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Background: End-Stage Renal Disease (ESRD) patients on hemodialysis suffered from many central and peripheral neurological insults. Aim of the work:This study aimed to assess the value of using MRA, MRV, and SWAN sequences in early visualization of the silent cerebrovascular complications in those patients. Patients and Methods: Our study was conducted on forty-five patients with well-documented ESRD on regular hemodialysis for more than 5 years with no neurological manifestation, all undergone unenhanced MRI, DWI with ADC and measuring the ADC value, SWAN, MRA, and MRV. Results: we found that 11% of cases have acute infarction at the basal ganglia region. 36.7% of patients are diagnosed with intracerebral hemorrhage, only 26.7% of them are seen by the conventional MRI, and 16.7% of cases showed microbleeds on SWAN with normal conventional MRI. The sensitivity and specificity of SWAN with ADC value to detect brain hemorrhage are 100% and 88.8% respectively. Conclusion: Visualization of cerebrovascular complications such as infarction, hemorrhage, atherosclerosis, and arterial and venous occlusion using DWI with ADC, MRA, MRV, and SWAN and is very useful in early management and better prognosis of ESRD patients even with silent complications that don’t give up symptoms with high sensitivity and specificity of SWAN in early detection of hemorrhage and microbleeds.

Objective The aim of this study was to clarify the association between epicardial fat volume and coronary atherosclerosis. Materials and methods A total of 90 patients with clinically suspected coronary artery disease underwent MDCT coronary angiography. The images were interpreted for Calcium score, quantification of epicardial adipose tissue (EAT) volume, and coronary artery disease (CAD) which was classified according to the number of affected vessels, location, extension, component of the lesion and degree of obstruction. EAT was correlated to CAD and Calcium score using 125 cm3 as a cutoff value for acceptable EAT volume. Results The patients were classified into 3 groups: patients with 1-normal CCTA, 2-non-significant CAD and 3-significant CAD. A high statistical significant difference was found among the 3 groups regarding mean coronary calcium score (P value = 0.00) and mean EAT volume; Group 1 (125.14 ± 56.88 cm3), in group 2 (217.38 ± 56.88 cm3) and the largest EAT volume was seen in group 3 (327.94 ± 90.17 cm3), (P value: 0.00). Conclusion The estimation of EAT volume could be considered as a screening test for any patients suspicious for CAD.

To compare the distance between the colon and the trajectory of percutaneous nephrolithotomy (PCNL) access both in prone and flank-free modified supine (FFMS) positions as measured on computed tomography and to study the effect of age, gender, BMI, side, and previous renal surgery as influencing factors.In this prospective study, we included 367 patients scheduled for PCNL. All patients underwent low dose abdominal computed tomography both in prone and FFMS positions. Patients18 years and those with previous colonic surgery or renal congenital anomalies were excluded. The perpendicular distance between the imaginary line of the renal access and the colon was measured. Findings were correlated to different influencing factors.Two hundred nineteen patients were males, and 148 were females. BMI of30 were reported in 158 patients whereas BMI30 in 209 patients. Data analysis showed that the mean perpendicular distance between colon and the renal access in FFMS and prone positions were 35.92 ± 0.22 mm and 17.78 ± 0.09 mm, respectively. In prone position only obesity, age, and overall interaction effect were the significant factors on the studied distance. In FFMS position, in addition to the effect of the prior factors, previous renal surgery also significantly reduces this distance.The distance between the colon and assumed PCNL trajectory at a puncture on the posterior axillary line was influenced mainly by patient position. In FFMS position the colon appears to be farther than in prone position. BMI and age significantly influence this distance to a lesser extent.

Objectives To evaluate the role of probe to bone test (PTB) and magnetic resonance imaging (MRI) in assessing the surgical intervention in diabetic foot. Study design 102 diabetic patients were included; 42 males and 60 females, mean age was 52 ± 6, all patients were subjected to PTB test followed by MRI, the presence of osteomyelitis was assessed in relation to histopathological examination. Results We had 80 (75.5%) feet of osteomyelitis, PTB test was true positive in 66 (82.5%), false negative in eight and false positive in 6 feet. MRI was true positive in 78, false positive in three and false negative in two feet. Other MRI finding include abscess in 37, tenosynovitis in 69, neuropathic changes in 20 feet, and all cases had cellulites. Sensitivity, specificity, PPV and NPV were 82.5%, 76.9%, 91.7%, and 58.8% for PTB test and 97.5%, 88.5%, 96.3% and 92% for MRI respectively. Conclusion PTB test is a simple, minimally invasive, low cost test and can be done at outpatient clinic. Its sensitivity and specificity are good when compared to those of MRI, but when we need to diagnose associated soft tissue infection and planning the surgical management MRI was the image of choice.

Objectives Evaluate whether maternal history and ultrasound can predict massive hemorrhage during cesarean section in placenta praevia. Study design Sixty singleton pregnant women with persistent placenta praevia (after 28 weeks’ gestation) were prospectively enrolled in this study. Comprehensive maternal history and findings obtained by antenatal ultrasound, including placental location, presence of lacunae, lack of a clear zone, abnormal color Doppler indices were reviewed, and their effect on the severity of maternal hemorrhage during cesarean section was analyzed. Results Twenty two cases had massive intra operative hemorrhage, among them 20 patients were confirmed to have placenta accreta and its variants (including increta and percreta) at the time of cesarean delivery. For diagnosis of severe bleeding (>1500 ml), the sensitivity of previous uterine surgery, abnormal color Doppler and lack of clear zone was high (95.5%, 81.8%, 81.8% respectively) while sensitivity of presence of lacunae was low (36.4%). And the specificity of abnormal color Doppler, lack of clear zone and presence of lacunae was high (94.7%, 94.7%, 97.4% respectively) while of previous uterine surgery was low (36.8%). Conclusion Prenatal maternal history and ultrasound examination can predict the amount of intraoperative hemorrhage and reduced the morbidity and mortality in patients with placenta previa.

Objectives To evaluate the role of MCTA in detecting neglected vascular injuries in the extremities. Study design This study included nineteen patients with previous trauma history, with clinically suspected vascular lesion. CTA was done for every patient and followed by surgical treatment. Results Out of the nineteen patients included, eighteen patients were accurately diagnosed by MCTA to have vascular lesions (94.7%), pseudoaneurysm in 10 (55.6%) patients, stenosis in 4 (22.2%) patients, AVF in 2 (11.1%) patients, and occlusion of an arterial segment in 2 (11.1%) patients. One patient (5%) had metallic artifact that alters image interpretation The accuracy of CTA in detecting vascular lesion in the examined patients was 94.7% with sensitivity and specificity of 94.4% and 100%, respectively. Conclusion MCT angiography is an initial accurate diagnostic method in evaluating patients with suspected neglected extremity trauma.

Objective Assessing the role of MSCT compared to TTE in pediatric patients with congenital heart diseases especially the thoracic congenital vascular anomalies. Methods 54 pediatric patients underwent a 128 detectors computed tomography cardiac angiography with retrospective ECG-gating. Images were reviewed based on segmental approach using the operative data (35/54 patients) or cardiac catheterization (19/54 patients) findings as reference standard. Sensitivity, specificity, positive and negative predictive values and accuracy of TTE and MDCT were evaluated. Results MDCT was superior to TTE in evaluating vascular lesions (aortic, conotruncal, coronary artery, major aorto-pulmonary collaterals, patent ductus arteriosus, venous anomalies and postoperative complications) as well as pulmonary lesions; while TTE was superior in intracardiac anomalies with equal performance in (pulmonary artery anomalies, concordance and valvular atresia). MDCT achieved (100%, 96.3% and 87%) accuracies compared to TTE (94.4%, 85.2% & 96.3%) for delineating isolated vascular anomalies, complex vascular anomalies and intracardiac anomalies respectively. Conclusion The main added value of cardiac MDCT to TTE is the precise illustration of the extracardiac anatomic structures, without adding significant information on intracardiac abnormalities. Using MDCT with TTE has improved the diagnostic accuracy thus obviating the need for diagnostic cardiac catheterization especially in critically ill patients.

Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does the study add? The subject of bladder preservation multimodality protocols in muscle invasive bladder TCC is not new. In our study, even in a highly selected group of patients, multimodality protocol with M-VAC and radiation therapy achieved suboptimal results at 1 year. This emphasized the role of radical cystectomy as the gold standard treatment for invasive bladder TCC. OBJECTIVE • To evaluate the efficacy of a bladder preservation multimodality protocol for patients with operable carcinoma invading bladder muscle. MATERIALS AND METHODS • In this prospective study, we included 33 patients with transitional cell carcinoma (TCC) (T2 and T3, Nx, M0) who were amenable to complete transurethral resection. • These patients refused radical cystectomy as their first treatment option. After maximum transurethral resection of bladder tumour (TURBT), all patients received three cycles of adjuvant chemotherapy in the form of methotrexate, vinblastin, adriamycin and cisplatin (MVAC) followed by radical radiotherapy. • Four weeks later, all cases had radiological and cystoscopical re-evaluation. • Complete responders were considered to be those patients who had no evidence of residual tumour. All patients were subjected to a regular follow-up by cystoscopy and tumour site biopsy conducted every 3 months. Abdomino-pelvic computed tomography and chest X-ray were conducted every 6 months. • The study endpoint was the response to treatment after completion of the first year of follow-up after therapy. RESULTS • Out of 33 eligible patients, a total of 28 patients completed the study treatment protocol. Their mean ± SD age was 56.7 ± 6 years. Trimodal therapy was well tolerated in most of cases, with no severe acute toxicities. After 12 months of follow-up, a complete response was achieved in 39.3% and a partial response in 7.1%, with an overall response rate of 46.4%. • By the end of the first year, disease-free survival was reported in 39.3%, whereas 25% were still alive with their disease, giving an overall survival of 64.3% for all patients who maintained their intact, well functioning bladders. • Tumour stage and completeness of transurethral resection of bladder tumour were the most important predictors of response and survival. T2 lesions had complete and partial response rates of 69.2% and 23%, respectively, whereas T3 lesions had rates of 40% and 13.3%, respectively (P= 0.001). • The response rate in patients who had complete TURBT was 82.6% vs 20% in those with cystoscopic biopsy only (P= 0.001). In addition, disease-free survival was 72.7% in T2 patients and 27.3% in T3 patients (P= 0.001). CONCLUSION • In the present study, bladder preservation protocol with MVAC and radical radiotherapy achieved suboptimal response rates at 1 year in patients with localized TCC invading bladder muscle. Patients with solitary T2 lesions that are amenable to complete TURBT achieved the best response rates. Longer follow-up is needed to verify these results. Patients with localized disease should be encouraged for radical cystectomy, which achieved better results.

Objectives: In this retrospective study we reviewed the outcome of non-operative management of high-grade blunt renal injuries (grade III–V) and evaluated the predictive indicators of management failure. Subjects and methods: The data review included the patients’ demographics, the mechanism of trauma and the clinical characteristics, as well as the laboratory and imaging data upon admission and at follow-up. The data of the patients who were successfully managed non-operatively and of those who needed intervention for renal injuries were compared. Results: Two hundred and six patients were enrolled in this study. Grade III, grade IV and grade V renal injuries were found in 39.8%, 44.2% and 16% of the patients, respectively. The overall success rate of non-operative management was 87.9%, including all patients with grade III, 86.8% of patients with grade IV and 60.6% of those with grade V injuries. Multivariate analysis revealed that trauma secondary to motor vehicle accident, hypotension at presentation, associated injuries to other organs, grade V renal injury and computed tomography (CT) imaging features, namely medial renal parenchymal laceration, perirenal hematoma ≥3.5 cm and intravascular extravasation were significant predictors for failure of non-operative management. Conclusion: Our findings suggest that high-grade renal injuries in hemodynamically stable patients can be managed conservatively with a high success rate. Multiple clinical and radiological variables can predict the treatment outcome. Keywords: High grade; Non-operative management; Outcome; Renal trauma

Objective To compare the accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in characterizing adrenal masses. Materials and methods A total of 45 adrenal masses in 38 patients underwent unenhanced CT, enhanced CT, and chemical-shift MRI. Sensitivities and accuracies using the lesion attenuation values, absolute or relative percentage washout for CT, and adrenal-to-spleen ratio or signal intensity index for MRI were calculated. Follow-up or histopathology was used as standard reference. Results A total of 15 lipid-rich adenomas, 6 lipid-poor adenomas, and 24 nonadenomas were obtained. The sensitivities for adenoma on MRI versus CT were 81% and 95%, respectively. The specificities were 100%. Conclusion CT is superior to MRI in characterizing adenomas.

• To evaluate the efficacy of a bladder preservation multimodality protocol for patients with operable carcinoma invading bladder muscle.• In this prospective study, we included 33 patients with transitional cell carcinoma (TCC) (T2 and T3, Nx, M0) who were amenable to complete transurethral resection. • These patients refused radical cystectomy as their first treatment option. After maximum transurethral resection of bladder tumour (TURBT), all patients received three cycles of adjuvant chemotherapy in the form of methotrexate, vinblastin, adriamycin and cisplatin (MVAC) followed by radical radiotherapy. • Four weeks later, all cases had radiological and cystoscopical re-evaluation. • Complete responders were considered to be those patients who had no evidence of residual tumour. All patients were subjected to a regular follow-up by cystoscopy and tumour site biopsy conducted every 3 months. Abdomino-pelvic computed tomography and chest X-ray were conducted every 6 months. • The study endpoint was the response to treatment after completion of the first year of follow-up after therapy.• Out of 33 eligible patients, a total of 28 patients completed the study treatment protocol. Their mean ± SD age was 56.7 ± 6 years. Trimodal therapy was well tolerated in most of cases, with no severe acute toxicities. After 12 months of follow-up, a complete response was achieved in 39.3% and a partial response in 7.1%, with an overall response rate of 46.4%. • By the end of the first year, disease-free survival was reported in 39.3%, whereas 25% were still alive with their disease, giving an overall survival of 64.3% for all patients who maintained their intact, well functioning bladders. • Tumour stage and completeness of transurethral resection of bladder tumour were the most important predictors of response and survival. T2 lesions had complete and partial response rates of 69.2% and 23%, respectively, whereas T3 lesions had rates of 40% and 13.3%, respectively (P = 0.001). • The response rate in patients who had complete TURBT was 82.6% vs 20% in those with cystoscopic biopsy only (P = 0.001). In addition, disease-free survival was 72.7% in T2 patients and 27.3% in T3 patients (P = 0.001).• In the present study, bladder preservation protocol with MVAC and radical radiotherapy achieved suboptimal response rates at 1 year in patients with localized TCC invading bladder muscle. Patients with solitary T2 lesions that are amenable to complete TURBT achieved the best response rates. Longer follow-up is needed to verify these results. Patients with localized disease should be encouraged for radical cystectomy, which achieved better results.