do not support the hypothesis that airborne cadmium exposure may play a role in advanced BC risk, but suggest that cadmium may be associated with an increased risk of ITC.

Published
2021

45. Antibiotic treatment of infections caused by carbapenem-resistant Gram-negative bacilli: an international ESCMID cross-sectional survey among infectious diseases specialists practicing in large hospitals

Author

Papst, Lea, Beović, Bojana, Pulcini, Céline, Durante-Mangoni, Emanuele, Rodríguez-Baño, Jesús, Kaye, Keith S, Daikos, George L, Raka, Lul, Paul, Mical, Esgap, Esgbis, ESGIE and the CRGNB treatment survey study group collaborators: Abbo, L, Abgueguen, P, Almirante, B, Azzini, Am, Bani-Sadr, F, Bassetti, M, Ben-Ami, R, Beović, B, Béraud, G, Botelho-Nevers, E, Bou, G, Boutoille, D, Cabié, A, Cacopardo, B, Cascio, A, Cassir, N, Castelli, F, Cecala, M, Charmillon, A, Chirouze, C, Cisneros, Jm, Colmenero, Jd, Coppola, N, Corcione, S, Daikos, Gl, Dalla Gasperina, D, De la Calle Cabrera, C, Delobel, P, Di Caprio, D, Durante Mangoni, E, Dupon, M, Ettahar, N, Falagas, Me, Falcone, M, Fariñas, Mc, Faure, E, Forestier, E, Foti, G, Gallagher, J, Gattuso, G, Gendrin, V, Gentile, I, Giacobbe, Dr, Gogos, Ca, Grandiere Perez, L, Hansmann, Y, Horcajada, Jp, Iacobello, C, Jacob, Jt, Justo, Ja, Kernéis, S, Komnos, A, Kotnik Kevorkijan, B, Lebeaux, D, Le Berre, R, Lechiche, C, Le Moing, V, Lescure, Fx, Libanore, M, Martinot, M, Merino de Lucas, E, Mondain, V, Mondello, P, Montejo, M, Mootien, J, Muñoz, P, Nir-Paz, R, Pan, A, Paño-Pardo, Jr, Patel, G, Paul, M, Pérez Rodríguez MT, Piroth, L, Pogue, J, Potoski, Ba, Pourcher, V, Pyrpasopoulou, A, Rahav, G, Rizzi, M, Rodríguez-Baño, J, Salavert, M, Scheetz, M, Sims, M, Spahija, G, Stefani, S, Stefos, A, Tamma, Pd, Tattevin, P, Tedesco, A, Torre-Cisneros, J, Tripolitsioti, P, Tsiodras, S, Uomo, G, Verdon, R, Viale, P, Vitrat, V, Weinberger, M, Wiener-Well, Y, Papst L., Beovic B., Pulcini C., Durante-Mangoni E., Rodriguez-Bano J., Kaye K.S., Daikos G.L., Raka L., Paul M., Abbo L., Abgueguen P., Almirante B., Azzini A.M., Bani-Sadr F., Bassetti M., Ben-Ami R., Beraud G., Botelho-Nevers E., Bou G., Boutoille D., Cabie A., Cacopardo B., Cascio A., Cassir N., Castelli F., Cecala M., Charmillon A., Chirouze C., Cisneros J.M., Colmenero J.D., Coppola N., Corcione S., Dalla Gasperina D., De la Calle Cabrera C., Delobel P., Di Caprio D., Durante Mangoni E., Dupon M., Ettahar N., Falagas M.E., Falcone M., Farinas M.C., Faure E., Forestier E., Foti G., Gallagher J., Gattuso G., Gendrin V., Gentile I., Giacobbe D.R., Gogos C.A., Grandiere Perez L., Hansmann Y., Horcajada J.P., Iacobello C., Jacob J.T., Justo J.A., Kerneis S., Komnos A., Kotnik Kevorkijan B., Lebeaux D., Le Berre R., Lechiche C., Le Moxing V., Lescure F.X., Libanore M., Martinot M., Merino de Lucas E., Mondain V., Mondello P., Montejo M., Mootien J., Munoz P., Nir-Paz R., Pan A., Pano-Pardo J.R., Patel G., Perez Rodriguez M.T., Piroth L., Pogue J., Potoski B.A., Pourcher V., Pyrpasopoulou A., Rahav G., Rizzi M., Salavert M., Scheetz M., Sims M., Spahija G., Stefani S., Stefos A., Tamma P.D., Tattevin P., Tedesco A., Torre-Cisneros J., Tripolitsioti P., Tsiodras S., Uomo G., Verdon R., Viale P., Vitrat V., Weinberger M., Wiener-Well Y., University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Monaldi Hospital, Hospital Virgen Macarena, University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, National and Kapodistrian University of Athens (NKUA), University Clinical Center of Kosova, Rambam Health Care Campus, Jackson Memorial Hospital, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Vall d'Hebron University Hospital [Barcelona], University of Verona (UNIVR), Centre Hospitalier Universitaire de Reims (CHU Reims), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Tel Aviv Sourasky Medical Centre, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hospital Universitario, A Coruña, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU de la Martinique [Fort de France], ARNAS 'Garibaldi, S. Luigi-Currò, Ascoli-Tomaselli', Università degli studi di Palermo - University of Palermo, Assistance Publique-Hôpitaux de Marseille (AP-HM), ASST Spedali Civili of Brescia, ARNAS Civico Palermo, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hospital Universitario Virgen del Rocío [Sevilla], Hospital Regional Universitario de Málaga [Spain], Università degli studi della Campania 'Luigi Vanvitelli', University of Turin, University of Insubria, Varese, Hospital Clínic de Barcelona, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], AO San Sebastiano, CHU Bordeaux [Bordeaux], CH Valenciennes, Henry Dunant Hospital, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Hospital Marques de Valdecillas, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Métropole Savoie [Chambéry], Ospedale di Reggio Calabria, Children’s Hospital of Philadelphia (CHOP ), Carlo Poma Hospital Mantova (ASST Mantova ), CH Belfort-Montbéliard, University of Naples Federico II, AUO San Martino IST Ist Nazl Ric Canc, I-16132 Genoa, Italy, University of Patras [Patras], Centre Hospitalier Le Mans (CH Le Mans), CHU Strasbourg, IMIM-Hospital del Mar, Generalitat de Catalunya, Cannizzaro Hospital, Emory University School of Medicine, Emory University [Atlanta, GA], University of South Carolina [Columbia], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Larissa, University medical centre Maribor (UKC Maribor), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), AP-HP - Hôpital Bichat - Claude Bernard [Paris], University of Ferrara at St. Anna Hospital, CH Colmar, Hospital General Universitario de Alicante, CHU Nice [Cimiez], Hôpital Cimiez [Nice] (CHU), AOU Policlinico 'G. Martino', Messina, Italy, Hospital Universitario Cruces = Cruces University Hospital, Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Hospital General Universitario 'Gregorio Marañón' [Madrid], Hadassah Hebrew University Medical Center [Jerusalem], Azienda Istituti Ospitalieri di Cremona, Lozano Blesa Clinical Hospital [Zaragoza, Spain], Mount Sinai Hospital [Toronto, Canada] (MSH), Complejo Hospitalario de Vigo, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Detroit Medical Center, University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hippokration General Hospital, Sheba Medical Centre, Ramat Gan, Israel, ASST Papa Giovanni XXIII [Bergamo, Italy], Hospital Universitario La Fe, Valencia, Northwestern Hospital Chicago, Beaumont Hospital, Lagjia e Universitetit, Rruga 1, nr.32, 10000 Prishtina, Kosovo, parent, Università degli studi di Catania [Catania], Larissa University Hospital, Johns Hopkins University School of Medicine [Baltimore], CHU Pontchaillou [Rennes], Ospedale Fracastoro San Bonifacio [Verona], Hospital Reina Sofia, Cordoba, Agioi Anargiroi Hospital, Attikon University Hospital, Ospedale Cardarelli, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), CH Annecy Genevois, Assah Harofeh Medical Centre, Zerifin, Israel, Shaare Zedek Medical Centre, Jerusalem, Israel, National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Red Española de Investigación en Patología Infecciosa, European Commission, Papst, Lea, Beović, Bojana, Pulcini, Céline, Durante-Mangoni, Emanuele, Rodríguez-Baño, Jesú, Kaye, Keith S, Daikos, George L, Raka, Lul, Paul, Mical, Papst, L., Beovic, B., Pulcini, C., Durante-Mangoni, E., Rodriguez-Bano, J., Kaye, K. S., Daikos, G. L., Raka, L., Paul, M., Abbo, L., Abgueguen, P., Almirante, B., Azzini, A. M., Bani-Sadr, F., Bassetti, M., Ben-Ami, R., Beraud, G., Botelho-Nevers, E., Bou, G., Boutoille, D., Cabie, A., Cacopardo, B., Cascio, A., Cassir, N., Castelli, F., Cecala, M., Charmillon, A., Chirouze, C., Cisneros, J. M., Colmenero, J. D., Coppola, N., Corcione, S., Dalla Gasperina, D., De la Calle Cabrera, C., Delobel, P., Di Caprio, D., Dupon, M., Ettahar, N., Falagas, M. E., Falcone, M., Farinas, M. C., Faure, E., Forestier, E., Foti, G., Gallagher, J., Gattuso, G., Gendrin, V., Gentile, I., Giacobbe, D. R., Gogos, C. A., Grandiere Perez, L., Hansmann, Y., Horcajada, J. P., Iacobello, C., Jacob, J. T., Justo, J. A., Kerneis, S., Komnos, A., Kotnik Kevorkijan, B., Lebeaux, D., Le Berre, R., Lechiche, C., Le Moxing, V., Lescure, F. X., Libanore, M., Martinot, M., Merino de Lucas, E., Mondain, V., Mondello, P., Montejo, M., Mootien, J., Munoz, P., Nir-Paz, R., Pan, A., Pano-Pardo, J. R., Patel, G., Perez Rodriguez, M. T., Piroth, L., Pogue, J., Potoski, B. A., Pourcher, V., Pyrpasopoulou, A., Rahav, G., Rizzi, M., Salavert, M., Scheetz, M., Sims, M., Spahija, G., Stefani, S., Stefos, A., Tamma, P. D., Tattevin, P., Tedesco, A., Torre-Cisneros, J., Tripolitsioti, P., Tsiodras, S., Uomo, G., Verdon, R., Viale, P., Vitrat, V., Weinberger, M., Wiener-Well, Y., Università degli studi di Verona = University of Verona (UNIVR), Assistance Publique - Hôpitaux de Marseille (APHM), Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain], and Università degli studi di Torino = University of Turin (UNITO)

Subjects
0301 basic medicine, Acinetobacter baumannii, Carbapenem, Antibiotics, Drug Resistance, Drug resistance, Tigecycline, Carbapenem-resistant Gram-negative bacilli, Combination therapy, Enterobacteriaceae, Polymyxin, Pseudomonas aeruginosa, Survey, 0302 clinical medicine, Surveys and Questionnaires, polycyclic compounds, 030212 general & internal medicine, Anti-Bacterial Agents, Carbapenems, Cross Infection, Cross-Sectional Studies, Drug Resistance, Bacterial, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Hospitals, Humans, Microbial Sensitivity Tests, Microbiology (medical), Infectious Diseases, biology, Microbial Sensitivity Test, Bacterial, antibiotic management, carbapenem-resistant Gram-negative bacteria, General Medicine, 3. Good health, medicine.drug, Human, medicine.medical_specialty, medicine.drug_class, 030106 microbiology, Fosfomycin, carbapenem-resistant Gram-negative bacteria, 03 medical and health sciences, Hospital, Internal medicine, Anti-Bacterial Agent, medicine, Gram-Negative Bacterial Infection, Cross-Sectional Studie, business.industry, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Infectious disease (medical specialty), Carbapenem-resistant gram-negative bacilli, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, antibiotic management, business, Rifampicin
Abstract

ESGAP, ESGBIS, ESGIE and the CRGNB treatment survey study group., [Objectives] To explore contemporary antibiotic management of infections caused by carbapenem-resistant Gram-negative bacteria in hospitals., [Methods] Cross-sectional, internet-based questionnaire survey. We contacted representatives of all hospitals with more than 800 acute-care hospital beds in France, Greece, Israel, Italy, Kosovo, Slovenia, Spain and selected hospitals in the USA. We asked respondents to describe the most common actual practice at their hospital regarding management of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa through close-ended questions., [Results] Between January and June 2017, 115 of 141 eligible hospitals participated (overall response rate 81.6%, country-specific rates 66.7%–100%). Most were tertiary-care (99/114, 86.8%), university-affiliated (110/115, 89.1%) hospitals and most representatives were infectious disease specialists (99/115, 86.1%). Combination therapy was prescribed in 114/115 (99.1%) hospitals at least occasionally. Respondents were more likely to consider combination therapy when treating bacteraemia, pneumonia and central nervous system infections and for Enterobacteriaceae, P. aeruginosa and A. baumannii similarly. Combination of a polymyxin with a carbapenem was used in most cases, whereas combinations of a polymyxin with tigecycline, an aminoglycoside, fosfomycin or rifampicin were also common. Monotherapy was used for treatment of complicated urinary tract infections, usually with an aminoglycoside or a polymyxin. The intended goal of combination therapy was to improve the effectiveness of the treatment and to prevent development of resistance. In general, respondents shared the misconception that combination therapy is supported by strong scientific evidence., [Conclusions] Combination therapy was the preferred treatment strategy for infections caused by carbapenem-resistant Gram-negative bacteria among hospital representatives, even though high-quality evidence for carbapenem-based combination therapy is lacking., EDM received funding by NIH for project HHSN272201000039C. JRB received funding for research from Plan Nacional de I + D + i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001)—co-financed by European Development Regional Fund A way to achieve Europe, Operative Programme Intelligent Growth 2014–2020.

Published
2018
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49. Antibiotics and chronic kidney disease: Dose adjustment update for infectious disease clinical practice

Author

Aloy, B., primary, Launay-Vacher, V., additional, Bleibtreu, A., additional, Bortolotti, P., additional, Faure, E., additional, Filali, A., additional, Gauzit, R., additional, Gilbert, M., additional, Lesprit, P., additional, Mahieu, R., additional, Meyssonnier, V., additional, Ogielska, M., additional, Romaru, J., additional, Salmon, D., additional, Alfandari, S., additional, and Lemaignen, A., additional

Published
2020
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