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10. Screening of specific aptamers for Bacillus cereus by Surface Plasmon Resonance imaging (SPRi)

Author

Manceau, Mathilde, Farre, Carole, Lagarde, Florence, Mathey, Raphaël, Buhot, Arnaud, Vidic, Jasmina, Hou, Yanxia, Chaix, Carole, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Interfaces & biosensors - Interfaces & biocapteurs, Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Chimie pour la Reconnaissance et l’Etude d’Assemblages Biologiques (CREAB ), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CNRS, ANR-21-CE21-0009,Siena,Tests sensibles exploitant la reconnaissance de peptides et aptamères pour une détection sur site de cellules et spores bactériens dans le lait et la viande(2021), CHAIX, Carole, and Tests sensibles exploitant la reconnaissance de peptides et aptamères pour une détection sur site de cellules et spores bactériens dans le lait et la viande - - Siena2021 - ANR-21-CE21-0009 - AAPG2021 - VALID

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [CHIM] Chemical Sciences, [CHIM]Chemical Sciences
Abstract

International audience; Bacillus cereus is a food poisoning bacterium present in dairy products. To detect it, antibody based biosensors are efficient but available antibodies are expensive and may cross-react with other Bacillus species. Aptamers are a good alternative to these issues. Herein, seven aptamer sequences derived from the literature (1,2) are compared and their specificity to B. cereus is assessed versus Escherichia coli and Bacillus subtilis by Surface Plasmon Resonance imaging (SPRi).

Published
2023

11. Looking at dynamic mRNA-miRNA interactions by 19F-NMR spectroscopy

Author

Troussicot, Laura, Mestdach, Emeline, Schlagnitweit, Judith, Farre, Carole, Chaix, Carole, Salmon, Loïc, INTERACT - Interactions biomoléculaires, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Interfaces & biosensors - Interfaces & biocapteurs, Centre de RMN à très hauts champs de Lyon (CRMN), and École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
microRNA, [CHIM]Chemical Sciences, NMR
Abstract

International audience

Published
2022

12. Etude d’aptamères spécifiques à Bacillus cereus par résonance plasmonique de surface

Author

Manceau, Mathilde, Golobciuc, Cristina Virginia, FARRE, carole, Lagarde, Florence, Hou-Broutin, Yanxia, Vidic, Jasmina, Bala, Camelia, Chaix, Carole, Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie pour la Reconnaissance et l’Etude d’Assemblages Biologiques (CREAB ), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Analytical Chemistry, University of Bucharest (UniBuc), ANR-21-CE21-0009,Siena,Tests sensibles exploitant la reconnaissance de peptides et aptamères pour une détection sur site de cellules et spores bactériens dans le lait et la viande(2021), CHAIX, Carole, and Tests sensibles exploitant la reconnaissance de peptides et aptamères pour une détection sur site de cellules et spores bactériens dans le lait et la viande - - Siena2021 - ANR-21-CE21-0009 - AAPG2021 - VALID

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences
Abstract

International audience

Published
2022

15. Multi-functionalized silica nanoparticles to improve the sensitivity of diagnostic assays

Author

Chaix, Carole, Farre, Carole, Manzano, Marisa, Vidic, Jasmina, Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université d'Udine, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Bussy, Agnès

Subjects
[SDV] Life Sciences [q-bio], InformationSystems_GENERAL, GeneralLiterature_INTRODUCTORYANDSURVEY, ComputerApplications_MISCELLANEOUS, [SDV]Life Sciences [q-bio], [CHIM] Chemical Sciences, diagnostic assays, [CHIM]Chemical Sciences, nanoparticles, ComputingMilieux_MISCELLANEOUS, GeneralLiterature_MISCELLANEOUS
Abstract

Keynote invitée; International audience

Published
2021

23. Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing

Author

Consejo Superior de Investigaciones Científicas (España), Université de Lyon, Agence Nationale de la Recherche (France), Bourquard, Florent, Bleu, Yannick, Loir, Anne-Sophie, Caja-Munoz, Borja, Ávila, José, Asensio, María C., Raimondi, Gaëtan, Shokouhi, Maryam, Rassas, Ilhem, Farre, Carole, Chaix, Carole, Barnier, Vincent, Jaffrezic-Renault, Nicole, Garrelie, Florence, Donnet, Christophe, Consejo Superior de Investigaciones Científicas (España), Université de Lyon, Agence Nationale de la Recherche (France), Bourquard, Florent, Bleu, Yannick, Loir, Anne-Sophie, Caja-Munoz, Borja, Ávila, José, Asensio, María C., Raimondi, Gaëtan, Shokouhi, Maryam, Rassas, Ilhem, Farre, Carole, Chaix, Carole, Barnier, Vincent, Jaffrezic-Renault, Nicole, Garrelie, Florence, and Donnet, Christophe

Abstract

Graphene-based materials are widely studied to enable significant improvements in electroanalytical devices requiring new generations of robust, sensitive and low-cost electrodes. In this paper, we present a direct one-step route to synthetize a functional nitrogen-doped graphene film onto a Ni-covered silicon electrode substrate heated at high temperature, by pulsed laser deposition of carbon in the presence of a surrounding nitrogen atmosphere, with no post-deposition transfer of the film. With the ferrocene methanol system, the functionalized electrode exhibits excellent reversibility, close to the theoretical value of 59 mV, and very high sensitivity to hydrogen peroxide oxidation. Our electroanalytical results were correlated with the composition and nanoarchitecture of the N-doped graphene film containing 1.75 at % of nitrogen and identified as a few-layer defected and textured graphene film containing a balanced mixture of graphitic-N and pyrrolic-N chemical functions. The absence of nitrogen dopant in the graphene film considerably degraded some electroanalytical performances. Heat treatment extended beyond the high temperature graphene synthesis did not significantly improve any of the performances. This work contributes to a better understanding of the electrochemical mechanisms of doped graphene-based electrodes obtained by a direct and controlled synthesis process.

Published
2019

24. Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing

Author

Bourquard, Florent, primary, Bleu, Yannick, additional, Loir, Anne-Sophie, additional, Caja-Munoz, Borja, additional, Avila, José, additional, Asensio, Maria-Carmen, additional, Raimondi, Gaëtan, additional, Shokouhi, Maryam, additional, Rassas, Ilhem, additional, Farre, Carole, additional, Chaix, Carole, additional, Barnier, Vincent, additional, Jaffrezic-Renault, Nicole, additional, Garrelie, Florence, additional, and Donnet, Christophe, additional

Published
2019
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25. Biomimetic vesicles for electrochemical sensing

Author

Lebègue, Estelle, primary, Farre, Carole, additional, Jose, Catherine, additional, Saulnier, Joelle, additional, Lagarde, Florence, additional, Chevalier, Yves, additional, Chaix, Carole, additional, and Jaffrezic-Renault, Nicole, additional

Published
2018
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26. Combining culture and microbead‐based immunoassay for the early and generic detection of bacteria in platelet concentrates

Author

Vossier, Ludivine, primary, Valera, Lionel, additional, Leon, Fanny, additional, Roche, Stéphanie, additional, Piquer, Dominique, additional, Rubrecht, Laetitia, additional, Favier, Christine, additional, Cremer, Gaelle‐Anne, additional, Pouzet, Agnès, additional, Dagland, Typhaine, additional, Rihet, Stéphane, additional, Galea, Pascale, additional, Farre, Carole, additional, Bonnet, Romaric, additional, Jaffrézic‐Renault, Nicole, additional, Chaix, Carole, additional, Fareh, Jeannette, additional, and Fournier‐Wirth, Chantal, additional

Published
2018
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28. Highly labeled methylene blue-ds DNA silica nanoparticles for signal enhancement of immunoassays: application to the sensitive detection of bacteria in human platelet concentrates

Author

Bonnet, Romaric, primary, Farre, Carole, additional, Valera, Lionel, additional, Vossier, Ludivine, additional, Léon, Fanny, additional, Dagland, Typhaine, additional, Pouzet, Agnès, additional, Jaffrézic-Renault, Nicole, additional, Fareh, Jeannette, additional, Fournier-Wirth, Chantal, additional, and Chaix, Carole, additional

Published
2018
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29. Combining culture and microbead-based immunoassay for the early and generic detection of bacteria in platelet concentrates.

Author

Vossier, Ludivine, Valera, Lionel, Leon, Fanny, Roche, Stéphanie, Piquer, Dominique, Rubrecht, Laetitia, Favier, Christine, Cremer, Gaelle‐Anne, Pouzet, Agnès, Dagland, Typhaine, Rihet, Stéphane, Galea, Pascale, Farre, Carole, Bonnet, Romaric, Jaffrézic‐Renault, Nicole, Chaix, Carole, Fareh, Jeannette, Fournier‐Wirth, Chantal, Cremer, Gaelle-Anne, and Jaffrézic-Renault, Nicole

Subjects
BLOOD platelets, BACTERIAL diseases, IMMUNOGLOBULINS, PATHOGENIC microorganisms, ANTIBIOTICS, BACTERIA, COMPARATIVE studies, ESCHERICHIA coli, IMMUNOASSAY, KLEBSIELLA, RESEARCH methodology, MEDICAL cooperation, MONOCLONAL antibodies, PSEUDOMONAS, RESEARCH, RESEARCH funding, SERRATIA, EVALUATION research, GRAM-negative aerobic bacteria
Abstract

Background: Despite current preventive strategies, bacterial contamination of platelets is the highest residual infectious risk in transfusion. Bacteria can grow from an initial concentration of 0.03-0.3 colony-forming units (CFUs)/mL up to 108 to 109 CFUs/mL over the product shelf life. The aim of this study was to develop a cost-effective approach for an early, rapid, sensitive, and generic detection of bacteria in platelet concentrates.Study Design and Methods: A large panel of bacteria involved in transfusion reactions, including clinical isolates and reference strains, was established. Sampling was performed 24 hours after platelet spiking. After an optimized culture step for increasing bacterial growth, a microbead-based immunoassay allowed the generic detection of bacteria. Antibody production and immunoassay development took place exclusively with bacteria spiked in fresh platelet concentrates to improve the specificity of the test.Results: Antibodies for the generic detection of either gram-negative or gram-positive bacteria were selected for the microbead-based immunoassay. Our approach, combining the improved culture step with the immunoassay, allowed sensitive detection of 1 to 10 CFUs/mL for gram-negative and 1 to 102 CFUs/mL for gram-positive species.Conclusion: In this study, a new approach combining bacterial culture with immunoassay was developed for the generic and sensitive detection of bacteria in platelet concentrates. This efficient and easily automatable approach allows tested platelets to be used on Day 2 after collection and could represent an alternative strategy for reducing the risk of transfusion-transmitted bacterial infections. This strategy could be adapted for the detection of bacteria in other cellular products. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Comparaison de deux aptacapteurs pour la détection de la thrombine par spectroscopie d'impédance

Author

Meini, Nadir, Farre, Carole, Chaix, Carole, Kherrat, K., Dzyadevych, Sergei, Jaffrezic-Renault, Nicole, Université Badji Mokhtar - Annaba [Annaba] (UBMA), SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratory of Biomolecular Electrochemistry, and National Academy of Sciences of Ukraine (NASU)

Subjects
[CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

communication par affiche; International audience

Published
2012

34. Polythiol probes for sensitive detection of nucleic acids : Application to hepatitis C virus genotyping

Author

Chaix, Carole, Morvan, François, Lereau, Myriam, Farre, Carole, Mayen, Julie, Meyer, Albert, Cantaloube, Jean François, Vasseur, Jean-Jacques, Fournier-Wirth, Chantal, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Laboratoire de recherche, Etablissement Français du Sang Pyrénées-Méditerranée, and Bussy, Agnès

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

35. Development of sensitive probes for direct and labelless detection of nucleic acids by electrochemistry : Application to hepatitis C virus genotyping

Author

Chaix, Carole, Lereau, Myriam, Farre, Carole, Vasseur, Jean-Jacques, Morvan, F., Fournier-Wirth, Chantal, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de recherche, Etablissement Français du Sang Pyrénées-Méditerranée, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)

Subjects
[CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

36. Oligonucleotide solid-phaOligonucleotide solid-phase synthesis on fluorescent nanoparticles grafted on controlled pore glass

Author

Crozals, Gabriel De, Farre, Carole, Hantier, Grégoire, Léonard, Didier, Marquette, Christophe A., Mandon, Céline A., Marmuse, Laurence, Louis, Cédric, Toulmé, Jean-Jacques, Billotey, Claire, Janier, Marc, Chaix, Carole, Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Surfaces, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Centre National de la Recherche Scientifique (CNRS)-École Supérieure Chimie Physique Électronique de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Laboratoire Interdisciplinaire d'Etude des Nanoparticules Aérosolisées (LINA-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CIS

Subjects
[CHIM]Chemical Sciences, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Abstract

International audience; Oligonucleotide solid-phase synthesis is now possible on nano-sized particles, thanks to the use of controlled pore glass-nanoparticle assemblies. We succeeded in anchoring silica nanoparticles (NPs) inside the pores of micrometric glass via a reversible covalent binding. The pore diameter must be at least six times the diameter of the nanoparticle in order to maintain efficient synthesis of oligonucleotides in the synthesizer. We demonstrated that the pores protect NP anchoring during DNA synthesis without decreasing the coupling rate of the phosphoramidite synthons. This bottom-up strategy for NP functionalization with DNA results in unprecedented DNA loading efficiency. We also confirmed that the DNA synthesized on the nanoparticle surface was accessible for hybridization with its complementary DNA strand

Published
2012

37. Nouvelles sondes polythiol pour la détection ADN sur microsystème électrochimique

Author

Farre, Carole, Mayen, Julie, Lereau, Myriam, Meyer, Albert, Vasseur, Jean-Jacques, Cantaloube, Jean-François, Fournier-Wirth, Chantal, Morvan, François, Chaix, Carole, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Laboratoire de recherche, and Etablissement Français du Sang Pyrénées-Méditerranée

Subjects
[CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

communication par affiche; National audience

Published
2012

38. Electroadressage par chimie ' Click ' sur électrode d'or pour une détection sans marquage et multiplexée de biomolécules

Author

Ripert, Micaël, Farre, Carole, Meini, Nadir, Jaffrezic-Renault, Nicole, Chaix, Carole, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Université Badji Mokhtar - Annaba [Annaba] (UBMA)

Subjects
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Published
2012

39. Etude d'une stratégie d'électroadressage par chimie ' Click ' sur électrode d'or

Author

Ripert, Micaël, Farre, Carole, Chatelain, Grégory, Chaix, Carole, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Bussy, Agnès

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

communication par affiche; National audience

Published
2011

40. Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework

Author

Jiang, Mengjuan, primary, Braiek, Mohamed, additional, Florea, Anca, additional, Chrouda, Amani, additional, Farre, Carole, additional, Bonhomme, Anne, additional, Bessueille, Francois, additional, Vocanson, Francis, additional, Zhang, Aidong, additional, and Jaffrezic-Renault, Nicole, additional

Published
2015
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44. Development of Innovative and Versatile Polythiol Probes for Use on ELOSA or Electrochemical Biosensors: Application in Hepatitis C Virus Genotyping

Author

Lereau, Myriam, primary, Fournier-Wirth, Chantal, additional, Mayen, Julie, additional, Farre, Carole, additional, Meyer, Albert, additional, Dugas, Vincent, additional, Cantaloube, Jean-François, additional, Chaix, Carole, additional, Vasseur, Jean-Jacques, additional, and Morvan, François, additional

Published
2013
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45. Boron-doped Diamond Electrodes Modified with Fe3O4@Au Magnetic Nanocomposites as Sensitive Platform for Detection of a Cancer Biomarker, Interleukin-8.

Author

Braiek, Mohamed, Yang, Yi, Farre, Carole, Chaix, Carole, Bessueille, François, Baraket, Abdoullatif, Errachid, Abdelhamid, Zhang, Aidong, and Jaffrezic‐Renault, Nicole

Subjects
INTERLEUKIN-8, BIOSENSORS, GOLD nanoparticles, CYSTEAMINE, CYCLIC voltammetry, IMPEDANCE spectroscopy, FERROCYANIDES, FERRICYANIDES
Abstract

Interleukin-8 (IL-8), a dimeric protein composed of two identical subunits, is overexpressed in different human cancers, among them pancreatic cancers and head and neck cancers. There is a strong demand for monitoring of this biomarker protein for early cancer detection. A new concept of label-free impedimetric immunosensors for IL-8 detection is described in this work. A nanocomposite of gold nanoparticles (AuNPs) decorating a magnetic Fe3O4 core is synthesized using cysteamine as linker, and characterized using TEM and UV-Vis spectrometry. After immobilization of these Fe3O4@Au magnetic nanocomposites on a boron doped diamond (BDD) electrode using a simple magnet, anti-human IL-8 monoclonal antibody is linked to the AuNPs, previously functionalized with thioctic acid. The functionalization of the immunosensor was characterized using two electrochemical techniques: cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), performed in phosphate buffer with ferro/ferricyanide as the redox probe. The EIS technique was used for affinity assays: antibody-Antigen binding. A linear relationship between the increment in the electron transfer resistance (RCT) and the logarithmic value of IL-8 concentration was observed between 0.1 pg/mL and 1000 pg/mL. The limit of detection (LOD) was estimated at 0.03 pg/mL. [ABSTRACT FROM AUTHOR]

Published
2016
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46. Oligonucleotide solid-phase synthesis on fluorescent nanoparticles grafted on controlled pore glass

Author

Crozals, Gabriel De, primary, Farre, Carole, additional, Hantier, Grégoire, additional, Léonard, Didier, additional, Marquette, Christophe A., additional, Mandon, Céline A., additional, Marmuse, Laurence, additional, Louis, Cédric, additional, Toulmé, Jean-Jacques, additional, Billotey, Claire, additional, Janier, Marc, additional, and Chaix, Carole, additional

Published
2012
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50. Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

Author

Taiariol L, Chaix C, Farre C, and Moreau E

Subjects
Click Chemistry methods, Nanomedicine, Nanoparticles chemistry
Abstract

Over the years, click and bioorthogonal reactions have been the subject of considerable research efforts. These high-performance chemical reactions have been developed to meet requirements not often provided by the chemical reactions commonly used today in the biological environment, such as selectivity, rapid reaction rate, and biocompatibility. Click and bioorthogonal reactions have been attracting increasing attention in the biomedical field for the engineering of nanomedicines. In this review, we study a compilation of articles from 2014 to the present, using the terms "click chemistry and nanoparticles (NPs)" to highlight the application of this type of chemistry for applications involving NPs intended for biomedical applications. This study identifies the main strategies offered by click and bioorthogonal chemistry, with respect to passive and active targeting, for NP functionalization with specific and multiple properties for imaging and cancer therapy. In the final part, a novel and promising approach for "two step" targeting of NPs, called pretargeting (PT), is also discussed; the principle of this strategy as well as all the studies listed from 2014 to the present are presented in more detail.

Published
2022
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