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1. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Author

Barr, Cathy L., Batterson, James R., Berlin, Cheston, Budman, Cathy L., Coppola, Giovanni, Cox, Nancy J., Darrow, Sabrina, Dion, Yves, Freimer, Nelson B., Grados, Marco A., Greenberg, Erica, Hirschtritt, Matthew E., Huang, Alden Y., Illmann, Cornelia, King, Robert A., Kurlan, Roger, Leckman, James F., Lyon, Gholson J., Malaty, Irene A., McMahon, William M., Neale, Benjamin M., Okun, Michael S., Osiecki, Lisa, Robertson, Mary M., Rouleau, Guy A., Sandor, Paul, Singer, Harvey S., Smit, Jan H., Sul, Jae Hoon, Androutsos, Christos, Basha, Entela, Farkas, Luca, Fichna, Jakub, Janik, Piotr, Kapisyzi, Mira, Karagiannidis, Iordanis, Koumoula, Anastasia, Nagy, Peter, Puchala, Joanna, Szejko, Natalia, Szymanska, Urszula, Tsironi, Vaia, Apter, Alan, Ball, Juliane, Bodmer, Benjamin, Bognar, Emese, Buse, Judith, Vela, Marta Correa, Fremer, Carolin, Garcia-Delgar, Blanca, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Madruga-Garrido, Marcos, Pellico, Alessandra, Ruhrman, Daphna, Schnell, Jaana, Silvestri, Paola Rosaria, Skov, Liselotte, Steinberg, Tamar, Gloor, Friederike Tagwerker, Turner, Victoria L., Weidinger, Elif, Alexander, John, Aranyi, Tamas, Buisman, Wim R., Buitelaar, Jan K., Driessen, Nicole, Drineas, Petros, Fan, Siyan, Forde, Natalie J., Gerasch, Sarah, van den Heuvel, Odile A., Jespersgaard, Cathrine, Kanaan, Ahmad S., Möller, Harald E., Nawaz, Muhammad S., Nespoli, Ester, Pagliaroli, Luca, Poelmans, Geert, Pouwels, Petra J.W., Rizzo, Francesca, Veltman, Dick J., van der Werf, Ysbrand D., Widomska, Joanna, Zilhäo, Nuno R., Brown, Lawrence W., Cheon, Keun-Ah, Coffey, Barbara J., Fernandez, Thomas V., Gilbert, Donald L., Hong, Hyun Ju, Ibanez-Gomez, Laura, Kim, Eun-Joo, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett L., Maras, Athanasios, Murphy, Tara L., Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, State, Matthew W., Visscher, Frank, Wang, Sheng, Zinner, Samuel H., Tsetsos, Fotis, Topaloudi, Apostolia, Jain, Pritesh, Yang, Zhiyu, Yu, Dongmei, Kolovos, Petros, Tumer, Zeynep, Rizzo, Renata, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Müller-Vahl, Kirsten R., Cath, Danielle C., Boomsma, Dorret I., Wolanczyk, Tomasz, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Padmanabhuni, Shanmukha S., Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Yannaki, Evangelia, Stamatoyannopoulos, John A., Benaroya-Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Mir, Pablo, Morer, Astrid, Mueller, Norbert, Munchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Roessner, Veit, Walitza, Susanne, Schrag, Anette, Martino, Davide, Tischfield, Jay A., Heiman, Gary A., Willsey, A. Jeremy, Dietrich, Andrea, Davis, Lea K., Crowley, James J., Mathews, Carol A., Scharf, Jeremiah M., Georgitsi, Marianthi, Hoekstra, Pieter J., and Paschou, Peristera

Published
2024
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9. Removal of Trimethoprim and 5-Fluorouracil by UV/Persulfate and UV/VUV Persulfate Methods †.

Author

Farkas, Luca, Szirmai, Adrienn, Covic, Anett, and Alapi, Tünde

Subjects
ULTRAVIOLET photolysis, FLUOROURACIL, TRIMETHOPRIM, PERSULFATES, MINERALIZATION
Abstract

The UV, UV/VUV photolysis and their combination with persulfate (S2O82−) were studied for the elimination of trimethoprim and 5-fluorouracil. Methods were examined in terms of transformation and mineralization rate and the matrix effect. The relative contribution of the direct UV photolysis and radical-based reactions (•OH, SO4•−) were also investigated. Without S2O82−, the efficiency of UV/VUV photolysis highly exceeds that of UV photolysis due to the •OH formation, while in the presence of S2O82−, the dominant reaction partner is SO4•−. However, SO4•−-based methods proved to be efficient for both transformation and mineralization; they are sensitive for the matrix components. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Comparison of TiO 2 and ZnO for Heterogeneous Photocatalytic Activation of the Peroxydisulfate Ion in Trimethoprim Degradation.

Author

Náfrádi, Máté, Alapi, Tünde, Veres, Bence, Farkas, Luca, Bencsik, Gábor, and Janáky, Csaba

Subjects
TITANIUM dioxide, SEWAGE, ZINC oxide, TRIMETHOPRIM, IONS
Abstract

The persulfate-based advanced oxidation process is a promising method for degrading organic pollutants. Herein, TiO2 and ZnO photocatalysts were combined with the peroxydisulfate ion (PDS) to enhance the efficiency. ZnO was significantly more efficient in PDS conversion and SO4•− generation than TiO2. For ZnO, the PDS increased the transformation rate of the trimethoprim antibiotic from 1.58 × 10−7 M s−1 to 6.83 × 10−7 M s−1. However, in the case of TiO2, the moderated positive effect was manifested mainly in O2-free suspensions. The impact of dissolved O2 and trimethoprim on PDS transformation was also studied. The results reflected that the interaction of O2, PDS, and TRIM with the surface of the photocatalyst and their competition for photogenerated charges must be considered. The effect of radical scavengers confirmed that in addition to SO4•−, •OH plays an essential role even in O2-free suspensions, and the contribution of SO4•− to the transformation is much more significant for ZnO than for TiO2. The negative impact of biologically treated domestic wastewater as a matrix was manifested, most probably because of the radical scavenging capacity of Cl− and HCO3−. Nevertheless, in the case of ZnO, the positive effect of PDS successfully overcompensates that, due to the efficient SO4•− generation. Reusability tests were performed in Milli-Q water and biologically treated domestic wastewater, and only a slight decrease in the reactivity of ZnO photocatalysts was observed. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Genome-wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Author

Tsetsos, Fotis, primary, Topaloudi, Apostolia, additional, Jain, Pritesh, additional, Yang, Zhiyu, additional, Yu, Dongmei, additional, Kolovos, Petros, additional, Tumer, Zeynep, additional, Rizzo, Renata, additional, Hartmann, Andreas, additional, Depienne, Christel, additional, Worbe, Yulia, additional, Müller-Vahl, Kirsten R., additional, Cath, Danielle C., additional, Boomsma, Dorret I., additional, Wolanczyk, Tomasz, additional, Zekanowski, Cezary, additional, Barta, Csaba, additional, Nemoda, Zsofia, additional, Tarnok, Zsanett, additional, Padmanabhuni, Shanmukha S., additional, Buxbaum, Joseph D., additional, Grice, Dorothy, additional, Glennon, Jeffrey, additional, Stefansson, Hreinn, additional, Hengerer, Bastian, additional, Yannaki, Evangelia, additional, Stamatoyannopoulos, John A., additional, Benaroya-Milshtein, Noa, additional, Cardona, Francesco, additional, Hedderly, Tammy, additional, Heyman, Isobel, additional, Huyser, Chaim, additional, Mir, Pablo, additional, Morer, Astrid, additional, Mueller, Norbert, additional, Munchau, Alexander, additional, Plessen, Kerstin J., additional, Porcelli, Cesare, additional, Roessner, Veit, additional, Walitza, Susanne, additional, Schrag, Anette, additional, Martino, Davide, additional, Tischfield, Jay A., additional, Heiman, Gary A., additional, Willsey, A. Jeremy, additional, Dietrich, Andrea, additional, Davis, Lea K., additional, Crowley, James J., additional, Mathews, Carol A., additional, Scharf, Jeremiah M., additional, Georgitsi, Marianthi, additional, Hoekstra, Pieter J., additional, Paschou, Peristera, additional, Barr, Cathy L., additional, Batterson, James R., additional, Berlin, Cheston, additional, Budman, Cathy L., additional, Coppola, Giovanni, additional, Cox, Nancy J., additional, Darrow, Sabrina, additional, Dion, Yves, additional, Freimer, Nelson B., additional, Grados, Marco A., additional, Greenberg, Erica, additional, Hirschtritt, Matthew E., additional, Huang, Alden Y., additional, Illmann, Cornelia, additional, King, Robert A., additional, Kurlan, Roger, additional, Leckman, James F., additional, Lyon, Gholson J., additional, Malaty, Irene A., additional, McMahon, William M., additional, Neale, Benjamin M., additional, Okun, Michael S., additional, Osiecki, Lisa, additional, Robertson, Mary M., additional, Rouleau, Guy A., additional, Sandor, Paul, additional, Singer, Harvey S., additional, Smit, Jan H., additional, Sul, Jae Hoon, additional, Androutsos, Christos, additional, Basha, Entela, additional, Farkas, Luca, additional, Fichna, Jakub, additional, Janik, Piotr, additional, Kapisyzi, Mira, additional, Karagiannidis, Iordanis, additional, Koumoula, Anastasia, additional, Nagy, Peter, additional, Puchala, Joanna, additional, Szejko, Natalia, additional, Szymanska, Urszula, additional, Tsironi, Vaia, additional, Apter, Alan, additional, Ball, Juliane, additional, Bodmer, Benjamin, additional, Bognar, Emese, additional, Buse, Judith, additional, Vela, Marta Correa, additional, Fremer, Carolin, additional, Garcia-Delgar, Blanca, additional, Gulisano, Mariangela, additional, Hagen, Annelieke, additional, Hagstrøm, Julie, additional, Madruga-Garrido, Marcos, additional, Pellico, Alessandra, additional, Ruhrman, Daphna, additional, Schnell, Jaana, additional, Silvestri, Paola Rosaria, additional, Skov, Liselotte, additional, Steinberg, Tamar, additional, Gloor, Friederike Tagwerker, additional, Turner, Victoria L., additional, Weidinger, Elif, additional, Alexander, John, additional, Aranyi, Tamas, additional, Buisman, Wim R., additional, Buitelaar, Jan K., additional, Driessen, Nicole, additional, Drineas, Petros, additional, Fan, Siyan, additional, Forde, Natalie J., additional, Gerasch, Sarah, additional, van den Heuvel, Odile A., additional, Jespersgaard, Cathrine, additional, Kanaan, Ahmad S., additional, Möller, Harald E., additional, Nawaz, Muhammad S., additional, Nespoli, Ester, additional, Pagliaroli, Luca, additional, Poelmans, Geert, additional, Pouwels, Petra J.W., additional, Rizzo, Francesca, additional, Veltman, Dick J., additional, van der Werf, Ysbrand D., additional, Widomska, Joanna, additional, Zilhäo, Nuno R., additional, Brown, Lawrence W., additional, Cheon, Keun-Ah, additional, Coffey, Barbara J., additional, Fernandez, Thomas V., additional, Gilbert, Donald L., additional, Hong, Hyun Ju, additional, Ibanez-Gomez, Laura, additional, Kim, Eun-Joo, additional, Kim, Young Key, additional, Kim, Young-Shin, additional, Koh, Yun-Joo, additional, Kook, Sodahm, additional, Kuperman, Samuel, additional, Leventhal, Bennett L., additional, Maras, Athanasios, additional, Murphy, Tara L., additional, Shin, Eun-Young, additional, Song, Dong-Ho, additional, Song, Jungeun, additional, State, Matthew W., additional, Visscher, Frank, additional, Wang, Sheng, additional, and Zinner, Samuel H., additional

Published
2023
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16. Risk-behaviour screening for identifying adolescents with mental health problems in Europe

Author

Kaess, Michael, Brunner, Romuald, Parzer, Peter, Carli, Vladimir, Apter, Alan, Balazs, Judit A., Bobes, Julio, Coman, Horia G., Cosman, Doina, Cotter, Padraig, Durkee, Tony, Farkas, Luca, Feldman, Dana, Haring, Christian, Iosue, Miriam, Kahn, Jean-Pierre, Keeley, Helen, Podlogar, Tina, Postuvan, Vita, Resch, Franz, Sáiz, Pilar A., Sisask, Merike, Tubiana, Alexandra, Värnik, Peeter, Sarchiapone, Marco, Hoven, Christina W., and Wasserman, Danuta

Published
2014
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18. Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families

Author

Karagiannidis, Iordanis, Dehning, Sandra, Sandor, Paul, Tarnok, Zsanett, Rizzo, Renata, Wolanczyk, Tomasz, Madruga-Garrido, Marcos, Hebebrand, Johannes, Nöthen, Markus M, Lehmkuhl, Gerd, Farkas, Luca, Nagy, Peter, Szymanska, Urszula, Anastasiou, Zachos, Stathias, Vasileios, Androutsos, Christos, Tsironi, Vaia, Koumoula, Anastasia, Barta, Csaba, Zill, Peter, Mir, Pablo, Müller, Norbert, Barr, Cathy, and Paschou, Peristera

Published
2013
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19. Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome

Author

Pagliaroli, Luca, primary, Vereczkei, Andrea, additional, Padmanabhuni, Shanmukha Sampath, additional, Tarnok, Zsanett, additional, Farkas, Luca, additional, Nagy, Peter, additional, Rizzo, Renata, additional, Wolanczyk, Tomasz, additional, Szymanska, Urszula, additional, Kapisyzi, Mira, additional, Basha, Entela, additional, Koumoula, Anastasia, additional, Androutsos, Christos, additional, Tsironi, Vaia, additional, Karagiannidis, Iordanis, additional, Paschou, Peristera, additional, and Barta, Csaba, additional

Published
2020
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20. Suicide prevention for youth - a mental health awareness program: lessons learned from the Saving and Empowering Young Lives in Europe (SEYLE) intervention study

Author

Wasserman Camilla, Hoven Christina W, Wasserman Danuta, Carli Vladimir, Sarchiapone Marco, Al-Halabí Susana, Apter Alan, Balazs Judit, Bobes Julio, Cosman Doina, Farkas Luca, Feldman Dana, Fischer Gloria, Graber Nadja, Haring Christian, Herta Dana, Iosue Miriam, Kahn Jean-Pierre, Keeley Helen, Klug Katja, McCarthy Jacklyn, Tubiana-Potiez Alexandra, Varnik Airi, Varnik Peeter, Žiberna Janina, and Poštuvan Vita

Subjects
Youth, Adolescents, Mental health, School-based, Awareness program, Suicide prevention, SEYLE, Intervention, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The Awareness program was designed as a part of the EU-funded Saving and Empowering Young Lives in Europe (SEYLE) intervention study to promote mental health of adolescents in 11 European countries by helping them to develop problem-solving skills and encouraging them to self-recognize the need for help as well as how to help peers in need. Methods For this descriptive study all coordinators of the SEYLE Awareness program answered an open-ended evaluation questionnaire at the end of the project implementation. Their answers were synthesized and analyzed and are presented here. Results The results show that the program cultivated peer understanding and support. Adolescents not only learned about mental health by participating in the Awareness program, but the majority of them also greatly enjoyed the experience. Conclusions Recommendations for enhancing the successes of mental health awareness programs are presented. Help and cooperation from schools, teachers, local politicians and other stakeholders will lead to more efficacious future programs.

Published
2012
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21. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Author

Wang, Sheng, primary, Mandell, Jeffrey D., additional, Kumar, Yogesh, additional, Sun, Nawei, additional, Morris, Montana T., additional, Arbelaez, Juan, additional, Nasello, Cara, additional, Dong, Shan, additional, Duhn, Clif, additional, Zhao, Xin, additional, Yang, Zhiyu, additional, Padmanabhuni, Shanmukha S., additional, Yu, Dongmei, additional, King, Robert A., additional, Dietrich, Andrea, additional, Khalifa, Najah, additional, Dahl, Niklas, additional, Huang, Alden Y., additional, Neale, Benjamin M., additional, Coppola, Giovanni, additional, Mathews, Carol A., additional, Scharf, Jeremiah M., additional, Fernandez, Thomas V., additional, Buxbaum, Joseph D., additional, De Rubeis, Silvia, additional, Grice, Dorothy E., additional, Xing, Jinchuan, additional, Heiman, Gary A., additional, Tischfield, Jay A., additional, Paschou, Peristera, additional, Willsey, A. Jeremy, additional, State, Matthew W., additional, Abdulkadir, Mohamed, additional, Bodmer, Benjamin, additional, Bromberg, Yana, additional, Brown, Lawrence W., additional, Cheon, Keun-Ah, additional, Coffey, Barbara J., additional, Deng, Li, additional, Elzerman, Lonneke, additional, Fremer, Carolin, additional, Garcia-Delgar, Blanca, additional, Gilbert, Donald L., additional, Hagstrøm, Julie, additional, Hedderly, Tammy, additional, Heyman, Isobel, additional, Hoekstra, Pieter J., additional, Hong, Hyun Ju, additional, Huyser, Chaim, additional, Kim, Eun-Joo, additional, Kim, Young Key, additional, Kim, Young-Shin, additional, Koh, Yun-Joo, additional, Kook, Sodahm, additional, Kuperman, Samuel, additional, Leventhal, Bennett L, additional, Ludolph, Andrea G., additional, Madruga-Garrido, Marcos, additional, Maras, Athanasios, additional, Mir, Pablo, additional, Morer, Astrid, additional, Morris, Montana T, additional, Müller-Vahl, Kirsten, additional, Münchau, Alexander, additional, Murphy, Tara L., additional, Plessen, Kerstin J., additional, Poisner, Hannah, additional, Roessner, Veit, additional, Sanders, Stephan J., additional, Shin, Eun-Young, additional, Song, Dong-Ho, additional, Song, Jungeun, additional, Thackray, Joshua K., additional, Tübing, Jennifer, additional, Visscher, Frank, additional, Wanderer, Sina, additional, Wang, Sheng, additional, Willsey, A Jeremy, additional, Woods, Martin, additional, Zhang, Yeting, additional, Zinner, Samuel H., additional, Androutsos, Christos, additional, Barta, Csaba, additional, Farkas, Luca, additional, Fichna, Jakub, additional, Georgitsi, Marianthi, additional, Janik, Piotr, additional, Karagiannidis, Iordanis, additional, Koumoula, Anastasia, additional, Nagy, Peter, additional, Puchala, Joanna, additional, Rizzo, Renata, additional, Szejko, Natalia, additional, Szymanska, Urszula, additional, Tarnok, Zsanett, additional, Tsironi, Vaia, additional, Wolanczyk, Tomasz, additional, Zekanowski, Cezary, additional, Barr, Cathy L., additional, Batterson, James R., additional, Berlin, Cheston, additional, Bruun, Ruth D., additional, Budman, Cathy L., additional, Cath, Danielle C., additional, Chouinard, Sylvain, additional, Cox, Nancy J., additional, Darrow, Sabrina, additional, Davis, Lea K., additional, Dion, Yves, additional, Freimer, Nelson B., additional, Grados, Marco A., additional, Hirschtritt, Matthew E., additional, Illmann, Cornelia, additional, Kurlan, Roger, additional, Leckman, James F., additional, Lyon, Gholson J., additional, Malaty, Irene A., additional, MacMahon, William M., additional, Okun, Michael S., additional, Osiecki, Lisa, additional, Pauls, David L., additional, Posthuma, Danielle, additional, Ramensky, Vasily, additional, Robertson, Mary M., additional, Rouleau, Guy A., additional, Sandor, Paul, additional, Singer, Harvey S., additional, Smit, Jan, additional, and Sul, Jae-Hoon, additional

Published
2018
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22. Direct Self-Injurious Behavior (D-SIB) and Life Events among Vocational School and High School Students

Author

Horváth, Lili, primary, Balint, Maria, additional, Ferenczi-Dallos, Gyongyver, additional, Farkas, Luca, additional, Gadoros, Julia, additional, Gyori, Dora, additional, Kereszteny, Agnes, additional, Meszaros, Gergely, additional, Szentivanyi, Dora, additional, Velo, Szabina, additional, Sarchiapone, Marco, additional, Carli, Vladimir, additional, Wasserman, Camilla, additional, Hoven, Christina, additional, Wasserman, Danuta, additional, and Balazs, Judit, additional

Published
2018
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23. Correlates of sexual initiation among European adolescents

Author

Gambadauro, Pietro, primary, Carli, Vladimir, additional, Hadlaczky, Gergö, additional, Sarchiapone, Marco, additional, Apter, Alan, additional, Balazs, Judit, additional, Banzer, Raphaela, additional, Bobes, Julio, additional, Brunner, Romuald, additional, Cosman, Doina, additional, Farkas, Luca, additional, Haring, Christian, additional, Hoven, Christina W., additional, Kaess, Michael, additional, Kahn, Jean Pierre, additional, McMahon, Elaine, additional, Postuvan, Vita, additional, Sisask, Merike, additional, Värnik, Airi, additional, Zadravec Sedivy, Nusa, additional, and Wasserman, Danuta, additional

Published
2018
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24. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, and Tümer, Zeynep

Abstract

BACKGROUND: Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations.METHODS: We screened a Danish cohort of 243 GTS patients and 1571 control subjects for submicroscopic deletions and duplications of these four genes. The most promising candidate gene, AADAC, identified in this Danish discovery sample was further investigated in cohorts from Iceland, the Netherlands, Hungary, Germany, and Italy, and a final meta-analysis, including a total of 1181 GTS patients and 118,730 control subjects from these six European countries, was performed. Subsequently, expression of the candidate gene in the central nervous system was investigated using human and mouse brain tissues.RESULTS: In the Danish cohort, we identified eight patients with overlapping deletions of AADAC. Investigation of the additional five countries showed a significant association between the AADAC deletion and GTS, and a final meta-analysis confirmed the significant association (p = 4.4 × 10(-4); odds ratio = 1.9; 95% confidence interval = 1.33-2.71). Furthermore, RNA in situ hybridization and reverse transcription-polymerase chain reaction studies revealed that AADAC is expressed in several brain regions previously implicated in GTS pathology.CONCLUSIONS: AADAC is a candidate susceptibility factor for GTS and the present findings warrant further genomic and functional studies to investigate the role of this gene in the pathogenesis of GTS.

Published
2016

25. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Leerstoel Hout, Experimental psychopathology, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep, Leerstoel Hout, Experimental psychopathology, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, and Tümer, Zeynep

Published
2016

26. Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology

Author

Alexander, John, primary, Potamianou, Hera, additional, Xing, Jinchuan, additional, Deng, Li, additional, Karagiannidis, Iordanis, additional, Tsetsos, Fotis, additional, Drineas, Petros, additional, Tarnok, Zsanett, additional, Rizzo, Renata, additional, Wolanczyk, Tomasz, additional, Farkas, Luca, additional, Nagy, Peter, additional, Szymanska, Urszula, additional, Androutsos, Christos, additional, Tsironi, Vaia, additional, Koumoula, Anastasia, additional, Barta, Csaba, additional, Sandor, Paul, additional, Barr, Cathy L., additional, Tischfield, Jay, additional, Paschou, Peristera, additional, Heiman, Gary A., additional, and Georgitsi, Marianthi, additional

Published
2016
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27. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Bertelsen, Birgitte, primary, Stefánsson, Hreinn, additional, Riff Jensen, Lars, additional, Melchior, Linea, additional, Mol Debes, Nanette, additional, Groth, Camilla, additional, Skov, Liselotte, additional, Werge, Thomas, additional, Karagiannidis, Iordanis, additional, Tarnok, Zsanett, additional, Barta, Csaba, additional, Nagy, Peter, additional, Farkas, Luca, additional, Brøndum-Nielsen, Karen, additional, Rizzo, Renata, additional, Gulisano, Mariangela, additional, Rujescu, Dan, additional, Kiemeney, Lambertus A., additional, Tosato, Sarah, additional, Nawaz, Muhammad Sulaman, additional, Ingason, Andres, additional, Unnsteinsdottir, Unnur, additional, Steinberg, Stacy, additional, Ludvigsson, Pétur, additional, Stefansson, Kari, additional, Kuss, Andreas Walter, additional, Paschou, Peristera, additional, Cath, Danielle, additional, Hoekstra, Pieter J., additional, Müller-Vahl, Kirsten, additional, Stuhrmann, Manfred, additional, Silahtaroglu, Asli, additional, Pfundt, Rolph, additional, and Tümer, Zeynep, additional

Published
2016
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28. Reading Books and Watching Films as a Protective Factor against Suicidal Ideation

Author

Kasahara-Kiritani, Mami, Hadlaczky, Gergö, Westerlund, Michael, Carli, Vladimir, Wasserman, Camilla, Apter, Alan, Balazs, Judit, Bobes, Julio, Brunner, Romuald, McMahon, Elaine, Cosman, Doina, Farkas, Luca, Haring, Christian, Kaess, Michael, Kahn, Jean-Pierre, Keeley, Helen, Nemes, Bogdan, Mars Bitenc, Urša, Postuvan, Vita, Saiz, Pilar, Sisask, Merike, Värnik, Airi, Sarchiapone, Marco, Hoven, Christina, Wasserman, Danuta, Kasahara-Kiritani, Mami, Hadlaczky, Gergö, Westerlund, Michael, Carli, Vladimir, Wasserman, Camilla, Apter, Alan, Balazs, Judit, Bobes, Julio, Brunner, Romuald, McMahon, Elaine, Cosman, Doina, Farkas, Luca, Haring, Christian, Kaess, Michael, Kahn, Jean-Pierre, Keeley, Helen, Nemes, Bogdan, Mars Bitenc, Urša, Postuvan, Vita, Saiz, Pilar, Sisask, Merike, Värnik, Airi, Sarchiapone, Marco, Hoven, Christina, and Wasserman, Danuta

Abstract

Reading books and watching films were investigated as protective factors for serious suicidal ideation (SSI) in young people with low perceived social belonging. Cross-sectional and longitudinal (12-month) analyses were performed using data from a representative European sample of 3256 students from the “Saving and Empowering Young Lives in Europe” study. Low social belonging was associated to SSI. However, reading books and watching films moderated this association, especially for those with lowest levels of belonging. This was true both at baseline and at 12 months of follow-up analyses. These media may act as sources of social support or mental health literacy and thus reduce the suicide risk constituted by low sense of belonging.

Published
2015

29. Reading Books and Watching Films as a Protective Factor against Suicidal Ideation

Author

Kasahara-Kiritani, Mami, primary, Hadlaczky, Gergö, additional, Westerlund, Michael, additional, Carli, Vladimir, additional, Wasserman, Camilla, additional, Apter, Alan, additional, Balazs, Judit, additional, Bobes, Julio, additional, Brunner, Romuald, additional, McMahon, Elaine, additional, Cosman, Doina, additional, Farkas, Luca, additional, Haring, Christian, additional, Kaess, Michael, additional, Kahn, Jean-Pierre, additional, Keeley, Helen, additional, Nemes, Bogdan, additional, Mars Bitenc, Urša, additional, Postuvan, Vita, additional, Saiz, Pilar, additional, Sisask, Merike, additional, Värnik, Airi, additional, Sarchiapone, Marco, additional, Hoven, Christina, additional, and Wasserman, Danuta, additional

Published
2015
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30. Risk-behaviour screening for identifying adolescents with mental health problems in Europe

Author

Kaess, Michael, primary, Brunner, Romuald, additional, Parzer, Peter, additional, Carli, Vladimir, additional, Apter, Alan, additional, Balazs, Judit A., additional, Bobes, Julio, additional, Coman, Horia G., additional, Cosman, Doina, additional, Cotter, Padraig, additional, Durkee, Tony, additional, Farkas, Luca, additional, Feldman, Dana, additional, Haring, Christian, additional, Iosue, Miriam, additional, Kahn, Jean-Pierre, additional, Keeley, Helen, additional, Podlogar, Tina, additional, Postuvan, Vita, additional, Resch, Franz, additional, Sáiz, Pilar A., additional, Sisask, Merike, additional, Tubiana, Alexandra, additional, Värnik, Peeter, additional, Sarchiapone, Marco, additional, Hoven, Christina W., additional, and Wasserman, Danuta, additional

Published
2013
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32. Wavelength Dependence of the Transformation Mechanism of Sulfonamides Using Different LED Light Sources and TiO 2 and ZnO Photocatalysts.

Author

Náfrádi, Máté, Alapi, Tünde, Farkas, Luca, Bencsik, Gábor, Kozma, Gábor, and Hernádi, Klára

Subjects
LIGHT sources, TITANIUM dioxide, PHOTOCATALYSTS, ZINC oxide, SULFONAMIDES, COUMARINS, SHAPE memory polymers
Abstract

The comparison of the efficiency of the commercially available photocatalysts, TiO2 and ZnO, irradiated with 365 nm and 398 nm light, is presented for the removal of two antibiotics, sulfamethazine (SMT) and sulfamethoxypyridazine (SMP). The •OH formation rate was compared using coumarin, and higher efficiency was proved for TiO2 than ZnO, while for 1,4-benzoquinone in O2-free suspensions, the higher contribution of the photogenerated electrons to the conversion was observed for ZnO than TiO2, especially at 398 nm irradiation. An extremely fast transformation and high quantum yield of SMP in the TiO2/LED398nm process were observed. The transformation was fast in both O2 containing and O2-free suspensions and takes place via desulfonation, while in other cases, mainly hydroxylated products form. The effect of reaction parameters (methanol, dissolved O2 content, HCO3− and Cl−) confirmed that a quite rarely observed energy transfer between the excited state P25 and SMP might be responsible for this unique behavior. In our opinion, these results highlight that "non-conventional" mechanisms could occur even in the case of the well-known TiO2 photocatalyst, and the effect of wavelength is also worth investigating. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Degradation of chlorinated and hydroxylated intermediates in UVA/ClO2systems: A chlorine-based advanced oxidation process investigation

Author

Firak, Daniele Scheres, Farkas, Luca, Náfrádi, Máté, and Alapi, Tünde

Abstract

The chlorination used in water treatment plants can promote the formation of toxic compounds, which can be minimized by substituting free available chlorine (FAC) with chlorine dioxide (ClO2). Besides disinfection, combining ClO2with UV radiation leads to the efficient elimination of organic substances. This work employed a lab-made reactor equipped with LEDs emitting at 367 nm with adjustable photon flux to investigate the efficiency of the UVA/ClO2process and the formation of hydroxylated and chlorinated products during the degradation of phenol and coumarin. The degradation of coumarin was investigated in a central composite design and depended on the ClO2concentration and pH. Increasing the ClO2concentration was necessary to promote the degradation. In higher ClO2/phenol ratios, 80% of the total phenolic compounds were removed at pH 3, 5.5, and 8. The mineralization efficiency increased with the pH, along with the concentration of chlorinated compounds, indicating these products are more persistent than the hydroxylated ones. The UVA/ClO2process was advantageous in removing and mineralizing phenol and coumarin if compared to direct oxidation, but the process needs to be improved to minimize the formation of chlorinated organic products, and elimination of ClO2-and ClO3-requires post-treatment method.

Published
2022
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34. Suicide prevention for youth - a mental health awareness program: lessons learned from the Saving and Empowering Young Lives in Europe (SEYLE) intervention study

Author

Poštuvan, Vita, Žiberna, Janina, Varnik, Peeter, Varnik, Airi, Tubiana-Potiez, Alexandra, McCarthy, Jacklyn, Klug, Katja, Keeley, Helen, Kahn, Jean-Pierre, Iosue, Miriam, Farkas, Luca, Feldman, Dana, Fischer, Gloria, Graber, Nadja, Haring, Christian, Herta, Dana Cristina, Cosman, Doina, Wasserman, Camilla, Hoven, Christina, Wasserman, Danuta, Carli, Vladimir, Sarchiapone, Marco, Al-Halabí, Susana, Apter, Alan, Balazs, Judit, and Bobes, Julio

Subjects
Public health, education, Teenagers--Mental health, Suicide--Prevention--Study and teaching, Mental health, 16. Peace & justice, Medical sciences, School mental health services, 3. Good health
Abstract

Background: The Awareness program was designed as a part of the EU-funded Saving and Empowering Young Lives in Europe (SEYLE) intervention study to promote mental health of adolescents in 11 European countries by helping them to develop problem-solving skills and encouraging them to self-recognize the need for help as well as how to help peers in need. Methods: For this descriptive study all coordinators of the SEYLE Awareness program answered an open-ended evaluation questionnaire at the end of the project implementation. Their answers were synthesized and analyzed and are presented here. Results: The results show that the program cultivated peer understanding and support. Adolescents not only learned about mental health by participating in the Awareness program, but the majority of them also greatly enjoyed the experience. Conclusions: Recommendations for enhancing the successes of mental health awareness programs are presented. Help and cooperation from schools, teachers, local politicians and other stakeholders will lead to more efficacious future programs.

35. Correlates of sexual initiation among European adolescents

Author

Gambadauro, Pietro, Carli, Vladimir, Hadlaczky, Gergo, Sarchiapone, Marco, Apter, Alan, Balazs, Judit, Banzer, Raphaela, Bobes, Julio, Brunner, Romuald, Cosman, Doina, Farkas, Luca, Haring, Christian, Hoven, Christina, Kaess, Michael, Kahn, Jean-Pierre, McMahon, Elaine, Postuvan, Vita, Sisask, Merike, Varnik, Airi, Sedivy, Nusa Zadravec, and Wasserman, Danuta

Subjects
Teenagers--Health and hygiene, Sex, 16. Peace & justice, Teenagers--Sexual behavior, Adolescent psychology
Abstract

Background Sexuality is a physiological component of adolescent development, though early initiation is associated with reproductive health risk. This study aimed at identifying correlates and predictors of sexual initiation in a large multinational cohort of European adolescents. Methods A questionnaire addressing socio-demographics, behaviours, mental health and sexual activity, was delivered to 11,110 adolescents recruited from 168 randomly selected schools in 10 European countries between 2009 and 2011. A follow-up questionnaire was delivered after 12 months. The longitudinal association of baseline risk behaviors, psychological attributes and contextual vulnerabilities, with sexual initiation during follow-up was evaluated through simple and multivariable age/sex stratified logistic regression. Multinomial logistic regression measured the association between predictors and sexual initiation with or without coexisting reproductive risk factors, such as multiple partners or infrequent condom use. Results Baseline sexual experience was reported by 19.2% of 10,757 respondents (median age 15; IQR 14–15; females 59.6%). This was significantly more frequent among pupils older than 15 (41%) and males (20.8%). Of 7,111 pupils without previous experience who were available at follow-up (response rate 81.8%), 17% reported sexual initiation, without differences between females and males. Baseline smoking (age/sex adjusted odds ratio [aOR] 3.63), alcohol use (aOR 2.95), illegal drugs use (aOR 2.72), and poor sleep (aOR 1.71) predicted sexual initiation. Stratified analyses showed a particularly strong association in case of younger and female pupils, and, among girls, when initiation was reported together with multiple partners and/or infrequent condom use. Externalizing (i.e. conduct and hyperactivity) symptoms independently predicted sexual initiation. Internalizing difficulties (i.e. emotional and peer problems) were negatively associated with early and risky sexual initiation among boys. Significant predictors included also being bullied, fighting, truancy, and low parental involvement. Conclusions Adolescent sexual behaviours are related to non-sexual risk behaviours, psychological difficulties and contextual vulnerabilities. While gateway effects explain some associations, a comprehensive model is needed to understand adolescent sexual behaviours, their physical, mental, and social health outcomes, and their potential positive effects on wellbeing. Tailored interventions may need to consider younger girls as a particularly vulnerable group in view of a strong association between non-sexual and sexual behaviors.

36. Correlates of sexual initiation among European adolescents

Author

Gambadauro, Pietro, Carli, Vladimir, Hadlaczky, Gergö, Sarchiapone, Marco, Apter, Alan, Balazs, Judit, Banzer, Raphaela, Bobes, Julio, Brunner, Romuald, Cosman, Doina, Farkas, Luca, Haring, Christian, Hoven, Christina W., Kaess, Michael, Kahn, Jean Pierre, McMahon, Elaine, Postuvan, Vita, Sisask, Merike, Värnik, Airi, Zadravec Sedivy, Nusa, and Wasserman, Danuta

Subjects
16. Peace & justice, 610 Medicine & health

37. De NovoSequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Author

Wang, Sheng, Mandell, Jeffrey D., Kumar, Yogesh, Sun, Nawei, Morris, Montana T., Arbelaez, Juan, Nasello, Cara, Dong, Shan, Duhn, Clif, Zhao, Xin, Yang, Zhiyu, Padmanabhuni, Shanmukha S., Yu, Dongmei, King, Robert A., Dietrich, Andrea, Khalifa, Najah, Dahl, Niklas, Huang, Alden Y., Neale, Benjamin M., Coppola, Giovanni, Mathews, Carol A., Scharf, Jeremiah M., Abdulkadir, Mohamed, Arbelaez, Juan, Bodmer, Benjamin, Bromberg, Yana, Brown, Lawrence W., Cheon, Keun-Ah, Coffey, Barbara J., Deng, Li, Dietrich, Andrea, Dong, Shan, Duhn, Clif, Elzerman, Lonneke, Fernandez, Thomas V., Fremer, Carolin, Garcia-Delgar, Blanca, Gilbert, Donald L., Grice, Dorothy E., Hagstrøm, Julie, Hedderly, Tammy, Heiman, Gary A., Heyman, Isobel, Hoekstra, Pieter J., Hong, Hyun Ju, Huyser, Chaim, Kim, Eun-Joo, Kim, Young Key, Kim, Young-Shin, King, Robert A., Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett L, Ludolph, Andrea G., Madruga-Garrido, Marcos, Mandell, Jeffrey D., Maras, Athanasios, Mir, Pablo, Morer, Astrid, Morris, Montana T, Müller-Vahl, Kirsten, Münchau, Alexander, Murphy, Tara L., Nasello, Cara, Plessen, Kerstin J., Poisner, Hannah, Roessner, Veit, Sanders, Stephan J., Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, State, Matthew W., Sun, Nawei, Thackray, Joshua K., Tischfield, Jay A., Tübing, Jennifer, Visscher, Frank, Wanderer, Sina, Wang, Sheng, Willsey, A Jeremy, Woods, Martin, Xing, Jinchuan, Zhang, Yeting, Zhao, Xin, Zinner, Samuel H., Androutsos, Christos, Barta, Csaba, Farkas, Luca, Fichna, Jakub, Georgitsi, Marianthi, Janik, Piotr, Karagiannidis, Iordanis, Koumoula, Anastasia, Nagy, Peter, Paschou, Peristera, Puchala, Joanna, Rizzo, Renata, Szejko, Natalia, Szymanska, Urszula, Tarnok, Zsanett, Tsironi, Vaia, Wolanczyk, Tomasz, Zekanowski, Cezary, Barr, Cathy L., Batterson, James R., Berlin, Cheston, Bruun, Ruth D., Budman, Cathy L., Cath, Danielle C., Chouinard, Sylvain, Coppola, Giovanni, Cox, Nancy J., Darrow, Sabrina, Davis, Lea K., Dion, Yves, Freimer, Nelson B., Grados, Marco A., Hirschtritt, Matthew E., Huang, Alden Y., Illmann, Cornelia, King, Robert A., Kurlan, Roger, Leckman, James F., Lyon, Gholson J., Malaty, Irene A., Mathews, Carol A., MacMahon, William M., Neale, Benjamin M., Okun, Michael S., Osiecki, Lisa, Pauls, David L., Posthuma, Danielle, Ramensky, Vasily, Robertson, Mary M., Rouleau, Guy A., Sandor, Paul, Scharf, Jeremiah M., Singer, Harvey S., Smit, Jan, Sul, Jae-Hoon, Yu, Dongmei, Fernandez, Thomas V., Buxbaum, Joseph D., De Rubeis, Silvia, Grice, Dorothy E., Xing, Jinchuan, Heiman, Gary A., Tischfield, Jay A., Paschou, Peristera, Willsey, A. Jeremy, and State, Matthew W.

Abstract

We previously established the contribution of de novodamaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novodamaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3(cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novocopy number variants in TD. Finally, we identify significant overlap of de novosequence variants between TD and obsessive-compulsive disorder and de novocopy number variants between TD and autism spectrum disorder, consistent with shared genetic risk.

Published
2018
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38. Wavelength Dependence of the Transformation Mechanism of Sulfonamides Using Different LED Light Sources and TiO 2 and ZnO Photocatalysts.

Author

Náfrádi M, Alapi T, Farkas L, Bencsik G, Kozma G, and Hernádi K

Abstract

The comparison of the efficiency of the commercially available photocatalysts, TiO 2 and ZnO, irradiated with 365 nm and 398 nm light, is presented for the removal of two antibiotics, sulfamethazine (SMT) and sulfamethoxypyridazine (SMP). The • OH formation rate was compared using coumarin, and higher efficiency was proved for TiO 2 than ZnO, while for 1,4-benzoquinone in O 2 -free suspensions, the higher contribution of the photogenerated electrons to the conversion was observed for ZnO than TiO 2 , especially at 398 nm irradiation. An extremely fast transformation and high quantum yield of SMP in the TiO 2 /LED 398nm process were observed. The transformation was fast in both O 2 containing and O 2 -free suspensions and takes place via desulfonation, while in other cases, mainly hydroxylated products form. The effect of reaction parameters (methanol, dissolved O 2 content, HCO 3 - and Cl - ) confirmed that a quite rarely observed energy transfer between the excited state P25 and SMP might be responsible for this unique behavior. In our opinion, these results highlight that "non-conventional" mechanisms could occur even in the case of the well-known TiO 2 photocatalyst, and the effect of wavelength is also worth investigating.

Published
2021
Full Text
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39. [Clinical characteristics of children with Tourette's Syndrome].

Author

Nagy P, Bognár E, Farkas L, Kenézlöi E, Vida P, Gádoros J, and Tárnok Z

Subjects
Adolescent, Child, Child, Preschool, Comorbidity, Humans, Severity of Illness Index, Tics physiopathology, Attention Deficit Disorder with Hyperactivity, Obsessive-Compulsive Disorder, Tourette Syndrome physiopathology, Tourette Syndrome psychology
Abstract

Introduction: Tourette Syndrome (TS) is a neurodevelopmental disorder presenting with motor and vocal tics. Although TS influences the everyday life of children, we only have fragmented knowledge on the topic of the developmental and comorbidity profile, symptom severity and genetical/environmental background. The aim of this article is to present the demographical characteristics, comorbidity profile and the tic symptom types and severity of patients from the Tourette Syndrome Outpatient Clinic of Vadaskert Child and Adolescent Psychiatry Hospital, Budapest., Methods: Our sample consists of all the patients (N=137), who visited the Tourette Syndrome Outpatient Clinic between February, 2012, and July, 2013. Patients were in the age range of 3 to 18 years. We recorded demographical and tic-specific data (age, symptom onset, TS in the family, comorbidity, adverse pre-/peri-/postnatal events) of the participants, and administered the Yale Global Tic Severity Scale (YGTSS)., Results: The average age at symptom onset was 5.9 years. Average symptom severity (measured by the YGTSS) was 22.4 points. Comorbid Attention Deficit and Hyperactivity Disorder (ADHD) was reported in 31%, Obsessive-Compulsive Disorder (OCD) in 10%, and Autism Spectrum Disorders (ASD) in 10% of the sample. The most common tic types were simple head tics (blinking, shaking of head). Symptom severity correlated positively with age (p <0.05), but not with gender, age at symptom onset, positive family history for TS, or adverse pre-, peri-, and postnatal events., Conclusion: The characteristics of our sample does not show any major differences from international reports of similar samples. Comorbidity is an exception: our sample shows lower rates of comorbidities than usually reported.

Published
2020

40. [Neurocognitive symptoms of childhood attention deficit hyperactivity disorder].

Author

Szérémi A, Tárnok Z, Farkas L, Dótzi J, and Gádoros J

Subjects
Analysis of Variance, Child, Child, Preschool, Cognition Disorders diagnosis, Factor Analysis, Statistical, Humans, Male, Neuropsychological Tests, Attention, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity psychology, Cognition
Abstract

Objectives: Attention Deficit Hyperactivity Disorder is the most common childhood-onset disorder that has been characterized with the dysfunction of executive functions. These functions are related to the frontal lobe, especially to different frontostriatal networks. The purpose of this study was to examine executive functions of 5-7 years old (non-literate) children with and without ADHD., Method: We used well-known neuropsychological tests (and some other tests developed by us) which measure the organisation and execution of behavior and thinking. 31 children with ADHD and 26 healthy children without ADHD -- comparable to the other sample with respect to age and sex -- participated in this examination. We compared the two groups in terms of various aspects of executive functions, such as inhibition, attention, motor implementation and visual memory. The test battery used included the Colour Raven Test, a version of the Tower of Hanoi for children, the Bender A and B Test, the Block Design Subtest of the Wechsler Intelligence Scale, the children version of Rey Complex Figure Test, the Picture Attention Test and the Fruit Stroop Test. In order to explore the characteristics of the variables, the factor-analytic method was used by which the various aspects of executive functions could be separated., Results: Statistical comparison of the two groups revealed that several aspects of executive dysfunctions (strategy-constitution, inhibition, attention and motor implementation) can be seen in ADHD.

Published
2005

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