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4. Iranian future healthcare professionals' knowledge and opinions about rare diseases: cross-sectional study

Author

Jahanshahi, Reza, Nasirzadeh, Amirreza, Farzan, Mahan, Domaradzki, Jan, Jouybari, Leila, Sanagoo, Akram, Farzan, Mahour, Aghazadeh-Habashi, Komeil, Fallah Faraghe, Ahmadreza, Bagheri, Sadegh, Samiee, Marziyeh, Ansari, Arina, Eskandari, Kimia, Namakkoobi, Negar, Soltanimoghadam, Fatemeh, Mashali, Hadi, Yavari, Erfan, Bay, Saba, Memaripanah, Nafiseh, Meftah, Elahe, Amanzadeh, Saeed, Talati, Fatemeh, and Bahramzadeh, Sasan

Published
2022
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6. Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: a comprehensive review of mechanistic studies.

Author

Farzan, Mahan, Farzan, Mahour, Shahrani, Mehrdad, Navabi, Seyedeh Parisa, Vardanjani, Hossien Rajabi, Amini-Khoei, Hossein, and Shabani, Sahreh

Subjects
*BETULINIC acid, *URSOLIC acid, *BETULIN, *ACID derivatives, *ALZHEIMER'S disease, *TRITERPENOIDS
Abstract

Cognitive deficits are the main outcome of neurological disorders whose occurrence has risen over the past three decades. Although there are some pharmacologic approaches approved for managing neurological disorders, it remains largely ineffective. Hence, exploring novel nature-based nutraceuticals is a pressing need to alleviate the results of neurodegenerative diseases, such as Alzheimer's disease (AD) and other neurodegenerative disorders. Some triterpenoids and their derivates can be considered potential therapeutics against neurological disorders due to their neuroprotective and cognitive-improving effects. Betulin (B), betulinic acid (BA), and ursolic acid (UA) are pentacyclic triterpenoid compounds with a variety of biological activities, including antioxidative, neuroprotective and anti-inflammatory properties. This review focuses on the therapeutic efficacy and probable molecular mechanisms of triterpenoids in damage prevention to neurons and restoring cognition in neurodegenerative diseases. Considering few studies on this concept, the precise mechanisms that mediate the effect of these compounds in neurodegenerative disorders have remained unknown. The findings can provide sufficient information about the advantages of these compounds against neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Iranian Future Healthcare Professionals' knowledge and opinions about rare diseases: cross-sectional study

Author

Jahanshahi, Reza, primary, Nasirzadeh, Amirreza, additional, Farzan, Mahan, additional, Domaradzki, Jan, additional, Jouybari, Leila, additional, Sanagoo, Akram, additional, Farzan, Mahour, additional, Aghazadeh-Habashi, Komeil, additional, Faraghe, Ahmadreza Fallah, additional, Bagheri, Sadegh, additional, Samiee, Marziyeh, additional, Ansari, Arina, additional, Eskandari, Kimia, additional, Namakkoobi, Negar, additional, Soltanimoghadam, Fatemeh, additional, Mashali, Hadi, additional, Yavari, Erfan, additional, Bay, Saba, additional, Memaripanah, Nafiseh, additional, Meftah, Elahe, additional, Amanzadeh, Saeed, additional, Talati, Fatemeh, additional, and Bahramzadeh, Sasan, additional

Published
2022
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10. Role of Antioxidants in Autoimmune Diseases

Author

Farrokhi, Mehrdad, Rigi, Amir, Mangouri, Amir, Fadaei, Mahta, Shabani, Elaheh, Mashouf, Parham, Shahraki, Tamkin, Gharei, Fatemeh, Mehran, Maryam, Dehghani, Sara, Nazarimanesh, Mohammadamin, Nasri, Parsa, Baharlouie, Negar, Siami, Haleh, Vafaei, Somayeh, Nikandish, Mehrasa, Alyari, Melika, Tajik, Michael, Sayyah, Amirhossein, Escroochi, Maryam, Farzan, Mahour, Farzan, Mahan, and Taheri, Fatemeh

Abstract

Free radicals and related compounds are commonly classified together as reactive oxygen species (ROS) to show their role in changing oxidative status within the cell. Cells commonly have different mechanisms to protect the body against damages created by free radicals. Problems are seen when synthesis of ROS is faster than their removal by the antioxidant protection mechanisms, or when the latter is impaired. This imbalance between cellular synthesis of ROS and the inability of cells to protect against them is known as oxidative stress. Oxidative stress can make cellular damage and then cell death due to the ROS oxidize cardinal cellular parts, such as lipids, proteins, and DNA. Antioxidants are exogenous (natural or synthetic) or endogenous factors play their role in several pathways including diminish of O2, scavenging ROS or their precursors, suppressing their production and binding metal ions required for catalysis of ROS production. The natural antioxidant mechanism can be classified into two major types: enzymatic (e. g., catalase, superoxide dismutase,) and nonenzymatic or the low molecular weight antioxidants (LMWA). Therefore, in this book, we aimed to shed a light on the role of antioxidants in autoimmune diseases.

Published
2021
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