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2 results on '"Fatemeh Izadfar"'

1. The effects of grapes and their products on immune system: a review

Author

Fatemeh Izadfar, Saba Belyani, Masomeh Pormohammadi, Simin Alizadeh, Mehrara Hashempor, Elaheh Emadi, Zohreh Sadat Sangsefidi, Mohammad Reza Jalilvand, Shima Abdollahi, and Omid Toupchian

Subjects
Grape, grape products, immune system, immune function, Immunologic diseases. Allergy, RC581-607
Abstract

AbstractImmune system plays a significant role in preventing and controlling diseases. Some studies reported the beneficial effects of grapes and their products on immunity. However, their results are controversial. This review aimed to discuss the effects of grapes and their products on immune system and their mechanisms of action. Although various in-vio and in-vitro studies and some human studies suggested that grapes and their products may help to improve the immune system’s function, clinical trials in this area are limited and inconsistent.In conclusions, although, consumption of grapes and their products may help to having a healthy immune syste, further studies particularly human studies are required to clarify the precise effects of them and their mechanisms regarding immune system.

Published
2023
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2. Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms

Author

Reza Heidari-Soureshjani, Ehsan Dadgostar, Hamed Mirzaei, Fatemeh Izadfar, Michael Aschner, Maryam Fallah, and Omid Reza Tamtaji

Subjects
Pharmacology, Flavonoids, Cell cycle checkpoint, business.industry, Autophagy, Apoptosis, General Medicine, Cell Cycle Checkpoints, Glioma, Resveratrol, medicine.disease, Primary tumor, Metastasis, Biological pathway, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Cancer research, Humans, business
Abstract

Glioma is a prevalent primary tumor of the brain and spinal cord. Several biological pathways play an important role in the pathogenesis of glioma, including apoptosis, autophagy, cell cycle arrest, migration, and invasion. The low efficacy of chemotherapy and radiation therapy has forced researchers to evaluate alternative treatments for glioma. In this regard, flavonoids have been studied. Resveratrol is a flavonoid with distinct pharmacological activities that has been used in the treatment of various diseases. Several recent studies have also focused on its therapeutic efficacy against glioma. Resveratrol exerts its pharmacological attributes by regulating various molecular and cellular pathways. Here, we review contemporary knowledge in support of the use of resveratrol in the treatment of glioma and its effects on various molecular and cellular mechanisms.

Published
2020

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