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2. Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit

Author

Lee, MJ, Drake, TM, Sayers, AE, Walsh, CJ, Davies, MM, Fearnhead, NS, Abercrombie, J, Acheson, A, Alderson, D, Anderson, I, Bach, S, Davies, M, Hamady, Z, Hind, D, Hollyman, M, Hare, S, Lee, E, Northover, J, Lewis, C, Marriott, P, Maynard, N, Murray, D, Tierney, G, Verjee, A, Wild, J, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McFall, M, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, and Zosimas, D

Subjects
Adult, Male, medicine.medical_specialty, National Audit of Small Bowel Obstruction Steering Group and National Audit of Small Bowel Obstruction Collaborators, Incisional hernia, lcsh:Surgery, 030230 surgery, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, NASBO Collaborators, medicine, Humans, Hernia, Hospital Mortality, General, Emergency Treatment, Aged, Proportional Hazards Models, Aged, 80 and over, Groin, business.industry, Mortality rate, Hazard ratio, West Midlands Research Collaborative, General Medicine, Odds ratio, Original Articles, lcsh:RD1-811, Middle Aged, medicine.disease, Quality Improvement, United Kingdom, Surgery, Hernia, Abdominal, Bowel obstruction, medicine.anatomical_structure, Logistic Models, 030220 oncology & carcinogenesis, Original Article, Female, business, NASBO Steering Group, Intestinal Obstruction
Abstract

Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. The aim of this study was to describe current management and outcomes of patients with obstructed hernia in the UK as identified in the National Audit of Small Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 UK hospitals between January and March 2017. Those with obstruction due to abdominal wall hernia were included in this study. Demographics, co‐morbidity, imaging, operative treatment, and in‐hospital outcomes were recorded. Modelling for factors associated with mortality and complications was undertaken using Cox proportional hazards and multivariable regression modelling. Results NASBO included 2341 patients, of whom 415 (17·7 per cent) had SBO due to hernia. Surgery was performed in 312 (75·2 per cent) of the 415 patients; small bowel resection was required in 198 (63·5 per cent) of these operations. Non‐operative management was reported in 35 (54 per cent) of 65 patients with a parastomal hernia and in 34 (32·1 per cent) of 106 patients with an incisional hernia. The in‐hospital mortality rate was 9·4 per cent (39 of 415), and was highest in patients with a groin hernia (11·1 per cent, 17 of 153). Complications were common, including lower respiratory tract infection in 16·3 per cent of patients with a groin hernia. Increased age was associated with an increased risk of death (hazard ratio 1·05, 95 per cent c.i. 1·01 to 1·10; P = 0·009) and complications (odds ratio 1·05, 95 per cent c.i. 1·02 to 1·09; P = 0·001). Conclusion NASBO has highlighted poor outcomes for patients with SBO due to hernia, highlighting the need for quality improvement initiatives in this group., This study shows that small bowel obstruction due to abdominal wall hernia is common, typically involves a co‐morbid group of patients and has poor outcomes, including high mortality rates. High mortality from this problem

Published
2020

3. National prospective cohort study of the burden of acute small bowel obstruction

Author

Lee, M. J., Sayers, A. E., Drake, T. M., Marriott, P. J., Anderson, I. D., Bach, S. P., Bradburn, M., Hind, D., Verjee, A., Fearnhead, N. S., Abercrombie, John, Acheson, Austin, Alderson, Derek, Anderson, Iain, Davies, Michael, Hamady, Zaed, Hollyman, Marianne, Hare, Sarah, Lee, Ellen, Northover, John, Lewis, Christopher, McFall, Malcolm, Murugananthan, Aravinth, Murray, David, Singh, Pritam, Tierney, Gillian, Walsh, Ciaran, Wild, Jonathan, Wilson, Timothy, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, Zosimas, D, Moug S Mondragon‐Pritchard, M, Rehan, S, and van Boxel, G

Abstract

Background: \ud Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this study was to describe the burden of small bowel obstruction in the UK.\ud \ud Methods: \ud This prospective cohort study was conducted in 131 acute hospitals in the UK between January and April 2017, delivered by trainee research collaboratives. Adult patients with a diagnosis of mechanical small bowel obstruction were included. The primary outcome was in‐hospital mortality. Secondary outcomes included complications, unplanned intensive care admission and readmission within 30 days of discharge. Practice measures, including use of radiological investigations, water soluble contrast, operative and nutritional interventions, were collected.\ud \ud Results: \ud Of 2341 patients identified, 693 (29·6 per cent) underwent immediate surgery (within 24 h of admission), 500 (21·4 per cent) had delayed surgery after initial conservative management, and 1148 (49·0 per cent) were managed non‐operatively. The mortality rate was 6·6 per cent (6·4 per cent for non‐operative management, 6·8 per cent for immediate surgery, 6·8 per cent for delayed surgery; P = 0·911). The major complication rate was 14·4 per cent overall, affecting 19·0 per cent in the immediate surgery, 23·6 per cent in the delayed surgery and 7·7 per cent in the non‐operative management groups (P < 0·001). Cox regression found hernia or malignant aetiology and malnutrition to be associated with higher rates of death. Malignant aetiology, operative intervention, acute kidney injury and malnutrition were associated with increased risk of major complication.\ud \ud Conclusion: \ud Small bowel obstruction represents a significant healthcare burden. Patient‐level factors such as timing of surgery, acute kidney injury and nutritional status are factors that might be modified to improve outcomes.

Published
2019

4. Pure laparoscopic versus open hemihepatectomy: A critical assessment and realistic expectations. A propensity score based analysis of right and left hemihepatectomies from 9 European tertiary referral centers

Author

Cipriani, F., primary, Alzoubi, M., additional, Fuks, D., additional, Ratti, F., additional, Kawai, T., additional, Berardi, G., additional, Barkhatov, L., additional, Lainas, P., additional, Van der Poel, M., additional, Faoury, M., additional, Besselink, M., additional, D'Hondt, M., additional, Dagher, I., additional, Edwin, B., additional, Troisi, R., additional, Scatton, O., additional, Gayet, B., additional, Aldrighetti, L., additional, and Hilal, M Abu, additional

Published
2020
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5. Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction

Author

Drake, Thomas M., primary, Lee, Matthew J., additional, Sayers, Adele E., additional, Abercrombie, John, additional, Acheson, Austin, additional, Alderson, Derek, additional, Anderson, Iain, additional, Bradburn, Mike, additional, Davies, Michael, additional, Hamady, Zaed, additional, Hind, Daniel, additional, Hollyman, Marianne, additional, Hare, Sarah, additional, Lee, Ellen, additional, Northover, John, additional, Lewis, Christopher, additional, Marriott, Paul J., additional, Maynard, Nick, additional, McFall, Malcolm, additional, Muragananthan, Aravinth, additional, Murray, David, additional, Singh, Pritam, additional, Tierney, Gillian, additional, Verjee, Azmina, additional, Walsh, Ciaran, additional, Wild, Jonathan RL., additional, Wilson, Timothy, additional, Abbott, S., additional, Abdulaal, Y., additional, Afshar, S., additional, Akhtar, M., additional, Anderson, D., additional, Appleton, S., additional, Bandyopadhyay, D., additional, Bashir, G., additional, Behar, N., additional, Bhandari, S., additional, Branagan, G., additional, Boulton, R., additional, Borg, C., additional, Bouras, G., additional, Boyle, J., additional, Brewer, H., additional, Brown, L., additional, Briggs, C., additional, Cartmell, M., additional, Chan, S., additional, Chandratreya, N., additional, Conaghan, P., additional, Cornish, J., additional, Cotton, D., additional, Coyne, P., additional, Crozier, J., additional, Cook, T., additional, Cunha, P., additional, Curtis, N., additional, Day, A., additional, Dayal, S., additional, Dennis, R., additional, Dent, P., additional, Dowson, H., additional, Fallaize, R., additional, Farag, S., additional, El Farran, M., additional, Faulkner, G., additional, Giordano, P., additional, Grey, T., additional, Halahakoon, V., additional, Hannay, J., additional, Harikrishnan, A., additional, Holtham, S., additional, Hawkin, P., additional, Hall, C., additional, Hancock, L., additional, Hartley, J., additional, Howse, F., additional, Kallam, R., additional, Kakaniaris, G., additional, Kelly, S., additional, Lockwood, S., additional, Leinhardt, D., additional, Levy, B., additional, Lal, R., additional, Lazim, T., additional, Lund, J., additional, Lunevicius, R., additional, Mathur, P., additional, Maude, K., additional, McArthur, D., additional, McIlroy, B., additional, Miles, A., additional, Moug, S., additional, Mondragon-Pritchard, M., additional, Messenger, D., additional, Mullan, M., additional, Myers, A., additional, Muhammad, K., additional, Mason, C., additional, Sarveswaran, J., additional, Shatkar, V., additional, Singh, B., additional, Skelly, B., additional, Subramonia, S., additional, Swinscoe, M., additional, Thava, B., additional, Thorn, C., additional, Panagiotopoulos, S., additional, Patel, P., additional, Phillips, J., additional, Peristerakis, I., additional, Qureshi, A., additional, Saunders, M., additional, Shah, P., additional, Sheel, A., additional, Siddiqui, S., additional, Skaife, P., additional, Smart, N., additional, Smith, I., additional, Stevenson, L., additional, Stylianides, N., additional, Steinke, J., additional, Stubbs, B., additional, Thompson, R., additional, Varcada, M., additional, Vimalachandran, D., additional, Virlos, I., additional, Watfah, J., additional, Watson, N., additional, Walker, M., additional, Ventham, N., additional, West, H., additional, Wilson, J., additional, Wijeyekoon, S., additional, Ah-Chuen, J., additional, Ahmed, T., additional, Akram, F., additional, Aldred, E., additional, Ali, A., additional, Aly, M., additional, Amajuoyi, A., additional, Amin, V., additional, Andreou, A., additional, Ansari, A., additional, Ardley, R., additional, Arshad, F., additional, Ashour, O., additional, Asour, A., additional, Ayoub, F., additional, Azeem, H., additional, Azhar, B., additional, Baillie, C., additional, Barker, J., additional, Barkham, B., additional, Baron, R., additional, Barrie, J., additional, Barry-Yarrow, E., additional, Battersby, N., additional, 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additional, Dent, H., additional, Di Benedetto, G., additional, Dindyal, S., additional, Donnelly, E., additional, Douka, E., additional, Downham, C., additional, Edent, H., additional, Edgerton, K., additional, El-Sharif, M., additional, Elamin, O., additional, Elsaid, N., additional, Evans, J., additional, Evans, M., additional, Ewe, R., additional, Ewing, A., additional, Ferguson, H., additional, Fisher, O., additional, Fletcher, J., additional, Forouzanfar, A., additional, Foster, A., additional, Fox, R., additional, Francis, N., additional, Fretwell, V., additional, Fung, D., additional, Gammeri, E., additional, Garnham, J., additional, Geraghty, A., additional, Gilbert, A., additional, Gill, M., additional, Gillespie, M., additional, Glasbey, J., additional, Golder, A., additional, Green, N., additional, Groundwater, E., additional, Grove, T., additional, Habib, H., additional, Haddow, J., additional, Halkias, C., additional, Hampson, A., additional, Hanna, T., additional, 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additional, Kosti, A., additional, Kotb, A., additional, Lau, A., additional, Lafaurie, G., additional, Lazzaro, A., additional, Lefroy, R., additional, Lennon, H., additional, Leong, K., additional, Lim, E., additional, Lim, J., additional, Lindley, S., additional, Liu, D., additional, Lloyd, P., additional, Locker, D., additional, Lowe, C., additional, Lunt, A., additional, Lutfi, S., additional, Luther, A., additional, Luwemba, S., additional, Mahankali-Rao, P., additional, Mai, D., additional, Majid, S., additional, Malik, A., additional, Manu, N., additional, Mapara, R., additional, Martin, C., additional, Martin, J., additional, Massey, L., additional, Mathias, J., additional, McCain, S., additional, McCluney, S., additional, McNair, A., additional, Mekhail, P., additional, Merchant, J., additional, Merker, L., additional, Mir, S., additional, Mistry, P., additional, Miu, V., additional, Moat, M., additional, Mohamed, E., additional, Mohamed, I., additional, Moore, N., additional, Moretti, L., additional, Morris, H., additional, Morrison, T., additional, Moss, J., additional, Mountford, D., additional, Moynihan, R., additional, Muldoon-Smith, D., additional, Mulholland, J., additional, Murgitroyd, E., additional, Murugaiyan, K., additional, Mykoniatis, I., additional, Nana, G., additional, Nash, T., additional, Nassar, A., additional, Newton, R., additional, Nguyen, K., additional, Nicholas, F., additional, Noor, M., additional, Nowers, J., additional, Nugent, C., additional, Nunn, A., additional, O'Callaghan, J., additional, O'Hara, R., additional, O'Neill, A., additional, Olivier, J., additional, Osei-Bordom, D., additional, Osgood, L., additional, Panchasara, B., additional, Parks, R., additional, Patel, H., additional, Pawelec, K., additional, Payne, C., additional, Pearson, K., additional, Perin, G., additional, Petronio, B., additional, Phelan, L., additional, Pisaneschi, C., additional, Pitt, J., additional, Ponchietti, L., additional, Powell, 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additional, Yeong, T., additional, and Fearnhead, Nicola S., additional

Published
2019
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9. rare presentation of a paediatric patient with acute otomastoiditis media caused by mycobacterium tuberculosis resulting in intracranial complications.

Author

Jayakody, N, Faoury, M, Hellier, W, Ismail-Koch, H, Patel, S, and Burgess, A

Subjects
*MYCOBACTERIUM tuberculosis, *DISEASE complications, *EARACHE, *HEALTH care teams, *MASTOIDITIS
Abstract

Mastoiditis caused by mycobacterium tuberculosis (TB) has an extremely low incidence in paediatric patients and intracranial complications are even rarer. We report the case of a 2-year-old Caucasian male who presented to a tertiary ENT centre with a left sided mastoid swelling and drowsiness after having been treated unsuccessfully for unresolving ear pain and discharge for 6 weeks. He was subsequently found to have mastoiditis with intracranial complications caused by mycobacterium TB. This report aims to increase awareness of TB as a potential cause of chronic unresolving ear pain in the paediatric age group, as well as the importance of multidisciplinary team management. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Pure laparoscopic versus open hemihepatectomy: a critical assessment and realistic expectations – a propensity score-based analysis of right and left hemihepatectomies from nine European tertiary referral centers

Author

Francesca Ratti, Brice Gayet, Panagiotis Lainas, Marc G. Besselink, Takayuki Kawai, Mathieu D'Hondt, Luca Aldrighetti, Mohammad Abu Hilal, Ibrahim Dagher, Federica Cipriani, Marcel J. van der Poel, Olivier Scatton, Morad Faoury, Mohammad Alzoubi, Giammauro Berardi, Bjørn Edwin, Roberto Troisi, Leonid Barkhatov, David Fuks, Cipriani, F., Alzoubi, M., Fuks, D., Ratti, F., Kawai, T., Berardi, G., Barkhatov, L., Lainas, P., Van der Poel, M., Faoury, M., Besselink, M. G., D'Hondt, M., Dagher, I., Edwin, B., Troisi, R. I., Scatton, O., Gayet, B., Aldrighetti, L., Abu Hilal, M., Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, and Surgery

Subjects
Adult, Male, medicine.medical_specialty, Referral, Malignancy, Hemihepatectomy, Postoperative Complications, Blood loss, Ascites, medicine, Hepatectomy, Humans, Propensity Score, Laparoscopy, Aged, Aged, 80 and over, Right hepatectomy, Hepatology, medicine.diagnostic_test, business.industry, Liver Diseases, Laparoscopic major hepatectomy, Middle Aged, Laparoscopic liver resection, medicine.disease, Surgery, Europe, Propensity score matching, Female, Critical assessment, Left hepatectomy, medicine.symptom, Complication, business
Abstract

Introduction: A stronger evidence level is needed to confirm the benefits and limits of laparoscopic hemihepatectomies. Methods: Laparoscopic and open hemihepatectomies from nine European referral centers were compared after propensity score matching (right and left hemihepatectomies separately, and benign and malignant diseases sub-analyses). Results: Five hundred and forty-five laparoscopic hemihepatectomies were compared with 545 open. Laparoscopy was associated with reduced blood loss (P < 0.001), postoperative stay (P&nbsp

Published
2020

11. Monozygotic twins and cholesteatomas: nature or nuture?

Author

Brar S, Wolf DM, Faoury M, Barwell J, Saggar A, and Daya H

Subjects
Humans, Female, Twins, Monozygotic, Ear, Middle pathology, Audiometry, Pure-Tone, Cholesteatoma, Middle Ear surgery, Cholesteatoma congenital
Abstract

Purpose: Cholesteatoma is a rare middle ear pathology. It can be classified into acquired and congenital forms. Although benign, cholesteatomas can cause significant morbidity including hearing loss, infection, facial palsy and thrombosis. Congenital cholesteatomas are incredibly rare and bilateral disease has not commonly been published in the literature., Method: We describe the case of female identical (monozygotic, monochorionic, diamniotic) twins who both developed congenital cholesteatomas. In this report, we review the aetiology, treatment, embryology and pathology of cholesteatoma., Results: The patients have been followed up 15 years after their initial surgery with promising results - pure-tone audiometry and repeat scans have not illustrated any disease recurrence., Conclusion: This paper presents one of the only cases of female monozygotic twins presenting with unilateral and bilateral cholesteatomas., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2023
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12. Noise Exposure on the London Underground, an Observational Study over a Decade.

Author

Singh T, Biggs T, Crossley E, Faoury M, Mahmood A, Salamat A, Patterson T, Jayakody N, Dando A, Sipaul F, Marinakis K, Sudhoff H, and Brown P

Subjects
Environmental Exposure, Environmental Monitoring, Humans, London epidemiology, Hearing Loss, Noise-Induced epidemiology, Noise, Transportation adverse effects
Abstract

Objectives: There are no hearing protection regulations in place for passengers using public transport, such as the London Underground. In light of this, we sought to examine sound pressure levels experienced by regular users of the London Underground., Methods: Sound pressure levels (A-weighted decibels: dBA) were taken on moving London Underground carriages between Euston and South Wimbledon on the Northern Line, and between Euston and Vauxhall on the Victoria Line, during 2006 and 2018. In addition, carriage sound pressure levels travelling within Zone 1 of the London Underground were tested in 2019. Three experimental and three technical repeats were undertaken using a hand-held calibrated multi-function sound level meter., Results: Passengers are routinely and consistently subjected to sound pressure levels exceeding 80 dBA, with levels sometimes reaching over 100 dBA., Conclusion: This study is unique within the literature, with no published studies outlining exposure levels for London Underground passengers. It provides evidence of elevated noise exposure to passengers, consistently along large stretches of the London Underground, over a prolonged study period (2006-2019)., Key Words: Sensorineural hearing losssound pressureexposureLondonundergroundtube., Level of Evidence: N/A Laryngoscope, 2020., (© 2020 The American Laryngological, Rhinological and Otological Society, Inc.)

Published
2020
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13. Pure laparoscopic versus open hemihepatectomy: a critical assessment and realistic expectations - a propensity score-based analysis of right and left hemihepatectomies from nine European tertiary referral centers.

Author

Cipriani F, Alzoubi M, Fuks D, Ratti F, Kawai T, Berardi G, Barkhatov L, Lainas P, Van der Poel M, Faoury M, Besselink MG, D'Hondt M, Dagher I, Edwin B, Troisi RI, Scatton O, Gayet B, Aldrighetti L, and Abu Hilal M

Subjects
Adult, Aged, Aged, 80 and over, Europe, Female, Humans, Male, Middle Aged, Postoperative Complications, Propensity Score, Hepatectomy methods, Laparoscopy methods, Liver Diseases surgery
Abstract

Introduction: A stronger evidence level is needed to confirm the benefits and limits of laparoscopic hemihepatectomies., Methods: Laparoscopic and open hemihepatectomies from nine European referral centers were compared after propensity score matching (right and left hemihepatectomies separately, and benign and malignant diseases sub-analyses)., Results: Five hundred and forty-five laparoscopic hemihepatectomies were compared with 545 open. Laparoscopy was associated with reduced blood loss (P < 0.001), postoperative stay (P < 0.001) and minor morbidity (P = 0.002), supported by a lower Comprehensive Complication Index (CCI) (P = 0.035). Laparoscopic right hemihepatectomies were associated with lower ascites (P = 0.016), bile leak (P = 0.001) and wound infections (P = 0.009). Laparoscopic left hemihepatectomies exhibited a lower incidence of bile leak and cardiovascular complications (P = 0.024; P = 0.041), lower minor and major morbidity (P = 0.003; P = 0.044) and reduced CCI (P = 0.002). Laparoscopic major hepatectomies (LMH) for benign disease were associated with lower blood loss (P = 0.001) and bile leaks (P = 0.037) and shorter total stay (P < 0.001). LMH for malignancy were associated with lower blood loss (P < 0.001) and minor morbidity (P = 0.027) supported by a lower CCI (P = 0.021) and shorter stay (P < 0.001)., Conclusion: This multicenter study confirms some associated advantages of laparoscopic left and right hemihepatectomies in malignant and benign conditions highlighting the need for realistic expectations of the minimally invasive approach based on the resected hemiliver and the patients treated., (© 2019 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)

Published
2020
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14. Composite poorly differentiated mucoepidermoid carcinoma of the thyroid and follicular variant of papillary thyroid carcinoma. Report of a case and review of the literature.

Author

Jayakody NS, Faoury M, Fraser LR, Jogai S, and Patel NN

Abstract

Mucoepidermoid variant of thyroid carcinoma is a rare and complex disease. Securing a diagnosis and formulating an evidence-based treatment plan is challenging. A case report of a patient with the dual pathology of a composite mucoepidermoid carcinoma of the thyroid and a follicular variant of papillary thyroid carcinoma with malignant metastasis is presented in this article. We discuss the challenges in diagnosis, prognostic factors and management of this rare presentation by reviewing current literature.

Published
2019
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15. Non-selective laryngeal reinnervation in a child with unilateral left vocal fold palsy utilizing laryngeal electromyography.

Author

Faoury M, Frampton S, Allen D, Burgess A, Heathcote K, and Ismail-Koch H

Abstract

Introduction: The impact of unilateral vocal fold palsy (UVFP) on quality of life cannot be underestimated. Management may be complicated by difficulty in determining prognosis. Currently, there is no standardized management pathway for UVFP. Surgery is considered when speech and language therapy has not been successful or when there is significant aspiration and dysphonia. Surgical options for UVFP include injection laryngoplasty, thyroplasty and laryngeal reinnervation., Methods: We report the case of a 6-year-old girl with a left UVFP sustained following PDA ligation. She suffered significant voice issues, aspiration and intermittent stridor limiting activities. Following multidisciplinary team reassessment including videofluoroscopy and perceptual and objective voice measures, laryngotracheobronchoscopy (LTB) and laryngeal electromyography (LEMG) with injection of Radiesse into the left vocal fold was undertaken. Consequently, she underwent non-selective laryngeal reinnervation with the aim of providing a permanent solution by the formation of an anastomosis between the ansa cervicalis and the main stump of the recurrent laryngeal nerve (RLN) resulting in improved muscle tone., Results: LEMG indicated no spontaneous recovery. The laryngeal injection allowed for temporary improvement of voice and feeding. Consequently non-selective left laryngeal reinnervation using ansa cervicalis and repeat vocal cord injection was performed. Twelve months following surgery her voice remain greatly improved and there are no feeding issues or aspiration., Conclusion: In this case so far the use of LEMG and laryngeal reinnervation has proved successful. Non-selective laryngeal reinnervation techniques for UVFP may provide a permanent solution and should be considered in children as a management option in suitable cases.

Published
2019
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