Search

Key clinical message Here, we present a case of relapsing–remitting multiple sclerosis that experienced petechiae and epistaxis following treatment with second dose of alemtuzumab. This study highlights such effects, emphasizing the need for vigilance as alemtuzumab usage increases. Timely recognition and management are vital for patient care.

Background: Language Development Disorders (LDD) is a common idiopathic impairment in children. Numerous risk factors play a role in the emergence of this disorder. Objectives: The present study aimed to examine risk factors of LDD in children aged two to five years. Materials & Methods: In this case-control study, 98 children (aged two to five years) with LDD and 98 children without LDD were selected as case and control groups, respectively. Research population comprised children with language development disorder diagnosed by a pediatric neurologist, and the control group consisted of children without this disorder. Risk factors affecting LDD were examined in both groups, and the two groups were compared using Chi-squared and independent samples t-test in SPSS V. 22. Results: Results showed no significant difference between the two groups in terms of weight at birth and at the last visit; parents’ age, education level, language, and occupation; level and hours of access to television and cell phone; place of residence; birth order of children, and going to the kindergarten (P>0.05). However, the two groups significantly differed in terms of a positive family history. Mean age of the onset of developmental behaviors was significantly higher in the case than that in the control group (P

Background: The critical-care pain observation tool (CPOT) is a standard visual method for determining the pain intensity of intubation. This study aimed to evaluate the severity of pain in patients under mechanical ventilation in the intensive care unit (ICU) of Alzahra educational hospital, Isfahan, Iran, based on CPOT criteria. Methods: In this cross-sectional study, 170 ICU-hospitalized patients under mechanical ventilation were enrolled, and their pain and CPOT scores were obtained. Then, the correlation of pain with other influential factors was evaluated. Findings: 135 patients (79.41%) had pain, and the mean CPOT score was 4.06 ± 1.46 among the patients. There was a significant relationship between the presence of pain and the cause of admission (P < 0.001). There was a significant positive correlation between the Glasgow coma scale (GCS) and CPOT (r = 0.24, P = 0.001). There was a significant relationship between the cause of hospitalization in patients and CPOT score (P < 0.001), too; so that CPOT scores were higher in postoperative, heart diseases, trauma, burn, brain damage, and respiratory diseases, respectively. Conclusion: The CPOT index is a good method to determine the severity of pain after intubation in patients admitted to ICU, who for any reason, have no ability to speak or express the pain.

Background: Scoliosis is a sideways curve in the spine. Considering that postoperative complications are common among these patients, the aim of this study is to examine the postoperative complications of posterior fusion surgery with instrumentation among adult patients with idiopathic scoliosis. Methods: In this cross-sectional descriptive study, the postoperative complications were examined among 93 patients with idiopathic scoliosis who underwent posterior fusion surgery with instrumentation. The convenience sampling was used by referring to the files of these patients. The patients were classified into four groups according to the type of scoliosis deformity (long C-shaped, thoracic, thoracolumbar/lumbar, and double-curve) and the complications were compared together. Results: Postoperative respiratory problems were significantly different between the four groups of scoliosis deformity (P = 0.009); 35 cases of postoperative complications occurred and 20 of them were related to postoperative pulmonary complications. Conclusion: Postoperative complications are common among patients with idiopathic scoliosis who underwent posterior fusion surgery with instrumentation; in addition, pulmonary complications are the most common postoperative complication among these patients.