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2. Cardiovascular System

Author

Bradley, Alys, primary, Fant, Pierluigi, additional, Guionaud, Silvia, additional, Boyle, Michael, additional, Alison, Roger, additional, and Hargreaves, Adam, additional

Published
2018
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3. List of Contributors

Author

Alison, Roger, primary, Baker, Julia F.M., additional, Bertrand, Lise, additional, Blackshear, Pamela E., additional, Blankenship, Brad, additional, Boorman, Gary, additional, Botts, Suzanne, additional, Boyle, Michael, additional, Bradley, Alys, additional, Brown, Danielle L., additional, Cesta, Mark F., additional, Chen, Vivian, additional, Cole, Phaedra, additional, Cora, Michelle C., additional, Dixon, Darlene, additional, Dunn, Dale G., additional, Eighmy, Johnnie J., additional, Elmore, Susan A., additional, Elwell, Michael R., additional, Eustis, Scot L., additional, Fant, Pierluigi, additional, Fossey, Stacey L., additional, Foster, John R., additional, Frost, Denzil, additional, Guionaud, Silvia, additional, Hall, D. Greg, additional, Hard, Gordon C., additional, Hargreaves, Adam, additional, Herbert, Ronald A., additional, Janardhan, Kyathanahalli S., additional, Jokinen, Michael P., additional, Latimer, Ken, additional, Leininger, Joel R., additional, Masson, Régis, additional, McKay, Jenny, additional, Mense, Mark G., additional, Miller, Rodney A., additional, Nakatsuji, Shunji, additional, Pandiri, Arun R., additional, Parry, Nicola, additional, Rao, Deepa B., additional, Rebelatto, Marlon C., additional, Remick, Amera K., additional, Rosol, Thomas J., additional, Roulois, Aude, additional, Schutten, Melissa, additional, Seely, John Curtis, additional, Sharma, Alok K., additional, Sorden, Steven D., additional, Sutcliffe, Catherine, additional, Suttie, Andrew W., additional, Szabo, Kathleen A., additional, Travlos, Gregory S., additional, Uehara, Takeki, additional, Vahle, John L., additional, Vidal, Justin D., additional, Whitney, Katharine M., additional, Yamate, Jyoji, additional, Yoshitomi, Katsuhiko, additional, Yoshizawa, Katsuhiko, additional, and Zimmerman, Bevin, additional

Published
2018
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4. Retinal and Systemic Toxicity of Vigabatrin Is Driven by the S-Enantiomer in the Long Evans Rat.

Author

Rasmussen, Allan D., Truchot, Nathalie, Dyssegaard, Agnete, and Fant, Pierluigi

Subjects
WEIGHT loss, ANIMAL housing, BODY weight, RATS, FOOD consumption, PHOTORECEPTORS, ENANTIOMERS, CHRONIC toxicity testing
Abstract

In this study, we assessed the toxicity and toxicokinetics of racemic vigabatrin and its S- and R-enantiomers (vigabatrin consists of 50:50% of the two enantiomers) by administering doses of the three test articles to male Long Evans rats via oral gavage. The animals were housed under high-intensity light conditions and the study consisted of an escalating dose phase and a 21-day fixed-dose phase. Systemic toxicity of vigabatrin appears to be due to the Vig-S-enantiomer only, as increasing doses of Vig-S or Vig-RS caused body weight loss, decreased food consumption, and affected activity. Administration of the Vig-R-enantiomer did not cause any such effects. Systemic exposure to R- and S-enantiomers was approximately linear with dose. Compared to administration of the racemate, there appeared to be a tendency for animals to take up higher amounts of Vig-R and lower amounts of Vig-S when administered as enantiomer. Bilateral retinal atrophy was observed in the fixed-dose phase in rats receiving Vig-S (either alone or as part of Vig-RS) and was characterized by irregular thinning and disorganization of the outer nuclear layer and thinning of the photoreceptor layer. The administration of the R-enantiomer alone did not cause any microscopic retinal change. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

Author

Valenzuela, Allan, primary, Tardiveau, Claire, additional, Ayuso, Miriam, additional, Buyssens, Laura, additional, Bars, Chloe, additional, Van Ginneken, Chris, additional, Fant, Pierluigi, additional, Leconte, Isabelle, additional, Braendli-Baiocco, Annamaria, additional, Parrott, Neil, additional, Schmitt, Georg, additional, Tessier, Yann, additional, Barrow, Paul, additional, and Van Cruchten, Steven, additional

Published
2021
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9. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)

Author

Colman, Karyn, primary, Andrews, Rachel N., additional, Atkins, Hannah, additional, Boulineau, Theresa, additional, Bradley, Alys, additional, Braendli-Baiocco, Annamaria, additional, Capobianco, Raffaella, additional, Caudell, David, additional, Cline, Mark, additional, Doi, Takuya, additional, Ernst, Rainer, additional, van Esch, Eric, additional, Everitt, Jeffrey, additional, Fant, Pierluigi, additional, Gruebbel, Margarita M., additional, Mecklenburg, Lars, additional, Miller, Andew D., additional, Nikula, Kristen J., additional, Satake, Shigeru, additional, Schwartz, Julie, additional, Sharma, Alok, additional, Shimoi, Akihito, additional, Sobry, Cécile, additional, Taylor, Ian, additional, Vemireddi, Vimala, additional, Vidal, Justin, additional, Wood, Charles, additional, and Vahle, John L., additional

Published
2021
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10. The Application, Challenges, and Advancement Toward Regulatory Acceptance of Digital Toxicologic Pathology: Results of the 7th ESTP International Expert Workshop (September 20-21, 2019)

Author

Schumacher, Vanessa L., primary, Aeffner, Famke, additional, Barale-Thomas, Erio, additional, Botteron, Catherine, additional, Carter, Jonathan, additional, Elies, Laëtitia, additional, Engelhardt, Jeffery A., additional, Fant, Pierluigi, additional, Forest, Thomas, additional, Hall, Peter, additional, Hildebrand, Deon, additional, Klopfleisch, Robert, additional, Lucotte, Thomas, additional, Marxfeld, Heike, additional, Mckinney, LuAnn, additional, Moulin, Pierre, additional, Neyens, Elizabeth, additional, Palazzi, Xavier, additional, Piton, Alain, additional, Riccardi, Elena, additional, Roth, Daniel R., additional, Rousselle, Serge, additional, Vidal, Justin D., additional, and Williams, Bethany, additional

Published
2020
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12. The Application, Challenges, and Advancement Toward Regulatory Acceptance of Digital Toxicologic Pathology: Results of the 7th ESTP International Expert Workshop (September 20-21, 2019).

Author

Schumacher, Vanessa L., Aeffner, Famke, Barale-Thomas, Erio, Botteron, Catherine, Carter, Jonathan, Elies, Laëtitia, Engelhardt, Jeffery A., Fant, Pierluigi, Forest, Thomas, Hall, Peter, Hildebrand, Deon, Klopfleisch, Robert, Lucotte, Thomas, Marxfeld, Heike, Mckinney, LuAnn, Moulin, Pierre, Neyens, Elizabeth, Palazzi, Xavier, Piton, Alain, and Riccardi, Elena

Subjects
DIGITAL images, PATHOLOGY, DIGITAL image correlation, MATERIALS analysis, PATHOLOGISTS, DIGITAL technology
Abstract

With advancements in whole slide imaging technology and improved understanding of the features of pathologist workstations required for digital slide evaluation, many institutions are investigating broad digital pathology adoption. The benefits of digital pathology evaluation include remote access to study or diagnostic case materials and integration of analysis and reporting tools. Diagnosis based on whole slide images is established in human medical pathology, and the use of digital pathology in toxicologic pathology is increasing. However, there has not been broad adoption in toxicologic pathology, particularly in the context of regulatory studies, due to lack of precedence. To address this topic, as well as practical aspects, the European Society of Toxicologic Pathology coordinated an expert international workshop to assess current applications and challenges and outline a set of minimal requirements needed to gain future regulatory acceptance for the use of digital toxicologic pathology workflows in research and development, so that toxicologic pathologists can benefit from digital slide technology. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies

Author

Palazzi, Xavier, primary, Burkhardt, John E., additional, Caplain, Henri, additional, Dellarco, Vicki, additional, Fant, Pierluigi, additional, Foster, John R., additional, Francke, Sabine, additional, Germann, Paul, additional, Gröters, Sibylle, additional, Harada, Takanori, additional, Harleman, Johannes, additional, Inui, Kosei, additional, Kaufmann, Wolfgang, additional, Lenz, Barbara, additional, Nagai, Hirofumi, additional, Pohlmeyer-Esch, Gabriele, additional, Schulte, Agnes, additional, Skydsgaard, Mikala, additional, Tomlinson, Lindsay, additional, Wood, Charles E., additional, and Yoshida, Midori, additional

Published
2016
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17. Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog.

Author

Zotti A, Fant P, De Zan G, Mollo A, and Busetto R

Subjects
Animals, Cystitis diagnostic imaging, Cystitis surgery, Diagnosis, Differential, Dog Diseases pathology, Dogs, Male, Ossification, Heterotopic diagnostic imaging, Ossification, Heterotopic surgery, Radiography, Treatment Outcome, Urinary Bladder diagnostic imaging, Urinary Bladder pathology, Urinary Bladder Calculi diagnostic imaging, Urinary Bladder Calculi surgery, Urinary Bladder Calculi veterinary, Cystitis veterinary, Dog Diseases diagnostic imaging, Ossification, Heterotopic veterinary
Abstract

Ossification of the bladder wall, detected radiographically as a nonhomogeneous radiopaque area in the cranioventral part of the bladder in a puppy, is reported. We speculate that chronic inflammation due to the presence of uroliths in the lumen may have stimulated a metaplastic transformation of the cells.

Published
2007

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