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158 results on '"Faulkner, Lee"'

1. Structural studies of the geminivirus : maize streak virus

Author: Faulkner, Lee
Subjects: 633.1598
Published: 2002

2. Expression of the c-fgr proto-oncogene in monoblastoid cells

Author: Faulkner, Lee
Subjects: 572, Myeloid cells
Abstract: Expression of the c-fgr proto-oncogene is normally restricted to differentiated cells which belong to the myeloid lineage and is also found in some B cell lines. The aim of this thesis was to investigate the role of c-fgr in myeloid cells using the monoblastoid U937 cell line as a model system. Expression of c-fgr was increased when U937 cells were induced to differentiate by phorbol 12-myristate 13-acetate [PMA], dihydroxycholecalciferol [DHCC], tumour necrosis factor alpha [TNFα] or retinoic acid. The level of c-fgr mRNA or p55c-fgr detected in these cells varied depending on the agent used and did not correlate with the degree of growth inhibition induced by the agent. FCγR crosslinking in U937 cells treated with PMA or DHCC resulted in the modulation of p55c-fgr and in tyrosine phosphorylation of cellular proteins. Both protein kinase C and protein kinase A [PKA] were implicated as second messengers in the induction of c-fgr mRNA by PMA, and PKA was implicated as a second messenger in the induction of c-fgr mRNA by TNFα. Tyrosine kinases were not involved in the regulation of c-fgr mRNA by either PMA or TNFα. The level of c-fgr mRNA detected in three Burkitt's lymphoma cell lines was increased by retinoic acid, but this also did not correlate with growth inhibition induced by this agent. To examine the role of c-fgr in more detail, the gene was inserted into an inducible expression vector and stably transfected U937 clones were isolated. Hyper-expression of the transfected c-fgr gene did not affect cell growth, responses to PMA, DHCC, TNFα or retinoic acid, adhesion to fibronectin, phagocytosis or tyrosine phosphorylation of cellular proteins, but did induce increased expression of 52U, a cytoplasmic antigen and ICAM-2, increased expression of ICAM-1 in the presence of DHCC and decreased expression of five myeloid antigens and ICAM-3.
Published: 1995

3. Mechanism of Transmembrane Signaling by the Epidermal Growth Factor Receptor/Kinase

Author: Staros, James V., primary, Fanger, Bradford O., additional, Faulkner, Lee Anne, additional, Palaszewski, Paul P., additional, and Russo, Mark W., additional
Published: 2018
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4. β-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells

Author: Sullivan, Andrew, Wang, Eryi, Farrell, John, Whitaker, Paul, Faulkner, Lee, Peckham, Daniel, Park, Kevin B., and Naisbitt, Dean J.
Published: 2018
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5. Development and Validation of a Simplified Method for Analysis of SARS-CoV-2 RNA in University Dormitories

Author: Strike, William, primary, Amirsoleimani, Atena, additional, Olaleye, Abisola, additional, Noble, Ann, additional, Lewis, Kevin, additional, Faulkner, Lee, additional, Backus, Spencer, additional, Lindeman, Sierra, additional, Eterovich, Katrina, additional, Fraley, Melicity, additional, Dehghan Banadaki, Mohammad, additional, Torabi, Soroosh, additional, Rockward, Alexus, additional, Zeitlow, Eli, additional, Liversedge, Matthew, additional, Keck, James, additional, and Berry, Scott, additional
Published: 2022
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6. Specific C-Terminal Cleavage and Inactivation of Interleukin-8 by Invasive Disease Isolates of "Streptococcus pyogenes"

Author: Edwards, Robert J., Taylor, Graham W., Ferguson, Melissa, Murray, Stephen, Rendell, Nigel, Wrigley, Amanda, Bai, Zhonghu, Boyle, Joseph, Finney, Simon J., Jones, Angus, Russell, Hugh H., Turner, Claire, Cohen, Jonathan, Faulkner, Lee, and Sriskandan, Shiranee
Published: 2005

7. Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate–induced liver injury

Author: Kim, Seung-Hyun, Saide, Katy, Farrell, John, Faulkner, Lee, Tailor, Arun, Ogese, Monday, Daly, Ann K., Pirmohamed, Munir, Park, Kevin B., and Naisbitt, Dean J.
Published: 2015
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8. Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model

Author: Nattrass, Ryan, Faulkner, Lee, Vocanson, Marc, Antoine, Daniel J., Kipar, Anja, Kenna, Gerry, Nicolas, Jean-Francois, Park, B. Kevin, and Naisbitt, Dean J.
Published: 2015
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9. Promiscuous T-cell responses to drugs and drug-haptens

Author: Yaseen, Fiazia S., Saide, Katy, Kim, Seung-Hyun, Monshi, Manal, Tailor, Arun, Wood, Sally, Meng, Xiaoli, Jenkins, Rosalind, Faulkner, Lee, Daly, Ann K., Pirmohamed, Munir, Park, Kevin B., and Naisbitt, Dean J.
Published: 2015
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10. Human Leukocyte Antigen (HLA)-B*57:01-Restricted Activation of Drug-Specific T cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury

Author: Monshi, Manal M., Faulkner, Lee, Gibson, Andrew, Jenkins, Rosalind E., Farrell, John, Earnshaw, Caroline J., Alfirevic, Ana, Cederbrant, Karin, Daly, Ann K., French, Neil, Pirmohamed, Munir, Park, Kevin B., and Naisbitt, Dean J.
Published: 2013
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11. The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

Author: Faulkner, Lee, Martinsson, Klara, Santoyo-Castelazo, Anahi, Cederbrant, Karin, Schuppe-Koistinen, Ina, Powell, Helen, Tugwood, Jonathan, Naisbitt, Dean J., and Park, B. Kevin
Published: 2012
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12. Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds

Author: Ogese, Monday O, primary, Watkinson, Joel, primary, Lister, Adam, primary, Faulkner, Lee, primary, Gibson, Andrew, primary, Hillegas, Aimee, primary, Sakatis, Melanie Z, primary, Park, Brian Kevin, primary, and Naisbitt, Dean J, primary
Published: 2020
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13. Sexual Dimorphism in Superantigen Shock Involves Elevated TNF-α and TNF-α-induced Hepatic Apoptosis

Author: Faulkner, Lee, Altmann, Daniel M., Ellmerich, Stephan, Huhtaniemi, Ilpo, Stamp, Gordon, and Sriskandan, Shiranee
Published: 2007
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14. Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation

Author: Sriskandan, Shiranee, Ferguson, Melissa, Elliot, Victoria, Faulkner, Lee, and Cohen, Jonathan
Published: 2006

15. IL-2 linked to a peptide from influenza hemagglutinin enhances T cell activation by affecting the antigen-presentation function of bone marrow-derived dendritic cells

Author: Faulkner, Lee, Buchan, Glenn, Lockhart, Euan, Slobbe, Lynn, Wilson, Michelle, and Baird, Margaret
Published: 2001

16. Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System

Author: Ogese, Monday O., primary, Jenkins, Rosalind E., additional, Adair, Kareena, additional, Tailor, Arun, additional, Meng, Xiaoli, additional, Faulkner, Lee, additional, Enyindah, Bright O., additional, Schofield, Amy, additional, Diaz‐Nieto, Rafael, additional, Ressel, Lorenzo, additional, Eagle, Gina L., additional, Kitteringham, Neil R., additional, Goldring, Chris E., additional, Park, B. Kevin, additional, Naisbitt, Dean J., additional, and Betts, Catherine, additional
Published: 2019
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17. Structure of the Maize Streak Virus Geminate Particle

Author: Zhang, Wei, Olson, Norman H, Baker, Timothy S, Faulkner, Lee, Agbandje-McKenna, Mavis, Boulton, Margaret I, Davies, Jeffrey W, and McKenna, Robert
Published: 2001
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18. HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Author: Usui, Toru, primary, Tailor, Arun, additional, Faulkner, Lee, additional, Meng, Xiaoli, additional, Farrell, John, additional, Daly, Ann K., additional, Dear, Gordon J., additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2018
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19. Correction: The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

Author: Gibson, Andrew, primary, Faulkner, Lee, additional, Lichtenfels, Maike, additional, Ogese, Monday, additional, Al-Attar, Zaid, additional, Alfirevic, Ana, additional, Esser, Philipp R., additional, Martin, Stefan F., additional, Pirmohamed, Munir, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2018
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20. Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

Author: Usui, Toru, primary, Faulkner, Lee, additional, Farrell, John, additional, French, Neil S., additional, Alfirevic, Ana, additional, Pirmohamed, Munir, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2018
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21. The Contribution of Rural Hospitals to Local Economies

Author: Christianson, Jon B. and Faulkner, Lee
Published: 1981

22. Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts

Author: Amali, Mohammed O., primary, Jenkins, Rosalind E., additional, Meng, Xiaoli, additional, Faulkner, Lee, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2017
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23. The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

Author: Gibson, Andrew, primary, Faulkner, Lee, additional, Lichtenfels, Maike, additional, Ogese, Monday, additional, Al-Attar, Zaid, additional, Alfirevic, Ana, additional, Esser, Philipp R., additional, Martin, Stefan F., additional, Pirmohamed, Munir, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2017
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24. Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells

Author: Gibson, Andrew, primary, Faulkner, Lee, additional, Wood, Sally, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2017
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25. Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells

Author: Ogese, Monday O., primary, Faulkner, Lee, additional, Jenkins, Roz E., additional, French, Neil S., additional, Copple, Ian M., additional, Antoine, Daniel J., additional, Elmasry, Mohamed, additional, Malik, Hasan, additional, Goldring, Christopher E., additional, Park, Brian Kevin, additional, Betts, Catherine J., additional, and Naisbitt, Dean J., additional
Published: 2017
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26. Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts

Author: Amali, Mohammed O., Jenkins, Rosalind E., Meng, Xiaoli, Faulkner, Lee, Whitaker, Paul, Peckham, Daniel, Park, B. Kevin, and Naisbitt, Dean J.
Abstract: The risk of developing hypersensitivity to alternative antibiotics is a concern for penicillin hypersensitive patients and healthcare providers. Herein we use piperacillin hypersensitivity as a model to explore the reactivity of drug-specific IgG against alternative β-lactam protein adducts. Mass spectrometry was used to show the drugs (amoxicillin, flucloxacillin, benzyl penicillin, aztreonam, and piperacillin) bind to similar lysine residues on the protein carrier bovine serum albumin. However, the hapten-specific IgG antibodies found in piperacillin hypersensitive patient plasma did not bind to other β-lactam protein conjugates. These data outline the fine specificity of piperacillin-specific IgG antibodies that circulate in patients with hypersensitivity.
Published: 2024
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27. Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

Author: Usui, Toru, Faulkner, Lee, Farrell, John, French, Neil S., Alfirevic, Ana, Pirmohamed, Munir, Park, B. Kevin, and Naisbitt, Dean J.
Abstract: It is unclear whether priming of naïve T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming with drugs associated with HLA risk alleles and control compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin activated T cells from all donors, whereas responses to carbamazepine and oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, respectively. Weak flucloxacillin-specific T cell responses were detected in donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming of T cells with certain drugs is skewed toward donors expressing specific HLA alleles.
Published: 2024
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28. No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury

Author: Faulkner, Lee, primary, Meng, Xiaoli, additional, Naisbitt, Dean J., additional, Spraggs, Colin F., additional, and Park, B. Kevin, additional
Published: 2016
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29. New Approaches to Investigate Drug-Induced Hypersensitivity

Author: Ogese, Monday O., primary, Ahmed, Shaheda, additional, Alferivic, Ana, additional, Betts, Catherine J., additional, Dickinson, Anne, additional, Faulkner, Lee, additional, French, Neil, additional, Gibson, Andrew, additional, Hirschfield, Gideon M., additional, Kammüller, Michael, additional, Meng, Xiaoli, additional, Martin, Stefan F., additional, Musette, Philippe, additional, Norris, Alan, additional, Pirmohamed, Munir, additional, Park, B. Kevin, additional, Purcell, Anthony W., additional, Spraggs, Colin F., additional, Whritenour, Jessica, additional, and Naisbitt, Dean J., additional
Published: 2016
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30. Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Author: Faulkner, Lee, primary, Gibson, Andrew, additional, Sullivan, Andrew, additional, Tailor, Arun, additional, Usui, Toru, additional, Alfirevic, Ana, additional, Pirmohamed, Munir, additional, Naisbitt, Dean J., additional, and Kevin Park, B., additional
Published: 2016
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31. 7th Drug hypersensitivity meeting: part two

Author: Elera, Javier Dionicio, primary, Boteanu, Cosmin, additional, Blanco, Maria Aranzazu Jimenez, additional, Gonzalez-Mendiola, Rosario, additional, García, Irene Carrasco, additional, Alvarez, Antonio, additional, Martinez, Jose Julio Laguna, additional, Garrido, Jaume Martí, additional, Barona, Carla Torán, additional, Chorda, Carolina Perales, additional, Salgueiro, Ramón López, additional, Palacios, Miguel Díaz, additional, De Rojas, Dolores Hernández Fernández, additional, Acar, Emre Ali, additional, Aktas, Ayse, additional, Ermertcan, Aylin Türel, additional, Temiz, Peyker, additional, Lin, Chien-Yio, additional, Hui, Chung-Yee Rosaline, additional, Chang, Ya-Ching, additional, Yang, Chih-Hsun, additional, Chung, Wen-Hung, additional, Carolino, Fabrícia, additional, Silva, Diana, additional, De Castro, Eunice Dias, additional, Cernadas, Josefina R., additional, Ensina, Luis Felipe, additional, Aranda, Carolina, additional, Nunes, Ines Camelo, additional, Lacerda, Alex, additional, Martins, Ana Maria, additional, Goudouris, Ekaterini, additional, Ribeiro, Marcia, additional, Da Silva Franco, José Francisco, additional, Queiroz, Leandra, additional, Solé, Dirceu, additional, Dalgiç, Ceyda Tunakan, additional, Sin, Aytül Zerrin, additional, Günsen, Fatma Düsünür, additional, Bulut, Gökten, additional, Ardeniz, Fatma Ömür, additional, Gülbahar, Okan, additional, Gökmen, Emine Nihal Mete, additional, Kokuludag, Ali, additional, De Francisco, Ana M. Montoro, additional, De Vicente Jiménez, Talía Mª, additional, Mendoza Parra, Adriana M., additional, Burgos Pimentel, Angella M., additional, Luque, Amelia García, additional, Amaral, Luis, additional, Leão, Leonor Carneiro, additional, Pinto, Nicole, additional, Belo, Joana, additional, Marques, João, additional, Carreiro-Martins, Pedro, additional, Leiria-Pinto, Paula, additional, Chaabane, Amel, additional, Romdhane, Haifa Ben, additional, Fredj, Nadia Ben, additional, Chadly, Zohra, additional, Boughattas, Naceur A., additional, Aouam, Karim, additional, Uyttebroek, Astrid P., additional, Bridts, Chris H., additional, Romano, Antonino, additional, Ebo, Didier G., additional, Sabato, Vito, additional, Lopes, Anabela, additional, Cosme, Joana, additional, Aguiar, Rita, additional, Lourenço, Tatiana, additional, Paes, Maria-João, additional, Spínola-Santos, Amélia, additional, Pereira-Barbosa, Manuel, additional, Cruz, Cíntia Rito, additional, Dos Reis, Rute Pereira, additional, Tomaz, Elza, additional, Pires, Ana Paula, additional, Inácio, Filipe, additional, Benito-Garcia, Filipe, additional, Mota, Inês, additional, Correia, Magna, additional, Gaspar, Ângela, additional, Chambel, Marta, additional, Piedade, Susana, additional, Morais-Almeida, Mário, additional, Nakonechna, Alla, additional, Antipkin, Yurij, additional, Umanets, Tetiana, additional, Pineda, Fernando, additional, Arribas, Francisca, additional, Lapshyn, Volodymyr, additional, Miranda, Pablo Andrés, additional, De La Cruz Hoyos, Bautista, additional, Blanco, Aranzazu Jimenez, additional, Del Pozo, Marta, additional, Vultaggio, Alessandra, additional, Nencini, Francesca, additional, Pratesi, Sara, additional, Matucci, Andrea, additional, Maggi, Enrico, additional, Cegec, Ivana, additional, Nahal, Danica Juricic, additional, Turk, Viktorija Erdeljic, additional, Aumiler, Matea Radacic, additional, Ausperger, Ksenija Makar, additional, Kraljickovic, Iva, additional, Simic, Iveta, additional, Yamaguchi, Yukie, additional, Watanabe, Tomoya, additional, Satoh, Megumi, additional, Tanegashima, Tomohiko, additional, Oda, Kayoko, additional, Wada, Hidefumi, additional, Aihara, Michiko, additional, Lee, Jaechun Jason, additional, Choi, Jay Chol, additional, Lee, Hwa Young, additional, Fernandes, Rosa-Anita Rodrigues, additional, Faria, Emília, additional, Pita, Joana, additional, Sousa, Nuno, additional, Ribeiro, Carmelita, additional, Carrapatoso, Isabel, additional, Bom, Ana Todo, additional, Rodolfo, Ana, additional, Dias-Castro, Eunice, additional, Voronova, Marina, additional, Valle, Diana Kury, additional, Coronel, Verónica Pacheco, additional, Chordá, Carolina Perales, additional, Madamba, Roselle Catherine Yu, additional, Ferrer, Marta, additional, Goikoetxea, Maria Jose, additional, D’Amelio, Carmen, additional, Bernad, Amalia, additional, Vega, Olga, additional, Gastaminza, Gabriel, additional, Bibián, Beatriz Pola, additional, Salazar, Marina Lluncor, additional, Vilà-Nadal, Gemma, additional, Roman, Ana María Fiandor, additional, Ortega, Javier Dominguez, additional, Muñoz, Miguel Gonzalez, additional, Gancedo, Santiago Quirce, additional, Moreno, Maria Rosario Cabañas, additional, Hofmeier, Kathrin Scherer, additional, Barzylovych, Vladyslava, additional, Pola, Beatriz, additional, Lluncor, Marina, additional, Fiandor, Ana, additional, Bellón, Teresa, additional, Domínguez, Javier, additional, Quirce, Santiago, additional, Yang, Min-Suk, additional, Kim, Sun-Sin, additional, Kim, Sae-Hoon, additional, Kang, Hye-Ryun, additional, Park, Heung-Woo, additional, Cho, Sang-Heon, additional, Min, Kyung-Up, additional, Chang, Yoon-Seok, additional, Delahaye, Clémence, additional, Flabbee, Jenny, additional, Waton, Julie, additional, Bauvin, Olivia, additional, Barbaud, Annick, additional, Fadhel, Najah Ben, additional, Gulin, Sandra Jerkovic, additional, Chiriac, Anca, additional, Cardoso, Bárbara Kong, additional, Viseu, Regina, additional, Moreira, Ana, additional, Cadinha, Susana, additional, Neves, Ana Castro, additional, Barreira, Patrícia, additional, Malheiro, Daniela, additional, Da Silva, J. P. Moreira, additional, Jurakic-Toncic, Ružica, additional, Ljubojevic, Suzana, additional, Turcic, Petra, additional, Gilissen, Liesbeth, additional, Huygens, Sara, additional, Goossens, An, additional, Andreu, Inmaculada, additional, Romero, Alicia Martinez, additional, Cabezas, Pau Gomez, additional, Parejo, Pedro Ayuso, additional, Del Carmen Plaza-Serón, Maria, additional, Doña, Inmaculada, additional, Blanca-López, Natalia, additional, Flores, Carlos, additional, Galindo, María Luisa, additional, Molina, Ana, additional, Perkins, James Richard, additional, Cornejo-García, José Antonio, additional, García-Agúndez, José Augusto, additional, García-Martín, Elena, additional, Campo, Paloma, additional, Canto, María Gabriela, additional, Blanca, Miguel, additional, Guéant-Rodríguez, Rosa María, additional, Jurado-Escobar, Raquel, additional, Barrionuevo, Esther, additional, Salas, María, additional, Canto, Gabriela, additional, Guéant, Jean-Louis, additional, Usui, Toru, additional, Tailor, Arun, additional, Faulkner, Lee, additional, Farrell, John, additional, Alfirevic, Ana, additional, Kevin Park, B., additional, Naisbitt, Dean J., additional, Trelles, Oswaldo, additional, Guerrero, María Auxiliadora, additional, Upton, Alex, additional, Ueta, Mayumi, additional, Sawai, Hiromi, additional, Sotozono, Chie, additional, Tokunaga, Katushi, additional, Kinoshita, Shigeru, additional, Sukasem, Chonlaphat, additional, Satapornpong, Patompong, additional, Tempark, Therdpong, additional, Rerknimitr, Pawinee, additional, Pairayayutakul, Kulprapat, additional, Klaewsongkram, Jettanong, additional, Koomdee, N., additional, Jantararoungtong, T., additional, Santon, S., additional, Puangpetch, A., additional, Intusoma, U., additional, Tassaneeyakul, W., additional, Theeramoke, V., additional, Ramirez, Elena, additional, Borobia, Alberto Manuel, additional, Tong, Hoi, additional, Castañer, Jose Luis, additional, De Abajo, Francisco José, additional, Galvao, Violeta Régnier, additional, Pavlos, Rebecca, additional, Mckinnon, Elizabeth, additional, Williams, Kristina, additional, Beeghly-Fadiel, Alicia, additional, Redwood, Alec, additional, Phillips, Elizabeth, additional, Castells, Mariana, additional, Boni, Elisa, additional, Russello, Marina, additional, Mauro, Marina, additional, Ue, Kok Loong, additional, Rutkowski, Krzysztof, additional, Gomis, Victor Soriano, additional, Ferre, Jorge Frances, additional, Rodriguez, Angel Esteban, additional, Reig, Vicente Cantó, additional, Sanchez, Javier Fernandez, additional, Breynaert, Christine, additional, Van Hoeyveld, Erna, additional, Schrijvers, Rik, additional, Irigoyen, Raquel Fuentes, additional, Collado, Daniel, additional, Vida, Yolanda, additional, Najera, Francisco, additional, Perez-Inestrosa, Ezequiel, additional, Mesa-Antunez, Pablo, additional, Mayorga, Cristobalina, additional, Torres, María José, additional, Tannert, Line K., additional, Mortz, Charlotte G., additional, Skov, Per Stahl, additional, Bindslev-Jensen, Carsten, additional, Pfützner, Wolfgang, additional, Dörnbach, Hannah, additional, Visse, Johanna, additional, Rauber, Michele, additional, Möbs, Christian, additional, Elzagallaai, Abdelbaset A., additional, Chow, Lindsey, additional, Abuzgaia, Awatif M., additional, Rieder, Michael J., additional, Trubiano, Jason, additional, Woolnough, Emily, additional, Stautins, Kaija, additional, Cheng, Christina, additional, Kato, Kenichi, additional, Azukizawa, Hiroaki, additional, Hanafusa, Takaaki, additional, Katayama, Ichiro, additional, Fujiyama, Toshiharu, additional, Hashizume, Hideo, additional, Umayahara, Takatsune, additional, Ito, Taisuke, additional, Tokura, Yoshiki, additional, Silar, Mira, additional, Zidarn, Mihaela, additional, Rupnik, Helena, additional, Korosec, Peter, additional, Redwood, Alec James, additional, Strautins, Kaija, additional, White, Katie, additional, Chopra, Abha, additional, Konvinse, Katherine, additional, Leary, Shay, additional, Mallal, Simon, additional, Cabañas, Rosario, additional, Fiandor, Ana María, additional, Sullivan, Andrew, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Haw, Wei Yann, additional, Polak, Marta E., additional, Mcguire, Carolann, additional, Ardern-Jones, Michael R., additional, Aoyama, Yumi, additional, Shiohara, Tetsuo, additional, Correia, Sara, additional, Gelincik, Asli, additional, Demir, Semra, additional, Sen, Fatma, additional, Bozbey, Hamza Ugur, additional, Olgac, Muge, additional, Unal, Derya, additional, Coskun, Raif, additional, Colakoglu, Bahauddin, additional, Buyuozturk, Suna, additional, Çatin-Aktas, Esin, additional, Deniz, Gunnur, additional, Laguna, Jose Julio, additional, Dionicio, J., additional, Fernandez, Tahia, additional, Olazabal, I., additional, Ruiz, Maria Dolores, additional, Torres, Maria José, additional, Lafuente, Alberto, additional, Núñez, Jorge, additional, Fernández, Tahia Diana, additional, Palomares, Francisca, additional, Fernández, Rubén, additional, Sanchez, Maria Isabel, additional, Fernandez, Tahía, additional, Ruiz, Arturo, additional, Ariza, Adriana, additional, Alonso, Amalia Bernad, additional, Garófalo, Carmen D’Amelio, additional, Matute, Olga Vega, additional, Puga, Marta Ferrer, additional, Lapresa, María José Goikoetxea, additional, Lasarte, Gabriel Gastaminza, additional, Thinnes, Antonia, additional, Merk, Hans F., additional, Baron, Jens Malte, additional, Leverkus, Martin, additional, Balakirski, Galina, additional, Gibson, Andrew, additional, Ogese, Monday, additional, Al-Attar, Zaid, additional, Yaseen, Fiazia, additional, Meng, Xiaoli, additional, Jenkins, Rozalind, additional, Farrel, John, additional, Alhilali, Khetam, additional, Xue, Yanni, additional, Illing, Patricia, additional, Mifsud, Nicole, additional, Fettke, Heidi, additional, Lai, Jeffrey, additional, Ho, Rebecca, additional, Kwan, Patrick, additional, Purcell, Anthony, additional, Ogese, Monday O., additional, Betts, Catherine, additional, Thomson, Paul, additional, Alhaidari, Mohammad, additional, Berry, Neill, additional, O’Neill, Paul M., additional, Alzahrani, Abdulaziz, additional, Azoury, Marie Eliane, additional, Fili, Lucia, additional, Bechara, Rami, additional, Scornet, Noémie, additional, Nhim, Cathy, additional, Weaver, Richard, additional, Claude, Nancy, additional, Joseph, Delphine, additional, Maillere, Bernard, additional, Parronchi, Paola, additional, Pallardy, Marc, additional, Villani, Axel Patrice, additional, Rozières, Aurore, additional, Bensaïd, Benoît, additional, Tardieu, Mathilde, additional, Albert, Floriane, additional, Mutez, Virginie, additional, Baysal, Tugba, additional, Maryanski, Janet, additional, Nicolas, Jean-François, additional, Kanagawa, Osami, additional, Vocanson, Marc, additional, Hung, Shuen-Iu, additional, Harrison, Caroline J., additional, Jenkins, Rosalind E., additional, French, Neil S., additional, Montañez, Maria Isabel, additional, Fernandez, Tahia D., additional, Martin-Serrano, Angela, additional, Torres, Maria Jose, additional, Molina, Noemi, additional, Wood, Sally, additional, Pirmohamed, Munir, additional, Montañez, María Isabel, additional, Martín-Serrano, Ángela, additional, Pérez-Inestrosa, Ezequiel, additional, Pérez-Sala, Dolores, additional, Guzmán, Antonio E., additional, Ko, Tai-Ming, additional, Chen, Yuan-Tsong, additional, Wu, Jer-Yuarn, additional, Sánchez-Gómez, Francisco J., additional, González-Morena, Juan M., additional, Torres, María J., additional, Arreola, Alejandra Monroy, additional, Corona, Jesus Agustin Badillo, additional, Flores, Silvia Mendez, additional, Cherit, Judith Dominguez, additional, Figueroa, Noe Valentin Duran, additional, Flores, Jose Luis Castrejon, additional, Perkins, James, additional, Pérez-Alzate, Diana, additional, Bogas, Gador, additional, Torres, María J, additional, Marti, Luis Mario Tubella, additional, De La Losa, Fernando Pineda, additional, Poves, Francisca Arribas, additional, Lopez, Jaime Tubella, additional, and Santiago, Teodora Lopez, additional
Published: 2016
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32. β-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells.

Author: Sullivan, Andrew, Eryi Wang, Farrell, John, Whitaker, Paul, Faulkner, Lee, Peckham, Daniel, Park, B. Kevin, and Naisbitt, Dean J.
Abstract: Background: β-Lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T cells. However, new T-cell subsets have not been considered. Objective: The objective of this study was to use piperacillin as a model of β-lactam hypersensitivity to study the nature of the drug-specific T-cell response induced in the blood and skin of hypersensitive patients and healthy volunteers. Methods: Drug-specific T cells were cloned from blood and inflamed skin, and cellular phenotype and function were explored. Naive T cells from healthy volunteers were primed to piperacillin, cloned, and subjected to the similar analyses. Results: PBMC and T-cell clones (n5570, 84% CD4+) fromblood of piperacillin-hypersensitive patients proliferated and secreted TH1/TH2 cytokines alongside IL-22 after drug stimulation. IL-17A secretion was not detected. Drug-specific clones from inflamed skin (n 5 96, 83% CD4+) secreted a similar profile of cytokines but displayed greater cytolytic activity, secreting perforin, granzyme B, and Fas ligand when activated. Blood- and skin-derived clones expressed high levels of skin-homing chemokine receptors and migrated in the presence of the ligands CCL17 and CCL27. Piperacillin-primed naive T cells from healthy volunteers also secreted IFN-γ, IL-13, IL-22, and cytolytic molecules. Aryl hydrocarbon receptor blockade prevented differentiation of the naive T cells into antigen-specific IL-22-secreting cells. Conclusion: Together, our results reveal that circulating and skin-resident, antigen-specific, IL-22-secreting T cells are detectable in patients with β-lactam hypersensitivity. Furthermore, differentiation of naive T cells into antigenspecific TH22 cells is dependent on aryl hydrocarbon receptor signaling. [ABSTRACT FROM AUTHOR]
Published: 2018
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33. In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski’s Base

Author: Gibson, Andrew, primary, Kim, Seung-Hyun, additional, Faulkner, Lee, additional, Evely, Jane, additional, Pirmohamed, Munir, additional, Park, Kevin B., additional, and Naisbitt, Dean J., additional
Published: 2015
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34. The B subunit ofEscherichia colienterotoxin helps control the in vivo growth of solid tumors expressing the Epstein-Barr virus latent membrane protein 2A

Author: Ondondo, Beatrice, primary, Faulkner, Lee, additional, Williams, Neil A., additional, Morgan, Andrew J., additional, and Morgan, David J., additional
Published: 2015
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35. Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase

Author: Ogese, Monday O., primary, Jenkins, Rosalind E., additional, Maggs, James L., additional, Meng, Xiaoli, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Faulkner, Lee, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2015
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36. New Approaches to Investigate Drug-Induced Hypersensitivity.

Author: Ogese, Monday O., Ahmed, Shaheda, Alferivic, Ana, Betts, Catherine J., Dickinson, Anne, Faulkner, Lee, French, Neil, Gibson, Andrew, Hirschfield, Gideon M., Kammüller, Michael, Xiaoli Meng, Martin, Stefan F., Musette, Philippe, Norris, Alan, Pirmohamed, Munir, Kevin Park, B., Purcell, Anthony W., Spraggs, Colin F., Whritenour, Jessica, and Naisbitt, Dean J.
Published: 2017
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37. The importance of hapten–protein complex formation in the development of drug allergy

Author: Faulkner, Lee, primary, Meng, Xiaoli, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2014
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38. Characterization of the TCR V repertoire of piperacillin‐specific T‐cells

Author: Al‐Attar, Zaid, primary, Faulkner, Lee, additional, Farrell, John, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Park, Kevin, additional, and Naisbitt, Dean, additional
Published: 2014
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39. Negative regulation by Programmed Death Ligand‐1 during drug‐specific priming of T‐cells and the influence of Programmed Death‐1 on effector T‐cell function

Author: Gibson, Andrew, primary, Ogese, Monday, additional, Sullivan, Andrew, additional, Wang, Eryi, additional, Saide, Katy, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Faulkner, Lee, additional, Park, B Kevin, additional, and Naisbitt, Dean J, additional
Published: 2014
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40. Skewing of the TCR V repertoire in SMX‐NO specific T cell responses

Author: Faulkner, Lee, primary, Lichtenfels, Maike, additional, Esser, Philipp, additional, Martin, Stefan, additional, Alfirevic, Ana, additional, Pirmohamed, Munir, additional, Naisbitt, Dean, additional, and Park, Kevin, additional
Published: 2014
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41. HLA‐DQ restricted activation of nitroso‐sulfamethoxazole‐specific CD4+ T‐lymphocytes

Author: Ogese, Monday, primary, Saide, Katy, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Faulkner, Lee, additional, Alfirevic, Ana, additional, Pirmohamed, Munir, additional, Park, Kevin, additional, and Naisbitt, Dean, additional
Published: 2014
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42. Characterization of primary human T‐cell responses to p‐phenylenediamine and Bandrowski's base

Author: Gibson, Andrew, primary, Seung‐Hyun, Kim, additional, Faulkner, Lee, additional, Park, B Kevin, additional, and Naisbitt, Dean J, additional
Published: 2014
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43. Characterization of Flucloxacillin‐specific CD8+ T‐cells in a mouse model

Author: Nattrass, Ryan, primary, Faulkner, Lee, additional, Jenkins, Roz, additional, Nicolas, Jean, additional, Vocanson, Marc, additional, Rozieres, Aurore, additional, Antoine, Daniel, additional, Kipar, Anja, additional, Park, Kevin, additional, and Naisbitt, Dean, additional
Published: 2014
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44. Establishment of an HLA‐typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs

Author: Faulkner, Lee, primary, Wood, Sally, additional, Van Eker, Diane, additional, Alfirevic, Ana, additional, Pirmohamed, Munir, additional, Naisbitt, Dean, additional, and Park, Kevin, additional
Published: 2014
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45. Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22–Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

Author: Gibson, Andrew, primary, Ogese, Monday, additional, Sullivan, Andrew, additional, Wang, Eryi, additional, Saide, Katy, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Faulkner, Lee, additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2014
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46. T-cells from HLA-B*57 : 01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

Author: Bell, Catherine C., Faulkner, Lee, Martinsson, Klara, Farrell, John, Alfirevic, Ana, Tugwood, Jonathan, Pirmohamed, Munir, Naisbitt, Dean J., Park, B. Kevin, Bell, Catherine C., Faulkner, Lee, Martinsson, Klara, Farrell, John, Alfirevic, Ana, Tugwood, Jonathan, Pirmohamed, Munir, Naisbitt, Dean J., and Park, B. Kevin
Abstract: Susceptibility to abacavir hypersensitivity has been attributed to possession of the specific human leukocyte antigen allele HLA-B*57:01. HLA-B*57:01-restricted activation of CD8+ T-cells provides a link between the genetic association and the iatrogenic disease. The objectives of this study were to characterize the functionality of drug-responsive CD8+ T-cell clones generated from HLA-B*57:01+ drug-naive subjects and to explore the relationship between abacavir accumulation in antigen presenting cells and the T-cell response. Seventy-four CD8+ clones expressing different Vβ receptors were shown to proliferate and kill target cells via different mechanisms when exposed to abacavir. Certain clones were activated with abacavir in the absence of antigen presenting cells. Analysis of the remaining clones revealed two pathways of drug-dependent T-cell activation. Overnight incubation of antigen presenting cells with abacavir, followed by repeated washing to remove soluble drug, activated approximately 50% of the clones, and the response was blocked by glutaraldehyde fixation. In contrast, a 1 h antigen presenting cell pulse did not activate any of the clones. Accumulation of abacavir in antigen presenting cells was rapid (less than 1 h), and the intracellular concentrations were maintained for 16 h. However, intracellular abacavir was not detectable by mass spectrometry after pulsing. These data suggest that T-cells can be activated by abacavir through a direct interaction with surface and intracellular major histocompatibility complex (MHC) molecules. With the former, abacavir seemingly participates in the MHC T-cell receptor binding interaction. In contrast, the latter pathway likely involves MHC binding peptides displayed as a consequence of abacavir exposure, but not abacavir itself.
Published: 2013
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47. T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

Author: Bell, Catherine C., primary, Faulkner, Lee, additional, Martinsson, Klara, additional, Farrell, John, additional, Alfirevic, Ana, additional, Tugwood, Jonathan, additional, Pirmohamed, Munir, additional, Naisbitt, Dean J., additional, and Park, B. Kevin, additional
Published: 2013
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48. IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers

Author: Kiorpelidou, Eva, primary, Foster, Brian, additional, Farrell, John, additional, Ogese, Monday O., additional, Faulkner, Lee, additional, Goldring, Chris E., additional, Park, B. Kevin, additional, and Naisbitt, Dean J., additional
Published: 2012
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49. Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

Author: Toru Usui, Faulkner, Lee, Farrell, John, French, Neil S., Alfirevic, Ana, Pirmohamed, Munir, Park, B. Kevin, and Naisbitt, Dean J.
Subjects: *T cells, *HLA histocompatibility antigens, *ANTIBODY-drug conjugates, *TRANSPLANTATION immunology, *ALLELES
Abstract: It is unclear whether priming of naïve T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming with drugs associated with HLA risk alleles and control compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin activated T cells from all donors, whereas responses to carbamazepine and oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, respectively. Weak flucloxacillin-specific T cell responses were detected in donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming of T cells with certain drugs is skewed toward donors expressing specific HLA alleles. [ABSTRACT FROM AUTHOR]
Published: 2018
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50. Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Author: Bell, Catherine, primary, Martinsson, Klara, additional, Faulkner, Lee, additional, Alfirevic, Ana, additional, French, Neil, additional, Tugwood, Jonathan, additional, Schuppe-Koistinen, Ina, additional, Cederbrant, Karin, additional, Pirmohamed, Munir, additional, Naisbitt, Dean, additional, and Park, B. Kevin, additional
Published: 2011
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