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43 results on '"Farthmann, E.H."'

4. Monitoring of the inflammatory response in early peritonitis

Author

Schoffel, U., Zeller, T., Lausen, M., Ruf, G., and Farthmann, E.H.

Subjects
blood -- analysis and chemistry, Abdomen -- Diseases, Peritonitis, Health
Abstract

All forms of peritonitis, the inflammation of the membrane lining the inside of the abdominal cavity (peritoneum), are similar. The degree of inflammation was recorded in a group of patients with different underlying diseases by examination of the affected cells and blood, and by analysis of the capacity of the blood to inhibit such inflammation. Blood testing in these patients began at the time of hospital admission when acute abdominal pain led to emergency laparotomy, a surgical incision into the abdominal cavity. Depending upon the duration of the illness and the severity of the peritonitis, levels of fibrinopeptide A and of C3a, two substances produced during blood clotting, significantly increased within a few hours of admission. Subsequently there was an increase in the level of elastase alpha-1-proteinase inhibitor complex, a substance which inhibits an enzyme necessary for protein digestion. There was a strong correlation between levels of these three substances before surgery and the course of the patient's postoperative recovery. A significant increase in the ability of a toxin produced by the body to inhibit growth of certain cells of the peritoneum was identified in the blood of patients who died. This toxin was present in trace amounts before surgery in four patients with peritonitis.

Published
1989

5. Hepatic Cryotherapy Involving the Vena cava

Author

Eggstein, S., primary, Neeff, H., additional, Szarzynski, M., additional, Jungraithmayr, W., additional, Haberstroh, J., additional, Kirste, G., additional, Schmitt-Graeff, A., additional, and Farthmann, E.H., additional

Published
2003
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10. Processing of Tumor Tissues for Vaccination with Autologous Tumor Cells

Author

Lahn, M., primary, Köhler, G., additional, Schmoor, C., additional, Dengler, W., additional, Veelken, H., additional, Brennscheidt, U., additional, Mackensen, A., additional, Kulmburg, P., additional, Hentrich, I., additional, Jesuiter, H., additional, Rosenthal, F.M., additional, Fiebig, H.H., additional, Sommerkamp, H., additional, Farthmann, E.H., additional, Hasse, J., additional, Mertelsmann, R., additional, and Lindemann, A., additional

Published
1997
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22. Kontinenzerhaltung in der rektalen Chirurgie

Author

Buhr, H.J., primary, Eigler, F.W., additional, Farthmann, E.H., additional, Germer, Ch.-Th., additional, Hohenberger, W., additional, Klempa, I., additional, Mappes, J.-J., additional, Schumpelick, V., additional, and Walz, M.K., additional

Published
1995
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32. Relapsing pancreatitis associated with duodenal wall cysts

Author

Holstege, A., Barner, S., Brambs, H.J., Wenz, W., Gerok, W., and Farthmann, E.H.

Abstract

A case of enterogenous cysts of the duodenum in a 44-yr-old man complicated by duodenal obstruction and relapsing pancreatitis is presented. The cystic duodenal lesions were visualized by endoscopic retrograde cholangiopancreatography and for the first time by computed tomography and abdominal sonography. Thus, the diagnosis was made preoperativeiy. The cysts were excised successfully during a Whipple procedure. Awareness of this rare condition combined with modern x-ray, sonographic, and endoscopic techniques permit accurate preoperative diagnosis.

Published
1985
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33. Processing of tumor tissues for vaccination with autologous tumor cells

Author

Lahn, M., Kohler, G., Schmoor, C., Dengler, W., Veelken, H., Breenscheidt, U., Mackensen, A., Kulmburg, P., Hentrich, I., Jesuiter, H., Rosenthal, F.M., Fiebig, H.H., Sommerkamp, H., Farthmann, E.H., Hasse, J., Mertelsmann, R., and Lindemann, A.

Subjects
Cancer vaccines -- Research, Health, Research
Abstract

Lahn, M.; Kohler, G.; Schmoor, C.; Dengler, W.; Veelken, H.; Breenscheidt, U.; Mackensen, A.; Kulmburg, P.; Hentrich, I.; Jesuiter, H.; Rosenthal, F.M.; Fiebig, H.H.; Sommerkamp, H.; Farthmann, E.H.; Hasse, J.; [...]

Published
1997

41. Predictive factors for response to neoadjuvant therapy in patients with oesophageal cancer

Author

Imdahl, A., Bognar, G., Schulte-Mönting, J., Schöffel, U., Farthmann, E.H., and Ihling, C.

Subjects
*DRUG therapy, *ESOPHAGEAL cancer
Abstract

Background: Preoperative radio-chemotherapy (RCX) was introduced to improve the outcome of patients with oesophageal cancer (EC), but conflicting results have been released. Some 20–30% of patients show a complete pathological response, however, the perioperative morbidity and mortality is increased. To search for factors indicating response prior to the onset of RCX we investigated the proliferative activity (MIB-1), the expression of vascular endothelial growth factor (VEGF), and the capillary density (CD34) in samples of EC obtained by endoscopy prior to the start of the treatment. Methods: Forty-six (MIB-1) and 21 (VEGF, CD34) tissue specimens of ECs were available from 56 patients undergoing pretherapeutic endoscopy, RCX and surgery. Perioperative morbidity was divided into surgery and non-surgery related morbidity. MIB-1, VEGF and CD34 expression were investigated immunohistochemically. Multivariate analysis was carried out to prove independence of investigated variables. Results: Postoperative morbidity was noticed in 54 of 56 operated patients. Eight of 56 patients who received RCX died in hospital. Survival was significantly different between the group of complete responders (n=14) and non-responders (n=23; P=0.0026). None of the investigated tumour samples from patients with a complete response (CR) had a proliferation index of less than 45. Tumour samples from patients with a CR showed a VEGF expression of 10.7 compared with 36.58 of tumours with no response (P=0.035). CD34 expression showed a correlation with VEGF expression. The relation of mean indices of VEGF expression and proliferative activity in tumours from patients with complete, partial or no response was 10.7:58.8, 18.3:53.8 and 36.6:43.5, respectively. Conclusions: According to these results, it may be expected that tumours with a VEGF/MIB-1 ratio of 1:6 or less prior to RCX will respond to this therapy. [Copyright &y& Elsevier]

Published
2002
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43. Autorenverzeichnis

Author

Bruch, H.-P., Trentz, O., Ackermann, R., Bartels, M., Bartsch, D.K., Bauer, M., Becker, H., Becker, T., Benz, S.R., Beyersdorf, F., Biemer, E., Birrer, S., Birth, M., Born, G., Broelsch, C.E., Broll, R., Büchler, M.W., Buhr, H.-J., Bühren, V., Burg, D., Bürk, C., Debus, S., Drücke, D., Eder, F., Fahlke, J., Farthmann, E.H., Frank, J., Frilling, A., Frühauf, N.R., Gaab, M.R., Goretzki, P.E., Gradinger, R., Grimm, M.-O., Heidecke, C.D., Heinzelmann, M., Hepp, W., Hildebrand, P., Hirner, A., Hoffmann, J., Hohenberger, W., Hohlbach, G., Holzinger, F., Hopt, U.T., Hünerbein, M., Izbicki, J.R., Jauch, K.-W., Joppich, I., Kania, U., Kauffmann, G., Keel, M., Keller, R., Kellnar, S., Kersting, S., Klempnauer, J., Klipstein, A., König, S., Kroesen, A.J., Kubler, N., Kujath, P., Kutup, A., Lammers, B.J., Larsen, R., Lewejohann, J.-C., Lippert, H., Malagó, M., Markus, P.M., Marzi, I., Meyer, V.E., Michel, B., Mirow, L., Muhl, E., Müller, G., Neugebauer, E., Nies, C., Piek, J., Post, S., Pross, M., Rechl, H., Reichart, B., Reuther, J.F., Richter, G.M., Rothmund, M., Saeger, H.D., Schenkengel, J.-P., Schiedeck, T., Schlag, M., Schmoeckel, M., Schwandner, O., Simon, D., Steinau, H.-U., Stier, A., Thetter, O., Thiede, A., Uhl, W., Wanner, G., Weder, W., Weißauer, W., Wilhelm, A., Z'graggen, K., and Zimmermann, A.

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