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1. The evaluation of anterior thalamic radiation with diffusion tensor imaging in children with neurofibromatosis type-1

Author

Bahar Atasoy, Serdar Balsak, Ummuhan Ebru Karabulut, Fatma Yabul, Ismail Yurtsever, Ahmet Akcay, Dilek Hacer Cesme, and Alpay Alkan

Subjects
neurofibromatosis type 1, diffusion tensor imaging, executive function, anterior thalamic radiation, neurofibromatosis bright objects, Medicine
Abstract

To determine whether there is a difference in the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of the anterior thalamic radiation (ATR), which are involved in the inhibitory control mechanism, in Neurofibromatosis type-1 (NF1) patients with or without Neurofibromatosis bright objects (NBOs), in comparison to the healthy control group. Thirty children diagnosed with NF1 and 17 age-matched children were included in the study. 30 children with NF1 had a mean age of 10.47±5.43, compared to 11.35±5.43 of the control group. NF1 patients were divided into two groups as those with and without NBOs. The comparison was made by measuring ADC and FA values of ATR in patients with NF1 and a healthy control group. There was a significant difference in terms of ADC and FA values of ATR between the patients with NF1 and the control group. While a significant decrease was seen in FA values of ATR, ADC values were increased. There was a significant difference in ATR ADC and FA values between NF1 patients with and without NBOs and the healthy control group. On the other hand, no major difference was displayed between NF1 patients with NBOs and without NBOs in terms of ATR ADC and FA values. The results of increased ADC and decreased FA values may denote the demyelination process in ATR. We speculate that the onset of microstructural damage in the ATR may result in executive function impairment, particularly in the inhibitory control mechanism. [Med-Science 2023; 12(3.000): 883-6]

Published
2023
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3. Importance of pre-treatment Fractional Anisotropy value in predicting volumetric response in patients with meningioma treated with Gamma Knife Radiosurgery

Author

Dilek Hacer Cesme, Mehmet Hakan Seyithanoglu, Alpay Alkan, Lutfullah Sari, Fatma Yabul, Mahmut Esat Aykan, Mustafa Aziz Hatiboglu, Hafize Otcu Temur, HATİBOĞLU, MUSTAFA AZİZ, and ÇEŞME, DİLEK HACER

Subjects
Gamma knife radiosurgery, Pre treatment, medicine.medical_treatment, Radiosurgery, Meningioma, Çeşme D. H. , Alkan A., Sarı L., Çelik Yabul F., Otçu Temur H., Aykan M. E. , Seyithanaoglu M. H. , Hatiboğlu M. A. , -Importance of pre-treatment Fractional Anisotropy value in predicting volumetric response in patients with meningioma treated with Gamma Knife Radiosurgery -, Current Medical Imaging Reviews, cilt.17, ss.1-6, 2021, Mean diffusivity, Fractional anisotropy, Meningeal Neoplasms, medicine, Tumor volume, Humans, Radiology, Nuclear Medicine and imaging, In patient, business.industry, medicine.disease, Diffusion tensor imaging, Diffusion Tensor Imaging, Anisotropy, Negative correlation, Nuclear medicine, business, Diffusion MRI
Abstract

Background: The importance of pre-treatment Diffusion Tensor Imaging (DTI) parameters in determining the response to treatment after radiosurgery in patients with meningioma has not yet been clearly revealed. Objective: This study was conducted to determine tumor volume changes in terms of radiological response in patients with meningioma treated with Gamma Knife Radiosurgery (GKR) and to analyze the relationship between Total Tumor Volume (TTV) and Diffusion Tensor Imaging (DTI) parameters. In addition, we investigated whether the response to treatment can be predicted by pre-radiosurgery DTI findings. Methods: Fifty-four patients were assessed using MRI and DTI before and after GKR. Mean Diffusivity (MD), Fractional Anisotropy (FA), Radial Diffusivity (RD), and TTV of tumour were determined. Patients with 10% or more decrease in TTV after GKR were classified as group 1 and those with less than 10% decrease in volume or increase in volume were considered group 2. The relationships between MD, RD, and FA values and TTV were investigated. Results: A decrease of 46.34% in TTV was detected in group 1 after GKR, while TTV increased by 42.91% in group 2. The lowest pre-treatment FA value was detected in group 1. In addition, after GKR, FA values showed a significant increase in group 1. MD and RD values increased in both groups after radiosurgery. There was a negative correlation between pre-treatment FA, RD, and MD values after radiosurgery. Conclusions: Detection of low FA values due to the poor fiber content in meningioma before radiosurgery may be a guide in predicting the response to treatment. Further studies are required to have a better understanding of the relationship between pre- and post-treatment follow-up FA values and tumor volume in determining the efficacy of GKR in patients with meningioma.

Published
2020

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