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939 results on '"Fang Xiaodong"'

12. PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper

Author

Kavita, Uma, Sun, Kefeng, Braun, Manuela, Lembke, Wibke, Mody, Hardik, Kamerud, John, Yang, Tong-Yuan, Braun, Inka V., Fang, Xiaodong, Gao, Wei, Gupta, Swati, Hofer, Magdalena, Liao, Michael Z., Loo, LiNa, McBlane, Fraser, Menochet, Karelle, Stubenrauch, Kay-Gunnar, Upreti, Vijay V., Vigil, Adam, Wiethoff, Christopher M., Xia, Cindy Q., Zhu, Xu, Jawa, Vibha, and Chemuturi, Nagendra

Published
2023
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13. The sequence and analysis of a Chinese pig genome

Author

Fang Xiaodong, Mu Yulian, Huang Zhiyong, Li Yong, Han Lijuan, Zhang Yanfeng, Feng Yue, Chen Yuanxin, Jiang Xuanting, Zhao Wei, Sun Xiaoqing, Xiong Zhiqiang, Yang Lan, Liu Huan, Fan Dingding, Mao Likai, Ren Lijie, Liu Chuxin, Wang Juan, Li Kui, Wang Guangbiao, Yang Shulin, Lai Liangxue, Zhang Guojie, Li Yingrui, Wang Jun, Bolund Lars, Yang Huanming, Wang Jian, Feng Shutang, Li Songgang, and Du Yutao

Subjects
Wuzhishan pig, Genome, Homozygosis, Transposable element, Endogenous retrovirus, Animal model, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome. Results Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes. Conclusion Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.

Published
2012
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24. Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Author

Han, Lijuan, Zhao, Ling, Zhou, Yong, Yang, Chao, Xiong, Teng, Lu, Lin, Deng, Yusheng, Luo, Wen, Chen, Yang, Qiu, Qinwei, Shang, Xiaoxiao, Huang, Li, Mo, Zongchao, Huang, Shaogang, Huang, Suiping, Liu, Zhi, Yang, Wei, Zhai, Lixiang, Ning, Ziwan, Lin, Chengyuan, Huang, Tao, Cheng, Chungwah, Zhong, Linda L. D., Li, Shuaicheng, Bian, Zhaoxiang, and Fang, Xiaodong

Published
2022
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25. Selective and comparative genome architecture of Asian cultivated rice (Oryza sativa L.) attributed to domestication and modern breeding

Author

Wang, Xueqiang, Wang, Wensheng, Tai, Shuaishuai, Li, Min, Gao, Qiang, Hu, Zhiqiang, Hu, Wushu, Wu, Zhichao, Zhu, Xiaoyang, Xie, Jianyin, Li, Fengmei, Zhang, Zhifang, Zhi, Linran, Zhang, Fan, Ma, Xiaoqian, Yang, Ming, Xu, Jiabao, Li, Yanhong, Zhang, Wenzhuo, Yang, Xiyu, Chen, Ying, Zhao, Yan, Fu, Binying, Zhao, Xiuqin, Li, Jinjie, Wang, Miao, Yue, Zhen, Fang, Xiaodong, Zeng, Wei, Yin, Ye, Zhang, Gengyun, Xu, Jianlong, Zhang, Hongliang, Li, Zichao, and Li, Zhikang

Published
2022
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29. Freezing non-radiative recombination in high-performance CsPbBr3 single crystal x-ray detector.

Author

Zhao, Xiao, Wang, Shimao, Song, Yanan, Aoki, Toru, Gnatyuk, Volodymyr, You, Libing, Deng, Zanhong, Tao, Ruhua, Fang, Xiaodong, and Meng, Gang

Subjects
CARRIER density, SINGLE crystals, ION migration & velocity, LIQUID nitrogen, DETECTION limit, PHOTOEMISSION
Abstract

Though CsPbBr3 single crystals (SCs) possess intriguing photoelectronic properties for x/γ-ray detection, the serious ion migration and high thermally activated carrier concentration at room temperature (RT), typically associated with defect states in CsPbBr3 crystals, result in a high dark current and drift of baseline, hindering their potential applications. In this investigation, liquid nitrogen cooling is proposed to freeze deep-level defects in CsPbBr3 SCs, thereby suppressing the ion migrations and decreasing the thermally excited carrier concentration. Utilizing photoluminescence (PL) and time-resolved PL spectra, coupled with theoretical models for photoexcitation and photoemission processes, the freezing of deep-level defects at liquid nitrogen temperature (LNT) is confirmed, which is conducive to decreasing non-radiative recombination. At LNT, the CsPbBr3 SC exhibits a higher resistivity of 4.95 × 1011 Ω cm and a higher mobility–lifetime product of 9.54 × 10−3 cm2 V−1, in contrast to the RT values of 3.86 × 109 Ω cm and 3.67 × 10−3 cm2 V−1, respectively. Furthermore, the x-ray detector at LNT exhibits a high sensitivity of 9309 μC Gyair−1 cm−2 and an impressively low detection limit of 0.054 nGy s−1, which offers a route for obtaining highly sensitive x-ray detectors for applications including ultra-low dose radiation imaging. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.

Author

Zhou, Xuming, Guang, Xuanmin, Sun, Di, Xu, Shixia, Li, Mingzhou, Seim, Inge, Jie, Wencai, Yang, Linfeng, Zhu, Qianhua, Xu, Jiabao, Gao, Qiang, Kaya, Alaattin, Dou, Qianhui, Chen, Bingyao, Ren, Wenhua, Li, Shuaicheng, Zhou, Kaiya, Gladyshev, Vadim, Nielsen, Rasmus, Fang, Xiaodong, and Yang, Guang

Subjects
Adaptation, Biological, Animals, Biological Evolution, China, Chromosome Mapping, Genome, Metagenomics, Phylogeny, Porpoises, Reproductive Isolation, Rivers, Seawater, Water-Electrolyte Balance
Abstract

Cetaceans (whales, dolphins, and porpoises) are a group of mammals adapted to various aquatic habitats, from oceans to freshwater rivers. We report the sequencing, de novo assembly and analysis of a finless porpoise genome, and the re-sequencing of an additional 48 finless porpoise individuals. We use these data to reconstruct the demographic history of finless porpoises from their origin to the occupation into the Yangtze River. Analyses of selection between marine and freshwater porpoises identify genes associated with renal water homeostasis and urea cycle, such as urea transporter 2 and angiotensin I-converting enzyme 2, which are likely adaptations associated with the difference in osmotic stress between ocean and rivers. Our results strongly suggest that the critically endangered Yangtze finless porpoises are reproductively isolated from other porpoise populations and harbor unique genetic adaptations, supporting that they should be considered a unique incipient species.

Published
2018

33. Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

Author

Zhou, Xuming, Sun, Di, Guang, Xuanmin, Ma, Siming, Fang, Xiaodong, Mariotti, Marco, Nielsen, Rasmus, Gladyshev, Vadim N, and Yang, Guang

Subjects
Bone and Bones, Animals, Cetacea, Adaptation, Physiological, cetacean, comparative genomics, aquatic adaptation, bone microanatomical structure, Adaptation, Physiological, Developmental Biology, Biochemistry and Cell Biology, Evolutionary Biology, Genetics
Abstract

Cetaceans (whales, dolphins, and porpoises) are a group of specialized mammals that evolved from terrestrial ancestors and are fully adapted to aquatic habitats. Taking advantage of the recently sequenced finless porpoise genome, we conducted comparative analyses of the genomes of seven cetaceans and related terrestrial species to provide insight into the molecular bases of adaptation of these aquatic mammals. Changes in gene sequences were identified in main lineages of cetaceans, offering an evolutionary picture of cetacean genomes that reveal new pathways that could be associated with adaptation to aquatic lifestyle. We profiled bone microanatomical structures across 28 mammals, including representatives of cetaceans, pinnipeds, and sirenians. Subsequent phylogenetic comparative analyses revealed genes (including leptin, insulin-like growth factor 1, and collagen type I alpha 2 chain) with the root-to-tip substitution rate significantly correlated with bone compactness, implicating these genes could be involved in bone mass control. Overall, this study described adjustments of the genomes of cetaceans according to lifestyle, phylogeny, and bone mass.

Published
2018

46. Correction for Chen et al., Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution

Author

Chen, Xiao-Guang, Jiang, Xuanting, Gu, Jinbao, Xu, Meng, Wu, Yang, Deng, Yuhua, Zhang, Chi, Bonizzoni, Mariangela, Dermauw, Wannes, Vontas, John, Armbruster, Peter, Huang, Xin, Yang, Yulan, Zhang, Hao, He, Weiming, Peng, Hongjuan, Liu, Yongfeng, Wu, Kun, Chen, Jiahua, Lirakis, Manolis, Topalis, Pantelis, Van Leeuwen, Thomas, Hall, Andrew Brantley, Jiang, Xiaofang, Thorpe, Chevon, Mueller, Rachel Lockridge, Sun, Cheng, Waterhouse, Robert Michael, Yan, Guiyun, Tu, Zhijian Jake, Fang, Xiaodong, and James, Anthony A

Subjects
Biological Sciences, Genetics
Published
2016

47. CropGS-Hub: a comprehensive database of genotype and phenotype resources for genomic prediction in major crops

Author

Chen, Jiaxin, primary, Tan, Cong, additional, Zhu, Min, additional, Zhang, Chenyang, additional, Wang, Zhihan, additional, Ni, Xuemei, additional, Liu, Yanlin, additional, Wei, Tong, additional, Wei, XiaoFeng, additional, Fang, Xiaodong, additional, Xu, Yang, additional, Huang, Xuehui, additional, Qiu, Jie, additional, and Liu, Huan, additional

Published
2023
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49. Long-read genome sequencing provides novel insights into the harmful algal bloom species Prymnesium parvum

Author

Jian, Jianbo, primary, Wu, Zhangyan, additional, Silva-Núñez, Arisbe, additional, Li, Xiaohui, additional, Zheng, Xiaomin, additional, Luo, Bei, additional, Liu, Yun, additional, Fang, Xiaodong, additional, Workman, Christopher T., additional, Larsen, Thomas Ostenfeld, additional, Hansen, Per Juel, additional, and Sonnenschein, Eva C., additional

Published
2023
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50. Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution.

Author

Chen, Xiao-Guang, Jiang, Xuanting, Gu, Jinbao, Xu, Meng, Wu, Yang, Deng, Yuhua, Zhang, Chi, Bonizzoni, Mariangela, Dermauw, Wannes, Vontas, John, Armbruster, Peter, Huang, Xin, Yang, Yulan, Zhang, Hao, He, Weiming, Peng, Hongjuan, Liu, Yongfeng, Wu, Kun, Chen, Jiahua, Lirakis, Manolis, Topalis, Pantelis, Van Leeuwen, Thomas, Hall, Andrew Brantley, Jiang, Xiaofang, Thorpe, Chevon, Mueller, Rachel Lockridge, Sun, Cheng, Waterhouse, Robert Michael, Yan, Guiyun, Tu, Zhijian Jake, Fang, Xiaodong, and James, Anthony A

Subjects
Animals, Aedes, Evolution, Molecular, Phylogeny, Genome, Insect, diapause, flavivirus, insecticide resistance, mosquito genome, transposons, Infectious Diseases, Rare Diseases, Biodefense, Vector-Borne Diseases, Vaccine Related, Human Genome, Emerging Infectious Diseases, Biotechnology, Prevention, Genetics, Infection, Good Health and Well Being
Abstract

The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success of Ae. albopictus as an invasive species.

Published
2015

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