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9. Impact of age on hospital outcomes after catheter ablation for ventricular tachycardia.

Author

Min Choon Tan, Yong Hao Yeo, Qi Xuan, Kiwan, Chrystina, Fatunde, Olubadewa, Lee, Justin Z., Tolat, Aneesh, and Sorajja, Dan

Subjects
PEARSON correlation (Statistics), RECEIVER operating characteristic curves, PATIENT readmissions, LOGISTIC regression analysis, TREATMENT effectiveness, AGE distribution, MULTIVARIATE analysis, RETROSPECTIVE studies, HOSPITAL mortality, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, VENTRICULAR tachycardia, ODDS ratio, CATHETER ablation, COMPARATIVE studies, CONFIDENCE intervals, DATA analysis software, REGRESSION analysis, EVALUATION
Abstract

Background: The real-world data on the safety profile of ventricular tachycardia (VT) ablation among elderly patients is not well-established. This study aimed to evaluate the procedural outcomes among those aged 18-64 years versus those aged ≥65 years who underwent catheter ablation of VT. Method: Using the Nationwide Readmissions Database, our study included patients aged ≥18 years who underwent VT catheter ablation between 2017 and 2020. We divided the patients into non-elderly (18-64 years old) and elderly age groups (≥65 years old). We then analyzed the in-hospital procedural outcome and 30-day readmission between these two groups. Results: Our study included 2075 (49.1%) non-elderly patients and 2153 (50.9%) elderly patients who underwent VT ablation. Post-procedurally, elderly patients had significantly higher rates of prolonged index hospitalization (≥7 days; 35.5% vs. 29.3%, p < .01), non-home discharge (13.4% vs. 6.0%, p < .01), 30-day readmission (17.0% vs. 11.4%, p < .01), and early mortality (5.5% vs. 2.4%, p < .01). There was no significant difference in the procedural complications between two groups, namely vascular complications, hemopericardium/cardiac tamponade, cerebrovascular accident (CVA), major bleeding requiring blood transfusion, and systemic embolization. Through multivariable analysis, the elderly group was associated with higher odds of early mortality (OR: 7.50; CI 1.86-30.31, p = .01), non-home discharge (OR: 2.41; CI: 1.93-3.00, p < .01) and 30-day readmission (OR: 1.58; CI 1.32-1.89, p < .01). Conclusion: Elderly patients have worse in-hospital outcome, early mortality, nonhome discharge, and 30-day readmission following catheter ablation for VT. There was no significant difference between elderly and non-elderly groups in the procedural complications. [ABSTRACT FROM AUTHOR]

Published
2024
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12. SYNCOPE AND ALL-CAUSE MORTALITY IN HEART FAILURE

Author

Rattanawong, Pattara, primary, Chao, Chieh Ju, additional, Sriramoju, Anil, additional, Tagle-Cornell, M. Cecilia A., additional, Farina, Juan, additional, Beirne, Ellen, additional, Fatunde, Olubadewa A., additional, Koepke, Laura M., additional, Ko, Nway L. Ko, additional, Shanbhag, Anusha, additional, Barry, Timothy, additional, and Shen, Win-Kuang, additional

Published
2023
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15. Raise the Flag

Author

Fatunde, Olubadewa A., primary, Fonseca, Rafael, additional, and Rosenthal, Julie L., additional

Published
2022
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21. ICD discharge rate in patients with hypertrophic cardiomyopathy who do not have massive left ventricular hypertrophy but extensive myocardial fibrosis.

Author

Ravi, Srekar, Farina, Juan M., O'Shea, Michael, baqal, Omar, Fatunde, Olubadewa, Savic, Juliana, Schwartz, Linda, Arsanjani, Reza, and Alsidawi, Said

Abstract

The current ACC/AHA guidelines recommend implantation of an ICD in patients who have hypertrophic cardiomyopathy (HCM) and wall thickness of ≥30 mm (massive LVH, class IIa) due to increased risk of sudden cardiac death (SCD). We hypothesize that patients who do not meet this cut off but have extensive myocardial fibrosis are at equally increased risk as measured by the rate of ICD discharge. We conducted a cohort study of people with HCM who received a CMR and an ICD between 2002-2022. We divided the patients into those with massive LVH (≥30 mm) vs. not and then further into those with extensive late gadolinium enhancement (LGE) (defined as LGE ≥15%) based on cardiac MRI (CMR). We assessed the incidence of device discharge and the Kaplan Meyer Curves of shock-free survival between groups. 222 patients were identified. Overall, the presence of massive LVH was associated with a significantly higher hazard ratio for receiving an appropriate device discharge as compared to those with LV wall thickness <30 mm (HR 2.37, 95%CI 1.10 to 5.10, p = 0.023). However, when CMR data were considered, the presence of LGE >15% identified a subgroup of patient without massive LVH who had a higher incidence of device discharge that was not statistically significant when compared to those with massive LVH (28% vs. 35%, HR 1.01, 95%CI 0.45-2.71, p=0.834). Furthermore, when only patient with massive LVH and LGE <15% were considered, the incidence of device discharge was almost identical to those with LVH <30 mm but with LGE >15% (30% vs. 28%, HR 1.14, 95%CI 0.41-3.17, p=0.797) (Figure 1). In this high-risk population with ICD implanted for primary prevention of SCD in the setting of HCM, the presence of massive LVH predicts a high incidence of ICD discharge. The presence of extensive myocardial fibrosis, however, identifies a subgroup of patient without massive LVH who have equally high incidence of receiving appropriate device discharge. These findings suggest that the presence of extensive LGE on CMR might need to be considered in the same category of massive LVH when assessing HCM patients for ICD implantation. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Abstract 8915: Unsupervised Machine Learning Clustering Identifies Low Flow-Low Gradient as High Mortality Risk Phenotypes in Transcatheter Aortic Valve Replacement Patients

Author

Chao, Chiehju, primary, Wu, Han-Lun, additional, Agasthi, Pradyumna, additional, Rayfield, Corbin, additional, Barry, Timothy, additional, Fatunde, Olubadewa, additional, Seri, Amith, additional, Eleid, Mackram F, additional, Fortuin, Floyd D, additional, Sweeney, John, additional, Pollak, Peter, additional, El Sabbagh, Abdallah, additional, Lester, Steven, additional, Holmes, David R, additional, Shen, Win K, additional, Patel, Bhavik, additional, and Arsanjani, Reza, additional

Published
2021
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28. ECHOCARDIOGRAPHY-BASED CONVOLUTIONAL NEURAL NETWORK MODEL SUPERSEDES THE CARDIOTOXICITY RISK SCORE IN PREDICTING CHEMOTHERAPY-INDUCED CARDIOMYOPATHY

Author

Chao, Chieh Ju, primary, Wu, Hau-Lun, additional, Barry, Timothy, additional, Seri, Amith Reddy, additional, Meyer, Megan, additional, Agasthi, Pradyumna, additional, Abdou, Merna, additional, O’Shea, Michael, additional, Campany, Megan, additional, Newman, Hana, additional, Fatunde, Olubadewa, additional, Larsen, Carolyn, additional, Rosenthal, Julie, additional, Hardaway, Brian, additional, Narayanasamy, Hemalatha, additional, Shah, Shimoli, additional, and Arsanjani, Reza, additional

Published
2021
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34. Prevalence and Incidence of Type-1 Brugada Pattern: A 30-Year Experience at Mayo Clinic

Author

Rattanawong, Pattara, Mead-Harvey, Carolyn, Fatunde, Olubadewa A., Van Der Walt, Charles, Ko, Nway Ko, Hooke, Patrick, Yinadsawaphan, Thanaboon, Kulthamrongsri, Narathorn, Shen, Win-Kuang, and Sorajja, Dan

Abstract

The incidence and prevalence of Type-1 Brugada pattern (BrP) among different ethnicities and races in the United States are unknown. We aim to identify the incidence and prevalence of Type-1 BrP at Mayo Clinic over 30 years.

Published
2024
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