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Purpose: Mechanical thrombectomies (MT) in patients with large vessel occlusion (LVO) related to calcified cerebral embolus (CCE) have been reported, through small case series, being associated with low reperfusion rate and worse outcome, compared to regular MT. The purpose of the MASC (Mechanical Thrombectomy in Acute Ischemic Stroke Related to Calcified Cerebral Embolus) study was to evaluate the incidence of CCEs treated by MT and the effectiveness of MT in this indication., Methods: The MASC study is a retrospective multicentric (n = 37) national study gathering the cases of adult patients who underwent MT for acute ischemic stroke with LVO related to a CCE in France from January 2015 to November 2019. Reperfusion rate (mTICI ≥ 2B), complication rate and 90-day mRS were systematically collected. We then conducted a systematic review by searching for articles in PubMed, Cochrane Library, Embase and Google Scholar from January 2015 to March 2020. A meta-analysis was performed to estimate clinical outcome at 90 days, reperfusion rate and complications., Results: We gathered data from 35 patients. Reperfusion was obtained in 57% of the cases. Good clinical outcome was observed in 28% of the patients. The meta-analysis retrieved 136 patients. Reperfusion and good clinical outcome were obtained in 50% and 29% of the cases, respectively., Conclusion: The MASC study found worse angiographic and clinical outcomes compared to regular thrombectomies. Individual patient-based meta-analysis including the MASC findings shows a 50% reperfusion rate and a 29% of good clinical outcome., Competing Interests: Declaration of Competing Interest Pr F. Clarençon is consultant for Medtronic, Guerbet, Balt Extrusion, Penumbra, Stryker (paid lectures), Artedrone (advisory board), Biomodex (consultant) and Microvention (core lab). Dr N. Sourour is consultant for Medtronic, Balt Extrusion, Microvention Dr F. Eugene is consultant for Biomodex SA Pr. JC. Gentric is consultant pour Medtronic, Stryker, Balt, Penumbra (paid lectures) /Advisory Board and stock options: Intradys Pr A. Biondi is consultant for Balt Extrusion, Medtronic, Microvention, Penumbra, Phenox, Stryker Neurovascular, (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)

The vertebroplasty is based on intracorporeal acrylic resin injection. Its 2 main objectives are analgesia and bone consolidation. Its main indications are painful and inflammatory fractures on a site of osteopathic fragility and bone metastases. Its clinical efficacy is strongly correlated with a treatment performed within 3 months post fracture. Transpedicular acrylic resin injection is performed under scopic control in order to continuously follow the intra-corporeal filling of the cement and thus limit the risk of complications. Main risks of vertebroplasty are rare and represented by the risk of extracorporeal leak, disc, foraminal, in the epidural space, the periventricular and epidural veins or the inferior vena cava or the lung about acrylic resin injection. For the spinal tumoral pathology, each file is the subject of a multidisciplinary discussion where essential elements to the global care of the patients are necessary to collect and to take into account, in particular the general state of the patient and its life expectancy and the goal of treatment (curative or palliative). The main techniques of hot ablathermy are represented by laser, radio frequency or microwaves and cold ablathermy by cryoablation. Different guidance techniques (fluoroscopy, CT, MRI, etc.) are available to interventional radiologists to perform their actions in conditions of maximum safety and efficiency. It is necessary to put in place a passive protection (thermocouple or electrostimulation) or active protection (displacement of the organs, insufflation of CO2, hydro-dissection, cooling or warming) of the neighboring organs, in particular of the nerves., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)