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3 results on '"Fang-Yan Xu"'

1. Study on potential biomarkers of energy metabolism‐related to early‐stage Yin‐deficiency‐heat syndrome based on metabolomics and transcriptomics

Author

Jing Chen, Ji-Cheng Li, Hui-Hui Tu, Huai Huang, Chang-Ming Liu, Zhi-Bin Li, Tingting Jiang, Lin Gan, Wen-Jing Yi, Fang-Yan Xu, Ren Lu, Yu-Ting Hu, and Yu-Shuai Han

Subjects
Adult, Male, 0301 basic medicine, Histology, Disease, Computational biology, Transcriptome, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Humans, Medicine, Chinese Traditional, Stage (cooking), Ecology, Evolution, Behavior and Systematics, Messenger RNA, Receiver operating characteristic, biology, NADH dehydrogenase, Computational Biology, Middle Aged, Yin Deficiency, 030104 developmental biology, Case-Control Studies, Metabolome, biology.protein, Female, Anatomy, Signal transduction, Energy Metabolism, Biomarkers, 030217 neurology & neurosurgery, Biotechnology
Abstract

Yin-deficiency-heat (YDH) syndrome is a common sub-health state of the human body in traditional Chinese medicine (TCM). However, due to the lack of objective quantitative diagnostic indicators, patients with early-stage YDH syndrome cannot be treated in time and can develop a pathological (disease) state. Therefore, it is necessary to apply modern diagnostic techniques in order to identify the biological markers for the diagnosis of early-stage YDH syndrome. In the present study, we performed Solexa sequencing and non-targeted metabolomics analysis using high-performance liquid chromatography coupled with mass spectrometry to screen differentially expressed mRNAs and differential metabolites in individuals with early-stage YDH syndrome and healthy controls. Bioinformatics methods were used to perform enrichment analysis of differentially expressed mRNAs and differential metabolites for biological functions and signaling pathways. Furthermore, we found that differentially expressed mRNAs and differential metabolites were related to energy metabolism. Real-time PCR was used to validate the mRNA expression in the serum of subjects with early-stage YDH syndrome. We found that the mitochondrially encoded NADH dehydrogenase 2 (MT-ND2) mRNA was differentially expressed in the serum of individuals with early-stage YDH syndrome. Receiver operating characteristic (ROC) curve and logistic regression analysis were used to evaluate the efficacy of the diagnostic model based on eight differential metabolites. We combined the three metabolites such as Glycine, Sphingomyelin, and Isocitrate to establish the diagnostic model with a sensitivity of 0.853 and a specificity of 0.800. The combination of the above three metabolites may serve as a potential biomarker for the diagnosis of early-stage YDH syndrome. Our study reveals potential biomarker for the diagnosis of early-stage YDH syndrome and also provides a new method for the quantification and objectification of TCM syndromes.

Published
2020
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2. Effects of irrigation with treated wastewater on nutrient distribution in cucumber and tomato plants and their fruit quality.

Author

Xue Yan-Dong, Yang Pei-Ling, Ren Shu-Mei, Liu Hong-Lu, Wu Wen-Yong, Su Yan-Ping, and Fang Yan-Xu

Abstract

A field experiment was conducted to investigate the effects of irrigation with treated wastewater on the nutrient distribution in cucumber and tomato plants and their fruit quality. Irrigation with treated wastewater promoted tomato growth significantly, but had definite inhibition effect on cucumber growth. After the irrigation with treated wastewater, the nitrogen in plants had the characteristics of upward translocation, potassium was easily to be accumulated in cucumber leaf but not accumulated in tomato root, and sodium was mostly accumulated in root but less enriched in leaf, not giving damage to the plants. No significant effects were observed on the distribution of calcium, magnesium, and chlorine in plants. Under the irrigation with treated wastewater, the overall quality of cucumber and tomato fruits was less affected. The nitrate concentration in cucumber and tomato fruits was increased by 5.3% and 32.9%,respectively, but still lower than the state food safety standard of China. [ABSTRACT FROM AUTHOR]

Published
2011

3. [Effects of irrigation with treated wastewater on nutrient distribution in cucumber and tomato plants and their fruit quality].

Author

Xue YD, Yang PL, Ren SM, Liu H, Wu WY, S u YP, and Fang YX

Subjects
Cucumis sativus growth & development, Fruit growth & development, Solanum lycopersicum growth & development, Nitrates analysis, Quality Control, Agricultural Irrigation methods, Cucumis sativus chemistry, Fruit chemistry, Solanum lycopersicum chemistry, Waste Disposal, Fluid methods
Abstract

A field experiment was conducted to investigate the effects of irrigation with treated wastewater on the nutrient distribution in cucumber and tomato plants and their fruit quality. Irrigation with treated wastewater promoted tomato growth significantly, but had definite inhibition effect on cucumber growth. After the irrigation with treated wastewater, the nitrogen in plants had the characteristics of upward translocation, potassium was easily to be accumulated in cucumber leaf but not accumulated in tomato root, and sodium was mostly accumulated in root but less enriched in leaf, not giving damage to the plants. No significant effects were observed on the distribution of calcium, magnesium, and chlorine in plants. Under the irrigation with treated wastewater, the overall quality of cucumber and tomato fruits was less affected. The nitrate concentration in cucumber and tomato fruits was increased by 5.3% and 32.9%, respectively, but still lower than the state food safety standard of China.

Published
2011

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