1. Effets des nitrates inorganiques sur l’aspect morphofonctionnel de la glande thyroïde chez le rat femelle
- Author
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A. Zaki, Abdelfettah Derouiche, Abdellah Talibi, T. Himmi, Touria Aboussaouira, Ahmed Ait Chaoui, Fatima Benabdjlil, and Abderrahman Chait
- Subjects
endocrine system ,medicine.medical_specialty ,Triiodothyronine ,Goiter ,endocrine system diseases ,business.industry ,Thyroid ,medicine.disease ,Muscle hypertrophy ,Glandula endocrina ,Endocrinology ,medicine.anatomical_structure ,Internal medicine ,Thyroid hormones ,Toxicity ,medicine ,Pharmacology (medical) ,business ,Endocrine gland - Abstract
The present study was undertaken to determine the effects of intake of inorganic nitrates in drinking water on thyroid gland activity and morphology in female rats. During 5 months of treatment, nitrates 50, 150 and 500 mg/L induced a significant dose-dependent decrease in bodyweight gain, compared with the control rats. At the end of the experiment, nitrates 150 and 500 mg/L induced hypertrophy of the thyroid gland, accompanied by an increase in the size of the thyroid follicles and hyposecretion of thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). We concluded that a high nitrate intake in water influenced thyroid gland activity and morphology and might be considered to be a goitrogenic factor.
- Published
- 2004
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