Search

Your search keyword '"Farrugia G"' showing total 761 results
Start Over Author "Farrugia G"
761 results on '"Farrugia G"'

5. Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis

Author

Hasler, W. L., May, K. P., Wilson, L. A., Van Natta, M., Parkman, H. P., Pasricha, P. J., Koch, K. L., Abell, T. L., McCallum, R. W., Nguyen, L. A., Snape, W. J., Sarosiek, I., Clarke, J. O., Farrugia, G., Calles‐Escandon, J., Grover, M., Tonascia, J., Lee, L. A., Miriel, L., Hamilton, F. A., Kim, Yale, Ullah, Nighat, DeVole, Nata, Greene, Mary, Lee, Candice, Ponsetto, Courtney, Shetler, Katerina, Kantor, Steven, Lytes, Vanessa, Palit, Amiya, Simmons, Kellie, Hejazi, Reza, Roeser, Kathy, Vasquez, Denise, Vega, Natalia, Beatty, Karen, Hatter, Lisa, Howard, Ronna, Nowotny, Lindsay, Tang, Shou, Amin, Om S, Henry, Olivia, Kedar, Archana, McNair, Valerie, Pruett, Susanne, Smith, Margaret, Spree, Danielle, Castle, Michelle, Coleski, Radoslav, Wootten, Sophanara, Baxter, Lynn, Brown, Anya, Culler, Samantha, Hooker, Judy, Stuart, Paula, Bernard, Cheryl, Lurken, Matthew, Serrano, Jose, James, Steven, Torrance, Rebecca, Van Raaphorst, Rebekah, Belt, Patricia, Hallinan, Erin Corless, Colvin, Ryan, Donithan, Michele, Green, Mika, Isaacson, Milana, Kim, Wana, Sternberg, Alice, Vaughn, Ivana, and Yates, Katherine

Published
2018
Full Text
View/download PDF

14. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

Author

Eijsbouts, C, Zheng, T, Kennedy, NA, Bonfiglio, F, Anderson, CA, Moutsianas, L, Holliday, J, Shi, J, Shringarpure, S, 23andMe Research Team, Voda, A-I, Bellygenes Initiative, Farrugia, G, Franke, A, Hübenthal, M, Abecasis, G, Zawistowski, M, Skogholt, AH, Ness-Jensen, E, Hveem, K, Esko, T, Teder-Laving, M, Zhernakova, A, Camilleri, M, Boeckxstaens, G, Whorwell, PJ, Spiller, R, McVean, G, D'Amato, M, Jostins, L, Parkes, M, Eijsbouts, C, Zheng, T, Kennedy, NA, Bonfiglio, F, Anderson, CA, Moutsianas, L, Holliday, J, Shi, J, Shringarpure, S, 23andMe Research Team, Voda, A-I, Bellygenes Initiative, Farrugia, G, Franke, A, Hübenthal, M, Abecasis, G, Zawistowski, M, Skogholt, AH, Ness-Jensen, E, Hveem, K, Esko, T, Teder-Laving, M, Zhernakova, A, Camilleri, M, Boeckxstaens, G, Whorwell, PJ, Spiller, R, McVean, G, D'Amato, M, Jostins, L, and Parkes, M

Abstract

Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain-gut interactions underlying IBS.

Published
2021

24. Mapping the Cellular Landscape of the Diabetic Heart

Author

Cohen, C., primary, De Blasio, M., additional, Farrugia, G., additional, Dona, M., additional, Hsu, I., additional, Prakoso, D., additional, Krstevski, C., additional, Nash, D., additional, Li, M., additional, Drummond, G., additional, Ritchie, R., additional, and Pinto, A., additional

Published
2021
Full Text
View/download PDF

28. Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture

Author

Rich, Adam, Miller, Steven M., Gibbons, Simon J., Malysz, John, Szurszewski, Joseph H., and Farrugia, G.

Subjects
Immunocytochemistry -- Research, Cellular signal transduction -- Physiological aspects, Digestive organs -- Physiological aspects, Proteolysis -- Physiological aspects, Immunity -- Physiological aspects, Biological sciences
Abstract

The binding of Steel factor (SF) to c-kit initiates a signaling pathway essential for development and maintenance of interstitial cells of Cajal (ICC). Soluble and membrane-bound isoforms of SF are expressed in the gastrointestinal tract, but the role for either isoform in supporting ICC development is unknown. The aim of this study was to determine the role of SF in supporting ICC in culture. ICC were cultured from dissociated mouse jejunum and grown with fibroblast cell lines that produced either soluble, membrane-bound or membrane-restricted SF. ICC were identified and counted by c-kit immunoreactivity. The number of c-kit immunoreactive cells was greater in the coculture system compared with cultures grown without SF-producing fibroblasts. All forms of SF-producing fibroblasts increased ICC number in culture but physical separation of the fibroblasts from the c-kit immunoreactive cells, the addition of exogenous SF to the culture medium, or fibroblast-conditioned media did not. These results are consistent with the hypothesis that the membranebound form of SF preferentially contributes to expression of c-kit-positive ICC under cell culture conditions. immunocytochemistry; gastrointestinal pacemaker; Steelfactor proteolysis

Published
2003

29. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. (Motility and Visceral Sensation)

Author

Lyford, G.L., He, C-L, Soffer, E., Hull, T.L., Strong, S.A., Senagore, A.J., Burgart, L.J., Young-Fadok, T., Szurszewski, J.H., and Farrugia, G.

Subjects
Medical tests -- Analysis -- Case studies -- Health aspects, Colon cancer -- Case studies -- Care and treatment -- Research -- Analysis -- Health aspects, Cancer patients -- Medical examination -- Health aspects -- Case studies -- Care and treatment -- Analysis, Cancer cells -- Research -- Case studies -- Health aspects -- Analysis, Constipation -- Case studies -- Care and treatment -- Research -- Analysis -- Health aspects, Health, Care and treatment, Analysis, Medical examination, Research, Case studies, Health aspects
Abstract

Background: Interstitial cells of Cajal (ICC] are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow [...]

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results