1. Cohort profile update: Tehran cardiometabolic genetic study
- Author
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Maryam S. Daneshpour, Mahdi Akbarzadeh, Hossein Lanjanian, Bahar Sedaghati-khayat, Kamran Guity, Sajedeh Masjoudi, Asiyeh Sadat Zahedi, Maryam Moazzam-Jazi, Leila Najd Hassan Bonab, Bita Shalbafan, Sara Asgarian, Goodarz Koli Farhood, Niloofar Javanrooh, Maryam Zarkesh, Parisa Riahi, Mohammad Reza Moghaddas, Parvaneh Arbab Dehkordi, Azar Delbarpour Ahmadi, Firoozeh Hosseini, Sara Jalali Farahani, Farzad Hadaegh, Parvin Mirmiran, Fahimeh Ramezani Tehrani, Arash Ghanbarian, Mohammad Sadegh Fallah Mahboob Pasand, Parisa Amiri, Majid Valizadeh, Farhad Hosseipanah, Maryam Tohidi, Asghar Ghasemi, Azita Zadeh-Vakili, Mohammad Piryaei, Shahram Alamdari, Davood Khalili, Amirabbas Momenan, Maryam Barzin, Sirous Zeinali, Mehdi Hedayati, Fereidoun Azizi, and Internal Medicine
- Subjects
SDG 3 - Good Health and Well-being ,Epidemiology - Abstract
The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine.
- Published
- 2023
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