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1,026 results on '"Farrell, Michael J."'

26. The Phantom Kicks Survey: Subjective Experiences of Foetal Kicks During and After Pregnancy

Author

Sasan, Disha, Ward, Phillip GD, Nash, Meredith, Orchard, Edwina R, Farrell, Michael J, Hohwy, Jakob, and Jamadar, Sharna D

Subjects
fetal kicks, phantom, phantom limb, pregnancy, proprioception, maternity, maternal mental health, phantom kicks
Abstract

During pregnancy, a woman will attribute increased abdominal sensations to foetal movement. Surprisingly, many women report anecdotallythat they feel kick-like sensations long after the pregnancy. However, this experience had never been reported in the scientific literature. We designed this survey to obtain a first impression of how common these subjective experiences of phantom kicks are in the Australian community. Results are reported in: Sasan et al. (2021). “Phantom Kicks: Women’s subjective experience of fetal kicks after the postpartum period. Journal of Women’s Health, 30 (1), 36-44. http://doi.org/10.1089/jwh.2019.8191 Please cite the above paper and this listing in Zenodo when using this material. Sasan et al. (2021). “Phantom Kicks: Women’s subjective experience of fetal kicks after the postpartum period. Journal of Women’s Health, 30 (1), 36-44. http://doi.org/10.1089/jwh.2019.8191 Sasan, Ward, Nash, Orchard, Farrell, Hohwy, Jamadar (2021). The phantom kicks survey: Subjective experiences of foetal kicks during and after pregnancy. Zenodo doi:10.5281/zenodo.5595552 &nbsp

Published
2021
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28. RECENT DEVELOPMENTS IN MEDICINE AND LAW

Author

Wojtylak, Melissa A., Bartholomew, Kenneth C., Bell, Peter A., Farrell, Michael J., Ferrell, Melissa K., Ganci, Amy, Horne, Nathan R., Jones, Christina M., King, Raymund C., Lynch, Peter J., McMenamin, Joseph P., Turner, Cameron D., and White, Tamela J.

Published
2004

35. Discussion

Author

Farrell, Michael J.

Published
1960

39. The relationship between medical comorbidity and self-rated pain, mood disturbance, and function in older people with chronic pain

Author

Leong, Ian Y., Farrell, Michael J., Helme, Robert D., and Gibson, Stephen J.

Subjects
Aging -- Physiological aspects, Aging -- Health aspects, Chronic pain -- Evaluation, Comorbidity -- Observations, Frail elderly -- Psychological aspects, Health, Seniors
Abstract

Background. Aging is associated with greater risk for many illnesses and the prospect of multiple, concurrent disease states. Chronic pain is also very common in advanced age, and there is likely to be a relationship with comorbid burden, but few studies have examined this issue. This study tests the hypothesis that comorbid burden is associated with greater levels of self-reported pain and associated disturbance in mood and function. Methods. Psychometric and medical data were collected from 562 patients (mean age = 76.3 years) attending a geriatric pain clinic. The number of categories endorsed on the Cumulative Illness Rating Scale (CIRS) score was used to measure accumulated comorbid burden. These groups were tested for differences in the severity of self-reported pain. The predictive capacity of comorbid burden for explaining variance in mood disturbance and functional disability was assessed after controlling for any differences in age and severity of pain. Results. Over 50% of the sample had three or more comorbid problems. Groups with greater levels of comorbidity scored higher on the Present Pain Intensity Index, the sensory and affective subscales of the McGill Pain Questionnaire. Multiple regression analysis showed that the CIRS score explained a significant proportion of the variance in scores on the Geriatric Depression Scale (4.1%), Human Activities Profile (4.8%), and the physical domain of the Sickness Impact Profile (5.9%). Conclusion. Greater levels of comorbidity are associated with reports of more severe pain, more depressive symptoms, reduced activity levels, and higher physical impact from pain.

Published
2007

50. Double-Stranded RNA Injection Produces Null Phenotypes in Zebrafish

Author

Li, Yin-Xiong, Farrell, Michael J., Liu, Ruiping, Mohanty, Nita, and Kirby, Margaret L.

Subjects
Developmental genetics -- Research, Embryology -- Research, Biological sciences
Abstract

Zebrafish is a simple vertebrate that has many attributes that make it ideal for the study of developmental genetics. One feature that has been lacking in this model system is the ability to disable specifically targeted genes. Recently, double-stranded RNA has been used to silence gene expression in the nematode Caenorhabditis elegans. We have found that expression of the green fluorescent protein (GFP) from a microinjected plasmid vector can be suppressed in zebrafish embryos by the coinjection of a double-stranded RNA that is specifically targeted to GFP. To determine that double-stranded RNA can attenuate endogenous gene expression, single-cell zebrafish embryos were injected with double-stranded RNA specifically targeted to Zf-T and Pax6.1. We found that microinjection of double-stranded Zf-T RNA resulted in a high incidence of a phenotype similar to that of ntl. Furthermore, Zf-T gene expression could not be detected by in situ hybridization and the message was decreased by 75% by semiquantitative RT-PCR in 12-h embryos that had been injected with the double-stranded RNA. Expression of the zebrafish genes sonic hedgehog and floating head was altered in the embryos microinjected with the Zf-T double-stranded RNA in a manner that is remarkably similar to the zebrafish no-tail mutant. Microinjection of double-stranded RNA targeted to Pax6.1 was associated with depressed expression of Pax6.1 and resulted in absent or greatly reduced eye and forebrain development, similar to the phenotype seen in mouse mutants. Simultaneous injection of Pax6.1 and Zf-T resulted in embryos lacking notochords, eyes, and brain structures.

Published
2000

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