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25 results on '"Fann, David Y."'

7. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

Author

Poh, Luting, Fann, David Y., Wong, Peiyan, Lim, Hong Meng, Foo, Sok Lin, Kang, Sung-Wook, Rajeev, Vismitha, Selvaraji, Sharmelee, Iyer, Vinaya Rajagopal, Parathy, Nageiswari, Khan, Mohammad Badruzzaman, Hess, David C., Jo, Dong-Gyu, Drummond, Grant R., Sobey, Christopher G., Lai, Mitchell K. P., Chen, Christopher Li-Hsian, Lim, Lina H. K., and Arumugam, Thiruma V.

Published
2021
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12. Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Author

Evans, Megan A., Lim, Rebecca, Kim, Hyun Ah, Chu, Hannah X., Gardiner-Mann, Chantelle V., Taylor, Kimberly W.E., Chan, Christopher T., Brait, Vanessa H., Lee, Seyoung, Dinh, Quynh Nhu, Vinh, Antony, Phan, Thanh G., Srikanth, Velandai K., Ma, Henry, Arumugam, Thiruma V., Fann, David Y., Poh, Luting, Hunt, Cameron P.J., Pouton, Colin W., Haynes, John M., Selemidis, Stavros, Kwan, William, Teo, Leon, Bourne, James A., Neumann, Silke, Young, Sarah, Gowing, Emma K., Drummond, Grant R., Clarkson, Andrew N., Wallace, Euan M., Sobey, Christopher G., and Broughton, Brad R.S.

Published
2018
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15. Intermittent Fasting Mitigates Vascular and Neuronal Pathologies in a Mouse Model of Vascular Dementia

Author

Rajeev, Vismitha, primary, Fann, David Y., additional, Dinh, Quynh Nhu, additional, Kim, Hyun Ah, additional, De Silva, T. Michael, additional, Jo, Dong-Gyu, additional, Drummond, Grant R., additional, Sobey, Christopher G., additional, Lai, Mitchell K.P., additional, Chen, Christopher Li-Hsian, additional, and Arumugam, Thiruma V., additional

Published
2022
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17. Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment

Author

Rajeev, Vismitha, primary, Fann, David Y., additional, Dinh, Quynh Nhu, additional, Kim, Hyun Ah, additional, De Silva, T. Michael, additional, Jo, Dong-Gyu, additional, Drummond, Grant R., additional, Sobey, Christopher G., additional, Lai, Mitchell K.P., additional, Chen, Christopher Li-Hsian, additional, and Arumugam, Thiruma V., additional

Published
2022
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19. Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging

Author

Baik, Sang-Ha, primary, Selvaraji, Sharmelee, additional, Fann, David Y., additional, Poh, Luting, additional, Jo, Dong-Gyu, additional, Herr, Deron R., additional, Zhang, Shenpeng R., additional, Kim, Hyun Ah, additional, Silva, Michael De, additional, Lai, Mitchell K.P., additional, Chen, Christopher Li-Hsian, additional, Drummond, Grant R., additional, Lim, Kah-Leong, additional, Sobey, Christopher G., additional, and Arumugam, Thiruma V., additional

Published
2021
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21. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

Author

Poh, Luting, primary, Fann, David Y., additional, Wong, Peiyan, additional, Lim, Hong Meng, additional, Foo, Sok Lin, additional, Kang, Sung-Wook, additional, Rajeev, Vismitha, additional, Selvaraji, Sharmelee, additional, Iyer, Vinaya Rajagopal, additional, Parathy, Nageiswari, additional, Khan, Mohammad Badruzzaman, additional, Hess, David C., additional, Jo, Dong-Gyu, additional, Drummond, Grant R., additional, Sobey, Christopher G., additional, Lai, Mitchell K. P., additional, Chen, Christopher Li-Hsian, additional, Lim, Lina H. K., additional, and Arumugam, Thiruma V., additional

Published
2020
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22. Hippocampal Transcriptome Profiling Reveals Common Disease Pathways in Chronic Hypoperfusion and Ageing

Author

Baik, Sang-Ha, primary, Selvaraji, Sharmelee, additional, Fann, David Y., additional, Jo, Dong-Gyu, additional, Herr, Deron R., additional, Lai, Mitchell K.P., additional, Chen, Christopher Li-Hsian, additional, Drummond, Grant R., additional, Lim, Kah-Leong, additional, Sobey, Christopher G., additional, and Arumugam, Thiruma V., additional

Published
2020
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23. Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke

Author

Kim, Joonki, primary, Kang, Sung-Wook, additional, Mallilankaraman, Karthik, additional, Baik, Sang-Ha, additional, Lim, James C, additional, Balaganapathy, Priyanka, additional, She, David T, additional, Lok, Ker-Zhing, additional, Fann, David Y, additional, Thambiayah, Uma, additional, Tang, Sung-Chun, additional, Stranahan, Alexis M, additional, Dheen, S Thameem, additional, Gelderblom, Mathias, additional, Seet, Raymond C, additional, Karamyan, Vardan T, additional, Vemuganti, Raghu, additional, Sobey, Christopher G, additional, Mattson, Mark P, additional, Jo, Dong-Gyu, additional, and Arumugam, Thiruma V, additional

Published
2018
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24. Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Author

Joonki Kim, Sung-Wook Kang, Mallilankaraman, Karthik, Sang-Ha Baik, Lim, James C., Balaganapathy, Priyanka, She, David T., Lok, Ker-Zhing, Fann, David Y., Thambiayah, Uma, Sung-Chun Tang, Stranahan, Alexis M., Dheen, S. Thameem, Gelderblom, Mathias, Seet, Raymond C., Karamyan, Vardan T., Vemuganti, Raghu, Sobey, Christopher G., Mattson, Mark P., and Dong-Gyu Jo

Published
2018
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25. A mechanistic perspective on the health promoting effects of alcohol – A focus on epigenetics modification.

Author

Guan, Shou Ping, Kumar, Shermila N., Fann, David Y., and Kennedy, Brian K.

Subjects
*HISTONE acetylation, *ALCOHOL drinking, *BINGE drinking, *ALCOHOL, *DNA methylation
Abstract

While the detrimental effects of binge drinking are well recognized, low-to-moderate alcohol consumption may be beneficial to health, although the underlying mechanism(s) remains elusive. In this opinion article, we will examine the effects of low dose alcohol consumption from the perspective of epigenetic modulation. Biochemically, alcohol is metabolized into acetate and subsequently to acetyl-coA, which can modulate histone acetylation levels. While elevated levels of acetyl-CoA are detrimental for longevity, we argue that diminished acetyl-CoA also negatively affects fatty acid biosynthesis and histone acetylation, which play a critical role in gene expression and, ultimately, health span. Since mitochondrial function and glucose metabolism, which provide the main source of nucleocytoplasmic acetyl-CoA, are compromised with age, alcohol-derived acetate could be an alternative source of acetyl-CoA to compensate. Hence, the health benefits of low ethanol consumption may be more pronounced after midlife, since mitochondrial function and/or glucose metabolism are diminished in this phase of the life course. Indeed, various clinical alcohol consumption studies concur with this notion, and have shown that a low dose of regular alcohol intake after midlife brings about various health and survival benefits. The requirement for regular alcohol intake may also reflect the transient nature of ethanol-induced histone acetylation. Conversely, ethanol may also stimulate carcinogenesis by inhibiting DNA methylation, as it was shown to reduce various pathways leading to DNA and histone methylation. However, unlike acetylation, where ethanol directly increases the substrate for acetylation, this effect was only observed in the high alcohol exposure cohort. While alcohol-derived acetate may be beneficial for health after midlife, various detrimental effects of alcohol consumption remain, and hence, we do not advocate excessive drinking to increase acetate. This opinion article establishes a possible role of ethanol-derived acetate in achieving homeostasis and sustaining an organism's health span. • Alcohol-derived acetate and maintenance of histone acetylation may be a major driver of health and lifespan extension. • As acetyl-coA level drop with age, the positive effects of ethanol-derived acetate may be more pronounced after midlife. • The detrimental effects of Alcohol on DNA methylation are only observed during chronic high dose exposure. [ABSTRACT FROM AUTHOR]

Published
2023
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