Author: "Faroux, Roger" - Searchworks@Jio Institute Digital Library Search Results

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1. First-line chemotherapy with raltitrexed in metastatic colorectal cancer: an Association des Gastro-entérologues Oncologues (AGEO) multicentre study

Author: Gallois, Claire, Hafliger, Emilie, Auclin, Edouard, Perret, Audrey, Coutzac, Clélia, Turpin, Anthony, Pellat, Anna, Randrian, Violaine, Basile, Debora, Faroux, Roger, Pernot, Simon, Locher, Christophe, Hautefeuille, Vincent, Dubreuil, Olivier, Palmieri, Lola-Jade, Dior, Marie, Artru, Pascal, and Taieb, Julien
Published: 2022
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2. Nal-IRI/LV5-FU versus paclitaxel as second-line therapy in patients with metastatic esophageal squamous cell carcinoma (OESIRI)-PRODIGE 62: A multicentre, randomised, non-comparative phase II study

Author: Randrian, Violaine, Adenis, Antoine, Desrame, Jérôme, Barbier, Emilie, Di Fiore, Frédéric, Lièvre, Astrid, Dahan, Laetitia, Laurent-Puig, Pierre, Mineur, Laurent, Breysacher, Gilles, Roquin, Guillaume, Louafi, Samy, Lopez, Anthony, Louvet, Christophe, Borg, Christophe, Metges, Jean Philippe, Faroux, Roger, Gaba, Lila, Manfredi, Sylvain, and Tougeron, David
Published: 2020
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3. Pravastatin combination with sorafenib does not improve survival in advanced hepatocellular carcinoma

Author: Jouve, Jean-Louis, Lecomte, Thierry, Bouché, Olivier, Barbier, Emilie, Khemissa Akouz, Faiza, Riachi, Ghassan, Nguyen Khac, Eric, Ollivier-Hourmand, Isabelle, Debette-Gratien, Maryline, Faroux, Roger, Villing, Anne-Laure, Vergniol, Julien, Ramee, Jean-François, Bronowicki, Jean-Pierre, Seitz, Jean-François, Legoux, Jean-Louis, Denis, Jacques, Manfredi, Sylvain, and Phelip, Jean-Marc
Published: 2019
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4. Intérêts et limites de la recherche du déficit en dihydropyrimidine déshydrogénase dans le suivi des patients traités par fluoropyrimidines : résultats de deux enquêtes nationales de pratiques réalisées auprès des médecins et des biologistes

Author: Loriot, Marie-Anne, Masskouri, Fadil, Carni, Paolo, Le Malicot, Karine, Seitz, Jean-François, Michel, Pierre, Legoux, Jean-Louis, Bouché, Olivier, André, Thierry, Faroux, Roger, Delaloge, Suzette, Malka, David, Guigay, Joel, Thariat, Juliette, Thomas, Fabienne, Barin-Le-Guellec, Chantal, Ciccolini, Joseph, Boyer, Jean-Christophe, and Étienne-Grimaldi, Marie-Christine
Published: 2019
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5. First-Line LV5FU2 with or without Aflibercept in Patients with Non-Resectable Metastatic Colorectal Cancer: A Randomized Phase II Trial (PRODIGE 25-FFCD-FOLFA).

Author: Legoux, Jean-Louis, Faroux, Roger, Barrière, Nicolas, Le Malicot, Karine, Tougeron, David, Lorgis, Véronique, Guerin-Meyer, Véronique, Bourgeois, Vincent, Malka, David, Aparicio, Thomas, Baconnier, Matthieu, Lebrun-Ly, Valérie, Egreteau, Joëlle, Khemissa Akouz, Faïza, Terme, Magali, Lepage, Côme, and Boige, Valérie
Subjects: *THERAPEUTIC use of antineoplastic agents, *VASCULAR endothelial growth factors, *DRUG toxicity, *ANTINEOPLASTIC agents, *COLORECTAL cancer, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics, *METASTASIS, *CYTOTOXINS, *FOLINIC acid, *RESEARCH, *FLUOROURACIL, *DATA analysis software, *PROGRESSION-free survival
Abstract: Simple Summary: In this randomized phase II trial, which included 117 older patients with metastatic colorectal cancer receiving LV5FU2 regimen with or without aflibercept, the primary endpoint was 6-month progression-free survival (PFS). The clinical hypotheses expected a PFS rate at 6 months of over 40% (60% expected). It was 54.7% in both arms (90% CI 42.5–66.5 in both). Given the 6-month PFS, the study can be considered positive. However, the toxicity of aflibercept in this elderly population was high (grade ≥ 3 toxicity in 82% of patients versus 58.2% with LV5FU2 alone), and continuation of the trial into phase III is not envisaged. Fluropyrimidine monotherapy is an option for some patients with inoperable metastatic colorectal cancer. Unlike bevacizumab, the addition of aflibercept, an antibody acting as an anti-angiogenic agent, has never been evaluated in this context. The aim of the study was to determine whether aflibercept could increase the efficacy of fluoropyrimidine monotherapy without increasing toxicity. This multicenter phase II non-comparative trial evaluated the addition of aflibercept to infusional 5-fluorouracil/folinic acid (LV5FU2 regimen) as first-line treatment in patients unfit to receive doublet cytotoxic chemotherapy. The primary endpoint was 6-month progression-free survival (PFS). The clinical hypotheses expected a PFS rate at 6 months of over 40% (60% expected). A total of 117 patients, with a median age of 81 years, were included: 59 in arm A (LV5FU2-aflibercept) and 58 in arm B (LV5FU2 alone). Six-month PFS was 54.7% in both arms (90% CI 42.5–66.5 in both). Median overall survival was 21.8 months (arm A) and 25.1 months (arm B). Overall toxicity was more common in arm A: grade ≥ 3 toxicity in 82% versus 58.2%. Given the 6-month PFS, the study can be considered positive. However, the toxicity of aflibercept in this population was high, and continuation of the trial into phase III is not envisaged. [ABSTRACT FROM AUTHOR]
Published: 2024
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6. Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Author: Adenis, A., Alessio, A., Aouakli, A., Azzedine, A., Bedjaoui, A., Bidault, A., Blanchi, A., Botton, A., Cadier-Lagnes, A., Fatisse, A., Gagnaire, A., Gilbert, A., Gueye, A., Hollebecque, A., Lemaire, A., Mahamat, A., Marre, A., Patenotte, A., Rotenberg, A., Roussel, A., Thirot-Bidault, A., Votte, A., Weber, A., Zaanan, A., Dupont-Gossart, A.C., Villing, A.L., Queuniet, A.M., Coudert, B., Denis, B., Garcia, B., Lafforgue, B., Landi, B., Leduc, B., Linot, B., Paillot, B., Rhein, B., Winkfield, B., Barberis, C., Becht, C., Belletier, C., Berger, C., Bineau, C., Borel, C., Brezault, C., Buffet, C., Cornila, C., Couffon, C., De La Fouchardière, C., Giraud, C., Lecaille, C., Lepere, C., Lobry, C., Locher, C., Lombard-Bohas, C., Paoletti, C., Platini, C., Rebischung, C., Sarda, C., Vilain, C., Briac-Levaché, C., Auby, D., Baudet-Klepping, D., Bechade, D., Besson, D., Cleau, D., Festin, D., Gargot, D., Genet, D., Goldfain, D., Luet, D., Malka, D., Peré-Vergé, D., Pillon, D., Sevin-Robiche, D., Smith, D., Soubrane, D., Tougeron, D., Zylberait, D., Carola, E., Cuillerier, E., Dorval Danquechin, E., Echinard, E., Janssen, E., Maillard, E., Mitry, E., Norguet-Monnereau, E., Suc, E., Terrebonne, E., Zrihen, E., Pariente, E.A., Almaric, F., Audemar, F., Bonnetain, F., Desseigne, F., Dewaele, F., Di Fiore, F., Ghiringhelli, F., Husseini, F., Khemissa, F., Kikolski, F., Morvan, F., Petit-Laurent, F., Riot, F., Subtil, F., Zerouala-Boussaha, F., Caroli-Bosc, F.X., Boilleau-Jolimoy, G., Bordes, G., Cavaglione, G., Coulanjon, G., Deplanque, G., Gatineau-Saillant, G., Goujon, G., Medinger, G., Roquin, G., Brixi-Benmansour, H., Castanie, H., Lacroix, H., Maechel, H., Perrier, H., Salloum, H., Senellart, H., Baumgaertner, I., Cumin, I., Graber, I., Trouilloud, I., Boutin, J., Butel, J., Charneau, J., Cretin, J., Dauba, J., Deguiral, J., Egreteau, J., Ezenfis, J., Forestier, J., Goineau, J., Lacourt, J., Lafon, J., Martin, J., Meunier, J., Moreau, J., Provencal, J., Taieb, J., Thaury, J., Tuaillon, J., Vergniol, J., Villand, J., Vincent, J., Volet, J., Bachet, J.B., Barbare, J.C., Souquet, J.C., Grangé, J.D., Dor, J.F., Paitel, J.F., Jouve, J.L., Raoul, J.L., Cheula, J.M., Gornet, J.M., Sabate, J.M., Vantelon, J.M., Vaillant, J.N., Aucouturier, J.P., Barbieux, J.P., Herr, J.P., Lafargue, J.P., Lagasse, J.P., Latrive, J.P., Plachot, J.P., Ramain, J.P., Robin, J.P., Spano, J.P., Douillard, J.Y., Beerblock, K., Bouhier-Leporrier, K., Slimane Fawzi, K., Cany, L., Chone, L., Dahan, L., Gasnault, L., Rob, L., Stefani, L., Wander, L., Baconnier, M., Ben Abdelghani, M., Benchalal, M., Blasquez, M., Carreiro, M., Charbit, M., Combe, M., Duluc, M., Fayolle, M., Gignoux, M., Giovannini, M., Glikmanas, M., Mabro, M., Mignot, M., Mornet, M., Mousseau, M., Mozer, M., Pauwels, M., Pelletier, M., Porneuf, M., Ramdani, M., Schnee, M., Tissot, M., Zawadi, M., Clavero-Fabri, M.C., Gouttebel, M.C., Kaminsky, M.C., Galais, M.P., Abdelli, N., Barrière, N., Bouaria, N., Bouarioua, N., Delas, N., Gérardin, N., Hess-Laurens, N., Stremsdoerfer, N., Berthelet, O., Boulat, O., Capitain, O., Favre, O., Amoyal, P., Bergerault, P., Burtin, P., Cassan, P., Chatrenet, P., Chiappa, P., Claudé, P., Couzigou, P., Feydy, P., Follana, P., Geoffroy, P., Godeau, P., Hammel, P., Laplaige, P., Lehair, P., Martin, P., Novello, P., Pantioni, P., Pienkowski, P., Pouderoux, P., Prost, P., Ruszniewski, P., Souillac, P., Texereau, P., Thévenet, P., Haineaux, P.A., Benoit, R., Coriat, R., Lamy, R., Mackiewicz, R., Beorchia, S., Chaussade, S., Hiret, S., Jacquot, S., Lavau Denes, S., Montembault, S., Nahon, S., Nasca, S., Nguyen, S., Oddou-Lagraniere, S., Pesque-Penaud, S., Fratte, S.P., Chatellier, T., Mansourbakht, T., Morin, T., Walter, T., Boige, V., Bourgeois, V., Derias, V., Guérin-Meyer, V., Hautefeuille, V., Jestin Le Tallec, V., Lorgis, V., Quentin, V., Sebbagh, V., Veuillez, V., Adhoute, X., Coulaud, X., Becouarn, Y., Coscas, Y., Courouble, Y., Le Bricquir, Y., Molin, Y., Rinaldi, Y., Lam, Y.H., Ladhib, Z., Aparicio, Thomas, Ducreux, Michel, Faroux, Roger, Barbier, Emilie, Manfredi, Sylvain, Lecomte, Thierry, Etienne, Pierre-Luc, Bedenne, Laurent, Bennouna, Jaafar, Phelip, Jean-Marc, François, Eric, Michel, Pierre, Legoux, Jean-Louis, Gasmi, Mohamed, Breysacher, Gilles, Rougier, Philippe, De Gramont, Aimery, Lepage, Come, Bouché, Olivier, and Seitz, Jean-François
Published: 2018
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7. High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease

Author: Colombel, Jean-Frédéric, Cosnes, Jacques, Gendre, Jean-Pierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Beaugerie, Laurent, Peyrin-Biroulet, Laurent, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Marteau, Philippe, Soulé, Jean-Claude, Gornet, Jean-Marc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, Etienne-Henry, Florent, Christian, Blain, Antoine, Faucheron, Jean-Luc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, Nion-Larmurier, Isabelle, Delchier, Jean-Charles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, Jean-Christophe, Bord, Pierre, Coffin, Benoit, D’almagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, Marc-Henry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, Anne-Marie, Latrive, Jean-Paul, Gerbal, Jean-Luc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, D’aubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, Raoul-Jacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, Pierre-Emile, Picon-Coste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, Jean-Pierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, Gatineau-Sailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, Jean-Michel, Merite, François, Roux, Jean-Pol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, Jean-Pierre, Humeau, Benoit, Sabate, Jean-Marc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, Jean-Charles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, Jean-Marc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Abitbol, Vered, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, L'Hirondel, Christian, Labérenne, Jean-Eric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, Ramond-Bouhali, Marie-José, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, Pierre-André, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, Jean-Louis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, Jean-Luc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, Jean-Paul, Caby, Christine Meicler, Meurisse, Jean-Jacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, Jean-Marie, Dupuy, J-François, Bellaiche, Guy, Guegan, Martine, Comte, Jean-Marc, Cayla, Jean-Michel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, Gaye-Bareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, Labat-Labourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, Jean-Michel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, D'Abrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, Marie-George, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, Xavier-Richard, Lombard, Frédéric, Granveau, Antoine, Hamon, Jean-François, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, Jean-Francois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, Wurtz-Huckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, Jean-François, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, Jean-Luc, Grimprel, Hubert, Auroux, Jean, Rey, Jean-François, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, Bonnet-Eymard, Pierre-Olivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, Jean-Claude, Genes, Julien, Leveque, Anne-Marie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, Jean-Michel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, Dartois-Hoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, Tawil-Longreen, Christine, Vincent, Edmond, Vitte, René-Louis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, Corrieri-Baizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, Boyer-Darrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, Jean-Louis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, Roussin-Bretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, Dubuc-Rey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, Janin-Manificat, Raoul, Galmiche, Jean-Paul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, Rinaldi-Dovio, Michel, Rouillon, Jean-Michel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, Elie-Legrand, Marie-Claire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, Jacques-Arnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, Francois-Xavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, Jean-Louis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, Terdiman-Pire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, Gautier-Jubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, Carlier-Bandu, Martine, Monnin, Jean-Luc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, Algard, Michèle, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, Jean-Pierre, Khaddari, Saïd, Mion, François, Puy-Montbrun, Thierry, Girardet, Jean-Philippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, Marie-Astrid, Escartin, Michel -Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, Jean-Lucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, Jean-Marc, Le Floch, Isabelle Joly, Vove, Jean-Paul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, Mozer-Bernardeau, Marianne, Nousbaum, Jean-Baptiste, Cattan, Philippe, Plane, Alain, Raymond, Jean-Michel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, Cordier-Collet, Mariepierre, Courat, Laurent, Croguennec, Bernard, Tardy, Karine Delaunay, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Dupont Gossart, Anne-Claire, Baroni, Jean-Luc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, Bridoux-Henno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, D'Abravanel, Pascale, Dall'Osto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, François-Jean, Roupret, Bernard, Soupison, Alain, Carrat, Fabrice, Zeitoun, Jean-David, Sabaté, Jean-Marc, Fléjou, Jean-François, Kirchgesner, Julien, and Svrcek, Magali
Published: 2018
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8. Evaluating lanreotide as maintenance therapy after first-line treatment in patients with non-resectable duodeno-pancreatic neuroendocrine tumours

Author: Lepage, Côme, Dahan, Laetitia, Bouarioua, Nadia, Toumpanakis, Christos, Legoux, Jean-Louis, Le Malicot, Karine, Guimbaud, Rosine, Smith, Denis, Tougeron, David, Lievre, Astrid, Cadiot, Guillaume, Di Fiore, Frédéric, Bouhier-Leporrier, Karine, Hentic, Olivia, Faroux, Roger, Pavel, Marianne, Borbath, Ivan, Valle, Juan W., Rinke, Anja, Scoazec, Jean-Yves, Ducreux, Michel, and Walter, Thomas
Published: 2017
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9. Geriatric factors analyses from FFCD 2001-02 phase III study of first-line chemotherapy for elderly metastatic colorectal cancer patients

Author: Aparicio, Thomas, Gargot, Dany, Teillet, Laurent, Maillard, Emilie, Genet, Dominique, Cretin, Jacques, Locher, Christophe, Bouché, Olivier, Breysacher, Gilles, Seitz, Jean-François, Gasmi, Mohamed, Stefani, Laetitia, Ramdani, Mohamed, Lecomte, Thierry, Auby, Dominique, Faroux, Roger, Bachet, Jean-Baptiste, Lepère, Céline, Khemissa, Faiza, Sobhani, Iradj, Boulat, Olivier, Mitry, Emmanuel, and Jouve, Jean-Louis
Published: 2017
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10. The Characteristics of Diverticular Disease in Caribbean Population: A Control Group Study

Author: Gelu-Simeon, Moana, primary, Schnee, Matthieu, additional, Lafrance, Marie-Josée, additional, Plazy-Chabrand, Pauline, additional, Schneck, Anne-Sophie, additional, Saint-Georges, Georgette, additional, Alexis, Marceline, additional, Delumeau, Stéphanie, additional, Montigny, Philippe, additional, Faroux, Roger, additional, Dimet, Jérome, additional, and Saillard, Eric, additional
Published: 2022
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11. Aflibercept-LV5FU2 as first-line treatment of non-resectable metastatic colorectal cancers: Results of the FOLFA randomized phase II trial.

Author: Legoux, Jean-Louis, primary, Faroux, Roger, additional, Barrière, Nicolas, additional, Le Malicot, Karine, additional, Tougeron, David, additional, Lorgis, Veronique, additional, Guerin-Meyer, Veronique, additional, Bourgeois, Vincent, additional, Malka, David, additional, Aparicio, Thomas, additional, Baconnier, Mathieu, additional, Lebrun Ly, Valérie, additional, Egreteau, Joëlle, additional, Khemissa Akouz, Faïza, additional, Lepage, Come, additional, and Boige, Valérie, additional
Published: 2022
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12. The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease

Author: Carrat, F., Seksik, P., Colombel, J.F., PeyrinBiroulet, L., Beaugerie, L., Colombel, JeanFrédéric, Cosnes, Jacques, Gendre, JeanPierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Beaugerie, Laurent, PeyrinBiroulet, Laurent, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Marteau, Philippe, Soulé, JeanClaude, Gornet, JeanMarc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, EtienneHenry, Florent, Christian, Blain, Antoine, Faucheron, JeanLuc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, NionLarmurier, Isabelle, Delchier, JeanCharles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, JeanChristophe, Bord, Pierre, Coffin, Benoit, Dʼalmagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, MarcHenry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, AnneMarie, Latrive, JeanPaul, Gerbal, JeanLuc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, Dʼaubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, RaoulJacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, PierreEmile, PiconCoste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, JeanPierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, GatineauSailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, JeanMichel, Merite, François, Roux, JeanPol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, JeanPierre, Humeau, Benoit, Sabate, JeanMarc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, JeanCharles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, JeanMarc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Abitbol, Vered, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, LʼHirondel, Christian, Labérenne, JeanEric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, RamondBouhali, MarieJosé, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, PierreAndré, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, JeanLouis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, JeanLuc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, JeanPaul, Caby, Christine Meicler, Meurisse, JeanJacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, JeanMarie, Dupuy, JFrançois, Bellaiche, Guy, Guegan, Martine, Comte, JeanMarc, Cayla, JeanMichel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, GayeBareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, LabatLabourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, JeanMichel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, DʼAbrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, MarieGeorge, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, XavierRichard, Lombard, Frédéric, Granveau, Antoine, Hamon, JeanFrançois, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, JeanFrancois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, WurtzHuckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, JeanFrançois, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, JeanLuc, Grimprel, Hubert, Auroux, Jean, Rey, JeanFrançois, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, BonnetEymard, PierreOlivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, JeanClaude, Genes, Julien, Leveque, AnneMarie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, JeanMichel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, DartoisHoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, TawilLongreen, Christine, Vincent, Edmond, Vitte, RenéLouis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, CorrieriBaizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, BoyerDarrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, JeanLouis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, RoussinBretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, DubucRey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, JaninManificat, Raoul, Galmiche, JeanPaul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, RinaldiDovio, Michel, Rouillon, JeanMichel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, ElieLegrand, MarieClaire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, JacquesArnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, FrancoisXavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, JeanLouis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, TerdimanPire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, GautierJubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, CarlierBandu, Martine, Monnin, JeanLuc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, Algard, Michèle, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, JeanPierre, Khaddari, Saïd, Mion, François, PuyMontbrun, Thierry, Girardet, JeanPhilippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, MarieAstrid, Escartin, Michel Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, JeanLucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, JeanMarc, Le Floch, Isabelle Joly, Vove, JeanPaul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, MozerBernardeau, Marianne, Nousbaum, JeanBaptiste, Cattan, Philippe, Plane, Alain, Raymond, JeanMichel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, CordierCollet, Mariepierre, Courat, Laurent, Croguennec, Bernard, DelaunayTardy, Karine, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Gossart, AnneClaire Dupont, Baroni, JeanLuc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, BridouxHenno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, DʼAbravanel, Pascale, DallʼOsto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, FrançoisJean, Roupret, Bernard, Soupison, Alain, AitOuadda, Djamila, Barbaza, Yves, Bayart, Brice, Bottini, Thomas, Cochet, Franck, Goderel, Isabelle, Maury, Orélien, Mbonyingo, Léa, Pourtau, Vanessa, Rasoanarivo, Elise, RomainHuttin, Laure, Sallé, AnneViolaine, Trang, Jonathan, Admane, Hakeem, and Drouet, Elodie
Published: 2017
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13. Bevacizumab Combined With Chemotherapy in the Second-Line Treatment of Metastatic Colorectal Cancer: Results from the Phase II BEVACOLOR Study

Author: Bennouna, Jaafar, Borg, Christophe, Delord, Jean-Pierre, Husseini, Faress, Trillet-Lenoir, Véronique, Faroux, Roger, François, Eric, Ychou, Marc, Goldwasser, François, Bouché, Olivier, Senellart, Helene, Kraemer, Sandrine, and Douillard, Jean-Yves
Published: 2012
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14. sj-docx-2-tam-10.1177_17588359221141307 – Supplemental material for Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial

Author: de Rauglaudre, Bernadette, Sibertin-Blanc, Camille, Fabre, Aurélie, Le Malicot, Karine, Bennouna, Jaafar, Ghiringhelli, François, Taïeb, Julien, Boige, Valérie, Bouché, Olivier, Chatellier, Thierry, Faroux, Roger, François, Eric, Jacquot, Stéphane, Genet, Dominique, Mulot, Claire, Olschwang, Sylviane, Seitz, Jean-François, Aparicio, Thomas, and Dahan, Laetitia
Subjects: 110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-docx-2-tam-10.1177_17588359221141307 for Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial by Bernadette de Rauglaudre, Camille Sibertin-Blanc, Aurélie Fabre, Karine Le Malicot, Jaafar Bennouna, François Ghiringhelli, Julien Taïeb, Valérie Boige, Olivier Bouché, Thierry Chatellier, Roger Faroux, Eric François, Stéphane Jacquot, Dominique Genet, Claire Mulot, Sylviane Olschwang, Jean-François Seitz, Thomas Aparicio and Laetitia Dahan in Therapeutic Advances in Medical Oncology
Published: 2022
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15. sj-docx-1-tam-10.1177_17588359221141307 – Supplemental material for Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial

Author: de Rauglaudre, Bernadette, Sibertin-Blanc, Camille, Fabre, Aurélie, Le Malicot, Karine, Bennouna, Jaafar, Ghiringhelli, François, Taïeb, Julien, Boige, Valérie, Bouché, Olivier, Chatellier, Thierry, Faroux, Roger, François, Eric, Jacquot, Stéphane, Genet, Dominique, Mulot, Claire, Olschwang, Sylviane, Seitz, Jean-François, Aparicio, Thomas, and Dahan, Laetitia
Subjects: 110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-docx-1-tam-10.1177_17588359221141307 for Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial by Bernadette de Rauglaudre, Camille Sibertin-Blanc, Aurélie Fabre, Karine Le Malicot, Jaafar Bennouna, François Ghiringhelli, Julien Taïeb, Valérie Boige, Olivier Bouché, Thierry Chatellier, Roger Faroux, Eric François, Stéphane Jacquot, Dominique Genet, Claire Mulot, Sylviane Olschwang, Jean-François Seitz, Thomas Aparicio and Laetitia Dahan in Therapeutic Advances in Medical Oncology
Published: 2022
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16. Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial

Author: de Rauglaudre, Bernadette, primary, Sibertin-Blanc, Camille, additional, Fabre, Aurélie, additional, Le Malicot, Karine, additional, Bennouna, Jaafar, additional, Ghiringhelli, François, additional, Taïeb, Julien, additional, Boige, Valérie, additional, Bouché, Olivier, additional, Chatellier, Thierry, additional, Faroux, Roger, additional, François, Eric, additional, Jacquot, Stéphane, additional, Genet, Dominique, additional, Mulot, Claire, additional, Olschwang, Sylviane, additional, Seitz, Jean-François, additional, Aparicio, Thomas, additional, and Dahan, Laetitia, additional
Published: 2022
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17. DPYD Genotyping to Predict Adverse Events Following Treatment With Fluorouracil-Based Adjuvant Chemotherapy in Patients With Stage III Colon Cancer: A Secondary Analysis of the PETACC-8 Randomized Clinical Trial

Author: Boige, Valérie, Vincent, Marc, Alexandre, Philippe, Tejpar, Sabine, Landolfi, Stefania, Le Malicot, Karine, Greil, Richard, Cuyle, Pieter Jan, Yilmaz, Mette, Faroux, Roger, Matzdorff, Axel, Salazar, Ramon, Lepage, Côme, Taieb, Julien, and Laurent-Puig, Pierre
Published: 2016
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18. Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

Author: Bourrier, A., Carrat, F., Colombel, J.-F., Bouvier, A.-M., Abitbol, V., Marteau, P., Cosnes, J., Simon, T., Peyrin-Biroulet, L., Beaugerie, L., Gendre, Jean-Pierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Soulé, Jean-Claude, Gornet, Jean-Marc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, Etienne-Henry, Florent, Christian, Blain, Antoine, Faucheron, Jean-Luc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, Nion-Larmurier, Isabelle, Delchier, Jean-Charles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, Jean-Christophe, Bord, Pierre, Coffin, Benoit, Dʼalmagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, Marc-Henry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, Anne-Marie, Latrive, Jean-Paul, Gerbal, Jean-Luc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, Dʼaubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, Raoul-Jacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, Pierre-Emile, Picon-Coste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, Jean-Pierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, Gatineau-Sailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, Jean-Michel, Merite, François, Roux, Jean-Pol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, Jean-Pierre, Humeau, Benoit, Sabate, Jean-Marc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, Jean-Charles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, Jean-Marc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, LʼHirondel, Christian, Labérenne, Jean-Eric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, Ramond-Bouhali, Marie-José, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, Pierre-André, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, Jean-Louis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, Jean-Luc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, Jean-Paul, Caby, Christine Meicler, Meurisse, Jean-Jacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, Jean-Marie, Dupuy, J-François, Bellaiche, Guy, Guegan, Martine, Comte, Jean-Marc, Cayla, Jean-Michel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, Gaye-Bareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, Labat-Labourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, Jean-Michel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, DʼAbrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, Marie-George, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, Xavier-Richard, Lombard, Frédéric, Granveau, Antoine, Hamon, Jean-François, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, Jean-Francois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, Wurtz-Huckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, Jean-François, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, Jean-Luc, Grimprel, Hubert, Auroux, Jean, Rey, Jean-François, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, Bonnet-Eymard, Pierre-Olivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, Jean-Claude, Genes, Julien, Leveque, Anne-Marie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, Jean-Michel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, Dartois-Hoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, Tawil-Longreen, Christine, Vincent, Edmond, Vitte, René-Louis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, Corrieri-Baizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, Boyer-Darrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, Jean-Louis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, Roussin-Bretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, Dubuc-Rey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, Janin-Manificat, Raoul, Galmiche, Jean-Paul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, Rinaldi-Dovio, Michel, Rouillon, Jean-Michel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, Elie-Legrand, Marie-Claire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, Jacques-Arnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, Francois-Xavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, Jean-Louis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, Terdiman-Pire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, Gautier-Jubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, Carlier-Bandu, Martine, Monnin, Jean-Luc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, le Algard, Michè, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, Jean-Pierre, Khaddari, Saïd, Mion, François, Puy-Montbrun, Thierry, Girardet, Jean-Philippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, Marie-Astrid, Escartin, Michel-Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, Jean-Lucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, Jean-Marc, Le Floch, Isabelle Joly, Vove, Jean-Paul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, Mozer-Bernardeau, Marianne, Nousbaum, Jean-Baptiste, Cattan, Philippe, Plane, Alain, Raymond, Jean-Michel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, Cordier-Collet, Mariepierre, Courat, Laurent, Croguennec, Bernard, Delaunay-Tardy, Karine, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Gossart, Anne-Claire Dupont, Baroni, Jean-Luc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, Bridoux-Henno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, DʼAbravanel, Pascale, DallʼOsto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, François-Jean, Roupret, Bernard, and Soupison, Alain
Published: 2016
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19. High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis

Author: Denis Musquer, Marie, Jouand, Nicolas, Pere, Morgane, Lamer, Juliette Eugène, Bézieau, Stéphane, Matysiak, Tamara, Faroux, Roger, Caroli Bosc, François-Xavier, Rousselet, Marie-Christine, Leclair, François, Mosnier, Jean-François, Toquet, Claire, Gervois, Nadine, Bossard, Céline, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), BOURGEAIS, Véronique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), and Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
Subjects: [SDV] Life Sciences [q-bio], HLA-E/NKG2A axis, tumor-associated neutrophils, Oncology, [SDV]Life Sciences [q-bio], cetuximab, chemical and pharmacologic phenomena, metastatic colorectal carcinoma, CD16, digestive system diseases, Original Research, antibody-dependent cellular cytotoxicity
Abstract: International audience; Antibody-dependent cellular cytotoxicity (ADCC) in the anti-tumor effect of cetuximab in metastatic colorectal cancer (mCRC) is only based on the impact of FcγRIIIA (CD16) polymorphisms as predictive of therapeutic response. However, nature, density and therapeutic impact of FcγRIIIA + (CD16) effector cells in tumor remain poorly documented. Moreover, the inhibition of cetuximab-mediated ADCC induced by NK cells by the engagement of the new inhibitory CD94-NKG2A immune checkpoint has only been demonstrated in vitro . This multicentric study aimed to determine, on paired primary and metastatic tissue samples from a cohort of mCRC patients treated with cetuximab: 1) the nature and density of FcγRIIIA + (CD16) immune cells, 2) the expression profile of HLA-E/β2m by tumor cells as well as the density of CD94 + immune cells and 3) their impact on both objective response to cetuximab and survival. We demonstrated that FcγRIIIA + (CD16) intraepithelial immune cells mainly correspond to tumor-associated neutrophils (TAN), and their high density in metastases was significantly associated with a better response to cetuximab, independently of the expression of the CD94/NKG2A inhibitory immune checkpoint. However, HLA-E/β2m, preferentially overexpressed in metastases compared with primary tumors and associated with CD94 + tumor infiltrating lymphocytes (TILs), was associated with a poor overall survival. Altogether, these results strongly support the use of bispecific antibodies directed against both EGFR and FcγRIIIA (CD16) in mCRC patients, to boost cetuximab-mediated ADCC in RAS wild-type mCRC patients. The preferential overexpression of HLA-E/β2m in metastases, associated with CD94 + TILs and responsible for a poor prognosis, provides convincing arguments to inhibit this new immune checkpoint with monalizumab, a humanized anti-NKG2A antibody, in combination with anti- FcγRIIIA/EGFR bispecific antibodies as a promising therapeutic perspective in RAS wild-type mCRC patients.
Published: 2021

20. Skeletal muscle loss during chemotherapy and its association with survival and systemic treatment toxicity in metastatic colorectal cancer: An AGEO prospective multicenter study

Author: Gallois, Claire, primary, Bourillon, Camille, additional, Auclin, Edouard, additional, Artru, Pascal, additional, Lièvre, Astrid, additional, Lecomte, Thierry, additional, Locher, Christophe, additional, Marthey, Lysiane, additional, Faroux, Roger, additional, Pernot, Simon, additional, Barret, Maximilien, additional, and Taieb, Julien, additional
Published: 2021
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21. Supplemental Material, Supplemental_material - Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives

Author: Capitain, Olivier, Seegers, Valérie, Jean-Philippe Metges, Faroux, Roger, Stampfli, Claire, Ferec, Marc, Budnik, Tamara Matysiak, Senellart, Hélène, Rossi, Valérie, Blouin, Nadège, Dauvé, Jonathan, and Campone, Mario
Subjects: 110320 Radiology and Organ Imaging, FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract: Supplemental Material, Supplemental_material for Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives by Olivier Capitain, Valérie Seegers, Jean-Philippe Metges, Roger Faroux, Claire Stampfli, Marc Ferec, Tamara Matysiak Budnik, Hélène Senellart, Valérie Rossi, Nadège Blouin, Jonathan Dauvé and Mario Campone in Dose-Response
Published: 2020
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22. Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab–irinotecan

Author: Etienne-Grimaldi, Marie-Christine, Bennouna, Jaafar, Formento, Jean-Louis, Douillard, Jean-Yves, Francoual, Mireille, Hennebelle, Isabelle, Chatelut, Etienne, Francois, Eric, Faroux, Roger, El Hannani, Chaza, Jacob, Jacques-Henri, and Milano, Gérard
Published: 2012
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23. Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX-6) as first-line treatment for metastatic colorectal cancer†‡

Author: Ducreux, Michel, Bennouna, Jaafar, Hebbar, Mohamed, Ychou, Marc, Lledo, Gérard, Conroy, Thierry, Adenis, Antoine, Faroux, Roger, Rebischung, Christine, Bergougnoux, Loic, Kockler, Leila, and Douillard, Jean-Yves
Published: 2011
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24. Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives

Author: Capitain, Olivier, primary, Seegers, Valérie, additional, Metges, Jean-Philippe, additional, Faroux, Roger, additional, Stampfli, Claire, additional, Ferec, Marc, additional, Budnik, Tamara Matysiak, additional, Senellart, Hélène, additional, Rossi, Valérie, additional, Blouin, Nadège, additional, Dauvé, Jonathan, additional, and Campone, Mario, additional
Published: 2020
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25. Skeletal muscle loss under chemotherapy and its association with survival and systemic treatment toxicity in metastatic colorectal cancer: An AGEO prospective multicenter study.

Author: Gallois, Claire, primary, Bourillon, Camille, additional, Auclin, Edouard, additional, Artru, Pascal, additional, Lievre, Astrid, additional, Lecomte, Thierry, additional, Locher, Christophe, additional, Marthey, Lysiane, additional, Faroux, Roger, additional, Pernot, Simon, additional, Barret, Maximilien, additional, and Taieb, Julien, additional
Published: 2020
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26. Erratum to ‘Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: An open-label, randomized Phase IIb trial’ [European Journal of Cancer, Volume 124 (January 2020) Pages 91-101]

Author: Hammel, Pascal, primary, Portales, Fabienne, additional, Mineur, Laurent, additional, Metges, Jean-Philippe, additional, Andre, Thierry, additional, De La Fouchardiere, Christelle, additional, Louvet, Christophe, additional, El Hajbi, Farid, additional, Faroux, Roger, additional, Guimbaud, Rosine, additional, Tougeron, David, additional, Bouche, Olivier, additional, Lecomte, Thierry, additional, Rebischung, Christine, additional, Tournigand, Christophe, additional, Cros, Jerome, additional, Kay, Richard, additional, Hamm, Adam, additional, Gupta, Anu, additional, Bachet, Jean-Baptiste, additional, and El Hariry, Iman, additional
Published: 2020
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27. Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with mFOLFOX6 (three versus six months) in the prospective IDEA France cohort study (PRODIGE-GERCOR).

Author: Pages, Franck, primary, Andre, Thierry, additional, Taieb, Julien, additional, Vernerey, Dewi, additional, Henriques, Julie, additional, Borg, Christophe, additional, Marliot, Florence, additional, Ben Jannet, Rim, additional, Louvet, Christophe, additional, Mineur, Laurent, additional, Bennouna, Jaafar, additional, Desrame, Jérôme, additional, Faroux, Roger, additional, Duval, Alex, additional, Laurent-Puig, Pierre, additional, Svrcek, Magali, additional, Hermitte, Fabienne, additional, Catteau, Aurelie, additional, Galon, Jerome, additional, and Emile, Jean-François, additional
Published: 2020
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28. Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: An open-label, randomized Phase IIb trial

Author: Hammel, Pascal, primary, Fabienne, Portales, additional, Mineur, Laurent, additional, Metges, Jean-Philippe, additional, Andre, Thierry, additional, De La Fouchardiere, Christelle, additional, Louvet, Christophe, additional, El Hajbi, Farid, additional, Faroux, Roger, additional, Guimbaud, Rosine, additional, Tougeron, David, additional, Bouche, Olivier, additional, Lecomte, Thierry, additional, Rebischung, Christine, additional, Tournigand, Christophe, additional, Cros, Jerome, additional, Kay, Richard, additional, Hamm, Adam, additional, Gupta, Anu, additional, Bachet, Jean-Baptiste, additional, and El Hariry, Iman, additional
Published: 2020
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29. PROGNOSIS OF UPPER GASTROINTESTINAL BLEEDING IN THE OLDEST-OLD PATIENTS: A POST HOC ANALYSIS OF A PROSPECTIVE STUDY

Author: Nahon, Stéphane, Pariente, Alexandre, Faroux, Roger, Rémy, André-Jean, and Nouel, Olivier
Published: 2010
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30. Analysis of circulating tumour DNA (ctDNA) from patients enrolled in the IDEA-FRANCE phase III trial: Prognostic and predictive value for adjuvant treatment duration

Author: Taieb, Julien, Taly, Valérie, Vernerey, Dewi, Bourreau, Camille, Bennouna, Jaafar, Faroux, Roger, Desramé, Jérôme, Bouché, Olivier, Mulot, Claire, Egreteau, J, Mineur, L., Lepere, Céline, Deplanque, G., Louvet, Christophe, Ychou, M., De Gramont, A., Laurent Puig, Pierre, Service d'hépatogastro-entérologie et d'oncologie digestive, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CRLCC René Gauducheau, Centre Hospitalier Départemental Les Oudairies, Hôpital privé Jean Mermoz, Centre Hospitalier Universitaire de Reims (CHU Reims), Institut Sainte Catherine [Avignon], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Mutualiste de Montsouris (IMM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UMR S775, and Université Paris Descartes - Paris 5 (UPD5)
Subjects: [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

31. [Dihydropyrimidine dehydrogenase deficiency screening for management of patients receiving a fluoropyrimidine: Results of two national practice surveys addressed to clinicians and biologists]

Author: Loriot, Marie-Anne, Masskouri, Fadil, Carni, Paolo, Le Malicot, Karine, Seitz, Jean-François, Michel, Pierre, Legoux, Jean-Louis, Bouche, Olivier, André, Thierry, Faroux, Roger, Delaloge, Suzette, Malka, David, Guigay, Joël, Thariat, Juliette, Thomas, Fabienne, Barin-Le-Guellec, Chantal, Ciccolini, Joseph, Boyer, Jean-Christophe, Etienne-Grimaldi, Marie-Christine, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Francophone de la Cancérologie Digestive, FFCD, Service d'oncologie digestive et hépato-gastro-entérologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), F2ME, PSA Peugeot - Citroën (PSA), PSA Peugeot Citroën (PSA)-PSA Peugeot Citroën (PSA)-Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique (PRISME), Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO), Regional Hospital of Orleans, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHD Vendée - Hôpital Les Oudairies [La Roche sur Yon], Institut Gustave Roussy (IGR), Onco-génétique, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Medical Oncology Department [Nice], COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Institute of Developmental Biology and Cancer (IBDC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Laboratoire de biochimie et biologie moléculaire, Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Biomedical Research, Dihydropyrimidine Dehydrogenase Deficiency, MESH: Pharmacovigilance, [SDV]Life Sciences [q-bio], Surveys, MESH: Health Care Surveys, Digestive System Neoplasms, MESH: Genotype, Pharmacovigilance, MESH: Practice Guidelines as Topic, Antineoplastic Combined Chemotherapy Protocols, MESH: Otorhinolaryngologic Neoplasms, Oncologists, MESH: Antimetabolites, Antineoplastic, Enquête, DPD, MESH: Antineoplastic Combined Chemotherapy Protocols, Practice Guidelines as Topic, Screening, Female, Fluorouracil, France, Dihydropyrimidine dehydrogenase, Fluoropyrimidine, Antimetabolites, Antineoplastic, Genotype, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Dihydropyrimidine déshydrogénase, Reimbursement Mechanisms, Toxicité, MESH: Reimbursement Mechanisms, MESH: Biology, Humans, Biology, Capecitabine, MESH: Humans, Toxicity, MESH: Digestive System Neoplasms, MESH: Biomedical Research, MESH: Oncologists, MESH: Capecitabine, MESH: France, Otorhinolaryngologic Neoplasms, Pyrimidines, Dépistage, Health Care Surveys, MESH: Pyrimidines, MESH: Dihydropyrimidine Dehydrogenase Deficiency, MESH: Female, MESH: Fluorouracil, MESH: Breast Neoplasms
Abstract: International audience; Dihydropyrimidine dehydrogenase (DPD) deficiency is the main cause of early severe toxicities induced by fluoropyrimidines (FP). The French Group of Clinical Oncopharmacology (GPCO)-Unicancer and the French Pharmacogenetics Network (RNPGx) initiated two surveys, one addressed to oncologists, the other to biologists, in order to evaluate routine practices regarding DPD deficiency screening at national level, as well as compliance, motivations and obstacles for implementation of these tests. These anonymized online surveys were performed with the logistic assistance of the Francophone Federation of Digestive Oncology (FFCD) and the support of numerous medical and biological societies. The surveys were conducted in 2016-2017 before the creation of the French INCa/HAS expert panel, which contributed to the drafting of rules and recommendations for DPD deficiency screening published in December 2018. In all, 554 questionnaires from clinicians were analyzed (23% participation) and 35 from biologists. The main arguments raised by clinicians for justifying the limited practice of DPD deficiency screening were: the lack of recommendations from medical societies or Health Authorities, delays in obtaining results, and the lack of adequate reimbursement by the health insurance system. The goal of these surveys was to provide the French Health Authorities with an overview on nationwide DPD-deficiency screening practices and thus help to design recommendations for the standardization and improvement of the management and safety of cancer patients receiving FP-based chemotherapy.
Published: 2019

32. ANNALS OF ONCOLOGY Volume: 30 Supplement: 5 Pages: 867-867 Meeting Abstract: LBA30_PR Published: OCT 2019

Author: Taieb, Julien, Taly, Valérie, Vernerey, Dewi, Bourreau, Camille, Bennouna, Jaafar, Faroux, Roger, Desramé, Jérôme, Bouché, Olivier, Mulot, Claire, Egreteau, J, Mineur, L., Lepere, Céline, Deplanque, G., Louvet, Christophe, Ychou, M., de Gramont, A., Laurent Puig, Pierre, TALY, Valerie, Service d'hépatogastro-entérologie et d'oncologie digestive, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CRLCC René Gauducheau, Centre Hospitalier Départemental Les Oudairies, Hôpital privé Jean Mermoz, Centre Hospitalier Universitaire de Reims (CHU Reims), Institut Sainte Catherine [Avignon], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Mutualiste de Montsouris (IMM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UMR S775, and Université Paris Descartes - Paris 5 (UPD5)
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

33. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

Author: Conroy, Thierry, Hammel, Pascal, Hebbar, Mohamed, Ben Abdelghani, Meher, Wei, Alice, Raoul, Jean-Luc, Choné, Laurence, Francois, Eric, Artru, Pascal, Biagi, James, Lecomte, Thierry, Assenat, Eric, Faroux, Roger, Ychou, Marc, Volet, Julien, Sauvanet, Alain, Breysacher, Gilles, Di Fiore, Frédéric, Cripps, Christine, Kavan, Petr, Texereau, Patrick, Bouhier-Leporrier, Karine, Khemissa-Akouz, Faiza, Legoux, Jean-Louis, Juzyna, Beata, Gourgou, Sophie, O'Callaghan, Christopher, Jouffroy-Zeller, Claire, Rat, Patrick, Malka, David, Castan, Florence, Bachet, Jean-Baptiste, Trials Group, Canadian Cancer, Group, Unicancer-GI–PRODIGE, Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Claude Huriez [Lille], CHU Lille, CRLCC Paul Strauss, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Hôpital privé Jean Mermoz, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Reims (CHU Reims), Service de chirurgie hepato-pancreato-biliaire, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Louis Pasteur [Colmar] (CH Colmar), CHU Rouen, Normandie Université (NU), CHU Mont de Marsan, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Saint Jean de Perpignan, Centre Hospitalier Régional d'Orléans (CHRO), R&D UNICANCER, Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCL/UNICANCER), UNICANCER-UNICANCER, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Oncologie digestive, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Cancérologie de Lorraine - Alexis Vautrin (ICL), Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Claude Huriez, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CRLCC Antoine Lacassagne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, Centre Hospitalier Régional d'Orléans (CHR), Service de Gastroentérologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Adult, Male, medicine.medical_specialty, FOLFIRINOX, Leucovorin, [SDV.CAN]Life Sciences [q-bio]/Cancer, Irinotecan, Deoxycytidine, Gastroenterology, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Pancreatic cancer, Antineoplastic Combined Chemotherapy Protocols, Organometallic Compounds, medicine, Adjuvant therapy, Humans, Prospective Studies, Survival rate, Aged, Proportional Hazards Models, Aged, 80 and over, business.industry, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, Gemcitabine, 3. Good health, Oxaliplatin, Pancreatic Neoplasms, Drug Combinations, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Fluorouracil, Folfirinox Regimen, Lung Diseases, Interstitial, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug
Abstract: International audience; BACKGROUND:Among patients with metastatic pancreatic cancer, combination chemotherapy with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) leads to longer overall survival than gemcitabine therapy. We compared the efficacy and safety of a modified FOLFIRINOX regimen with gemcitabine as adjuvant therapy in patients with resected pancreatic cancer.METHODS:We randomly assigned 493 patients with resected pancreatic ductal adenocarcinoma to receive a modified FOLFIRINOX regimen (oxaliplatin [85 mg per square meter of body-surface area], irinotecan [180 mg per square meter, reduced to 150 mg per square meter after a protocol-specified safety analysis], leucovorin [400 mg per square meter], and fluorouracil [2400 mg per square meter] every 2 weeks) or gemcitabine (1000 mg per square meter on days 1, 8, and 15 every 4 weeks) for 24 weeks. The primary end point was disease-free survival. Secondary end points included overall survival and safety.RESULTS:At a median follow-up of 33.6 months, the median disease-free survival was 21.6 months in the modified-FOLFIRINOX group and 12.8 months in the gemcitabine group (stratified hazard ratio for cancer-related event, second cancer, or death, 0.58; 95% confidence interval [CI], 0.46 to 0.73; P
Published: 2018

34. Carcinoembryonic antigen levels and survival in stage III colon cancer: Post hoc analysis of the MOSAIC and PETACC-8 trials

Author: Auclin, Edouard, Taieb, Julien, Lepage, Come, Aparicio, Thomas, Faroux, Roger, Mini, Enrico, Folprecht, Gunnar, Salazar, Ramon, Benetkiewicz, Magdalena, Banzi, Maria, Louvet, Christophe, Van Laethem, Jean-Luc, Tabernero, Josep, Hickish, Tamas, de Gramont, Aimery, André, Thierry, Vernerey, Déwi, Auclin, Edouard, Taieb, Julien, Lepage, Come, Aparicio, Thomas, Faroux, Roger, Mini, Enrico, Folprecht, Gunnar, Salazar, Ramon, Benetkiewicz, Magdalena, Banzi, Maria, Louvet, Christophe, Van Laethem, Jean-Luc, Tabernero, Josep, Hickish, Tamas, de Gramont, Aimery, André, Thierry, and Vernerey, Déwi
Abstract: Background: We explored and validated the association of postoperative carcinoembryonic antigen (CEA) with disease-free survival (DFS) and overall survival (OS) in stage III colon cancer. Methods: Patients with stage III colon cancer from the MOSAIC and PETACC-8 trials were enrolled. The relation between CEA and outcomes was continuously modeled with the restricted cubic splines (RCS) method. Association of CEA with outcomes was assessed by the Kaplan–Meier method, with two risk groups among patients with a CEA level 5 ng/mL. Multivariate Cox proportional hazard models were constructed. Results: The CEA level was available in 1,292 (96%) and 2,477 (97%) patients in the discovery and validation cohorts. The RCS analysis confirmed that patients with a CEA level >5 ng/mL were at highest risk of recurrence or death and those with a CEA level 5 ng/mL presented a heterogeneous risk population. In the discovery cohort, the 3-year DFS rate was 75%, 65%, and 45% in a group of patients with CEA level of 0–1.30 ng/mL (n ¼ 630), 1.30–5 ng/mL (n ¼ 613), and >5 ng/mL (n ¼ 49), respectively (P < 0.001). CEA was independently associated with endpoints. All findings were confirmed in the validation cohort. Conclusions: Postoperative CEA level was highly and independently associated with DFS and OS, especially in patients with a CEA level of 5 ng/mL, suggesting that this cutoff is not optimal. Impact: CEA levels should be applied more accurately in future trials and clinical practice., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2019

35. High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis.

Author: Denis Musquer, Marie, Jouand, Nicolas, Pere, Morgane, Lamer, Juliette Eugène, Bézieau, Stéphane, Matysiak, Tamara, Faroux, Roger, Caroli Bosc, François-Xavier, Rousselet, Marie-Christine, Leclair, François, Mosnier, Jean-François, Toquet, Claire, Gervois, Nadine, and Bossard, Céline
Subjects: CETUXIMAB, COLORECTAL cancer, ANTIBODY-dependent cell cytotoxicity, METASTASIS, IMMUNE checkpoint proteins, BISPECIFIC antibodies
Abstract: Antibody-dependent cellular cytotoxicity (ADCC) in the anti-tumor effect of cetuximab in metastatic colorectal cancer (mCRC) is only based on the impact of FcγRIIIA (CD16) polymorphisms as predictive of therapeutic response. However, nature, density and therapeutic impact of FcγRIIIA+ (CD16) effector cells in tumor remain poorly documented. Moreover, the inhibition of cetuximab-mediated ADCC induced by NK cells by the engagement of the new inhibitory CD94-NKG2A immune checkpoint has only been demonstrated in vitro. This multicentric study aimed to determine, on paired primary and metastatic tissue samples from a cohort of mCRC patients treated with cetuximab: 1) the nature and density of FcγRIIIA+ (CD16) immune cells, 2) the expression profile of HLA-E/β2m by tumor cells as well as the density of CD94+ immune cells and 3) their impact on both objective response to cetuximab and survival. We demonstrated that FcγRIIIA+ (CD16) intraepithelial immune cells mainly correspond to tumor-associated neutrophils (TAN), and their high density in metastases was significantly associated with a better response to cetuximab, independently of the expression of the CD94/NKG2A inhibitory immune checkpoint. However, HLA-E/β2m, preferentially overexpressed in metastases compared with primary tumors and associated with CD94+ tumor infiltrating lymphocytes (TILs), was associated with a poor overall survival. Altogether, these results strongly support the use of bispecific antibodies directed against both EGFR and FcγRIIIA (CD16) in mCRC patients, to boost cetuximab-mediated ADCC in RAS wild-type mCRC patients. The preferential overexpression of HLA-E/β2m in metastases, associated with CD94+ TILs and responsible for a poor prognosis, provides convincing arguments to inhibit this new immune checkpoint with monalizumab, a humanized anti-NKG2A antibody, in combination with anti- FcγRIIIA/EGFR bispecific antibodies as a promising therapeutic perspective in RAS wild-type mCRC patients. [ABSTRACT FROM AUTHOR]
Published: 2021
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36. Evaluation of two nutritional scores' association with systemic treatment toxicity and survival in metastatic colorectal cancer: an AGEO prospective multicentre study

Author: Gallois, Claire, primary, Artru, Pascal, additional, Lièvre, Astrid, additional, Auclin, Edouard, additional, Lecomte, Thierry, additional, Locher, Christophe, additional, Marthey, Lysiane, additional, Zaimi, Yosra, additional, Faroux, Roger, additional, Pernot, Simon, additional, Barret, Maximilien, additional, and Taieb, Julien, additional
Published: 2019
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37. Carcinoembryonic Antigen Levels and Survival in Stage III Colon Cancer: Post hoc Analysis of the MOSAIC and PETACC-8 Trials

Author: Auclin, Edouard, primary, Taieb, Julien, additional, Lepage, Come, additional, Aparicio, Thomas, additional, Faroux, Roger, additional, Mini, Enrico, additional, Folprecht, Gunnar, additional, Salazar, Ramon, additional, Benetkiewicz, Magdalena, additional, Banzi, Maria, additional, Louvet, Christophe, additional, Van Laethem, Jean-Luc, additional, Tabernero, Josep, additional, Hickish, Tamas, additional, de Gramont, Aimery, additional, André, Thierry, additional, and Vernerey, Dewi, additional
Published: 2019
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38. Increased incidence of Campylobacter enteritis and their quinolone resistance between 2010 and 2015: Results of a French national observatory conducted in 21 general hospitals (CHG)

Author: Trompette, Marie, primary, Le Guilloux, Laura, additional, Souply, Laurent, additional, Denis, Bernard, additional, Tsouria, Ahmed, additional, Garrec, Hélène, additional, Quentin, Vincent, additional, Vaucel, Jacques, additional, Locher, Christophe, additional, Barjonet, Georges, additional, Marthelet, Patrick, additional, Causse, Xavier, additional, Poisson, Didier, additional, Nahon, Stéphane, additional, Joubrel-Guyot, Caroline, additional, Grasset, Denis, additional, Pouedras, Pascal, additional, Renou, Christophe, additional, Toyer, Anne-Lise, additional, Boruchowicz, Arnaud, additional, Cattoen, Christian, additional, Heluwaert, Frédéric, additional, Bland, Stéphane, additional, Faroux, Roger, additional, Desroys, Valérie, additional, Paupard, Thierry, additional, Verhaeghe, Annick, additional, Correro, Maria Ortiz, additional, Pujol, Charlotte, additional, Picon, Magali, additional, Gallou, Jenny, additional, Kaassi, Meddi, additional, Touroult-Jupin, Pauline, additional, Arotcarena, Ratmutcho, additional, Villeneuve, Laurent, additional, Payen, Jean-Louis, additional, Libier, Lydie, additional, Charpignon, Claire, additional, Rahma, Mahjoub, additional, Manuardi, Aude Grébert, additional, Jeanne, Audrey, additional, Lahmek, Pierre, additional, Condat, Bertrand, additional, and Macaigne, Gilles, additional
Published: 2019
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39. Adjuvant chemotherapy versus perioperative chemotherapy (CTx) for resectable gastric signet ring cell (SRC) gastric cancer: A multicenter, randomized phase II study (PRODIGE 19).

Author: Eveno, Clarisse, primary, Adenis, Antoine, additional, Bouche, Olivier, additional, Le Malicot, Karine, additional, Hautefeuille, Vincent, additional, Faroux, Roger, additional, Thirot Bidault, Anne, additional, Egreteau, Joëlle, additional, Meunier, Bernard, additional, Mabro, May, additional, Carrere, Nicolas, additional, Barriere, Nicolas, additional, Ben Abdelghani, Meher, additional, Mauvais, François, additional, Di Fiore, Frédéric, additional, Malka, David, additional, Manfredi, Sylvain, additional, and Piessen, Guillaume, additional
Published: 2019
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40. Screening patients for fluoropyrimidine-related toxicity risk.

Author: Capitain, Olivier, primary, Seegers, Valérie, additional, Metges, Jean-Philippe, additional, Faroux, Roger, additional, Stampfli, Claire, additional, Ferec, Marc, additional, Matysiak-Budnik, Tamara, additional, Senellart, Helene, additional, Rossi, Valerie, additional, Blouin, Nadege, additional, Boisdron-Celle, Michele, additional, Dauve, Jonathan, additional, and Campone, Mario, additional
Published: 2019
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41. Validation of the Immunoscore prognostic value in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR).

Author: Pages, Franck, primary, Andre, Thierry, additional, Taieb, Julien, additional, Vernerey, Dewi, additional, Henriques, Julie, additional, Borg, Christophe, additional, Marliot, Florence, additional, Ben Jannet, Rim, additional, Louvet, Christophe, additional, Mineur, Laurent, additional, Bennouna, Jaafar, additional, Desrame, Jérôme, additional, Faroux, Roger, additional, Duval, Alex, additional, Laurent-Puig, Pierre, additional, Svrcek, Magali, additional, Hermitte, Fabienne, additional, Catteau, Aurelie, additional, Galon, Jerome, additional, and Emile, Jean-François, additional
Published: 2019
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42. Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab

Author: Dohan, Anthony, primary, Gallix, Benoit, additional, Guiu, Boris, additional, Le Malicot, Karine, additional, Reinhold, Caroline, additional, Soyer, Philippe, additional, Bennouna, Jaafar, additional, Ghiringhelli, Francois, additional, Barbier, Emilie, additional, Boige, Valérie, additional, Taieb, Julien, additional, Bouché, Olivier, additional, François, Eric, additional, Phelip, Jean-Marc, additional, Borel, Christian, additional, Faroux, Roger, additional, Seitz, Jean-Francois, additional, Jacquot, Stéphane, additional, Ben Abdelghani, Meher, additional, Khemissa-Akouz, Faiza, additional, Genet, Dominique, additional, Jouve, Jean Louis, additional, Rinaldi, Yves, additional, Desseigne, Françoise, additional, Texereau, Patrick, additional, Suc, Etienne, additional, Lepage, Come, additional, Aparicio, Thomas, additional, and Hoeffel, Christine, additional
Published: 2019
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43. Gemcitabine and Oxaliplatin Chemotherapy or Surveillance in Resected Biliary Tract Cancer (PRODIGE 12-ACCORD 18-UNICANCER GI): A Randomized Phase III Study

Author: Edeline, Julien, primary, Benabdelghani, Meher, additional, Bertaut, Aurélie, additional, Watelet, Jérôme, additional, Hammel, Pascal, additional, Joly, Jean-Paul, additional, Boudjema, Karim, additional, Fartoux, Laetitia, additional, Bouhier-Leporrier, Karine, additional, Jouve, Jean-Louis, additional, Faroux, Roger, additional, Guerin-Meyer, Véronique, additional, Kurtz, Jean-Emmanuel, additional, Assénat, Eric, additional, Seitz, Jean-François, additional, Baumgaertner, Isabelle, additional, Tougeron, David, additional, de la Fouchardière, Christelle, additional, Lombard-Bohas, Catherine, additional, Boucher, Eveline, additional, Stanbury, Trevor, additional, Louvet, Christophe, additional, Malka, David, additional, and Phelip, Jean-Marc, additional
Published: 2019
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44. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

Author: Chupin Louis-Dominique, Lafraise Bernard, Ollivry Jean, Faroux Roger, Le Houérou Claire, Le Neel Tanguy, Colman Hélène, Scoul Catherine, Robiou-du-Pont Sébastien, Buecher Bruno, Küry Sébastien, Sébille Véronique, and Bézieau Stéphane
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-penetrance alleles of extremely varied genes to be involved in susceptibility to CRC in Caucasian populations. Methods Through a large genetic association study based on 1023 patients with sporadic CRC and 1121 controls, we tested a panel of these low-penetrance alleles to find out whether they could determine "genotypic profiles" at risk for CRC among individuals of the French population. We examined 52 polymorphisms of 35 genes – drawn from inflammation, xenobiotic detoxification, one-carbon, insulin signaling, and DNA repair pathways – for their possible contribution to colorectal carcinogenesis. The risk of cancer associated with these polymorphisms was assessed by calculation of odds ratios (OR) using multivariate analyses and logistic regression. Results Whereas all these polymorphisms had previously been found to be associated with CRC risk, especially in Caucasian populations, we were able to replicate the association for only five of them. Three SNPs were shown to increase CRC risk: PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu). On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk. Further analyses highlighted genotypic combinations having a greater predisposing effect on CRC (OR 1.97, 95%CI 1.31–2.97, p = 0.0009) than the allelic variants that were examined separately. Conclusion The identification of CRC-predisposing combinations, composed of alleles PTGS1 c.639A, PLA2G2A c.435+230C, PPARG c.1431C, IL8 c.-352A, and MTHFR c.1286C, highlights the importance of inflammatory processes in susceptibility to sporadic CRC, as well as a possible crosstalk between inflammation and one-carbon pathways.
Published: 2008
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45. Phase 2 trial comparing sorafenib, pravastatin, their combination or supportive care in HCC with Child–Pugh B cirrhosis.

Author: Blanc, Jean-Frédéric, Khemissa, Faiza, Bronowicki, Jean-Pierre, Monterymard, Carole, Perarnau, Jean-Marc, Bourgeois, Vincent, Obled, Stéphane, Abdelghani, Meher Ben, Mabile-Archambeaud, Isabelle, Faroux, Roger, Seitz, Jean-François, Locher, Christophe, Senellart, Hélène, Villing, Anne-Laure, Audemar, Franck, Costentin, Charlotte, Deplanque, Gaël, Manfredi, Sylvain, Edeline, Julien, and for the PRODIGE 21 collaborators
Abstract: Background and aims: There is limited data regarding the role for systemic treatment in patients with Hepatocellular Carcinoma with Child–Pugh B cirrhosis. Methods: PRODIGE 21 was a multicentric prospective non-comparative randomized trial. Patients were randomized to receive sorafenib (Arm A), pravastatin (Arm B), sorafenib–pravastatin (Arm C) combination, or best supportive care (Arm D). Primary endpoint was time to progression (TTP), secondary endpoints included safety and overall survival (OS). Results: 160 patients were randomized and 157 patients were included in the final analysis. 86% of patients were BCLC C and 55% had macrovascular invasion. The safety profiles of the drugs were as expected. Median TTP was 3.5, 2.8, 2.0 and 2.2 months in arms A, B, C and D, respectively, but analysis was limited by the number of patients deceased without radiological progression (59%). Median OS was similar between the four arms: 3.8 [95% CI: 2.4–6.5], 3.1 [95% CI: 1.9–4.3], 4.0 [95% CI: 3.2–5.5] and 3.5 months [95% CI: 2.2–5.4] in arms A, B, C and D, respectively. Median OS was 4.0 months [95% CI: 3.3–5.5] for patients treated with sorafenib, vs 2.9 months [95% CI: 2.2–3.9] for patients not treated with sorafenib. In patients with ALBI grade 1/2, median OS was 6.1 months [95% CI: 3.8–8.3] in patients treated with sorafenib vs 3.1 months [95% CI: 1.9–4.8] for patients not treated with sorafenib. Conclusion: In the overall Child–Pugh B population, neither sorafenib nor pravastatin seemed to provide benefit. In the ALBI grade 1/2 sub-population, our trial suggests potential benefit of sorafenib. Clinical trial registration: The study was referenced in clinicaltrials.gov (NCT01357486). [ABSTRACT FROM AUTHOR]
Published: 2021
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46. Efficacy and safety of panitumumab in a cohort of patients with metastatic colorectal cancer in France: PANI OUEST, a post-EMA-approval descriptive study with a geriatric oncology focus.

Author: Metges, Jean-Philippe, Douillard, Jean-Yves, Ramée, Jean-François, Dupuis, Olivier, Senellart, Helene, Porneuf, Marc, Deguiral, Philippe, Achour, Nach Eddine, Edeline, Julien, Cumin, Isabelle, Artignan, Xavier, Faroux, Roger, Stampfli, Claire, Cojocarasu, Oana, Gourlaouen, Alain, Bideau, Karine, Meyer, Véronique Guérin, Fichet, Aurelie, Klein, Vincent, and Touchefeu, Yann
Published: 2020
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47. Predictive factors for early progression during induction chemotherapy and chemotherapy-free interval: analysis from PRODIGE 9 trial.

Author: Aparicio, Thomas, Bennouna, Jaafar, Le Malicot, Karine, Boige, Valérie, Taieb, Julien, Bouché, Olivier, Phelip, Jean-Marc, François, Eric, Borel, Christian, Faroux, Roger, Dahan, Laetitia, Bachet, Jean-Baptiste, Egreteau, Joelle, Kaminsky, Marie-Christine, Gornet, Jean-Marc, Cojocarasu, Oana, Gasmi, Mohamed, Guerin-Meyer, Véronique, Lepage, Côme, and Ghiringhelli, François
Subjects: DISEASE progression, COLORECTAL cancer
Abstract: Background: Identifying patients with metastatic colorectal cancer who will have an early disease progression during induction chemotherapy (IC) and identifying patients who may have a chemotherapy-free interval (CFI) after IC are two major challenges.Methods: A logistic model was used to identify factors associated with early progression during IC and with short duration of the first CFI in 488 patients enrolled in the PRODIGE 9 trial. Independent factors were defined with a threshold 0.10.Results: In multivariate analysis, baseline leukocytes >10 × 109/L (OR = 1.98 [1.02-3.8], p = 0.04), and stable or increasing CEA at 2 months (OR = 3.61 [1.68-7.75], p = 0.01) were independent factors associated with progression during IC. Male gender (OR = 1.725 [0.92-3.325], p = 0.09) and no tumour response at first evaluation (OR = 1.90 [0.96-3.76], p = 0.07) were significantly associated with a short CFI. The presence of BRAF V600E mutation was also associated with short CFI (OR = 4.59 [0.95; 22.3], p = 0.058).Conclusion: High baseline leukocyte count and the lack of CEA decrease level at first evaluation were associated with early progression, and could be in favour of early chemotherapy intensification. Male gender, no tumour response at first evaluation and BRAF mutation are associated with a short CFI, and may be considered for maintenance chemotherapy after IC.Clinical Trial Number: NCT00952029. [ABSTRACT FROM AUTHOR]
Published: 2020
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48. Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab.

Author: Dohan, Anthony, Gallix, Benoit, Guiu, Boris, Le Malicot, Karine, Reinhold, Caroline, Soyer, Philippe, Bennouna, Jaafar, Ghiringhelli, Francois, Barbier, Emilie, Boige, Valérie, Taieb, Julien, Bouché, Olivier, François, Eric, Phelip, Jean-Marc, Borel, Christian, Faroux, Roger, Seitz, Jean-Francois, Jacquot, Stéphane, Ben Abdelghani, Meher, and Khemissa-Akouz, Faiza
Subjects: LIVER metastasis, COLORECTAL cancer
Published: 2020
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49. Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Author: Aparicio, Thomas, primary, Ducreux, Michel, additional, Faroux, Roger, additional, Barbier, Emilie, additional, Manfredi, Sylvain, additional, Lecomte, Thierry, additional, Etienne, Pierre-Luc, additional, Bedenne, Laurent, additional, Bennouna, Jaafar, additional, Phelip, Jean-Marc, additional, François, Eric, additional, Michel, Pierre, additional, Legoux, Jean-Louis, additional, Gasmi, Mohamed, additional, Breysacher, Gilles, additional, Rougier, Philippe, additional, De Gramont, Aimery, additional, Lepage, Come, additional, Bouché, Olivier, additional, Seitz, Jean-François, additional, Adenis, A., additional, Alessio, A., additional, Aouakli, A., additional, Azzedine, A., additional, Bedjaoui, A., additional, Bidault, A., additional, Blanchi, A., additional, Botton, A., additional, Cadier-Lagnes, A., additional, Fatisse, A., additional, Gagnaire, A., additional, Gilbert, A., additional, Gueye, A., additional, Hollebecque, A., additional, Lemaire, A., additional, Mahamat, A., additional, Marre, A., additional, Patenotte, A., additional, Rotenberg, A., additional, Roussel, A., additional, Thirot-Bidault, A., additional, Votte, A., additional, Weber, A., additional, Zaanan, A., additional, Dupont-Gossart, A.C., additional, Villing, A.L., additional, Queuniet, A.M., additional, Coudert, B., additional, Denis, B., additional, Garcia, B., additional, Lafforgue, B., additional, Landi, B., additional, Leduc, B., additional, Linot, B., additional, Paillot, B., additional, Rhein, B., additional, Winkfield, B., additional, Barberis, C., additional, Becht, C., additional, Belletier, C., additional, Berger, C., additional, Bineau, C., additional, Borel, C., additional, Brezault, C., additional, Buffet, C., additional, Cornila, C., additional, Couffon, C., additional, De La Fouchardière, C., additional, Giraud, C., additional, Lecaille, C., additional, Lepere, C., additional, Lobry, C., additional, Locher, C., additional, Lombard-Bohas, C., additional, Paoletti, C., additional, Platini, C., additional, Rebischung, C., additional, Sarda, C., additional, Vilain, C., additional, Briac-Levaché, C., additional, Auby, D., additional, Baudet-Klepping, D., additional, Bechade, D., additional, Besson, D., additional, Cleau, D., additional, Festin, D., additional, Gargot, D., additional, Genet, D., additional, Goldfain, D., additional, Luet, D., additional, Malka, D., additional, Peré-Vergé, D., additional, Pillon, D., additional, Sevin-Robiche, D., additional, Smith, D., additional, Soubrane, D., additional, Tougeron, D., additional, Zylberait, D., additional, Carola, E., additional, Cuillerier, E., additional, Dorval Danquechin, E., additional, Echinard, E., additional, Janssen, E., additional, Maillard, E., additional, Mitry, E., additional, Norguet-Monnereau, E., additional, Suc, E., additional, Terrebonne, E., additional, Zrihen, E., additional, Pariente, E.A., additional, Almaric, F., additional, Audemar, F., additional, Bonnetain, F., additional, Desseigne, F., additional, Dewaele, F., additional, Di Fiore, F., additional, Ghiringhelli, F., additional, Husseini, F., additional, Khemissa, F., additional, Kikolski, F., additional, Morvan, F., additional, Petit-Laurent, F., additional, Riot, F., additional, Subtil, F., additional, Zerouala-Boussaha, F., additional, Caroli-Bosc, F.X., additional, Boilleau-Jolimoy, G., additional, Bordes, G., additional, Cavaglione, G., additional, Coulanjon, G., additional, Deplanque, G., additional, Gatineau-Saillant, G., additional, Goujon, G., additional, Medinger, G., additional, Roquin, G., additional, Brixi-Benmansour, H., additional, Castanie, H., additional, Lacroix, H., additional, Maechel, H., additional, Perrier, H., additional, Salloum, H., additional, Senellart, H., additional, Baumgaertner, I., additional, Cumin, I., additional, Graber, I., additional, Trouilloud, I., additional, Boutin, J., additional, Butel, J., additional, Charneau, J., additional, Cretin, J., additional, Dauba, J., additional, Deguiral, J., additional, Egreteau, J., additional, Ezenfis, J., additional, Forestier, J., additional, Goineau, J., additional, Lacourt, J., additional, Lafon, J., additional, Martin, J., additional, Meunier, J., additional, Moreau, J., additional, Provencal, J., additional, Taieb, J., additional, Thaury, J., additional, Tuaillon, J., additional, Vergniol, J., additional, Villand, J., additional, Vincent, J., additional, Volet, J., additional, Bachet, J.B., additional, Barbare, J.C., additional, Souquet, J.C., additional, Grangé, J.D., additional, Dor, J.F., additional, Paitel, J.F., additional, Jouve, J.L., additional, Raoul, J.L., additional, Cheula, J.M., additional, Gornet, J.M., additional, Sabate, J.M., additional, Vantelon, J.M., additional, Vaillant, J.N., additional, Aucouturier, J.P., additional, Barbieux, J.P., additional, Herr, J.P., additional, Lafargue, J.P., additional, Lagasse, J.P., additional, Latrive, J.P., additional, Plachot, J.P., additional, Ramain, J.P., additional, Robin, J.P., additional, Spano, J.P., additional, Douillard, J.Y., additional, Beerblock, K., additional, Bouhier-Leporrier, K., additional, Slimane Fawzi, K., additional, Cany, L., additional, Chone, L., additional, Dahan, L., additional, Gasnault, L., additional, Rob, L., additional, Stefani, L., additional, Wander, L., additional, Baconnier, M., additional, Ben Abdelghani, M., additional, Benchalal, M., additional, Blasquez, M., additional, Carreiro, M., additional, Charbit, M., additional, Combe, M., additional, Duluc, M., additional, Fayolle, M., additional, Gignoux, M., additional, Giovannini, M., additional, Glikmanas, M., additional, Mabro, M., additional, Mignot, M., additional, Mornet, M., additional, Mousseau, M., additional, Mozer, M., additional, Pauwels, M., additional, Pelletier, M., additional, Porneuf, M., additional, Ramdani, M., additional, Schnee, M., additional, Tissot, M., additional, Zawadi, M., additional, Clavero-Fabri, M.C., additional, Gouttebel, M.C., additional, Kaminsky, M.C., additional, Galais, M.P., additional, Abdelli, N., additional, Barrière, N., additional, Bouaria, N., additional, Bouarioua, N., additional, Delas, N., additional, Gérardin, N., additional, Hess-Laurens, N., additional, Stremsdoerfer, N., additional, Berthelet, O., additional, Boulat, O., additional, Capitain, O., additional, Favre, O., additional, Amoyal, P., additional, Bergerault, P., additional, Burtin, P., additional, Cassan, P., additional, Chatrenet, P., additional, Chiappa, P., additional, Claudé, P., additional, Couzigou, P., additional, Feydy, P., additional, Follana, P., additional, Geoffroy, P., additional, Godeau, P., additional, Hammel, P., additional, Laplaige, P., additional, Lehair, P., additional, Martin, P., additional, Novello, P., additional, Pantioni, P., additional, Pienkowski, P., additional, Pouderoux, P., additional, Prost, P., additional, Ruszniewski, P., additional, Souillac, P., additional, Texereau, P., additional, Thévenet, P., additional, Haineaux, P.A., additional, Benoit, R., additional, Coriat, R., additional, Lamy, R., additional, Mackiewicz, R., additional, Beorchia, S., additional, Chaussade, S., additional, Hiret, S., additional, Jacquot, S., additional, Lavau Denes, S., additional, Montembault, S., additional, Nahon, S., additional, Nasca, S., additional, Nguyen, S., additional, Oddou-Lagraniere, S., additional, Pesque-Penaud, S., additional, Fratte, S.P., additional, Chatellier, T., additional, Mansourbakht, T., additional, Morin, T., additional, Walter, T., additional, Boige, V., additional, Bourgeois, V., additional, Derias, V., additional, Guérin-Meyer, V., additional, Hautefeuille, V., additional, Jestin Le Tallec, V., additional, Lorgis, V., additional, Quentin, V., additional, Sebbagh, V., additional, Veuillez, V., additional, Adhoute, X., additional, Coulaud, X., additional, Becouarn, Y., additional, Coscas, Y., additional, Courouble, Y., additional, Le Bricquir, Y., additional, Molin, Y., additional, Rinaldi, Y., additional, Lam, Y.H., additional, and Ladhib, Z., additional
Published: 2018
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50. Unicancer GI PRODIGE 24/CCTG PA.6 trial: A multicenter international randomized phase III trial of adjuvant mFOLFIRINOX versus gemcitabine (gem) in patients with resected pancreatic ductal adenocarcinomas.

Author: Conroy, Thierry, primary, Hammel, Pascal, additional, Hebbar, Mohamed, additional, Ben Abdelghani, Meher, additional, Wei, Alice Chia-chi, additional, Raoul, Jean-Luc, additional, Chone, Laurence, additional, Francois, Eric, additional, Artru, Pascal, additional, Biagi, James Joseph, additional, Lecomte, Thierry, additional, Assenat, Eric, additional, Faroux, Roger, additional, Ychou, Marc, additional, Volet, Julien, additional, Sauvanet, Alain, additional, Jouffroy-Zeller, Claire, additional, RAT, Patrick, additional, Castan, Florence, additional, and Bachet, Jean-Baptiste, additional
Published: 2018
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