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1. Drug-resistant tuberculosis among foreign-born persons in Italy

Author

Fattorini, L, Mustazzolu, A, Piccaro, G, Pardini, M, Filippini, P, Giannoni, F, Migliori, Gb, Sotgiu, G, Borroni, E, Cirillo, Dm, Piersimoni, C, Lorenzetti, P, Costa, D, Grimaldi, A, Arosio, M, Goglio, A, Mazza, C, Squintani, L, Larcher, C, Frizzera, E, Pinsi, G, Caddeu, R, Farris, Ag, Di Naso, C, Cavalcanti, P, Tomei, G, Mantini, G, Tortoli, E, Simonetti, Mt, di Taranto, A, Senno, E, Nisticò, S, Colonna, C, Buono, L, Mazzola, E, Gesu, G, Cichero, P, Lombardi, A, Fabio, A, Santoro, G, Molinari, Gl, Camaggi, A, Chirillo, Mg, Peracchi, M, Fallico, L, Marone, P, Bono, L, Mazzolla, R, Tiecco, C, Chiaradonna, P, Tronci, M, Altieri, Am, Bordi, E, De Mori, P, Di Caro, A, Libanori, E, De Lorenzo, S, Milano, R, Mondo, A, Barbui, A, Centis, R, D'Ambrosio, L, Spanevello, Antonio, Caola, I, Fabris, C, Screm, Mc, and Scarparo, C.

Subjects
Adult, Male, Italy, Residence Characteristics, Communicable Disease Control, Tuberculosis, Multidrug-Resistant, Prevalence, Emigrants and Immigrants, Humans, Female, Middle Aged, Aged
Published
2012

2. Proficiency testing of first- and second-line anti-tuberculosis drugs in Italy

Author

Fattorini, L, Migliori, Gb, Cassone, A, Mustazzolu, A, Piccaro, G, Filippini, P, Cirillo, Dm, Borroni, E, Piersimoni, C, Costa, D, Grimaldi, A, De Santis, A, Arosio, M, Goglio, A, Mazza, C, Squintani, L, Di Pede, B, Gaspari, G, Marchetti, D, Nanetti, A, Larcher, C, Frizzera, E, Rizza, F, Pinsi, G, Turano, A, Caddeu, R, Farris, Ag, Di Naso, C, Cavalcanti, P, Tomei, G, Mantini, G, Ceruti, T, Ferrari, L, Rossi, Mr, Tortoli, E, Montini, G, Senno, E, Nisticò, S, Colonna, C, Buono, L, Mazzola, E, Gesu, G, Penati, V, Vaccarino, P, Piana, F, Cichero, P, Lombardi, A, Mantovani, G, Fabio, A, Bertoli, G, Rumpianesi, F, Santoro, G, Molinari, Gl, Camaggi, A, Chirillo, Mg, Peracchi, M, Fallico, L, Menozzi, M, Dettori, G, Marone, P, Bono, L, Matteo, S, Mazzolla, R, Sposini, T, Tiecco, C, Barbaro, A, Vecchia, L, Piscina, A, Chiaradonna, P, Tronci, M, Bordi, E, De Mori, P, Diamare, F, Libanori, E, Panaiota, T, Milano, R, Mondo, A, Barbui, A, Fabbro, L, Centis, R, D'Ambrosio, L, Spanevello, Antonio, Caola, I, Mottola, A, Fabris, C, Scagnelli, M, Screm, Mc, and Scarparo, C.

Subjects
Pulmonary and Respiratory Medicine, Treatment Outcome, Italy, Tuberculosis, Multidrug-Resistant, Antitubercular Agents, Humans, Tuberculosis, Mycobacterium tuberculosis, Pulmonary, Multidrug-Resistant, Tuberculosis, Pulmonary, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Published
2012

3. Surveillance of anti-tuberculosis drug resistance: Results of the 1998/1999 proficiency testing in Italy

Author

Migliori GB, Ambrosetti M, Fattorini L, Penati V, Vaccarino P, Besozzi G, Ortona L, Saltini C, Orefici G, Moro ML, Iona E, Cassone A, De Santis A, Giorgio V, Vinciguerra P, Angarano G, Petrozzi L, Costa D, Gozzellino F, Perboni A, Marchetti D, Pascali A, Falcone F, Mariano V, Rizza F, Pretto P, Turano A, Matteelli A, Carosi GP, Tedoldi S, Pinsi G, Farris AG, Ligia GP, Orani G, Farris B, Foschi C, Trucco G, Aiolfi S, Ceruti T, Parpanesi M, Calabro S, Felisatti G, Tortoli E, Nutini S, Montini G, Fiorentini F, D'Ambrosio V, Ceraminiello A, Bernorio S, Buono L, Montesano P, Vinci E, Sabato E, Gamba S, Crepaldi P, Bertoli G, Rupianesi F, Losi M, Richeldi L, Ferrara G, Muccio E, Napolitano G, Molinari GL, Saini L, Garzone A, Vertuccio C, Marcias, Menozzi, Marone P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M.B., Bistoni, Sposini, Colorizio, Confalonieri M, Bottrighi P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Le Donne, Farinelli, Mancini, Ermeti, Migliori, Gb, Ambrosetti, M, Fattorini, L, Penati, V, Vaccarino, P, Besozzi, G, Ortona, L, Saltini, C, Orefici, G, Moro, Ml, Iona, E, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, A, Matteelli, A, Carosi, Gp, Tedoldi, S, Pinsi, G, Farris, Ag, Ligia, Gp, Orani, G, Farris, B, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, S, Montini, G, Fiorentini, F, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Crepaldi, P, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Muccio, E, Napolitano, G, Molinari, Gl, Saini, L, Garzone, A, Vertuccio, C, Marcias, Menozzi, Marone, P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M., B., Bistoni, Sposini, Colorizio, Confalonieri, M, Bottrighi, P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Le, Donne, Farinelli, Mancini, and Ermeti

Subjects
Tuberculosi, Drug susceptibility testing, Proficiency testing
Published
2000

4. Surveillance of anti-tuberculosis drug resistance: Results of the 1998/1999 proficiency testing in Italy

Author

Migliori, Gb, Ambrosetti, M, Fattorini, L, Penati, V, Vaccarino, P, Besozzi, G, Ortona, L, Saltini, C, Orefici, G, Moro, Ml, Iona, E, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, A, Matteelli, A, Carosi, Gp, Tedoldi, S, Pinsi, G, Farris, Ag, Ligia, Gp, Orani, G, Farris, B, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, S, Montini, G, Fiorentini, F, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Crepaldi, P, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Muccio, E, Napolitano, G, Molinari, Gl, Saini, L, Garzone, A, Vertuccio, C, Marcias, Menozzi, Marone, P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M. B., Bistoni, Sposini, Colorizio, Confalonieri, M, Bottrighi, P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Donne, Le, Farinelli, Mancini, and Ermeti

Subjects
Drug susceptibility testing, Tuberculosis, Proficiency testing
Published
2000

5. Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand.

Author

Terry GE, Liow JS, Zoghbi SS, Hirvonen J, Farris AG, Lerner A, Tauscher JT, Schaus JM, Phebus L, Felder CC, Morse CL, Hong JS, Pike VW, Halldin C, and Innis RB

Subjects
Adult, Computer Simulation, Female, Humans, Kinetics, Magnetic Resonance Imaging, Male, Models, Neurological, Positron-Emission Tomography, Reproducibility of Results, Brain diagnostic imaging, Brain metabolism, Pyrrolidinones blood, Pyrrolidinones pharmacokinetics, Receptor, Cannabinoid, CB1 agonists, Receptor, Cannabinoid, CB1 metabolism
Abstract

[11C]MePPEP is a high affinity, CB1 receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [11C]MePPEP to quantify CB1 receptors in human brain as distribution volume calculated with the "gold standard" method of compartmental modeling and compared results with the simple measure of brain uptake. A total of 17 healthy subjects participated in 26 positron emission tomography (PET) scans, with 8 having two PET scans to assess retest variability. After injection of [11C]MePPEP, brain uptake of radioactivity was high (e.g., 3.6 SUV in putamen at approximately 60 min) and washed out very slowly. A two-tissue compartment model yielded values of distribution volume (which is proportional to receptor density) that were both well identified (SE 5%) and stable between 60 and 210 min. The simple measure of brain uptake (average concentration of radioactivity between 40 and 80 min) had good retest variability ( approximately 8%) and moderate intersubject variability (16%, coefficient of variation). In contrast, distribution volume had two-fold greater retest variability ( approximately 15%) and, thus, less precision. In addition, distribution volume had three-fold greater intersubject variability ( approximately 52%). The decreased precision of distribution volume compared to brain uptake was likely due to the slow washout of radioactivity from brain and to noise in measurements of the low concentrations of [11C]MePPEP in plasma. These results suggest that brain uptake can be used for within subject studies (e.g., to measure receptor occupancy by medications) but that distribution volume remains the gold standard for accurate measurements between groups.

Published
2009
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6. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation.

Author

Fujita M, Imaizumi M, Zoghbi SS, Fujimura Y, Farris AG, Suhara T, Hong J, Pike VW, and Innis RB

Subjects
Adult, Biomarkers, Biotransformation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Statistical, Monte Carlo Method, Positron-Emission Tomography, Pyrimidines adverse effects, Radiopharmaceuticals adverse effects, Reproducibility of Results, Inflammation diagnostic imaging, Inflammation metabolism, Peripheral Nerves diagnostic imaging, Peripheral Nerves metabolism, Pyrimidines pharmacokinetics, Radiopharmaceuticals pharmacokinetics, Receptors, GABA-A drug effects
Abstract

The peripheral benzodiazepine receptor (PBR) is upregulated on activated microglia and macrophages and thereby is a useful biomarker of inflammation. We developed a novel PET radioligand, [(11)C]PBR28, that was able to image and quantify PBRs in healthy monkeys and in a rat model of stroke. The objective of this study was to evaluate the ability of [(11)C]PBR28 to quantify PBRs in brain of healthy human subjects. Twelve subjects had PET scans of 120 to 180 min duration as well as serial sampling of arterial plasma to measure the concentration of unchanged parent radioligand. One- and two-tissue compartmental analyses were performed. To obtain stable estimates of distribution volume, which is a summation of B(max)/K(D) and nondisplaceable activity, 90 min of brain imaging was required. Distribution volumes in human were only approximately 5% of those in monkey. This comparatively low amount of receptor binding required a two-rather than a one-compartment model, suggesting that nonspecific binding was a sizeable percentage compared to specific binding. The time-activity curves in two of the twelve subjects appeared as if they had no PBR binding-i.e., rapid peak of uptake and fast washout from brain. The cause(s) of these unusual findings are unknown, but both subjects were also found to lack binding to PBRs in peripheral organs such as lung and kidney. In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs.

Published
2008
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7. [Piperacillin: comparison of antibacterial activity in vitro during the triennium 1986-88 versus the biennium 1981-82].

Author

Farris AG and Goffi MB

Subjects
Anti-Bacterial Agents pharmacology, Bacteria isolation & purification, Cross Infection microbiology, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Humans, Microbial Sensitivity Tests, Bacteria drug effects, Piperacillin pharmacology
Abstract

The antibacterial activity in vitro of piperacillin on strains commonly isolated in hospital practice in 1986-88 was compared with that obtained for piperacillin from 1981 to 1982 and with the activity of other antibiotics usually employed. Piperacillin showed a good antibacterial activity on Gram-positive and Gram-negative strains, while few resistant strains were found.

Published
1992

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