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143 results on '"Fataccioli, Virginie"'

1. Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas

Author

Fischer, Anja, Albert, Thomas K., Moreno, Natalia, Interlandi, Marta, Mormann, Jana, Glaser, Selina, Patil, Paurnima, de Faria, Flavia W., Richter, Mathis, Verma, Archana, Balbach, Sebastian T., Wagener, Rabea, Bens, Susanne, Dahlum, Sonja, Göbel, Carolin, Münter, Daniel, Inserte, Clara, Graf, Monika, Kremer, Eva, Melcher, Viktoria, Di Stefano, Gioia, Santi, Raffaella, Chan, Alexander, Dogan, Ahmet, Bush, Jonathan, Hasselblatt, Martin, Cheng, Sylvia, Spetalen, Signe, Fosså, Alexander, Hartmann, Wolfgang, Herbrüggen, Heidi, Robert, Stella, Oyen, Florian, Dugas, Martin, Walter, Carolin, Sandmann, Sarah, Varghese, Julian, Rossig, Claudia, Schüller, Ulrich, Tzankov, Alexandar, Pedersen, Martin B., d’Amore, Francesco A., Mellgren, Karin, Kontny, Udo, Kancherla, Venkatesh, Veloza, Luis, Missiaglia, Edoardo, Fataccioli, Virginie, Gaulard, Philippe, Burkhardt, Birgit, Soehnlein, Oliver, Klapper, Wolfram, de Leval, Laurence, Siebert, Reiner, and Kerl, Kornelius

Published
2024
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3. Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations

Author

Nicolae, Alina, Bouilly, Justine, Lara, Diane, Fataccioli, Virginie, Lemonnier, François, Drieux, Fanny, Parrens, Marie, Robe, Cyrielle, Poullot, Elsa, Bisig, Bettina, Bossard, Céline, Letourneau, Audrey, Missiaglia, Edoardo, Bonnet, Christophe, Szablewski, Vanessa, Traverse-Glehen, Alexandra, Delfau-Larue, Marie-Hélène, de Leval, Laurence, and Gaulard, Philippe

Published
2022
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4. Lymph node excisions provide more precise lymphoma diagnoses than core biopsies: a French Lymphopath network survey

Author

Syrykh, Charlotte, Chaouat, Charlotte, Poullot, Elsa, Amara, Nadia, Fataccioli, Virginie, Parrens, Marie, Traverse-Glehen, Alexandra, Molina, Thierry-Jo, Xerri, Luc, Martin, Laurent, Dubois, Romain, Lacheretz-Szablewski, Vanessa, Copin, Marie-Christine, Moreau, Anne, Chenard, Marie-Pierre, Cabarrou, Bastien, Lusque, Amélie, Gaulard, Philippe, Brousset, Pierre, and Laurent, Camille

Published
2022
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5. Comprehensive genetic profiling reveals frequent alterations of driver genes on the X chromosome in extranodal NK/T-cell lymphoma

Author

Ito, Yuta, primary, Marouf, Amira, additional, Kogure, Yasunori, additional, Koya, Junji, additional, Liévin, Raphaël, additional, Bruneau, Julie, additional, Tabata, Mariko, additional, Saito, Yuki, additional, Shingaki, Sumito, additional, Yuasa, Mitsuhiro, additional, Yamaguchi, Kentaro, additional, Murakami, Koichi, additional, Weil, Robert, additional, Vavasseur, Manon, additional, Andrieu, Guillaume P., additional, Latiri, Mehdi, additional, Veleanu, Layla, additional, Dussiot, Michaël, additional, André, Isabelle, additional, Joshi, Akshay, additional, Lagresle-Peyrou, Chantal, additional, Magerus, Aude, additional, Chaubard, Sammara, additional, Lavergne, David, additional, Bachy, Emmanuel, additional, Brunet, Erika, additional, Fataccioli, Virginie, additional, Brouzes, Chantal, additional, Laurent, Camille, additional, De Leval, Laurence, additional, Traverse-Glehen, Alexandra, additional, Bossard, Céline, additional, Parrens, Marie-Cécile, additional, Meignin, Véronique, additional, Philippe, Laure, additional, Rossignol, Julien, additional, Suarez, Felipe, additional, Michot, Jean-Marie, additional, Tournilhac, Olivier, additional, Damaj, Gandhi, additional, Lemonnier, François, additional, Bôle-Feysot, Christine, additional, Nitschké, Patrick, additional, Tesson, Bruno, additional, Laurent, Cécile, additional, Molina, Thierry, additional, Asnafi, Vahid, additional, Watatani, Yosaku, additional, Chiba, Kenichi, additional, Okada, Ai, additional, Shiraishi, Yuichi, additional, Tsukita, Sachiko, additional, Izutsu, Koji, additional, Miyoshi, Hiroaki, additional, Ohshima, Koichi, additional, Sakata, Seiji, additional, Dobashi, Akito, additional, Takeuchi, Kengo, additional, Sanada, Masashi, additional, Gaulard, Philippe, additional, Jaccard, Arnaud, additional, Ogawa, Seishi, additional, Hermine, Olivier, additional, Kataoka, Keisuke, additional, and Couronné, Lucile, additional

Published
2024
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6. Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma

Author

Lemonnier, François, Safar, Violaine, Beldi-Ferchiou, Asma, Cottereau, Anne-Ségolène, Bachy, Emmanuel, Cartron, Guillaume, Fataccioli, Virginie, Pelletier, Laura, Robe, Cyrielle, Letourneau, Audrey, Missiaglia, Edoardo, Fourati, Slim, Moles-Moreau, Marie-Pierre, Delmer, Alain, Bouabdallah, Reda, Voillat, Laurent, Becker, Stéphanie, Bossard, Céline, Parrens, Marie, Casasnovas, Olivier, Cacheux, Victoria, Régny, Caroline, Camus, Vincent, Delfau-Larue, Marie-Hélène, Meignan, Michel, de Leval, Laurence, Gaulard, Philippe, and Haioun, Corinne

Published
2021
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7. Clinical and histological study of follicular helper T-cell lymphomas with indolent evolution

Author

Messéant, Ondine, primary, Drieux, Fanny, additional, Sako, Nouhoum, additional, Fataccioli, Virginie, additional, Camus, Vincent, additional, Robe, Cyrielle, additional, Houot, Roch, additional, Tas, Patrick, additional, Llamas-Gutierrez, Francisco, additional, Lamaison, Claire, additional, Abraham, Julie, additional, Delage-Corre, Manuela, additional, Benguerfi, Soraya, additional, Bossard, Jean-Baptiste, additional, Gaulard, Philippe, additional, and Lemonnier, François, additional

Published
2023
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8. Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

Author

Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, and Merkel, Olaf

Published
2021
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9. S226: EFFICACY OF ANTI-PD1 THERAPY IN RELAPSED OR REFRACTORY EXTRANODAL NK/T CELL LYMPHOMA: A MATCHED COHORT ANALYSIS FROM THE LYSA

Author

Marouf, Amira, primary, Chaubard, Sammara, additional, Michot, Jean Marie, additional, Rossignol, Julien, additional, Golfier, Camille, additional, Allangba, Olivier, additional, Philippe, Laure, additional, Tessoulin, Benoit, additional, Chauchet, Adrien, additional, Deau, Bénédicte, additional, Oberic, Lucie, additional, Vargaftig, Jacques, additional, Moignet, Aline, additional, Clavert, Aline, additional, Duléry, Rémy, additional, Brisou, Gabriel, additional, Tardy, Stéphanie, additional, Fataccioli, Virginie, additional, Houot, Roch, additional, Olivier Casasnovas, Rene, additional, Thieblemont, Catherine, additional, Ghesquieres, Herve, additional, Carras, Sylvain, additional, Le Gouill, Steven, additional, Cartron, Guillaume, additional, Marabelle, Aurélien, additional, Tournilhac, Olivier, additional, Laurent Damaj, Gandhi, additional, Gaulard, Philippe, additional, Leval, Laurence De, additional, Lemonnier, Francois, additional, Bachy, Emmanuel, additional, Hermine, Olivier, additional, Couronné, Lucile, additional, and Jaccard, Arnaud, additional

Published
2023
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10. The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Author

Lemonnier, François, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Dupuy, Aurelie, Broutin, Sophie, Martin, Nadine, Fataccioli, Virginie, Pelletier, Romain, Wakeham, Andrew, Snow, Bryan E., de Leval, Laurence, Pujals, Anais, Haioun, Corinne, Paci, Angelo, Tobin, Erica R., Narayanaswamy, Rohini, Yen, Katherine, Jin, Shengfang, Gaulard, Philippe, and Mak, Tak W.

Published
2016

11. Data from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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12. Supplementary Tables S1 - S10 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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13. Supplementary Methods, Figures S1 - S9 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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14. Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome

Author

Veloza, Luis, Cavalieri, Doriane, Missiaglia, Edoardo, Ledoux-Pilon, Albane, Bisig, Bettina, Pereira, Bruno, Bonnet, Christophe, Poullot, Elsa, Quintanilla-Martinez, Leticia, Dubois, Romain, Llamas-Gutierrez, Francisco, Bossard, Céline, De Wind, Roland, Drieux, Fanny, Fontaine, Juliette, Parrens, Marie, Sandrini, Jeremy, Fataccioli, Virginie, Delfau-Larue, Marie Hélène, Daniel, Adrien, Lhomme, Faustine, Clément-Filliatre, Lauriane, Lemonnier, François, Cairoli, Anne, Morel, Pierre, Glaisner, Sylvie, Joly, Bertrand, Yamani, Abderrazak El, Laribi, Kamel, Bachy, Emmanuel, Siebert, Reiner, Vallois, David, Gaulard, Philippe, Tournilhac, Olivier, de Leval, Laurence, Veloza, Luis, Cavalieri, Doriane, Missiaglia, Edoardo, Ledoux-Pilon, Albane, Bisig, Bettina, Pereira, Bruno, Bonnet, Christophe, Poullot, Elsa, Quintanilla-Martinez, Leticia, Dubois, Romain, Llamas-Gutierrez, Francisco, Bossard, Céline, De Wind, Roland, Drieux, Fanny, Fontaine, Juliette, Parrens, Marie, Sandrini, Jeremy, Fataccioli, Virginie, Delfau-Larue, Marie Hélène, Daniel, Adrien, Lhomme, Faustine, Clément-Filliatre, Lauriane, Lemonnier, François, Cairoli, Anne, Morel, Pierre, Glaisner, Sylvie, Joly, Bertrand, Yamani, Abderrazak El, Laribi, Kamel, Bachy, Emmanuel, Siebert, Reiner, Vallois, David, Gaulard, Philippe, Tournilhac, Olivier, and de Leval, Laurence

Abstract

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and genomic study of 71 European MEITL patients (36 males, 35 females, median age 67 years). The majority presented with gastrointestinal involvement and had emergency surgery, and 40% had stage IV disease. The tumors were morphologically classified into two groups: typical (58%) and atypical (i.e. non-monomorphic or with necrosis, angiotropism or starry-sky pattern) (42%), sharing a homogeneous immunophenotypic profile (CD3+ [98%] CD4- [94%] CD5- [97%] CD7+ [97%] CD8+ [90%] CD56+ [86%] CD103+ [80%] cytotoxic marker+ [98%]) with more frequent expression of TCRgd (50%) than TCRab (32%). MYC expression (30% of cases) partly reflecting MYC gene locus alterations, correlated with non-monomorphic cytology. Almost all cases (97%) harbored deleterious mutation(s) and/or deletion of the SETD2 gene and 90% had defective H3K36 trimethylation. Other frequently mutated genes were STAT5B (57%), JAK3 (50%), TP53 (35%), JAK1 (12.5%), BCOR and ATM (11%). Both TP53 mutations and MYC expression correlated with atypical morphology. The median overall survival (OS) of 63 patients (43/63 only received chemotherapy after initial surgery) was 7.8 months. Multivariate analysis found a strong negative impact on outcome of MYC expression, TP53 mutation, STAT5B mutation and poor performance status while aberrant B-cell marker expression (20% of cases) correlated with better survival. In conclusion, MEITL is an aggressive disease with resistance to conventional therapy, predominantly characterized by driver gene alterations deregulating histone methylation and JAK/STAT signaling and encompasses genetic and morphologic variants associated with very high clinical risk., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

15. Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas

Author

Vallois, David, Dobay, Maria Pamela D., Morin, Ryan D., Lemonnier, François, Missiaglia, Edoardo, Juilland, Mélanie, Iwaszkiewicz, Justyna, Fataccioli, Virginie, Bisig, Bettina, Roberti, Annalisa, Grewal, Jasleen, Bruneau, Julie, Fabiani, Bettina, Martin, Antoine, Bonnet, Christophe, Michielin, Olivier, Jais, Jean-Philippe, Figeac, Martin, Bernard, Olivier A., Delorenzi, Mauro, Haioun, Corinne, Tournilhac, Olivier, Thome, Margot, Gascoyne, Randy D., Gaulard, Philippe, and de Leval, Laurence

Published
2016
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16. ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study

Author

Sibon, David, primary, Bisig, Bettina, additional, Bonnet, Christophe, additional, Poullot, Elsa, additional, Bachy, Emmanuel, additional, Cavalieri, Doriane, additional, Fataccioli, Virginie, additional, Bregnard, Cloe, additional, Drieux, Fanny, additional, Bruneau, Julie, additional, Lemonnier, Francois, additional, Dupuy, Aurelie, additional, Bossard, Celine, additional, Parrens, Marie, additional, Bouabdallah, Krimo, additional, Ketterer, Nicolas, additional, Berthod, Gregoire, additional, Cairoli, Anne, additional, Damaj, Gandhi, additional, Tournilhac, Olivier, additional, Jais, Jean-Philippe, additional, Gaulard, Philippe, additional, and De Leval, Laurence, additional

Published
2022
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17. Frequent Alterations of Driver Genes in Chromosome X and Their Clinical Relevance in Extranodal NK/T-Cell Lymphoma

Author

Ito, Yuta, primary, Marouf, Amira, additional, Kogure, Yasunori, additional, Koya, Junji, additional, Tabata, Mariko, additional, Saito, Yuki, additional, Shingaki, Sumito, additional, Yuasa, Mitsuhiro, additional, Yamaguchi, Kentaro, additional, Bruneau, Julie, additional, Vavasseur, Manon, additional, Dussiot, Michaël, additional, Andre, Isabelle, additional, Joshi, Akshay, additional, Lagresle-Peyrou, Chantal, additional, Magerus, Aude, additional, Chaubard, Sammara, additional, Lavergne, David, additional, Bachy, Emmanuel, additional, Brunet, Erika, additional, Fataccioli, Virginie, additional, Brouzes, Chantal, additional, Laurent, Camille, additional, De Leval, Laurence, additional, Traverse-Glehen, Alexandra, additional, Bossard, Céline, additional, Parrens, Marie, additional, Meignin, Véronique, additional, Philippe, Laure, additional, Rossignol, Julien, additional, Suarez, Felipe, additional, Michot, Jean-Marie, additional, Tournilhac, Olivier, additional, Bole-Feysot, Christine, additional, Nitschke, Patrick, additional, Tesson, Bruno, additional, Laurent, Cécile, additional, Molina, Thierry Jo, additional, Asnafi, Vahid, additional, Tsukita, Sachiko, additional, Izutsu, Koji, additional, Miyoshi, Hiroaki, additional, Sakata, Seiji, additional, Dobashi, Akito, additional, Takeuchi, Kengo, additional, Ohshima, Koichi, additional, Gaulard, Philippe, additional, Jaccard, Arnaud, additional, Ogawa, Seishi, additional, Hermine, Olivier, additional, Kataoka, Keisuke, additional, and Couronne, Lucile, additional

Published
2022
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18. Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome

Author

Veloza, Luis, primary, Cavalieri, Doriane, additional, Missiaglia, Edoardo, additional, Ledoux-Pilon, Albane, additional, Bisig, Bettina, additional, Pereira, Bruno, additional, Bonnet, Christophe, additional, Poullot, Elsa, additional, Quintanilla-Martinez, Leticia, additional, Dubois, Romain, additional, Llamas-Gutierrez, Francisco, additional, Bossard, Céline, additional, De Wind, Roland, additional, Drieux, Fanny, additional, Fontaine, Juliette, additional, Parrens, Marie, additional, Sandrini, Jeremy, additional, Fataccioli, Virginie, additional, Delfau-Larue, Marie-Hélène, additional, Daniel, Adrien, additional, Lhomme, Faustine, additional, Clément-Filliatre, Lauriane, additional, Lemonnier, François, additional, Cairoli, Anne, additional, Morel, Pierre, additional, Glaisner, Sylvie, additional, Joly, Bertrand, additional, El Yamani, Abderrazak, additional, Laribi, Kamel, additional, Bachy, Emmanuel, additional, Siebert, Reiner, additional, Vallois, David, additional, Gaulard, Philippe, additional, Tournilhac, Olivier, additional, and De Leval, Laurence, additional

Published
2022
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19. Breast Implant Associated-Anaplastic Large-Cell Lymphoma (BIA-ALCL): Data Based on the Lymphoma Study Association (LYSA) Registry. Promising Results of Brentuximab Vedotin Combined with Cyclophosphamide, Doxorubicin and Prednisone (BV-CHP) As First Line Treatment for Patient Requiring Chemotherapy

Author

Le Bras, Fabien, primary, Schiano De Colella, Jean Marc, additional, Oberic, Lucie, additional, Itti, Emmanuel, additional, Dao, Thua-Ha, additional, Laurent, Camille, additional, Xerri, Luc, additional, Bachy, Emmanuel, additional, Traverse-Glehen, Alexandra, additional, Bonnet, Christophe, additional, André, Marc, additional, Fornecker, Luc Mathieu, additional, Bannier, Marie, additional, Slama, Bohrane, additional, Kirova, Youlia, additional, Nicolas-Virelizier, Emmanuelle, additional, Croix, Manon, additional, Fogarty, Patrick, additional, Amara, Nadia, additional, Fataccioli, Virginie, additional, Ricci, Romain, additional, Tilly, Hervé, additional, Tortolano, Lionel, additional, Bosc, Romain, additional, Gaulard, Philippe, additional, and Haioun, Corinne, additional

Published
2021
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20. Detection of Gene Fusion Transcripts in Peripheral T-Cell Lymphoma Using a Multiplexed Targeted Sequencing Assay

Author

Drieux, Fanny, primary, Ruminy, Philippe, additional, Sater, Vincent, additional, Marchand, Vinciane, additional, Fataccioli, Virginie, additional, Lanic, Marie-Delphine, additional, Viennot, Mathieu, additional, Viailly, Pierre-Julien, additional, Sako, Nouhoum, additional, Robe, Cyrielle, additional, Dupuy, Aurélie, additional, Vallois, David, additional, Veresezan, Liana, additional, Poullot, Elsa, additional, Picquenot, Jean-Michel, additional, Bossard, Céline, additional, Parrens, Marie, additional, Lemonnier, François, additional, Jardin, Fabrice, additional, de Leval, Laurence, additional, and Gaulard, Philippe, additional

Published
2021
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21. Impact of Brentuximab Vedotin in Patients with Breast Implant-Associated Anaplastic Large Cell Lymphoma with Capsule Infiltration Requiring Chemotherapy

Author

Sibon, David, Schiano De Colella, Jean Marc, Itti, Emmanuel, Dao, Thu-Ha, Oberic, Lucie, Ricci, Romain, Laurent, Camille, Xerri, Luc, André, Marc, Nicolas Virelizier, Emmanuelle, Bonnet, Christophe, Karangwa, Alexandre, Fornecker, Luc-Matthieu, Bachy, Emmanuel, Bannier, Marie, Traverse-Glehen, Alexandra, Kirova, Youlia, de Lacheisserie, Cyrielle, Ould-Ammar, Romain, Fogarty, Patrick, Amara, Nadia, Fataccioli, Virginie, Tilly, Hervé, Tortolano, Lionel, Bosc, Romain, Le Bras, Fabien, Gaulard, Philippe, and Haioun, Corinne

Published
2023
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22. Defining the signatures of peripheral T-cell lymphoma, with a targeted 20-markers gene expression profiling assay (RT-MLPA)

Author

Drieux, Fanny, Ruminy, Philippe, Abdel-Sater, Ahmad, Lemonnier, François, Viailly, Pierre-Julien, Fataccioli, Virginie, Machand, Vinciane, Bisig, Bettina, Letourneau, Audrey, Parrens, Marie, Bossard, Céline, Bruneau, Julie, Dobay, Pamela, Veresezan, Liana, Dupuy, Aurélie, Pujals, Anaïs, Robe, Cyrielle, Sako, Nouhoum, Copie-Bergman, Christiane, Delfau-Larue, Marie-Hélène, Picquenot, Jean-Michel, Tilly, Hervé, Delarue, Richard, Jardin, Fabrice, de Leval, Laurence, Gaulard, Philippe, Service d'Anatomie et Cytologie Pathologique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pathology, Centre Hospitalier Universitaire Sart Tilman, Service de pathologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Laboratoire d'anatomie et cytologie pathologiques, Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'anatomie et cythologie pathologique, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Cellectis SA, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'immunologie biologique, Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pathology, and CHU Sart-Tilman

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

24. RNA fusions involving are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells

Author

Vallois, David, Dupuy, Aurélie, Lemonnier, François, Allen, George, Missiaglia, Edoardo, Fataccioli, Virginie, Ortonne, Nicolas, Clavert, Aline, Delarue, Richard, Rousselet, Marie-Christine, Fabiani, Bettina, Llamas-Gutierrez, Francisco, Ogawa, Seishi, Thome, Margot, Ko, Young, Kataoka, Keisuke, Gaulard, Philippe, De Leval, Laurence, Cellectis SA, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service de Pathologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie clinique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Rennes (UR)-Hôpital Pontchaillou, Univ Angers, Okina, CHU Saint-Antoine [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

25. Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.

Author

Laurent, Camille, primary, Nicolae, Alina, additional, Laurent, Cécile, additional, Le Bras, Fabien, additional, Haioun, Corinne, additional, Fataccioli, Virginie, additional, Amara, Nadia, additional, Adélaïde, José, additional, Guille, Arnaud, additional, Schiano, Jean-Marc, additional, Tesson, Bruno, additional, Traverse-Glehen, Alexandra, additional, Chenard, Marie-Pierre, additional, Mescam, Lénaïg, additional, Moreau, Anne, additional, Chassagne-Clement, Catherine, additional, Somja, Joan, additional, Escudié, Fréderic, additional, André, Marc, additional, Martin, Nadine, additional, Lacroix, Laetitia, additional, Lemonnier, François, additional, Hamy, Anne-Sophie, additional, Reyal, Fabien, additional, Bannier, Marie, additional, Oberic, Lucie, additional, Prade, Nais, additional, Frénois, François-Xavier, additional, Beldi-Ferchiou, Asma, additional, Delfau-Larue, Marie-Helene, additional, Bouabdallah, Reda, additional, Birnbaum, Daniel, additional, Brousset, Pierre, additional, Xerri, Luc, additional, and Gaulard, Philippe, additional

Published
2019
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26. Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL): The Lymphoma Study Association (LYSA) Registry Data

Author

Le Bras, Fabien, primary, Gaulard, Philippe, additional, Andre, Marc, additional, Haioun, Corinne, additional, Bosc, Romain, additional, Laurent, Camille, additional, Tortelano, Lionel, additional, Dao, Thua-Ha, additional, Itti, Emmanuel, additional, Malhaire, Caroline, additional, Jean Marc, Schiano de Colella, additional, Bannier, Marie, additional, Bachy, Emmanuel, additional, Slama, Borhane, additional, Fornecker, Luc Mathieu, additional, Oberic, Lucie, additional, Traverse-Glehen, Alexandra, additional, Croix, Manon, additional, Bonnefoy, Julie, additional, Fogarty, Patrick, additional, Bouabbas, Feriel, additional, Amara, Nadia, additional, Fataccioli, Virginie, additional, Ricci, Romain, additional, Cassubie-Mercier, Tania, additional, Kirova, Youlia, additional, Reyal, Fabien, additional, Tilly, Herve, additional, Nicolas-Virelizier, Emmanuelle, additional, Xerri, Luc, additional, and Bonnet, Christophe, additional

Published
2019
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27. Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay

Author

Drieux, Fanny, primary, Ruminy, Philippe, additional, Abdel-Sater, Ahmad, additional, Lemonnier, François, additional, Viailly, Pierre-Julien, additional, Fataccioli, Virginie, additional, Marchand, Vinciane, additional, Bisig, Bettina, additional, Letourneau, Audrey, additional, Parrens, Marie, additional, Bossard, Céline, additional, Bruneau, Julie, additional, Dobay, Pamela, additional, Veresezan, Liana, additional, Dupuy, Aurélie, additional, Pujals, Anaïs, additional, Robe, Cyrielle, additional, Sako, Nouhoum, additional, Copie-Bergman, Christiane, additional, Delfau-Larue, Marie-Hélène, additional, Picquenot, Jean-Michel, additional, Tilly, Hervé, additional, Delarue, Richard, additional, Jardin, Fabrice, additional, de Leval, Laurence, additional, and Gaulard, Philippe, additional

Published
2019
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28. Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T‐cell lymphoma

Author

Crickx, Etienne, primary, Poullot, Elsa, additional, Moulis, Guillaume, additional, Goulabchand, Radjiv, additional, Fieschi, Claire, additional, Galicier, Lionel, additional, Meignin, Véronique, additional, Coppo, Paul, additional, Delarue, Richard, additional, Casasnovas, Olivier, additional, Roos‐Weil, Damien, additional, de Leval, Laurence, additional, Parrens, Marie, additional, Michel, Marc, additional, Dupuis, Jehan, additional, Le Bras, Fabien, additional, Fataccioli, Virginie, additional, Martin‐Garcia, Nadine, additional, Godeau, Bertrand, additional, Haïoun, Corinne, additional, Gaulard, Philippe, additional, and Mahévas, Matthieu, additional

Published
2019
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29. Serum 2-Hydroxyglutarate in Angioimmunoblastic T Cell Lymphomas: A New Marker for IDH2 Mutation Detection and Monitoring

Author

Broutin, Sophie, primary, Lemonnier, Francois, additional, Dupuy, Aurélie, additional, Delahousse, Julia, additional, Fataccioli, Virginie, additional, Ribrag, Vincent, additional, Safar, Violaine, additional, Pelletier, Laura, additional, Robe, Cyrielle, additional, Tilly, Herve, additional, Cottereau, Anne Ségolène, additional, Bossard, Céline, additional, de Leval, Laurence, additional, Delfau, Marie-Helene, additional, Haioun, Corinne, additional, Paci, Angelo, additional, and Gaulard, Philippe, additional

Published
2018
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30. DNA methylation profiling of hepatosplenic T-cell lymphoma

Author

Bergmann, Anke K., primary, Fataccioli, Virginie, additional, Castellano, Giancarlo, additional, Martin-Garcia, Nadine, additional, Pelletier, Laura, additional, Ammerpohl, Ole, additional, Bergmann, Juri, additional, Bhat, Jaydeep, additional, Pau, Enrique Carrillo-de Santa, additional, Martín-Subero, José I., additional, Moffitt, Andrea B., additional, Valencia, Alfonso, additional, Oberg, Hans-Heinrich, additional, Wesch, Daniela, additional, Jayne, Sandrine, additional, Dyer, Martin J.S., additional, Kabelitz, Dieter, additional, Gaulard, Philippe, additional, and Siebert, Reiner, additional

Published
2018
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31. Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing

Author

Dupuy, Aurélie, primary, Lemonnier, François, additional, Fataccioli, Virginie, additional, Martin-Garcia, Nadine, additional, Robe, Cyrielle, additional, Pelletier, Romain, additional, Poullot, Elsa, additional, Moktefi, Anissa, additional, Mokhtari, Karima, additional, Rousselet, Marie C., additional, Traverse-Glehen, Alexandra, additional, Delarue, Richard, additional, Tournilhac, Olivier, additional, Delfau-Larue, Marie H., additional, Haioun, Corinne, additional, Ortonne, Nicolas, additional, Copie-Bergman, Christiane, additional, de Leval, Laurence, additional, Pujals, Anaïs, additional, and Gaulard, Philippe, additional

Published
2018
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32. RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells

Author

Vallois, David, primary, Dupuy, Aurélie, additional, Lemonnier, Francois, additional, Allen, George, additional, Missiaglia, Edoardo, additional, Fataccioli, Virginie, additional, Ortonne, Nicolas, additional, Clavert, Aline, additional, Delarue, Richard, additional, Rousselet, Marie-Christine, additional, Fabiani, Bettina, additional, Llamas-Gutierrez, Francisco, additional, Ogawa, Seishi, additional, Thome, Margot, additional, Ko, Young Hyeh, additional, Kataoka, Keisuke, additional, Gaulard, Philippe, additional, and de Leval, Laurence, additional

Published
2018
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33. Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas

Author

Lemonnier, François, primary, Poullot, Elsa, additional, Dupuy, Aurélie, additional, Couronné, Lucile, additional, Martin, Nadine, additional, Scourzic, Laurianne, additional, Fataccioli, Virginie, additional, Bruneau, Julie, additional, Cairns, Rob A, additional, Mak, Tak W., additional, Bernard, Olivier A., additional, de Leval, Laurence, additional, and Gaulard, Philippe, additional

Published
2017
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34. The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., additional, Gaulard, Philippe, additional, Travert, Marion, additional, De Leval, Laurence, additional, Nicolae, Alina, additional, Raffeld, Mark, additional, Jaffe, Elaine S., additional, Pittaluga, Stefania, additional, Xi, Liqiang, additional, Heavican, Tayla, additional, Iqbal, Javeed, additional, Belhadj, Karim, additional, Delfau-Larue, Marie Helene, additional, Fataccioli, Virginie, additional, Czader, Magdalena B., additional, Lossos, Izidore S., additional, Chapman-Fredricks, Jennifer R., additional, Richards, Kristy L., additional, Fedoriw, Yuri, additional, Ondrejka, Sarah L., additional, Hsi, Eric D., additional, Low, Lawrence, additional, Weisenburger, Dennis, additional, Chan, Wing C., additional, Mehta-Shah, Neha, additional, Horwitz, Steven, additional, Bernal-Mizrachi, Leon, additional, Flowers, Christopher R., additional, Beaven, Anne W., additional, Parihar, Mayur, additional, Baseggio, Lucile, additional, Parrens, Marie, additional, Moreau, Anne, additional, Sujobert, Pierre, additional, Pilichowska, Monika, additional, Evens, Andrew M., additional, Chadburn, Amy, additional, Au-Yeung, Rex K.H., additional, Srivastava, Gopesh, additional, Choi, William W. L., additional, Goodlad, John R., additional, Aurer, Igor, additional, Basic-Kinda, Sandra, additional, Gascoyne, Randy D., additional, Davis, Nicholas S., additional, Li, Guojie, additional, Zhang, Jenny, additional, Rajagopalan, Deepthi, additional, Reddy, Anupama, additional, Love, Cassandra, additional, Levy, Shawn, additional, Zhuang, Yuan, additional, Datta, Jyotishka, additional, Dunson, David B., additional, and Davé, Sandeep S., additional

Published
2017
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35. Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

Author

Dobay, Maria Pamela, primary, Lemonnier, Francois, additional, Missiaglia, Edoardo, additional, Bastard, Christian, additional, Vallois, David, additional, Jais, Jean-Philippe, additional, Scourzic, Laurianne, additional, Dupuy, Aurélie, additional, Fataccioli, Virginie, additional, Pujals, Anais, additional, Parrens, Marie, additional, Le Bras, Fabien, additional, Rousset, Thérèse, additional, Picquenot, Jean-Michel, additional, Martin, Nadine, additional, Haioun, Corinne, additional, Delarue, Richard, additional, Bernard, Olivier A., additional, Delorenzi, Mauro, additional, de Leval, Laurence, additional, and Gaulard, Philippe, additional

Published
2017
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36. Treatment with Hypomethylating Agent 5-Azacytidine Induces Sustained Response in Angioimmunoblastic T Cell Lymphomas

Author

Delarue, Richard, primary, Dupuis, Jehan, additional, Sujobert, Pierre, additional, Barbieux, Sarah, additional, Marçais, Ambroise, additional, Tournilhac, Olivier, additional, Lachenal, Florence, additional, Cheminant, Morgane, additional, Sarkozy, Clementine, additional, Fataccioli, Virginie, additional, Morschhauser, Franck, additional, Hermine, Olivier, additional, Haioun, Corinne, additional, Gaulard, Philippe, additional, and Lemonnier, Francois, additional

Published
2016
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37. Clinical Spectrum, Evolution and Management of Autoimmune Cytopenia Associated with Angioimmunoblastic T-Cell Lymphoma: A Retrospective, Multicenter Study

Author

Crickx, Etienne, primary, Goulabchand, Radjiv, additional, Fieschi, Claire, additional, Galicier, Lionel, additional, Coppo, Paul, additional, Meignin, Veronique, additional, Delarue, Richard, additional, Casasnovas, Olivier, additional, Leblond, Veronique, additional, Moulis, Guillaume, additional, Michel, Marc, additional, Dupuis, Jehan, additional, Le Bras, Fabien, additional, Fataccioli, Virginie, additional, Haioun, Corinne, additional, Godeau, Bertrand, additional, Gaulard, Philippe, additional, and Mahevas, Matthieu, additional

Published
2016
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38. Gene Expression Profiling Using a Reverse Transcriptase-Multiplex Ligation Dependant Probe Amplification Assay Allows for an Accurate Classification of Peripheral T-Cell Lymphoma and Highlights Novel Subgroups within the PTCL-NOS Category

Author

Drieux, Fanny, primary, Ruminy, Philippe, additional, Fataccioli, Virginie, additional, Marchand, Vinciane, additional, Parrens, Marie, additional, Bossard, Céline, additional, Viailly, Pierre Julien, additional, Dobay, Maria Pamela, additional, Veresezan, Elena Liana, additional, Pujals, Anais, additional, Dupuy, Aurélie, additional, Picquenot, Jean-Michel, additional, Tilly, Hervé, additional, de Leval, Laurence, additional, Jardin, Fabrice, additional, and Gaulard, Philippe, additional

Published
2016
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39. Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant–associated ALCL

Author

Laurent, Camille, Nicolae, Alina, Laurent, Cécile, Le Bras, Fabien, Haioun, Corinne, Fataccioli, Virginie, Amara, Nadia, Adélaïde, José, Guille, Arnaud, Schiano, Jean-Marc, Tesson, Bruno, Traverse-Glehen, Alexandra, Chenard, Marie-Pierre, Mescam, Lénaïg, Moreau, Anne, Chassagne-Clement, Catherine, Somja, Joan, Escudié, Frédéric, André, Marc, Martin, Nadine, Lacroix, Laetitia, Lemonnier, François, Hamy, Anne-Sophie, Reyal, Fabien, Bannier, Marie, Oberic, Lucie, Prade, Nais, Frénois, François-Xavier, Beldi-Ferchiou, Asma, Delfau-Larue, Marie-Helene, Bouabdallah, Reda, Birnbaum, Daniel, Brousset, Pierre, Xerri, Luc, and Gaulard, Philippe

Abstract

The oncogenic events involved in breast implant–associated anaplastic large cell lymphoma (BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor and 19 in situ subtypes) collected from 54 BI-ALCL patients diagnosed through the French Lymphopathnetwork. Whole-exome sequencing (n = 22, with paired tumor/germline DNA) and/or targeted deep sequencing (n = 24) showed recurrent mutations of epigenetic modifiers in 74% of cases, involving notably KMT2C(26%), KMT2D(9%), CHD2(15%), and CREBBP(15%). KMT2Dand KMT2Cmutations correlated with a loss of H3K4 mono- and trimethylation by immunohistochemistry. Twenty cases (59%) showed mutations in ≥1 member of the JAK/STATpathway, including STAT3(38%), JAK1(18%), and STAT5B(3%), and in negative regulators, including SOCS3(6%), SOCS1(3%), and PTPN1(3%). These mutations were more frequent in tumor-type samples than in situ samples (P =.038). All BI-ALCLs expressed pSTAT3, regardless of the mutational status of genes in the JAK/STATpathway. Mutations in the EOMESgene (12%) involved in lymphocyte development, PI3K-AKT/mTOR(6%), and loss-of-function mutations in TP53(12%) were also identified. Copy-number aberration (CNA) analysis identified recurrent alterations, including gains on chromosomes 2, 9p, 12p, and 21 and losses on 4q, 8p, 15, 16, and 20. Regions of CNA encompassed genes involved in the JAK/STATpathway and epigenetic regulators. Our results show that the BI-ALCL genomic landscape is characterized by not only JAK/STATactivating mutations but also loss-of-function alterations of epigenetic modifiers.

Published
2020
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40. Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells

Author

BOUSSAT, SANDRINE, EDDAHIBI, SAADIA, COSTE, ANDRE, FATACCIOLI, VIRGINIE, GOUGE, MALLAURY, HOUSSET, BRUNO, ADNOT, SERGE, and MAITRE, BERNARD

Subjects
Neovascularization -- Research, Bronchi -- Physiological aspects, Lungs -- Injuries, Biological sciences
Abstract

Boussat, Sandrine, Saadia Eddahibi, Andre Coste, Virginie Fataccioli, Mallaury Gouge, Bruno Housset, Serge Adnot, and Bernard Maitre. Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 279: L371-L378, 2000.--Vascular endothelial growth factor (VEGF) is a potent endothelial cell growth and permeability factor highly expressed in rodent alveolar epithelium after injury and repair. To investigate VEGF synthesis in human lung epithelial cells, we examined VEGF expression by cultured cells under basal conditions and after cytokine treatment or oxidative stress. Basal VEGF expression was detected in transformed human epithelial cell lines (A549 and 1HAEo-) and in primary human bronchial epithelial cells with RT-PCR, Western blot, and immunocytochemistry. Among the cytokines tested, only transforming growth factor-[Beta]1 increased the levels of excreted [VEGF.sub.165] as measured by ELISA. Under hypoxia (0% [O.sub.2] for 24 h), the [VEGF.sub.165] level increased fivefold, and this effect was [O.sub.2] concentration dependent. VEGF concentrations in the medium of all the cell types studied reached values similar to those found in bronchoalveolar lavage fluids from normal patients. Endothelial cells (human umbilical vein endothelial cells) exposed to conditioned medium from primary bronchial epithelial cell cultures showed an increased growth rate, which was inhibited in the presence of a specific neutralizing antibody to VEGF. These results suggest that lung epithelial cells participate in the endothelial repair and angiogenesis that follow lung injury through the synthesis of VEGF. angiogenesis; bronchial epithelial cells; lung injury

Published
2000

41. Multiple Ways to Detect IDH2Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing

Author

Dupuy, Aurélie, Lemonnier, François, Fataccioli, Virginie, Martin-Garcia, Nadine, Robe, Cyrielle, Pelletier, Romain, Poullot, Elsa, Moktefi, Anissa, Mokhtari, Karima, Rousselet, Marie C., Traverse-Glehen, Alexandra, Delarue, Richard, Tournilhac, Olivier, Delfau-Larue, Marie H., Haioun, Corinne, Ortonne, Nicolas, Copie-Bergman, Christiane, de Leval, Laurence, Pujals, Anaïs, and Gaulard, Philippe

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma associated with chemoresistance and a poor prognosis. Various nonsynonymous mutations in the R172 residue of IDH2are present in 20% to 30% of AITL patients. In addition to their diagnostic value, these mutations are potentially targetable, especially by isocitrate dehydrogenase (IDH) 2 inhibitor, and therefore their identification in a routine setting is clinically relevant. However, in AITL, the neoplastic cells may be scarce, making the identification of molecular anomalies difficult. We evaluated the diagnostic value of different methods to detect IDH2mutations in formalin-fixed, paraffin-embedded tumor samples. Immunohistochemistry with an anti-IDH2 R172K antibody, Sanger sequencing, high-resolution melting PCR, allele-specific real-time quantitative PCR, and next-generation sequencing (NGS) were applied to biopsy specimens from 42 AITL patients. We demonstrate that the IDH2 R172K antibody is specific to this amino acid substitution and highly sensitive for the detection of the IDH2R172Kvariant, the most frequent substitution in this disease. In our study, NGS and allele-specific real-time quantitative PCR displayed a good sensitivity, detecting 96% and 92% of IDH2mutations, respectively, in contrast to Sanger sequencing and high-resolution melting PCR, which showed a significantly lower detection rate (58% and 42%, respectively). These results suggest that a combination of immunohistochemistry and AS-PCR or NGS should be considered for the identification of IDH2mutations in AITL in a routine setting.

Published
2018
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42. Whole Genome and Exome Sequencing Defines The Genetic Landscape Of Hepatosplenic T-Cell Lymphoma

Author

Scotland, Paula, primary, Gaulard, Philippe, additional, Love, Cassandra L, additional, Fataccioli, Virginie, additional, Travert, Marion, additional, De Leval, Laurence, additional, Weisenburger, Dennis D., additional, Czader, Magdalena, additional, Parihar, Mayur, additional, Nair, Reena, additional, Sengar, Manju, additional, Beaven, Anne W, additional, Crow, Jennifer H., additional, Miles, Rodney R., additional, Gordon, Leo I., additional, Chadburn, Amy, additional, Evens, Andrew M, additional, Gill, Javed, additional, Fedoriw, Yuri D., additional, Richards, Kristy L., additional, Srivastava, Gopesh, additional, Choi, William W. L., additional, Flowers, Christopher R., additional, Bernal-Mizrachi, Leon, additional, Mann, Karen P., additional, Naresh, Kikkeri, additional, Hsi, Eric D., additional, Horna, Pedro, additional, Tao, Jianguo, additional, Sun, Zhen, additional, Long, Kevin, additional, Zhang, Jenny, additional, and Dave, Sandeep, additional

Published
2013
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43. Small Nucleolar RNA Expression Profiling Identifies Potential Prognostic Markers in Peripheral T-Cell Lymphoma.

Author

Ysebaert, Loic, primary, Valleron, Wilfried, additional, Berquet, Laure, additional, Fataccioli, Virginie, additional, Quelen, Cathy, additional, Martin, Antoine, additional, Parrens, Marie, additional, Lamant, Laurence, additional, de Leval, Laurence, additional, Gisselbrecht, Christian, additional, Gaulard, Philippe, additional, and Brousset, Pierre, additional

Published
2012
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44. Angioimmunoblastic T-Cell Lymphoma (AITL) Is the Most Prevalent T-Cell Lymphoma Entity in Western Europe

Author

Parrens, Marie, primary, Martin, Antoine, additional, Lamant, Laurence, additional, Delarue, Richard, additional, Haioun, Corinne, additional, Tournilhac, Olivier, additional, Berger, Francoise, additional, Bossard, Céline, additional, Bouchind'homme, Brigitte, additional, Briere, Josette, additional, Canioni, Danielle, additional, Charlotte, Frederic, additional, Fabiani, Bettina, additional, Molina, Thierry Jo, additional, Patey, Martine, additional, Petrella, Tony, additional, Picquenot, Jean-Michel, additional, Rousset, Therese, additional, Fataccioli, Virginie, additional, Delsol, Georges, additional, de Leval, Laurence, additional, and Gaulard, Philippe, additional

Published
2012
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45. Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma

Author

Valleron, Wilfried, primary, Ysebaert, Loic, additional, Berquet, Laure, additional, Fataccioli, Virginie, additional, Quelen, Cathy, additional, Martin, Antoine, additional, Parrens, Marie, additional, Lamant, Laurence, additional, de Leval, Laurence, additional, Gisselbrecht, Christian, additional, Gaulard, Philippe, additional, and Brousset, Pierre, additional

Published
2012
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48. INACTIVATION OF CEREBELLAR NITRIC OXIDE SYNTHASE BY ETHANOL IN VITRO.

Author

FATACCIOLI, VIRGINIE, GENTIL, MONIQUE, NORDMANN, ROGER, and ROUACH, HELENE

Subjects
*AMINO acids, *BIOCHEMISTRY, *BINDING sites, *ARGININE, *BRAIN research, *ETHANOL, *PHYSIOLOGY
Abstract

The N-methyl-D-aspartate receptor/nitric oxide synthase (NOS)/guanylate cyclase pathway, which plays a crucial role in synaptic plasticity in the brain, is modulated by ethanol. We studied the effect of ethanol in vitro on NOS in rat cerebellum and showed that ethanol (25–200 mM) inactivated NOS in a dose-dependent manner. This inactivation was prevented by the biopterin cofactor tetrahydrobiopterin (BH4) as well as by L-arginine, a NOS substrate, but not by NADPH. These results suggest that ethanol reduces NOS activity by modulating the conformation of the enzyme and thereby its stability, probably by interacting with the binding sites of BH4 and/or of L-arginine. Our data also suggest that inactivation of NOS may contribute to the decrease in the cGMP level, and thus may play a role in the pharmacological actions of ethanol in vivo. [ABSTRACT FROM PUBLISHER]

Published
1997
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49. Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

Author

Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W, Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A, Abraham, Brian J, Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, De Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D, Look, A Thomas, Mathas, Stephan, Kenner, Lukas, and Merkel, Olaf

Subjects
Interleukin-15, Immunoconjugates, Cell Survival, Interleukin-2 Receptor alpha Subunit, Ki-1 Antigen, Receptors, Interleukin-2, Regulatory Sequences, Nucleic Acid, Xenograft Model Antitumor Assays, 3. Good health, Gene Expression Regulation, Neoplastic, Repressor Proteins, Mice, Basic-Leucine Zipper Transcription Factors, hemic and lymphatic diseases, Cell Line, Tumor, Animals, Humans, Interleukin-2, Lymphoma, Large-Cell, Anaplastic, Cell Proliferation, Signal Transduction
Abstract

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, and already in second line effective treatment options are lacking. To identify genes defining ALCL cell state and dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. In addition to known ALCL key regulators, the AP-1-member BATF3 and IL-2 receptor (IL2R)-components are among the top hits. Specific and high-level IL2R expression in ALCL correlates with BATF3 expression. Confirming a regulatory link, IL-2R-expression decreases following BATF3 knockout, and BATF3 is recruited to IL2R regulatory regions. Functionally, IL-2, IL-15 and Neo-2/15, a hyper-stable IL-2/IL-15 mimic, accelerate ALCL growth and activate STAT1, STAT5 and ERK1/2. In line, strong IL-2Rα-expression in ALCL patients is linked to more aggressive clinical presentation. Finally, an IL-2Rα-targeting antibody-drug conjugate efficiently kills ALCL cells in vitro and in vivo. Our results highlight the importance of the BATF3/IL-2R-module for ALCL biology and identify IL-2Rα-targeting as a promising treatment strategy for ALCL.

50. Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

Author

Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W, Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A, Abraham, Brian J, Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, De Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D, Look, A Thomas, Mathas, Stephan, Kenner, Lukas, and Merkel, Olaf

Subjects
hemic and lymphatic diseases, 3. Good health
Abstract

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, and already in second line effective treatment options are lacking. To identify genes defining ALCL cell state and dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. In addition to known ALCL key regulators, the AP-1-member BATF3 and IL-2 receptor (IL2R)-components are among the top hits. Specific and high-level IL2R expression in ALCL correlates with BATF3 expression. Confirming a regulatory link, IL-2R-expression decreases following BATF3 knockout, and BATF3 is recruited to IL2R regulatory regions. Functionally, IL-2, IL-15 and Neo-2/15, a hyper-stable IL-2/IL-15 mimic, accelerate ALCL growth and activate STAT1, STAT5 and ERK1/2. In line, strong IL-2Rα-expression in ALCL patients is linked to more aggressive clinical presentation. Finally, an IL-2Rα-targeting antibody-drug conjugate efficiently kills ALCL cells in vitro and in vivo. Our results highlight the importance of the BATF3/IL-2R-module for ALCL biology and identify IL-2Rα-targeting as a promising treatment strategy for ALCL.

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