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6. Methotrexate versus conventional disease-modifying antirheumatic drugs in the treatment of non-anterior sarcoidosis-associated uveitis

Author

Leclercq, Mathilde, Sève, Pascal, Biard, Lucie, Vautier, Mathieu, Maalouf, Georgina, Leroux, Gae¨lle, Domont, Fanny, Toutée, Adélai¨de, Fardeau, Christine, Sales de Gauzy, Thomas, Touhami, Sara, Kodjikian, Laurent, Cacoub, Patrice, Bodaghi, Bahram, Saadoun, David, and Desbois, Anne-Claire

Abstract

AimsTo compare the safety and efficacy of methotrexate (MTX), mycophenolate mofetil (MMF) and azathioprine (AZA) in non-anterior sarcoidosis-associated uveitis.MethodsRetrospective study including non-anterior sarcoidosis-associated uveitis according to the revised International Workshop on Ocular Sarcoidosis criteria. The primary outcome was defined as the median time to relapse or occurrence of serious adverse events leading to treatment discontinuation.Results58 patients with non-anterior sarcoidosis-associated uveitis (MTX (n=33), MMF (n=16) and AZA (n=9)) were included. The time to treatment failure (ie, primary outcome) after adjustment for corticosteroids dose and the presence of vasculitis was significantly higher with MTX (median time of 34.5 months with MTX (IQR: 11.8 –not reached) vs 8.4 months (3.1–22.9) with MMF and 16.8 months (8.0–90.1) with AZA (p=0.020)). The risk of relapse at 12 months was more than twice lower in MTX as compared with MMF (p=0.046). Low visual acuity at the last visit was significantly lower with MTX (4% vs 9% in MMF vs 57% in AZA group (p=0.008)). Regarding all 75 lines of treatment (MTX (n=39), MMF (n=24) and AZA (n=12)), MTX was more effective than MMF and AZA to obtain treatment response at 3 months (OR 10.85; 95% CI 1.13 to 104.6; p=0.039). Significant corticosteroid-sparing effect at 12 months (p=0.035) was only observed under MTX. Serious adverse events were observed in 6/39 (15%), 5/24 (21%) and 2/12 (17%) with MTX, MMF and AZA, respectively.ConclusionIn non-anterior sarcoidosis-associated uveitis, MTX seems to be more efficient compared with AZA and MMF and with an acceptable safety profile.

Published
2025
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7. Ocular Toxocariasis in Adult Caucasian Patients: Clinical Presentations and Treatment Outcomes.

Author

Desurmont, Marie-Gwenola, Bourdin, Alexandre, Paris, Luc, Toutée, Adélaide, Faudi, Emilien, Fardeau, Christine, Bodaghi, Bahram, and Touhami, Sara

Subjects
AQUEOUS humor, VITREOUS humor, RETINAL detachment, SYMPTOMS, MACULAR edema
Abstract

Purpose: To report the clinical features and treatment outcomes in adult Caucasians with ocular toxocariasis (OT) and investigate their prognosis depending on their serological status. Methods: Retrospective observational cohort study (2016–2021) including consecutive adults with uveitis and positive western blot (WB) in the aqueous humor or vitreous. The presence of serum antibodies was not necessary for inclusion, allowing to compare the outcomes depending on the serological status. Results: Seventeen eyes of 15 patients were included. Mean age at diagnosis was 51.9 years. Vitreous inflammation was the most frequent sign (100%). Vitreoretinal tractions (41.2%) and chorioretinal granulomas (58.8%) were less prevalent. Atypical features were: spontaneous intravitreal hemorrhage (23.5%), exudative retinal detachment (11.8%), isolated macular edema (17.6%), papillitis (29.4%) and vasculitis (47.1%). Twenty percent of patients had a positive serum serology. Baseline clinical features did not differ statistically depending on the serological status; however, the degree of inflammation was numerically higher in patients with negative serology. Overall, macular thickness, anterior and posterior segment inflammation improved significantly after treatment with oral albendazole, systemic ± local corticosteroids. Vitrectomy (47.1%) was performed in case of persistent vitritis (62.5%), retinal detachment (12.5%) and intravitreous hemorrhage (25%). Conclusion: OT has no pathognomonic sign and atypical presentations were not infrequent in this adult Caucasian cohort. Serum antibodies were rarely positive, stressing on the importance of ocular sample analysis, especially in case of atypical features. Serum antibodies may prove useful in forecasting the rapidity of inflammation clearance. Antiparasitic and anti-inflammatory treatment was safe and efficient in most cases. [ABSTRACT FROM AUTHOR]

Published
2024
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12. CTNI-33. TARGET TRIAL: A PHASE I/II OPEN-LABEL MULTICENTER STUDY TO ASSESS SAFETY, TOLERABILITY, AND CLINICAL EFFICACY OF AZD4547 IN PATIENTS WITH RELAPSED/REFRACTORY FGFR FUSION POSITIVE GLIOMA

Author

Picca, Alberto, primary, Stefano, Anna Luisa Di, additional, Savatovsky, Julien, additional, Ducray, Francois, additional, Chinot, Olivier, additional, Moyal, Elisabeth Cohen-Jonathan, additional, Augereau, Paule, additional, Schmitt, Yohann, additional, Lerond, Julie, additional, Rousseaux, Nabila, additional, Fardeau, Christine, additional, Mokhtari, Karima, additional, Bielle, Franck, additional, Meyronet, David, additional, Iavarone, Antonio, additional, and Sanson, Marc, additional

Published
2023
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14. Ocular Complications in Survivors of the Ebola Outbreak in Guinea

Author

Ayouba, Ahidjo, Baize, Sylvain, Barry, Moumié, Camara, Amadou, Cissé, Mohammed, Delaporte, Eric, Delfraissy, Jean-François, Delmas, Christelle, Desclaux, Alice, Diallo, Saliou Bella, Diallo, Mariama Sadio, Étard, Jean François, Etienne, Cécile, Granouillac, Bruno, Izard, Suzanne, Kassé, Djenaba, Keita, Alpha Kabinet, Keita, Sakoba, Hébert, Esther Hereth, Koivugui, Lamine, Kpamou, Cece, Lacarabaratz, Christine, Leroy, Sandrine, Marchal, Claire Levy, Levy, Yves, Magassouba, N'Fally, March, Laura, Peeters, Martine, Raoul, Hervé, Savané, Ibrahima, Sow, Mamadou Saliou, Taverne, Bernard, Touré, Abdoulaye, Yazdanpanah, Yazdan, Hereth-Hebert, Esther, Bah, Mamadou Oury, Etard, Jean François, Resnikoff, Serge, Fardeau, Christine, Toure, Abdoulaye, Ouendeno, Alexis Niouma, Sagno, Isaac Ceougna, and Lama, Pierre Louis

Published
2017
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15. Scleroderma

Author

Bouchenaki, Nadia, Fardeau, Christine, Chizzolini, Carlo, Lehoang, Phuc, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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20. TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma.

Author

Picca, Alberto, Stefano, Anna Luisa Di, Savatovsky, Julien, Ducray, François, Chinot, Olivier, Moyal, Elisabeth Cohen-Jonathan, Augereau, Paule, Rhun, Emilie Le, Schmitt, Yohann, Rousseaux, Nabila, Yepnang, Ariane Murielle Mbekwe, Estellat, Candice, Charbonneau, Frédérique, Letourneur, Quentin, Branger, Dominique Figarella, Meyronet, David, Fardeau, Christine, Mokhtari, Karima, Bielle, Franck, and Iavarone, Antonio

Published
2024
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22. ROSAH syndrome mimicking chronic uveitis

Author

Fardeau, Christine, primary, Alafaleq, Munirah, additional, Dhaenens, Claire‐Marie, additional, Dollfus, Hélène, additional, Koné‐Paut, Isabelle, additional, Grunewald, Olivier, additional, Morel, Jean‐Baptiste, additional, Titah, Cherif, additional, Saadoun, David, additional, Lazeran, Patrice Olivier, additional, and Meunier, Isabelle, additional

Published
2022
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24. Severe macular complications in glaucoma: high-resolution multimodal imaging characteristics and review of the literature

Author

Lama, Hugo, primary, Pâques, Michel, additional, Brasnu, Emmanuelle, additional, Vu, Jade, additional, Chaumette, Céline, additional, Dupas, Bénédicte, additional, Fardeau, Christine, additional, Chehaibou, Ismaël, additional, Rouland, Jean-François, additional, Besombes, Guillaume, additional, LABETOULLE, Marc, additional, Labbé, Antoine, additional, and Rousseau, Antoine, additional

Published
2022
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26. Three-year visual and anatomic results of administrating intravitreal bevacizumab in inflammatory ocular neovascularization

Author

Mansour, Ahmad M., Arevalo, J. Fernando, Fardeau, Christine, Hrisomalos, Emily N., Chan, Wai-Man, Lai, Timothy Y.Y., Ziemssen, Focke, Ness, Thomas, Sibai, Abla Mehio, Mackensen, Friederike, Wolf, Armin, Hrisomalos, Nicholas, Heiligenhaus, Arnd, Spital, Georg, Jo, Yukari, Gomi, Fumi, Ikuno, Yasushi, Akesbi, Jad, LeHoang, Phuc, Adan, Alfredo, Mahendradas, Padmamalini, Khairallah, Moncef, Guthoff, Rainer, Ghandour, Blanche, Küçükerdönmez, Cem, and Kurup, Shree K.

Published
2012
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27. Casitas B-lineage lymphoma Gene Mutation Ocular Phenotype

Author

Fardeau, Christine, primary, Alafaleq, Munirah, additional, Ferchaud, Marie-Adélaïde, additional, Hié, Miguel, additional, Besnard, Caroline, additional, Meynier, Sonia, additional, Rieux-Laucat, Frédéric, additional, Roos-Weil, Damien, additional, Cohen, Fleur, additional, and Meunier, Isabelle, additional

Published
2022
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28. Efficacy and safety of Aflibercept for the treatment of inflammatory choroidal neovascularization: The ALINEA study

Author

Kodjikian, Laurent, primary, Abukhashabah, Amro, additional, Fardeau, Christine, additional, Tadayoni, Ramin, additional, Brézin, Antoine, additional, Dumas, Stéphane, additional, Weber, Michel, additional, Bernard, Lorraine, additional, Loria, Olivier, additional, Decullier, Evelyne, additional, Huot, Laure, additional, and Mathis, Thibaud, additional

Published
2022
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30. ROSAH syndrome mimicking chronic uveitis.

Author

Fardeau, Christine, Alafaleq, Munirah, Dhaenens, Claire‐Marie, Dollfus, Hélène, Koné‐Paut, Isabelle, Grunewald, Olivier, Morel, Jean‐Baptiste, Titah, Cherif, Saadoun, David, Lazeran, Patrice Olivier, and Meunier, Isabelle

Subjects
*DYSTROPHY, *NUCLEOTIDE sequencing, *GENETIC variation, *MISSENSE mutation, *MACULAR edema, *SUMATRIPTAN, *RETINAL degeneration
Abstract

To suggest a unique missense variant candidate based on long‐term ophthalmological changes and associated systemic signs described in five patients from two unrelated families affected by an autosomal dominant multi‐systemic disorder including Retinal dystrophy, Optic nerve oedema, Splenomegaly, Anhidrosis and migraine Headaches, called ROSAH syndrome, related to a unique missense variant in ALPK1 gene. Observational longitudinal follow‐up study of unrelated families. Clinical analysis of ophthalmological and systemic examinations was performed, followed by genetic analysis, including targeted Next Generation Sequencing (NGS) and Whole‐Genome Sequencing (WGS). The ophthalmological phenotype showed extensive optic nerve swelling associated with early macular oedema and vascular leakage. The main associated systemic manifestations were recurrent fever, splenomegaly, anhidrosis, mild cytopenia, anicocytosis and hypersegmented polynuclear cells. WGS, shortened in the second family by the gene candidate suggestion, revealed in all patients the heterozygous missense variant c.710C>T; p.(Thr237Met) in ALPK1. The primary morbidity in ROSAH syndrome in this cohort appeared ophthalmological. Comprehensive, detailed phenotype changes aided by the advancement in genetic testing could allow an early genetic diagnosis of ROSAH syndrome and targeted treatment. The unique missense variant may be suggested as a target of gene correction therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Efficacy and safety of Aflibercept for the treatment of inflammatory choroidal neovascularization: The ALINEA study.

Author

Kodjikian, Laurent, Abukhashabah, Amro, Fardeau, Christine, Tadayoni, Ramin, Brézin, Antoine, Dumas, Stéphane, Weber, Michel, Bernard, Lorraine, Loria, Olivier, Decullier, Evelyne, Huot, Laure, and Mathis, Thibaud

Subjects
PATHOLOGIC neovascularization, POLYPOIDAL choroidal vasculopathy, INTRAVITREAL injections, NEOVASCULARIZATION, AFLIBERCEPT, ENDOTHELIAL growth factors, VISUAL acuity
Abstract

Purpose: To evaluate mean change in best‐corrected visual acuity (BCVA) at 52 weeks in patients with inflammatory choroidal neovascularization (CNV) treated with aflibercept. Methods: We conducted a prospective non‐comparative open‐label trial. Following one mandatory intravitreal injection of aflibercept, patients were treated under a pro re nata (PRN) dosing regimen with monthly visits. Results: A total of 19 patients were included, but one presented exclusion criteria; 16 patients were followed for the whole 52‐week study, and data for the primary endpoint analysis were available for 14. At baseline, mean BCVA and mean central retinal thickness (CRT) were 64.53 (±19.64) letters and 351.79 (±97.77) μm, respectively. At 52 weeks, the mean change in BCVA was +9.50 (±12.90) letters [95%CI = +2.05–+16.95]. One patient had lost more than 15‐letters at 24 weeks, and another one at 52 weeks. CRT change was −62.77 (±100.73) μm at 24 weeks and −66.53 (±97.47) μm at 52 weeks. There was a mean number of 3.56 (±3.29) intravitreal injections at 52 weeks (min = 1; max = 12). No serious ocular adverse events related to the treatment were reported. Conclusions: Our study shows that aflibercept is clinically effective, both anatomically and functionally in the treatment of inflammatory CNV. Following the first injection, the PRN strategy appears sufficient for treating most choroidal neovessels. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Uveitis associated with cancer immunotherapy: long-term outcomes

Author

Fardeau, Christine, primary, Bencheqroun, Mehdi, additional, Levy, Arielle, additional, Bonnin, Sophie, additional, Ferchaud, Marie-Adélaïde, additional, Fardeau, Leila, additional, Coscas, Florence, additional, Bodaghi, Bahram, additional, and Lebrun-Vignes, Bénédicte, additional

Published
2021
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36. Long-term Visual Outcomes of Intravitreal Bevacizumab in Inflammatory Ocular Neovascularization

Author

Mansour, Ahmad M., Arevalo, J. Fernando, Ziemssen, Focke, Mehio-Sibai, Abla, Mackensen, Friederike, Adan, Alfredo, Chan, Wai-Man, Ness, Thomas, Banker, Alay S., Dodwell, David, Chau Tran, Thi Ha, Fardeau, Christine, LeHoang, Phuc, Mahendradas, Padmamalini, Berrocal, Maria, Tabbarah, Zuheir, Hrisomalos, Nicholas, Hrisomalos, Frank, Al-Salem, Khalil, and Guthoff, Rainer

Published
2009
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39. Ciclosporin A in bilateral auto-immune chronic posterior uveitis associated with macular oedema: a Long-term Observational Safety and Efficacy Study

Author

Alafaleq, Munirah, primary, Freund, Romain, additional, Penet, Marie-Aude, additional, Fardeau, Christine, additional, Isnard-Bagnis, Corinne, additional, Tezenas du Montcel, Sophie, additional, Deray, Gilbert, additional, LE Hoang, Phuc, additional, Bodaghi, Bahram, additional, and Tostivint, Isabelle, additional

Published
2021
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43. Temozolomide is effective and well tolerated in patients with primary vitreoretinal lymphoma

Author

Baron, Marine, Belin, Lisa, Cassoux, Nathalie, Fardeau, Christine, Blaizeau, Marion, Soussain, Carole, Houillier, Caroline, Hoang-Xuan, Khê, Gyan, Emmanuel, Le Lez, Marie-Laure, Lavaud, Anne, Soubeyran, Pierre, Bodaghi, Bahram, Costopoulos, Myrto, Leblond, Véronique, Touitou, Valérie, Maloum, Karim, Errera, Marie-Hélène, Roos-Weil, Damien, Le Garff-Tavernier, Magali, and Choquet, Sylvain

Published
2020
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