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9 results on '"Fatma Didem Yucel Yetiskin"'

1. Longer anogenital distance in female fetus of diabetic and obese pregnant women

Author

Filiz Halici-Ozturk, Fatma Didem Yucel Yetiskin, Beril Gurlek, Fatma Doga Ocal, Kadriye Yakut, Yaprak Engin-Ustun, Sevki Celen, and Dilek Sahin

Subjects
Maternal diabetes, Maternal obesity, Anogenital distance, Prenatal ultrasound, Hyperandrogenism, Gynecology and obstetrics, RG1-991
Abstract

Objective: Previous studies revealed that prenatal exposure to androgen excess such as polycystic ovary syndrome (PCOS) is associated with offspring's anogenital distance (AGD) length, and AGD is a biomarker of intrauterine androgen exposure. This study aims to investigate a possible relationship of fetal AGD with maternal diabetes and obesity, and to evaluate whether AGD predicts the fetal androgen exposure related to diabetes and obesity in female fetus. This study is the first to focus on the relationship between offspring's AGD and maternal diabetes and obesity. Materials and methods: This is a prospective study investigating 218 pregnant women (125 in control group and 93 in study group). Fetal AGD was measured from the center of anus to the posterior convergence of the fourchette by ultrasound. Multivariate linear regression analysis was applied to assess the association of the fetal AGD length with maternal diabetes and obesity. Results: The control patients had significantly shorter fetal AGD (mean:10.7 mm, P

Published
2023
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2. The Association of Serum Electrolytes with Disease Severity and Obstetric Complications in Pregnant Women with COVID-19: a Prospective Cohort Study from a Tertiary Reference Center

Author

Atakan Tanacan, Seyit Ahmet Erol, Ali Taner Anuk, Fatma Didem Yucel Yetiskin, Eda Ozden Tokalioglu, Selin Sahin, Serpil Unlu, Huseyin Levent Keskin, Aziz Ahmet Surel, Ozlem Moraloglu Tekin, and Dilek Sahin

Subjects
Maternity and Midwifery, Obstetrics and Gynecology
Abstract

Introduction To evaluate the association of serum electrolytes with disease severity and obstetric complications in pregnant women with Coronavirus disease 2019 (COVID-19). Materials and Methods This prospective cohort study was conducted on pregnant women with confirmed COVID-19. Study population was divided into two groups: 1) Mild COVID-19 group (n = 811) and 2) Moderate/severe COVID-19 group (n = 52). Demographic features, clinical characteristics, obstetric complications, and serum electrolytes were compared between the groups. Afterward, a correlation analysis was performed to investigate the association between serum electrolyte disturbances with COVID-19 severity and obstetric complications. Results Highest serum sodium, hypernatremia, potassium replacement, hypopotassemia, hyperchloremia, initial serum magnesium, hypermagnesemia, and hypocalcemia were significantly higher in the moderate/severe COVID-19 group. The lowest serum sodium, lowest serum potassium, and initial serum calcium were significantly higher in the mild COVID-19 group (p Conclusion Electrolyte disturbances in pregnant women with COVID-19 seem to be associated with disease severity and obstetric complications.

Published
2022
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3. Doppler assessment of the fetus in pregnant women recovered from <scp>COVID</scp> ‐19

Author

Hüseyin Levent Keskin, Selvi Aydin Senel, Atakan Tanacan, Ali Taner Anuk, Gul Nihal Buyuk, Dilek Uygur, Fatma Didem Yucel Yetiskin, and Özlem Moraloğlu

Subjects
Middle Cerebral Artery, medicine.medical_specialty, Gestational Age, SARS‐CoV‐2, Ultrasonography, Prenatal, Umbilical Arteries, Fetus, fetal Doppler ultrasound, COVID‐19, Pregnancy, medicine.artery, Humans, Medicine, Prospective Studies, Prospective cohort study, SARS-CoV-2, business.industry, Obstetrics, Case-control study, COVID-19, Obstetrics and Gynecology, Gestational age, Ultrasonography, Doppler, Umbilical artery, Original Articles, medicine.disease, Case-Control Studies, Pulsatile Flow, Middle cerebral artery, Gestation, Original Article, Female, Pregnant Women, business
Abstract

Objective The aim of this study was to evaluate the maternal‐fetal Doppler patterns in pregnant women recovered from COVID‐19. Methods This prospective case–control study was conducted in Ankara City Hospital between July 1, 2020 and August 30, 2020. Thirty pregnant women who were diagnosed with COVID‐19 and completed the quarantine process were compared with 40 healthy pregnant women in terms of the fetal Doppler parameters. All pregnant women diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection were followed up in our clinic and their diagnoses have been confirmed in nasopharyngeal and oropharyngeal samples by quantitative real time reverse transcriptase polymerase chain reaction (RT‐PCR) method. Doppler ultrasonographic assessment of the uterine arteries (UtA) and middle cerebral artery (MCA) were used in addition to umbilical artery (UA) Doppler between 23 and 40 weeks of gestation. Also, cerebroplacental ratio (CPR) was calculated according to gestational age. Results The pulsatility and resistance indices of umbilical and UtA showed a significant increase in pregnant women in the study group compared to the control group (p 1000, 95%CI 9.77 to >1000, p = 0.009; OR 0,000 95%CI 0,000‐0,944, p = 0,049), respectively. Medical treatment was given to 16/30 (53%) of pregnant women diagnosed with COVID‐19. Conclusion In conclusion, uterine artery Doppler indices in the third trimester may have clinical value in pregnant women recovered from COVID‐19.

Published
2021
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4. Experience of a tertiary pandemic centre on the labour and delivery of 337 pregnant women with COVID-19: a prospective cohort study from Turkey

Author

Dilek Sahin, Atakan Tanacan, Seyit Ahmet Erol, Ali Taner Anuk, Eda Ozden Tokalioglu, Fatma Didem Yucel Yetiskin, Berhan Besimoglu, Yuksel Oguz, Sule Goncu Ayhan, Orhan Altinboga, Serpil Unlu, Namik Ozcan, Huseyin Levent Keskin, and Ozlem Moraloglu Tekin

Subjects
Oxygen, Turkey, Cesarean Section, Pregnancy, SARS-CoV-2, Obstetrics and Gynecology, COVID-19, Humans, Female, Pregnant Women, Prospective Studies, Pandemics
Abstract

The aim of the present study is to share the experience of a tertiary reference pandemic centre on the labour and delivery of pregnant women with coronavirus disease 2019 (COVID-19). This prospective cohort study was conducted on pregnant women with COVID-19 (

Published
2022

6. Updated experience of a tertiary pandemic center on 533 pregnant women with COVID-19 infection: A prospective cohort study from Turkey

Author

Özlem Moraloğlu, Dilek Sahin, Serpil Unlu, Cuneyt Tayman, Namik Ozcan, Aykan Yucel, Ali Taner Anuk, Aziz Ahmet Surel, Seyit Ahmet Erol, Elif Gül Yapar Eyi, Bedia Dinc, A. Seval Ozgu-Erdinc, Hüseyin Levent Keskin, Eyup Sari, Atakan Tanacan, and Fatma Didem Yucel Yetiskin

Subjects
myalgia, Adult, medicine.medical_specialty, Adolescent, Turkey, medicine.medical_treatment, Comorbidity, Breast milk, Asymptomatic, law.invention, Miscarriage, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Patient Admission, law, Pregnancy, Intensive Care Units, Neonatal, Obstetrics and Gynaecology, medicine, Humans, 030212 general & internal medicine, Pregnancy Complications, Infectious, Prospective cohort study, Mechanical ventilation, 030219 obstetrics & reproductive medicine, Milk, Human, Obstetrics, business.industry, Cesarean Section, Infant, Newborn, Obstetrics and Gynecology, COVID-19, General Medicine, Myalgia, Middle Aged, medicine.disease, Intensive care unit, Respiration, Artificial, Hospitalization, Intensive Care Units, Cough, Asymptomatic Diseases, Female, medicine.symptom, business
Abstract

Objective To investigate the clinical course and impact of coronavirus disease 2019 (COVID-19) infection on pregnant women. Methods A prospective cohort study was conducted on pregnant women with confirmed COVID-19 infection. Demographic features, clinical characteristics, and perinatal outcomes were prospectively evaluated. Results Of the 533 cases, 161 (30.2%) had co-morbidities and 165 (30.9%) were asymptomatic. Cough (n = 178, 33.4%) and myalgia (n = 168, 31.5%) were the leading symptoms. In total, 261 patients (48.9%) received COVID-19 therapy, 509 (95.5%) had mild disease, 7 (1.3%) were admitted to the intensive care unit (ICU), and invasive mechanical ventilation was necessary in 2 (0.4%) patients. Maternal mortality was observed in 2 (0.4%) cases. Of the patients, 297 (55.7%) were hospitalized, 39 (7.3%) had suspicious radiologic imaging findings, 66 (12.4) had pregnancy complications (preterm delivery [n =22, 4.1%] and miscarriage [n =12, 2.2%] were the most common pregnancy complications), 131 births occurred, and the cesarean section rate was 66.4%. All neonates were negative for COVID-19. The rate of admission to the neonatal ICU was 9.9%. One specimen of breast milk was positive for the infection. Conclusion The course of COVID-19 was mild in the majority of cases. However, increased rates of pregnancy complications and cesarean delivery were observed.

Published
2020

7. The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study

Author

Ozlem Moraloglu Tekin, Nuray Yazihan, A. Seval Ozgu-Erdinc, Dilek Sahin, Fatma Didem Yucel Yetiskin, Seyit Ahmet Erol, Atakan Tanacan, Hüseyin Levent Keskin, Ali Taner Anuk, and Derya Biriken

Subjects
0301 basic medicine, medicine.medical_specialty, Immunology, Enzyme-Linked Immunosorbent Assay, cytokine profile, Biochemistry, Gastroenterology, Article, Procalcitonin, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Humans, Immunology and Allergy, Medicine, Prospective Studies, Pregnancy Complications, Infectious, Risk factor, Pregnancy Trimesters, Prospective cohort study, Molecular Biology, medicine.diagnostic_test, interleukin, SARS-CoV-2, business.industry, Interleukin-17, Case-control study, COVID-19, interferon, Hematology, medicine.disease, Interleukin-10, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis, Erythrocyte sedimentation rate, Host-Pathogen Interactions, Cytokines, Interleukin-2, Gestation, Female, business
Abstract

Highlights • COVID-19 infection seems to have an impact on the cytokine profile of pregnant women varying according to pregnancy trimesters and cytokine levels seem to be correlated with disease severity., Objective To compare the levels of various cytokines between pregnant women with confirmed coronavirus disease (COVID-19) infection and pregnant women without any defined risk factor. Materials and Methods Pregnant women with confirmed COVID-19 infection (study group)(n=90) were prospectively compared to a gestational age-matched control group of pregnant women without any defined risk factors (n=90). Demographic features, clinical characteristics, laboratory parameters, interferon-gamma (IFN γ), interleukin (IL-2), IL-6, IL-10, and IL-17 levels were compared between the groups. Additionally, a correlation analysis was performed in the study group for the assessment of IFN γ, IL-2, IL-6, IL-10, and IL-17 levels with disease severity and CRP levels. Results Study group had significantly higher pregnancy complication rate, erythrocyte sedimentation rate, C-reactive protein, procalcitonin, ferritin, D-dimer, lactate dehydrogenase, IFN γ, and IL-6 values (p

Published
2021
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8. The influence of COVID-19 pandemic on intrauterine fetal demise and possible vertical transmission of SARS-CoV-2

Author

Doğa Fatma Öcal, Filiz Halıcı Öztürk, Selvi Aydın Şenel, Selcan Sinaci, Fatma Didem Yücel Yetişkin, Can Keven, Bedia Dinç, Ezgi Turgut, Deniz Oluklu, Özlem Moraloğlu Tekin, and Dilek Şahin

Subjects
SARS-CoV-2, Vertical transmission, Second trimester, COVID-19, Placenta, Gynecology and obstetrics, RG1-991
Abstract

Objective: The impact of COVID-19 on intrauterine fetal demise (IUFD) and vertical transmission of the SARS-CoV-2 from the mother to the fetus are crucial issues of the COVID-19 pandemic. In the current study, we aimed to detect the pandemic's influence on the IUFD and evaluate the vertical transmission of the SARS-CoV-2 through analysis of placental tissues collected from PCR positive women with IUFD above 20 weeks of gestation. Materials and methods: The pregnant women above 20 weeks of gestation and had a fetus intrauterine demised during pandemic were included in the study. The pregnant women screened for COVID-19. Vertical transmission searched from placental tissues of COVID-19 positive women by RT-PCR tests for the presence of SARS-CoV-2 RNA. The number of IUFD before the pandemic and during the pandemic compared to assess the influence of the COVID-19 pandemic on the IUFD ratio. Results: Among 138 pregnant women with IUFD, 100 of them could screen for COVID-19 status. RT-PCR test results of 6 of the screened pregnant women were positive for SARS-CoV-2. Placental tissues of these six women were analyzed, and one test result was positive for SARS-CoV-2 RNA. The IUFD ratio was significantly increased during the pandemic. Conclusion: It is clear that COVID-19 increases the IUFD ratio. Previous data for vertical transmission of SARS-CoV-2 during the second trimester is limited. We present the third case of literature that has positive placental results for SARS-CoV-2 RNA in the second trimester of pregnancy.

Published
2022
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9. Has the COVID-19 delayed the diagnosis of fetal anomalies and reduced in the follow-up of high-risk pregnancies?

Author

Eda Özden Tokalıoğlu, Şule Göncü Ayhan, Fatma Didem Yücel Yetişkin, Deniz Oluklu, Berchan Besimoğlu, Esin Merve Erol Koç, Betül Yakıştıran, Atakan Tanaçan, Elif Gül Eyi, Özlem Moraloğlu Tekin, and Dilek Şahin

Subjects
Pediatrics, RJ1-570, Gynecology and obstetrics, RG1-991
Abstract

Objective: COVID-19 has deeply affected our lives in terms of social, economic, education and health issues. Pregnant women have had concerns about routine antenatal care visits and decreased follow-up numbers due to concern of COVID-19 transmission. We aimed to evaluate whether there is a delay in the diagnosis of fetal anomaly during the COVID-19 pandemic period and whether patients diagnosed with fetal anomaly attend antenatal care regularly or not, and to investigate the factors that prevent them from regular follow-up. Methods: Pregnant women diagnosed with fetal anomaly during pandemic period (March 1, 2020 to September 1, 2020) and diagnosed with fetal anomaly before pandemic period (September 1, 2019 to February 28, 2020) were compared with a questionnaire in terms of antenatal follow-up frequency and gestational age of fetal anomaly diagnosis. Results: In the during pandemic period group, regular pregnancy follow-up was decreased from 87% to 51% because of maternal anxiety, fear of virus transmission in hospital and the anxiety of passing it on to baby. Attending a detailed ultrasound scan for detecting fetal anomaly at 18–22 weeks was significantly lower in the during pandemic group. In the pandemic period, the most commonly diagnosed fetal anomalies were central and peripheral nervous system, and cardiovascular and gastrointestinal system anomalies similar to the before pandemic period group. The mean frequency of follow-ups in the third trimester in the before pandemic period group and during pandemic period group was 6.02 (±2.36) times and 4.02 (±1.97) times, respectively, and it was a considerable and statistically significant decrease. In addition, the mean week of fetal anomaly diagnosis was 23±6 weeks in during pandemic group, while it was 22±5 weeks in before pandemic group, and there was no statistically significant difference. Conclusion: Antenatal follow-up of the patients has been decreased significantly during the pandemic period, although it does not seem to cause delay in the diagnosis of fetal anomaly. In experienced perinatal centers, if the concerns of patients are relieved and they are examined under suitable conditions for the pandemic, there will be no delay in diagnosis of fetal anomalies.

Published
2022
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