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30 results on '"Fann, C. S. J."'

1. A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples

Author

Cohen, O S, Weickert, T W, Hess, J L, Paish, L M, McCoy, S Y, Rothmond, D A, Galletly, C, Liu, D, Weinberg, D D, Huang, X-F, Xu, Q, Shen, Y, Zhang, D, Yue, W, Yan, J, Wang, L, Lu, T, He, L, Shi, Y, Xu, M, Che, R, Tang, W, Chen, C-H, Chang, W-H, Hwu, H-G, Liu, C-M, Liu, Y-L, Wen, C-C, Fann, C S-J, Chang, C-C, Kanazawa, T, Middleton, F A, Duncan, T M, Faraone, S V, Weickert, C S, Tsuang, M T, and Glatt, S J

Published
2016
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2. Genome-wide association study of bipolar I disorder in the Han Chinese population

Author

Lee, M T M, Chen, C H, Lee, C S, Chen, C C, Chong, M Y, Ouyang, W C, Chiu, N Y, Chuo, L J, Chen, C Y, Tan, H K L, Lane, H Y, Chang, T J, Lin, C H, Jou, S H, Hou, Y M, Feng, J, Lai, T J, Tung, C L, Chen, T J, Chang, C J, Lung, F W, Chen, C K, Shiah, I S, Liu, C Y, Teng, P R, Chen, K H, Shen, L J, Cheng, C S, Chang, T P, Li, C F, Chou, C H, Chen, C Y, Wang, K H T, Fann, C S J, Wu, J Y, Chen, Y T, and Cheng, A T A

Published
2011
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13. Mapping of psoriasis to 17q terminus

Author

Hwu, W-L, Yang, C-F, Fann, C S J, Chen, C-L, Tsai, T-F, Chien, Y-H, Chiang, S-C, Chen, C-H, Hung, S-I, Wu, J-Y, and Chen, Y-T

Published
2005

18. A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples

Author

Cohen, O S, primary, Weickert, T W, additional, Hess, J L, additional, Paish, L M, additional, McCoy, S Y, additional, Rothmond, D A, additional, Galletly, C, additional, Liu, D, additional, Weinberg, D D, additional, Huang, X-F, additional, Xu, Q, additional, Shen, Y, additional, Zhang, D, additional, Yue, W, additional, Yan, J, additional, Wang, L, additional, Lu, T, additional, He, L, additional, Shi, Y, additional, Xu, M, additional, Che, R, additional, Tang, W, additional, Chen, C-H, additional, Chang, W-H, additional, Hwu, H-G, additional, Liu, C-M, additional, Liu, Y-L, additional, Wen, C-C, additional, Fann, C S-J, additional, Chang, C-C, additional, Kanazawa, T, additional, Middleton, F A, additional, Duncan, T M, additional, Faraone, S V, additional, Weickert, C S, additional, Tsuang, M T, additional, and Glatt, S J, additional

Published
2015
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20. Genome-wide association study of bipolar I disorder in the Han Chinese population

Author

Lee, M T M, primary, Chen, C H, additional, Lee, C S, additional, Chen, C C, additional, Chong, M Y, additional, Ouyang, W C, additional, Chiu, N Y, additional, Chuo, L J, additional, Chen, C Y, additional, Tan, H K L, additional, Lane, H Y, additional, Chang, T J, additional, Lin, C H, additional, Jou, S H, additional, Hou, Y M, additional, Feng, J, additional, Lai, T J, additional, Tung, C L, additional, Chen, T J, additional, Chang, C J, additional, Lung, F W, additional, Chen, C K, additional, Shiah, I S, additional, Liu, C Y, additional, Teng, P R, additional, Chen, K H, additional, Shen, L J, additional, Cheng, C S, additional, Chang, T P, additional, Li, C F, additional, Chou, C H, additional, Wang, K H T, additional, Fann, C S J, additional, Wu, J Y, additional, Chen, Y T, additional, and Cheng, A T A, additional

Published
2010
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23. Association evidence of schizophrenia with distal genomic region of NOTCH4 in Taiwanese families

Author

Liu, C.‐M., primary, Liu, Y.‐L., additional, Fann, C. S‐J., additional, Chen, W. J., additional, Yang, W.‐C., additional, Ouyang, W.‐C., additional, Chen, C.‐Y., additional, Jou, Y.‐S., additional, Hsieh, M.‐H., additional, Liu, S.‐K., additional, Hwang, T.‐J., additional, Faraone, S. V., additional, Tsuang, M. T., additional, and Hwu, H.‐G., additional

Published
2006
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25. A splicing-regulatory polymorphism in DRD2disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples

Author

Cohen, O S, Weickert, T W, Hess, J L, Paish, L M, McCoy, S Y, Rothmond, D A, Galletly, C, Liu, D, Weinberg, D D, Huang, X-F, Xu, Q, Shen, Y, Zhang, D, Yue, W, Yan, J, Wang, L, Lu, T, He, L, Shi, Y, Xu, M, Che, R, Tang, W, Chen, C-H, Chang, W-H, Hwu, H-G, Liu, C-M, Liu, Y-L, Wen, C-C, Fann, C S-J, Chang, C-C, Kanazawa, T, Middleton, F A, Duncan, T M, Faraone, S V, Weickert, C S, Tsuang, M T, and Glatt, S J

Abstract

The rs1076560 polymorphism of DRD2(encoding dopamine receptor D2) is associated with alternative splicing and cognitive functioning; however, a mechanistic relationship to schizophrenia has not been shown. Here, we demonstrate that rs1076560(T) imparts a small but reliable risk for schizophrenia in a sample of 616 affected families and five independent replication samples totaling 4017 affected and 4704 unaffected individuals (odds ratio=1.1; P=0.004). rs1076560(T) was associated with impaired verbal fluency and comprehension in schizophrenia but improved performance among healthy comparison subjects. rs1076560(T) also associated with lower D2 short isoform expression in postmortembrain. rs1076560(T) disrupted a binding site for the splicing factor ZRANB2, diminished binding affinity between DRD2pre-mRNA and ZRANB2 and abolished the ability of ZRANB2 to modulate short:long isoform-expression ratios of DRD2minigenes in cell culture. Collectively, this work implicates rs1076560(T) as one possible risk factor for schizophrenia in the Han Chinese population, and suggests molecular mechanisms by which it may exert such influence.

Published
2016
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30. A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments.

Author

Yang HC, Liang YJ, Huang MC, Li LH, Lin CH, Wu JY, Chen YT, and Fann CS

Subjects
Databases, Nucleic Acid, Genome, Human, Humans, Nucleic Acid Hybridization, Gene Frequency, Nucleic Acid Amplification Techniques, Oligonucleotide Array Sequence Analysis methods, Polymorphism, Single Nucleotide
Abstract

Microarray-based pooled DNA methods overcome the cost bottleneck of simultaneously genotyping more than 100 000 markers for numerous study individuals. The success of such methods relies on the proper adjustment of preferential amplification/hybridization to ensure accurate and reliable allele frequency estimation. We performed a hybridization-based genome-wide single nucleotide polymorphisms (SNPs) genotyping analysis to dissect preferential amplification/hybridization. The majority of SNPs had less than 2-fold signal amplification or suppression, and the lognormal distributions adequately modeled preferential amplification/hybridization across the human genome. Comparative analyses suggested that the distributions of preferential amplification/hybridization differed among genotypes and the GC content. Patterns among different ethnic populations were similar; nevertheless, there were striking differences for a small proportion of SNPs, and a slight ethnic heterogeneity was observed. To fulfill appropriate and gratuitous adjustments, databases of preferential amplification/hybridization for African Americans, Caucasians and Asians were constructed based on the Affymetrix GeneChip Human Mapping 100 K Set. The robustness of allele frequency estimation using this database was validated by a pooled DNA experiment. This study provides a genome-wide investigation of preferential amplification/hybridization and suggests guidance for the reliable use of the database. Our results constitute an objective foundation for theoretical development of preferential amplification/hybridization and provide important information for future pooled DNA analyses.

Published
2006
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