Search

A crystal of organic salt, 2,4,6-trimethylpyridinium picrate (TMPPc), was synthesized and magnified by slow evaporation in a polar aprotic solvent and characterized by 1H NMR, 13C NMR, and FT-IR spectroscopic methods. X-ray diffraction analysis of the crystal structure of the compound TMPPc showed the presence of a monoclinic space group with a = 4.0174(4) Å, b = 27.863(3) Å, c = 13.9247(17) Å, β = 95.741(4)°, V = 1550.9(3) Å3, Z = 4, T = 296 K, μ(MoKα) = 0.123 mm-1, Dcalc = 1.500 g/cm3, 62749 reflections measured (5.88° ≤ 2Θ ≤ 57.058°), 3911 unique (Rint = 0.0536, Rsigma = 0.0226) which were used in all calculations. The final R1 was 0.0569 (I > 2σ(I)) and wR2 was 0.1710 (all data). Detailed investigation of molecular packing of the TMPPc molecule indicated the presence of intermolecular hydrogen bond between N4-H44···O1 and C13-H13B···O4 that generates C22(14) chain running parallel to the [001] direction. The infrared and Raman spectra of the prepared TMPPc compound were recorded and discussed. The thermal stability of the obtained TMPPc crystal was analysed by TGA/DTG technique and revealed that the crystal was stable up to 162 °C. Density functional theory calculations such as the value of the HOMO and LUMO energy gap, the parameters of the molecular electrostatic potential, the global reactivity and thermodynamic properties of the compound TMPPc were also performed using the DFT/B3LYP method with the level of the 6-311G (d, p) basis set.

Kestane (Castanea sativa Mill.), Türkiye’de ve tüm dünyada meyvesi, çiçekleri, yaprakları ve kerestesi için yetiştirilen ve ticari öneme sahip meyve türlerinden biridir. İstanbul Beykoz’da doğal olarak yetişen yoğun kestane popülasyonu bulunmaktadır. İlçede Dereseki bölgesinin doğal ormanlık alanlarında çok sayıda genotip bulunmaktadır. Bu çalışmada, İstanbul Beykoz bölgesinde bulunan kestanelerinin agromorfolojik özellikleri belirlenmiştir. Araştırmada, bölgedeki kestane genotipleri içerisinden 10 genotip ümivar olarak belirlenmiştir. Ümitvar genotiplerin meyve ağırlığı 6.6-12.4 g, eni 23.42-31,56 mm, boyu 12.36-20.22 mm ve yüksekliği 23.11-30.34 mm arasında değişim göstermiştir. 7 genotipin meyve kabuğunun yumuşak, tohum zarının kolay soyulduğu ve tohum kabuğunun tohum içine çoğunlukla girmediği tespit edilmiş ve ümitvar genotiplerin ileride yürütülecek ıslah çalışmaları için bir temel oluşturabileceği kanaatine varılmıştır., Chestnut is one of the important fruit species for commercially to grown with its nut, flower, leaf and timber in Turkey and all over the world. There is a dense natural chestnuts population in Beykoz, Istanbul. There are many genotypes in the natural forest areas of the Dereseki region in the district. In this study, agromorphological characteristics of chestnuts genotypes were determined in Istanbul Beykoz region. In the study, 10 genotypes were determined from chestnut genotypes in the region as promising. Nut weight varied between 6.6-12.4 g, width 23.42-31.56 mm, length 12.36-20.22 mm and height 23.11-30.34 mm in promising genotypes. It was determined that the nut pericarp of 7 genotypes is soft, the seed coat is easily peeled and the seed coat does not penetrate into the seed mostly, and it has been concluded that promising genotypes can form a basis for future breeding studies.

The present study investigates the impact of individual differences in language knowledge, namely general L2 proficiency and L2 vocabulary knowledge, and metacognitive awareness of strategies used in the listening process. It seeks an answer to what proportion of the variance in intermediate-level adult Turkish EFL learners’ listening comprehension is explained by general L2 language proficiency, L2 vocabulary knowledge and metacognition. A total of 99 intermediate-level adult Turkish EFL learners, studying at Anadolu University School of Foreign Languages (AUSFL) participated in the present study. Data were gathered using Oxford Quick Placement test (OQPT), the New Vocabulary Levels Test (NVLT) (McLean & Kramer, 2015), a researcher designed Listening Comprehension Test (LCT) and Metacognitive Awareness Listening Questionnaire (MALQ) (Vandergrift, Goh & Mareschal, 2006). Results reveal that vocabulary knowledge and some sub-components of the MALQ (Person Knowledge, Problem Solving and Directed Attention) play a significant role in L2 listening comprehension. The results are interpreted and discussed within the light of the previous research, and a number of pedagogical implications are suggested accordingly.

Background: Systemic therapies commonly used in adult psoriasis are mostly used only off-label in children and little is known about the efficacy and tolerability of these drugs in this population. In this study, we aimed to evaluate the efficacy and safety of systemic treatments in pediatric patients with psoriasis. Methods: Data were obtained retrospectively from the Department of Dermatology, Ondokuz Mayis University, School of Medicine between 2010–2019. Our study consisted of 742 pediatric patients (age ≤18 years) with psoriasis. Demographic data, adverse events of systemic treatments and healing periods were considered. Results: A total of 195 patients received systemic treatment. The mean age of onset of disease and the initiation of systemic therapy were 9.68±4.62 and 11.33±4.38 years, respectively. Patients received methotrexate (n=52, 26.67%), cyclosporine (n=18, 9.24%), acitretin (n=106, 54.35%) and others (biologics and/or one of conventional treatments) (n=19, 9.74%) as systemic therapy. Adverse events occurred in 12 patients (incidence of 6.15%, and its related 95% confidence interval of 2.75%, 9.56%) and nine of them had to discontinue the medication due to those adverse events. Healing periods calculated in the remaining 186 patients were 13.25±5.87, 10.85±5.67, 11.05±7.00, and 9.41±4.16 (mean±SD) weeks for acitretin, methotrexate, cyclosporine, and others, respectively. No statistically significant differences were noted between the treatments regarding the healing periods. Conclusion: All treatments were effective and none of them was superior in terms of the healing period. Systemic treatments used in adults can also be used in pediatric patients with psoriasis with similar efficacy and safety rates as long as routine monitoring is provided.

Juvenile Behcet’s disease is a rare and severe disease of childhood characterized by a chronic inflammatory vasculitis. The aim of the present study is reporting demographic, clinical and therapeutic outcomes of juvenile Behcet’s disease in a tertiary center. The retrospective study included patients who were diagnosed Behcet’s disease before 16 years. The demographic and clinical features, and diagnostic and therapeutic strategies of patients were recorded. Seventy-two patients with jBD were included in this study; 32 were male (44.4%). Thirty (41.7%) patients had BD cases in their family. We observed oral ulceration (100%), genital ulceration (68.1%), joint involvement (36.1%) and cutaneous manifestations (34.7%) as the most common clinical findings, respectively. As severe organ involvements, 20.8% ocular, 18.1% vascular and 15.3% neurologic pathologies were seen. All patients had colchicine. Corticosteroid (20.8%) was used to treat severe cases and acute attacks. Azathioprine (23.6%) was the main immunosuppressive agent and cyclophosphamide (8.3%) was applied initially for life-threatening conditions with pulse methylprednisolone. In this cohort, the prevalence of genital ulceration and family history was high, and we observed less ocular involvement, a few permanent neurological morbidities and no death.

To investigate: (a) the interrater and test-retest reliability of the 3-m backward walk test (3MBW) in ambulant people with multiple sclerosis (PwMS); (b) minimal detectable change (MDC); (c) concurrent and known-groups validity; and (d) the cutoff time to best discriminate fallers from nonfallers with multiple sclerosis (MS). Forty-nine PwMS and 36 healthy people were included in this cross-sectional study. The 3MBW was administered with the timed up and go test, Berg Balance Scale, four square step test, Falls Efficacy Scale-International, and Expanded Disability Status Scale. The 3MBW was simultaneously performed by two independent raters to examine the interrater reliability while was repeated after 7-10 days to examine the test-retest reliability. The 3MBW showed good interrater reliability [intraclass correlation coefficient (ICC) = 0.987-0.989] and excellent test-retest reliability (ICC = 0.854-0.889). The MDC was found to be 1.69 s. The 3MBW had moderate-to-strong correlations with the other measures. For the 3MBW, PwMS had worse performance than healthy people (P < 0.001), whereas fallers with MS had worse performance than nonfallers with MS (P < 0.001). The 3MBW time of 7.86 s was determined to best discriminate fallers from nonfallers with MS. The 3MBW is a reliable, simple, and easy-to-administer tool for assessing backward walking among ambulant PwMS.

The title molecule, N-(4-Nitrobenzoyl)-S-(2-hydroxyethyl)-carbamodithioate, (C10H10N2O4S2), was synthesized and its structure verified by single crystal X-ray diffraction and FT-IR, 1H-NMR, 13C-NMR...

The aim of this paper is to extend and generalize Picard-Green’s fixed point iteration method for the solution of fourth-order Boundary Value Problems. Several numerical applications to linear and nonlinear fourth-order Boundary Value Problems are discussed to illustrate the main results.

Aim: The aim of this study is to evaluate the demographic and clinic findings in immunoglobulin A-associated vasculitis (IgAV) patients with scrotal involvement and also to determine predictive factors for assessing the development of scrotal involvement. Materiel and Methods: The medical records of 181 boys who were diagnosed with IgAV in the Pediatric Rheumatology Clinic of our center between September 2015-January 2021 were evaluated retrospectively. Results: A total number of 181 boys with IgAV included in the study. Twenty-seven (14.9%) of the 181 boys with IgAV had scrotal involvement. Among the scrotal-involved patients, 160 boys (88.4%) had scrotal swelling, 120 (66.3%) had erythema and 145 (80.1%) had scrotal pain or tenderness. Scrotal involvement was the first symptom of IgAV in one patient. CRP and WBC were significantly higher in the scrotal-involved group compared to the non-involved group (p=0.018, p=0.04, respectively). There were no significant differences in clinical findings and organ involvements between two groups. On ultrasonography, bilateral scrotal soft tissue thickening was observed in all patients. In 130 of the patients (71.8%), the epididymis was swollen with increased vascularity. The size, echogenicity and vascularity of the testicles were within normal limits. Eighty-seven of the patients (48%) were given steroids, 22 of them (11.7%) nonsteroidal anti-inflammatory drug. Conclusion: Scrotal involvement in boys with IgAV is not rare, it should be considered in the differential diagnosis in patients with scrotal pain, swelling and erythema. In addition, inflammatory markers may be higher in patients with scrotal involvement.

Androgenetik alopesi genetik yatkınlığı olan kişilerde farklı patolojik mekanizmalarla ortaya çıkabilen, erkek ve kadınlarda kliniği değişiklik gösterebilen bir saç dökülme şeklidir. Androgenetik alopesi her ne kadar sık görülüyor ve tanısı genellikle kolay koyuluyor olsa da hasta yönetimi için standart bir tedavi rehberi yoktur. Androgenetik alopesi yönetiminde amaç foliküler minyatürizasyonu durdurmak ve saç dansitesini arttırmaktır. Androgenetik alopesi yönetiminde kullanılan tedaviler potasyum iyon kanalı düzenleyicileri (topikal minoksidil ve oral minoksidil), 5α redüktaz inhibitörleri (oral finasterid, topikal finasterid ve oral dutasterid), androjen reseptör antagonistleri (spironolakton, siproteron asetat, flutamid, korteksolon 17 alfa propionat ve topikal fluridil), diğer medikal tedaviler (topikal prostoglandin analogları, topikal ketokonazol, topikal melatonin, Wnt/β katenin sinyal yolağı aktivatörleri ve JAK-STAT yolağı inhibitörleri), fiziksel tedaviler (düşük dereceli lazer ışık tedavisi, lazer tedavileri, mikro iğneleme, mezoterapi, PRP ve kök hücre tedavileri), tamamlayıcı tedaviler (saç transplantasyonu, besin takviyeleri ve kamuflaj yöntemleri) ve kombinasyon tedavileridir. Bu derlemede erkek ve kadında androgenetik alopesi yönetiminde güncel tedavi yöntemleri hakkında bilgi verilmesi amaçlanmıştır. Androgenetic alopecia is a form of hair loss that can occur with different pathological mechanisms in people with genetic predisposition, and the clinic may vary in men and women. Although androgenetic alopecia is common and its diagnosis is usually easy, there is no standard treatment guideline for patient management. The purpose of the management of androgenetic alopecia is to stop follicular miniaturization and to increase hair density. Therapies used in the management of androgenetic alopecia are potassium ion channel modifiers (topical minox idil and oral minoxidil), 5α reductase inhibitors (oral finasteride, topical finasteride and oral dutasteride), androgen receptor antagonists (spironolactone, cyproterone acetate, flutamide, cortexolone 17 alpha propionate solution and topical minoxidil) , other medical treatments (topical prostaglandin analogues, topical ketoconazole, topical melatonin, Wnt / β catenin signaling pathway activators and JAK-STAT pathway inhibitors), physical treatments (low-grade laser light therapy, laser treatments, microneedling, mesotherapy, PRP and stem cell treatments), complementary therapies (hair transplantation, nutritional supplements and camouflage methods) and combination therapies. In this review, it is aimed to provide information about current treatment methods in the management of androgenetic alopecia in men and women

Background Patch testing with the European Baseline Series (EBS) is an essential diagnostic tool for the assessment of allergic contact dermatitis. Objective The aims of the study were to describe the most common contact allergens identified with patch testing in Turkey and to establish the distribution of contact allergens among different regions in Turkey. Patients and methods Twelve centers consisting of tertiary health care institutions were included in the study. A total of 1169 patients were patch tested with the EBS from 2015 to 2017. Results A total of 596 patients (51.0%) had 1 or more positive patch test reactions to the EBS. A total of 30.2% (n = 353) of those tested had clinical relevance. Contact sensitivity was more common in young patients. The most common 10 allergens were nickel sulfate (20.4%), followed by textile dye mix (8.6%), cobalt chloride (8.3%), potassium dichromate (8.0%), p-phenylenediamine base (4.5%), balsam of Peru (4.3%), methylchloroisothiazolinone/methylisothiazolinone (3.8%), thiuram mix (3.6%), fragrance mix I (3.0%), and methylisothiazolinone (2.9%). Conclusions This study provides a comprehensive profile of patch test results with the EBS in Turkey. An ongoing decrease in contact allergy to methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone was observed. Textile dye mix and p-phenylenediamine are beginning to pose a new risk in Turkey.

Introduction: The most important agent in cervical cancer is the human papilloma virüs (HPV). The association between HPV and cervical cancer is much more powerful than that between lung cancer and tobacco. Human papilloma virus is transmitted sexually. There are more than 200 types of HPV, 40 of which lead to warts in anogenital organs, precancerous lesions, and cancer. HPV types 6 and 11 cause genital warts, while HPV 16, 18, 45, 31, 33, 52, 58, 35, 59, 56, 51, 39, 68, 73 and 82 lead to cancer. The purpose of the present study was to determine the knowledge levels and behaviors concerning human papilloma virus and human papilloma virus vaccination in non-health worker women. Materials and Methods: Two hundred thirty-seven non-health worker and non-educated volunteer women presenting to the infectious diseases clinic and the gynecology and obstetrics clinic participated in the study. A questionnaire was completed during face-to-face interviews, which contained questions about individuals’ demographic characteristics and knowledge levels concerning HPV infection. Data were analyzed on SPSS 20.0 software. Results: The mean age of the 237 women participating in the study was 33.85 ± 10.51 (18-73) years. Married women constituted 70.9% of the participants, and 27.4% had undergone smear tests. In addition, 34.2% of participants possessed knowledge concerning human papilloma virus, with 42.6% knowing that HPV causes disease, although only 33.3% knew the route of transmission. Thirty-five percent correctly responded that human papilloma virus causes cervical cancer. No participants had been vaccinated. Statistically highly significant associations were found between knowledge of HPV infection, education level, mean scores for knowledge concerning the route of transmission and awareness of the virus causing disease and cancer. Conclusion: Participating women possessed inadequate knowledge about HPV and vaccination. Education programs must be developed to improve women’s level of knowledge about HPV.

Amaç: Sistemik juvenil idiyopatik artrit (sJİA), JİA’nın yedi alt tipinden biridir. Bu çalışmanın amacı, kliniğimizdeki sJİA hastalarının özelliklerini, seyrini ve sonuçlarını araştırmak ve son on yılda sJİA’da nelerin değiştiğini belirlemektir.Gereç ve Yöntemler: Mart 2002 ile Nisan 2019 arasında takip edilen sJİA hastalarının dosyaları geriye dönük olarak değerlendirildi ve verileri kaydedildi.Bulgular: Çalışma süresince kliniğimizde 36 hastaya sJİA tanısı konuldu (19 erkek). Hastalığın başlangıcında hastaların ortalama yaşı 81.7±50.1 aydı. Başvuru esnasında en sık saptanan bulgular ateş (%100), artrit (%83.3), döküntü (% 66.7) ve hepatosplenomegali (%38.9)’du. Yedi hasta (%19.4) sJİA’ya bağlı gelişen makrofaj aktivasyon sendromu (MAS) tanısı aldı. Tüm hastalara kortikosteroid tedavisi verildi. 29 hastaya ek tedaviler (hastalığı modifiye edici ilaçlar, intravenöz immünoglobulin ve biyolojik ajanlar) verildi. Kliniğimizde 2011 yılından itibaren anti interlökin (İL) -1 ajanlar kullanılmaktadır. Bu grupta 26 (%72.2) hasta 2011 yılından sonra tanı almıştır. 2011 yılından sonra tanı alan ve biyolojik ajan tedavisi kullanılan hastalarda (n: 26) 2011 yılından önce tanı alan hastalara (n:10) göre steroid maruziyet süresi anlamlı olarak kısalmıştır (p = 0.001 ).Sonuç: Biyolojik ajanların sJİA tedavisinde kullanılmaya başlamasından sonra steroid maruziyet süresi önemli ölçüde azalmıştır. Anti İL-1 ve anti İL-6 tedavilerinin sJİA hastalarında öncelikli tedaviler arasında düşünülmesi hem hızlı hastalık kontrolünü sağlamak hem de ilaçlara bağlı ortaya çıkabilecek yan etkileri azaltmak açısından önemlidir., Objective: Systemic juvenile idiopathic arthritis (sJIA) is one of seven subtypes of JIA. The aim of this study was to investigate the characteristics, the course and the outcome of sJIA patients in our clinic and to identify what has changed over the last decade in sJIA. Material and Methods: Files of sJIA patients that were followed between March 2002 and April 2019 were evaluated. Results: During the study period 36 patients were diagnosed with sJIA in our clinic (19 were male). Mean age of patients was 81.7±50.1 months at the onset of disease. Most common presenting features were fever (100%), arthritis (83.3%), rash (66.7%) and hepatosplenomegaly (38.9%). Seven patients (19.4%) were diagnosed as macrophage activation syndrome (MAS) due to sJIA. All patients had received corticosteroids. Additional treatments (disease-modifying drugs, intravenous immunoglobulin and biological agents) were given to 29 patients. In our clinic, anti-IL-1 agents have been used since 2011. In this group 26 (72.2%) patients were diagnosed after 2011. After the usage of biological agents, the duration of steroid exposure significantly decreased (p= 0.001).Conclusion: After the introduction of biological agents in the treatment of sJIA, the duration of steroid exposure decreased significantly. Considering anti interleukin (IL)-1 and anti IL-6 treatments among the priority treatments in sJIA patients is important in terms of both providing rapid disease control and reducing side effects related to drugs.

In this study, a new iterative method for third-order boundary value problems based on embedding Green’s function is introduced. The existence and uniqueness theorems are established, and necessary conditions are derived for convergence. The accuracy, efficiency and applicability of the results are demonstrated by comparing with the exact results and existing methods. The results of this paper extend and generalize the corresponding results in the literature.

Kamusal bir mekân olarak botanik parkın kullanıcıları çok farklı yeti durumuna sahip, yaş, cinsiyet, dil gibi konularda geniş bir yelpaze oluşturmaktadır. Kullanıcı çeşitliliği dikkate alındığında özellikle yaşlılar, engelliler ve çocuklar açısından bu tür alanların kapsayıcı nitelikte tasarlanmaması kullanım ve erişim sorunlarına neden olmaktadır. Buradan hareketle, çalışmanın amacı Trabzon Botanik Parkı’nın evrensel tasarım bakış açısıyla erişilebilirlik ve kullanılabilirlik analizini yapmak ve oluşturulan senaryolarla farklı engel ve yeti durumuna sahip insanların karşılaştıkları sorunları ortaya koyarak çözümler üretmektir. Ele alınan çalışma başlıkları girişler –otoparklar, işaret ve tabelalar, kaldırım ve yürüyüş yolları, hissedilebilir yüzey kaplamaları, merdiven, rampa ve kent mobilyalarıdır. Çalışmada veri toplama aracı olarak nitel ve nicel araçlardan yararlanılmış; yerinde tespit, kontrol listelerinin doldurulması, kullanım gözlemleri, ölçüm ve fotoğraflama teknikleri ile alan analiz edilmiştir. Çalışma sonucunda, Botanik Parkının her kesimden ziyaretçi tarafından kullanımı değerlendirildiğinde erişilebilirliğin sorunlu olduğu ve verimli bir kullanıma sahip olmadığı ortaya çıkmıştır.

Amaç: Çocuklarda SARS-Cov-2 enfeksiyonu sonrasında ateş, kardiyojenik şok ve hiperinflamasyon bulguları ile gelişen multisistem inflamatuar sendrom tablosu yaşamı tehdit edici olabilmektedir. Bu çalışma ile multisistem inflamatuar sendrom tanısı alan hastaların başvuru şikayet ve sürenin hastalık şiddetine etkisini araştırmak amaçlandı.Gereç ve yöntem: Eylül 2020-Ağustos 2021 tarihleri arasında merkezimizde Hastalık Kontrol ve Önleme Merkezleri (CDC) vaka tanımı ile multisistem inflamatuar sendrom tanısı alan 99 çocuk hasta tıbbi kayıtları geriye dönük olarak değerlendirildi. Demografik özellikleri, başlangıç klinik bulguları, başvuru süreleri not edildi. Hastalar yoğun bakım ihtiyacına göre sınıflandırıldı.Bulgular: Hastaların medyan yaşı 10 (6-14) ve %62,6’sı erkekti. Tanıdan önceki medyan semptom süresi 4 (3-5) gündü. Başvuru sırasında hastaların tümünde ateş, %81,8’inde gastrointestinal ve %75,8’inde kardiyovasküler tutulum mevcuttu. Ağır ve orta şiddette MİS-C olarak değerlendirilen %56,6 hastanın yoğun bakım gereksinimi oldu. Ateş süresinin uzun olması, sağlık kuruluşuna gecikmiş başvuru, hastanın kardiyovasküler etkileniminin ön planda olması, yüksek inflamatuvar belirteçler, lenfopeni ve trombositopeni varlığı yoğun bakım gereksinimini etkileyen önemli parametreler olarak bulundu.Sonuç: Çocuklarda multisistem inflamatuar sendrom, SARS-CoV-2 enfeksiyonu ile ilişkili ateş, inflamasyon belirtileri ve organ disfonksiyonu ile karakterize yeni bir hastalıktır. Gecikmiş başvuru ile uzamış ateş, ilk başvuru anında kardiyak ve inflamatuar belirteçlerin yüksek olması yoğun bakım gereksinimini artırmaktadır., Purpose: Multisystem inflammatory syndrome that occurs after SARS-Cov-2 infection with fever, cardiogenic shock and hyperinflammation in children, can be life threatening. In this study, it was aimed to investigate the effects of the complaint and duration at diagnosis on the severity of multisystem inflammatory syndrome in children.Materials and methods: The medical records of 99 pediatric patients, who were diagnosed multisystem inflammatory syndrome between September 2020 and August 2021 according to Centers for Disease Control and Prevention, were evaluated retrospectively. Demographic features, initial findings, and admission time of patients were noted. Patients were categorized according to intensive care necessity.Results: The median age of the patients was 10 (2-18) and 62 (62.6%) of patients were male. The median duration before admission was 4 (1-10) days. All patients has fever, 81.8% had gastrointestinal and 75.8% had cardiovascular involvement at admission. The patients (56.6%) who were accepted as severe and moderate MIS-C required intensive care. Prolonged fever, delayed admission, cardiovascular involvement, high inflammatory markers, lymphopenia and thrombocytopenia were found to key parameters determining the need for intensive care.Conclusion: Multisystem inflammatory syndrome in children is a new disease characterized by fever, signs of inflammation and organ dysfunction associated with SARS-CoV-2 infection. Delayed admission, high cardiac and inflammatory markers at diagnosis increase the need for intensive care.

Objectives and background Percutaneous edge-to-edge mitral valve (MV) repair (PMVR) is broadly applied in high-risk patients with relevant mitral regurgitation (MR). We investigated the incidence of cleft-like indentations (CLI) and their impact on PMVR. Methods and results In a retrospective single center analysis including 263 patients undergoing PMVR with the MitraClip®-system between 11/2012 and 7/2016, MV anatomy was assessed by 3-dimensional transesophageal echocardiography. CLI were present in 37/263 patients (14.1%). Of these, 62.2% had 1 CLI, 27% had 2 CLI, and 10.8% had 3 CLI, mostly concerning segment P2 or P2/3 of the MV. Baseline characteristics were similarly distributed. Interestingly, most patients with CLI suffered from secondary MR (n = 29, 78%). The number of deployed MitraClips was higher in patients with CLI (2 [1.25-2] vs. 2 [1, 2], p = .035), whereas procedural as well as clinical success was similar: MR grade (1.2 vs. 1.5, p = .061), vena contracta width (4.2 vs. 4.5 mm, p = .293), dPmean (4.2 vs. 4.0 mmHg, p = .618) at discharge and NYHA class at 30 days did not differ between groups. Periprocedural complications were rare and equally distributed between groups. At 30 days, MR reduction persisted in patients with CLI (95.8% of these selected patients had a MR grade ≤ 2). Conclusions CLI of the MV are common in patients undergoing PMVR, also when presenting mainly with secondary MR. While the number of clips needed to address MR is slightly higher in patients with CLI, procedural success rates appear not to be affected. PMVR seems to be a safe treatment option for patients with CLI.

Bu çalışmanın amacı, 𝑏2 -metrik uzayında çok değişkenli operatörler için sabit nokta teoremi oluşturmak ve Chifu ve Petruşel (2017) ve Yihao, Ren ve Zhong (2018) sonuçlarını genelleştirmektir. Ayrıca, ana teoremi göstermek için bir örnek verilmiştir. Bu çalışmanın amacı, 𝑏2 -metrik uzayında çok değişkenli operatörler için sabit nokta teoremi oluşturmak ve Chifu ve Petruşel (2017) ve Yihao, Ren ve Zhong (2018) sonuçlarını genelleştirmektir. Ayrıca, ana teoremi göstermek için bir örnek verilmiştir.

In this paper we obtain a sufficient condition for the E-J summability of certain orthogonal series. Our results generalize the corresponding theorems for ordinary Hausdorff summability obtained by Kalaivana and Youvaraj.