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3. A Randomized Trial of Robotic Mastectomy Versus Open Surgery in Women With Breast Cancer or BrCA Mutation

Author

Toesca, Antonio, Sangalli, Claudia, Maisonneuve, Patrick, Massari, Giulia, Girardi, Antonia, Baker, Jennifer L., Lissidini, Germana, Invento, Alessandra, Farante, Gabriel, Corso, Giovanni, Rietjens, Mario, Peradze, Nickolas, Gottardi, Alessandra, Magnoni, Francesca, Bottiglieri, Luca, Lazzeroni, Matteo, Montagna, Emilia, Labo, Piergiorgio, Orecchia, Roberto, Galimberti, Viviana, Intra, Mattia, Sacchini, Virgilio, and Veronesi, Paolo

Published
2022
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4. Update on the Feasibility and Progress on Robotic Breast Surgery

Author

Toesca, Antonio, Invento, Alessandra, Massari, Giulia, Girardi, Antonia, Peradze, Nickolas, Lissidini, Germana, Sangalli, Claudia, Maisonneuve, Patrick, Manconi, Andrea, Gottardi, Alessandra, Baker, Jennifer L., Bottiglieri, Luca, Naninato, Paola, Farante, Gabriel, Magnoni, Francesca, De Scalzi, Alessandra, Corso, Giovanni, Colleoni, Marco, De Lorenzi, Francesca, Sacchini, Virgilio, Galimberti, Viviana, Intra, Mattia, Rietjens, Mario, and Veronesi, Paolo

Published
2019
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8. A Model to Predict Upstaging to Invasive Carcinoma in Patients Preoperatively Diagnosed with Low-Grade Ductal Carcinoma In Situ of the Breast

Author

Nicosia, Luca, primary, Bozzini, Anna Carla, additional, Penco, Silvia, additional, Trentin, Chiara, additional, Pizzamiglio, Maria, additional, Lazzeroni, Matteo, additional, Lissidini, Germana, additional, Veronesi, Paolo, additional, Farante, Gabriel, additional, Frassoni, Samuele, additional, Bagnardi, Vincenzo, additional, Fodor, Cristiana, additional, Fusco, Nicola, additional, Sajjadi, Elham, additional, Cassano, Enrico, additional, and Pesapane, Filippo, additional

Published
2022
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9. A Model to Predict Upstaging to Invasive Carcinoma in Patients Preoperatively Diagnosed with Low-grade Ductal Carcinoma In Situ of the Breast

Author

Nicosia, Luca, primary, Bozzini, Anna Carla, additional, Penco, Silvia, additional, Trentin, Chiara, additional, Pizzamiglio, Maria, additional, Lazzeroni, Matteo, additional, Lissidini, Germana, additional, Veronesi, Paolo, additional, Farante, Gabriel, additional, Frassoni, Samuele, additional, Bagnardi, Vincenzo, additional, Fodor, Cristiana, additional, Fusco, Nicola, additional, Sajjadi, Elham, additional, Cassano, Enrico, additional, and Pesapane, Filippo, additional

Published
2021
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10. A Randomized Trial of Robotic Mastectomy Versus Open Surgery in Women With Breast Cancer or BrCA Mutation

Author

Toesca, Antonio, primary, Sangalli, Claudia, additional, Maisonneuve, Patrick, additional, Massari, Giulia, additional, Girardi, Antonia, additional, Baker, Jennifer L., additional, Lissidini, Germana, additional, Invento, Alessandra, additional, Farante, Gabriel, additional, Corso, Giovanni, additional, Rietjens, Mario, additional, Peradze, Nickolas, additional, Gottardi, Alessandra, additional, Magnoni, Francesca, additional, Bottiglieri, Luca, additional, Lazzeroni, Matteo, additional, Montagna, Emilia, additional, Labo, Piergiorgio, additional, Orecchia, Roberto, additional, Galimberti, Viviana, additional, Intra, Mattia, additional, Sacchini, Virgilio, additional, and Veronesi, Paolo, additional

Published
2021
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15. Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity

Author

Lissidini, Germana, primary, Papa, Giovanni, additional, Ashoor, Arwa Ahmed, additional, Girardi, Antonia, additional, Crown, Angelena, additional, Toesca, Antonio, additional, Pennacchioli, Elisabetta, additional, Trifirò, Giuseppe, additional, Pizzamiglio, Maria, additional, Rossi, Diana Esther, additional, Gottardi, Alessandra, additional, Farante, Gabriel, additional, Galimberti, Viviana, additional, and Veronesi, Paolo, additional

Published
2020
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16. Biologic activity of tamoxifen at low doses in healthy women

Author

Decensi, Andrea, Bonanni, Bernardo, Guerrieri-Gonzaga, Aliana, Gandini, Sara, Robertson, Chris, Johansson, Harriet, Travaglini, Roberto, Sandri, Maria Teresa, Tessadrelli, Antonella, Farante, Gabriel, Salinaro, Federica, Bettega, Donato, Barreca, Antonina, Boyle, Peter, Costa, Alberto, and Veronesi, Umberto

Subjects
Tamoxifen -- Adverse and side effects, Breast cancer -- Prevention, Drugs -- Dosage and administration, Health
Abstract

Background: Results of a clinical trial recently completed in the United States indicate that administration of tamoxifen (20 mg/day) to women at risk can reduce breast cancer incidence by approximately 50% but is associated with an increased risk of developing endometrial cancer and venous thromboembolic events. Since these adverse effects may be dose related, we investigated the effect of tamoxifen on several biomarkers when the drug was given at doses lower than those currently in use. Methods: In two sequential experiments, 127 healthy hysterectomized women aged 35-70 years were randomly assigned to one of the following four treatment arms: placebo (n = 31) or tamoxifen at 20 mg/day (n = 30) (first experiment); or tamoxifen at 10 mg/day (n = 34) or tamoxifen at 10 mg/ alternate days (n = 32) (second experiment). Baseline and 2-month measurements of the following parameters were compared: 1) total cholesterol (primary end point) and other surrogate markers of cardiovascular disease, e.g., low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and lipoprotein(a); 2) blood cell count; 3) fibrinogen; 4) antithrombin III; 5) osteocalcin; and, 6) in a subgroup of 103 women, insulin-like growth factor-I (IGF-I), a possible surrogate marker for breast cancer. Results: After adjustment for the baseline values, there were reductions in circulating levels of total cholesterol and IGF-I of the same magnitude in all three tamoxifen treatment arms. A similar pattern was observed for most of the other parameters. In the placebo arm, fibrinogen level, which showed a decrease, was the only parameter exhibiting change. Conclusions: Up to a 75% reduction in the conventional dose of tamoxifen (i.e., 20 mg/day) does not affect the activity of the drug on a large number of biomarkers, most of which are surrogate markers of cardiovascular disease. This study was hypothesis generating, and larger studies are warranted to assess the efficacy of tamoxifen at low doses. [J Natl Cancer Inst 1998;90:1461-7]

Published
1998

18. Ipsilateral Breast Tumor Reappearance and Contralateral Breast Cancer after Primary Breast Cancer Treatment: A Comprehensive Retrospective Study of 15,168 Patients.

Author

Corso, Giovanni, Maisonneuve, Patrick, Santomauro, Giorgia Irene, De Scalzi, Alessandra Margherita, Toesca, Antonio, Bassi, Fabio Domenico, Farante, Gabriel, Caldarella, Pietro, Intra, Mattia, Galimberti, Viviana, and Veronesi, Paolo

Subjects
ANTINEOPLASTIC agents, BREAST tumor treatment, CANCER relapse, CARCINOGENESIS, AGE distribution, CANCER chemotherapy, BREAST tumors, LONGITUDINAL method, METASTASIS, PROBABILITY theory, RETROSPECTIVE studies, ODDS ratio, TUMOR grading, GENETICS, CANCER risk factors, DISEASE risk factors
Abstract

Objective: The aim of this retrospective study was to assess the risk factors for developing ipsilateral breast tumor reappearance (IBTR) and de novo contralateral breast cancer (BC) after primary BC treatment. Methods: Retrospectively, 15,168 consecutive patients with primary monolateral BC were enrolled in this monocentric study (from June 1994 to December 2006). Clinicopathological features, follow-up, and survival at 15 years were considered for statistical analysis. Results: Significant associations of increased risk for IBTR were verified with metastatic axillary lymph nodes (HR 1.37 [1.15–1.62], p = 0.0004), high tumor grade G2 (HR 1.35 [1.05–1.74], p = 0.02) and G3 (HR 1.35 [1.01–1.79], p = 0.04), luminal B (HR 1.51 [1.25–1.82], p < 0.0001), and HER2-positive (HR1.66 [1.14–2.41], p = 0.008) and triple-negative subtype (HR 1.54 [1.07–2.21], p = 0.02). Older age (HR 1.44 [1.08–1.91], p = 0.01) and positive family history (HR 1.85 [1.47–2.32], p < 0.0001) were risk factors for contralateral BC. Significant protective factors for IBTR were hormonotherapy (HR 0.71 [0.59–0.85], p = 0.0003), chemotherapy (HR 0.72 [0.60–0.87], p = 0.001), and radiotherapy (HR 0.73 [0.61–0.87], p = 0.0005). Hormonotherapy was also confirmed as a protective factor for contralateral second BC (HR 0.43 [0.30–0.60], p < 0.0001). Conclusions: We classified factors for IBTR and contralateral BC in high- and low-risk groups. In the high-risk group, breast surgery still remains more important than in the low-risk group, which seems to benefit more from adjuvant treatments. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Preoperative staging of primary breast cancer. A multicentric study.

Author

Ciatto, Stefano, Pacini, Paolo, Azzini, Vincenzo, Neri, Alberto, Jannini, Annamaria, Gosso, Patrizia, Molino, Annamaria, Capelli, M. Carla, Costanzo, Francesco Di, Pucciatti, M. Assunta, Andreoli, Claudio, Santoro, Giuseppe, Farante, Gabriel, Ciurli, Massimo, Costa, Alberto, Brignone, Giuseppe, Ravaioli, Alberto, Scarpellini, Marilena, Rosetti, Paolo, and De Leo, Giuseppe

Published
1988
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25. Preoperative staging of primary breast cancer.A multicentric study

Author

Ciatto, Stefano, primary, Pacini, Paolo, additional, Azzini, Vincenzo, additional, Neri, Alberto, additional, Jannini, Annamaria, additional, Gosso, Patrizia, additional, Molino, Annamaria, additional, Capelli, M. Carla, additional, Costanzo, Francesco Di, additional, Pucciatti, M. Assunta, additional, Andreoli, Claudio, additional, Santoro, Giuseppe, additional, Farante, Gabriel, additional, Ciurli, Massimo, additional, Costa, Alberto, additional, Brignone, Giuseppe, additional, Ravaioli, Alberto, additional, Scarpellini, Marilena, additional, Rosetti, Paolo, additional, De Leo, Giuseppe, additional, Punzo, Clelia, additional, and Oliva, Vincenzo, additional

Published
1988
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26. Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity

Author

Giuseppe Trifirò, Paolo Veronesi, Giovanni Papa, Antonio Toesca, Antonia Girardi, Diana Esther Rossi, Angelena Crown, Alessandra Gottardi, G. Farante, Arwa Ahmed Ashoor, Elisabetta Pennacchioli, Germana Lissidini, Maria Pizzamiglio, Viviana Galimberti, Lissidini, Germana, Papa, Giovanni, Ashoor, Arwa Ahmed, Girardi, Antonia, Crown, Angelena, Toesca, Antonio, Pennacchioli, Elisabetta, Trifirò, Giuseppe, Pizzamiglio, Maria, Rossi, Diana Esther, Gottardi, Alessandra, Farante, Gabriel, Galimberti, Viviana, and Veronesi, Paolo

Subjects
medicine.medical_specialty, business.industry, MEDLINE, Breast Neoplasms, Malignant phyllodes tumor, Plastic Surgery Procedures, breast surgery, Optimal management, Oncology, Phyllodes Tumor, Internal Medicine, medicine, Humans, Female, Surgery, Breast, Radiology, business
Abstract

Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity

Published
2020

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