Search

Purpose: The present study aims to assess and compare the effects of carvedilol and terazosin plus enalapril on lower urinary tract symptoms (LUTS), the urine flow, and blood pressure (BP) in patients with moderate hypertension (HTN) and benign prostatic hyperplasia (BPH).Materials and Methods: In this randomized crossover trial, a total of 40 men with HTN and LUTS symptoms were enrolled. The first group was treated with carvedilol, and the second one received terazosin plus enalapril. After eight weeks of treatment, the patients experienced a one-month washout period, and the treatments changed and continued for eight weeks. To diagnose BPH in the study, the international prostate symptom score (IPSS) questionnaire was used. Moreover, the prostate-specific antigen (PSA), the post-void residual (PVR) urine volume, and the maximum urinary flow rate (Q-max using the uroflowmetry test) were measured.Results: Effect assessment results in this crossover trial illustrated neither carryover effects nor significant treatment effects on all primary outcomes (P > 0.05). Moreover, the results for the period effect indicated a significant reduction in BP (systolic and diastolic), PVR, and IPSS, yet a significant raise in Qmax.Conclusion: The effects of carvedilol are similar to those of the combination of terazosin and enalapril in patients with moderate HTN and BPH in controlling LUTS. Carvedilol could be used as an appropriative drug in patients with moderate HTN and cardiac problems with LUTS of BPH. Further studies are recommended to be conducted to investigate and compare the efficacy of carvedilol with that of other alpha-blockers with a larger sample size and over a longer period of time. [ABSTRACT FROM AUTHOR]

Objective: To investigate the hypothesis that extracorporeal shock wave lithotripsy (ESWL) increases the risk of new onset diabetes mellitus (DM) or significant changes in fasting blood sugar (FBS). Materials and Methods: A total number of 307 patients enrolled in this study. All of them had undergone ESWL for kidney stone from 1991 to 1994. In 2009, after 15-19 years, we invited patients to check their blood sugar. Results: There were 307 patients, 19.8% females, and 80.1% males. The mean age of the patients was 44 for females and 42 years for males. 47.5% had kidney stone in the left side, 42.9% in the right side and 9.4% bilateral. The mean FBS increasing was 11.86 g/dl. It was 14.54 g/dl for the right side, 8.57 g/dl for left and 16.24 g/dl for bilateral ESWL. Discussions: The increasing of FBS is more significant in shock wave intensities higher than 15.5 KV. And there wasn't any significant relationship between age, sex, body mass index (BMI) and total number of shock waves with increasing of FBS. ESWL treatment might associate with increasing FBS without any relation to age, sex and BMI. [ABSTRACT FROM AUTHOR]

Background and Objectives:Radical Nephrectomy (RN) is a standard treatment modality for localized Renal Cell Carcinoma (RCC), and recently laparoscopic RN is coming popular for RCC treatment. The advantages of retroperitoneal laparoscopy to the intraperitoneal approach include less visceral and vascular injury, easier access to renal vessels and no peritoneal seeding. Accordingly that in our country intraperitoneal approach is known as a common option, we decided to report our experience in retroperitoneal laparoscopic RN in these patients. Materials and Methods: In this retrospective study, 12 patients (6 male and 6 female) with 3-11 cm renal masses who were hospitalized from 2008 to 2012, underwent the retroperitoneal laparoscopic RN with hand assisted intact kidney removal by Gibson incision, assessed for local recurrence, perioperative hemorrhage and other postoperative complications. Results: Mean operation time was 193 ± 32 min with during operation blood loss of 162 ± 48 ml. Post operation hospital stay was 2-5 days. Conversion to open surgery was not required. There was no blood transfusion during and post operation. No major complication occurred. At mean 47.5 ± 18 months fallow up local recurrence was not seen. Conclusion: Retroperitoneal laparoscopic RN has become safe, simplified and effective although not easy. Complications, blood loss, hospital stay and convalescence times are low, therefore this approach is a good option for selected case of renal mass. [ABSTRACT FROM AUTHOR]

Background and Objectives: Renal Failure (RF) is considered as a major cause of morbidity and mortality worldwide. Kidney transplantation remains the most appropriate therapeutic option in these patients. The allograft kidney is required to be washed in order to prevent thrombosis. The collected fluid form renal vein and ureter could be indicative of the kidney condition. The aim of this study was to evaluate the differences between the collected fluid from ureter and renal vein regarding the temperature, PH and specific gravity of the irrigation fluid at two different irrigation volumes of less and more than 500 mL. Materials and Methods: In a descriptive cross-sectional study, all renal transplantation patients. After the allograft, kidneys being harvested from the donors, they were irrigated via renal artery; collected fluid form renal vein and ureter was evaluated regarding temperature, PH and Specific Gravity SG at two different irrigation volumes of less and more than 500 mL. Results: Twenty one subjects (11males, 10females) with a mean age of 34.23±11.86 years were studied. There were no significant relations between the irrigation fluid volume and temperature and also between irrigation fluid volume and PH of the collected fluid from ureter and renal vein (P=0.57 and P=0.56, respect). The SG of the collected fluid from ureter and renal vein had significant relation with the irrigation fluid volume (P=0.04). Conclusion: There was non-significant relation between the temperature and PH of irrigation fluid and collected fluid. [ABSTRACT FROM AUTHOR]

The article reports on research which was conducted to investigate the association between opium consumption and serum prostate-specific antigen (PSA). Researchers evaluated 438 opium addicted men. They found that opium consumption is independently and negatively associated with serum total PSA, free PSA and the percentage of free PSA levels.