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331 results on '"Fang, Hong-Bin"'

9. Experimental design for multi-drug combination studies using signaling networks.

Author

Huang, Hengzhen, Fang, Hong-Bin, and Tan, Ming T

Subjects
Humans, Drug Combinations, Drug Therapy, Combination, Drug Evaluation, Preclinical, Signal Transduction, Dose-Response Relationship, Drug, Research Design, Computer Simulation, Dose-response, Drug combinations, Experimental design, Functional ANOVA, Signaling network, Rare Diseases, Orphan Drug, 8.4 Research design and methodologies (health services), Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Health and social care services research, Cancer, Statistics, Other Mathematical Sciences, Statistics & Probability
Abstract

Combinations of multiple drugs are an important approach to maximize the chance for therapeutic success by inhibiting multiple pathways/targets. Analytic methods for studying drug combinations have received increasing attention because major advances in biomedical research have made available large number of potential agents for testing. The preclinical experiment on multi-drug combinations plays a key role in (especially cancer) drug development because of the complex nature of the disease, the need to reduce development time and costs. Despite recent progresses in statistical methods for assessing drug interaction, there is an acute lack of methods for designing experiments on multi-drug combinations. The number of combinations grows exponentially with the number of drugs and dose-levels and it quickly precludes laboratory testing. Utilizing experimental dose-response data of single drugs and a few combinations along with pathway/network information to obtain an estimate of the functional structure of the dose-response relationship in silico, we propose an optimal design that allows exploration of the dose-effect surface with the smallest possible sample size in this article. The simulation studies show our proposed methods perform well.

Published
2018

13. Loss of ANCO1 Expression Regulates Chromatin Accessibility and Drives Progression of Early-Stage Triple-Negative Breast Cancer

Author

Yuan, Meng, primary, Barefoot, Megan E., additional, Peterson, Kendell, additional, Campbell, Moray J., additional, Blancato, Jan K., additional, Chen, Manjing, additional, Schmidt, Marcel O., additional, Kiliti, Amber J., additional, Fang, Hong-Bin, additional, Wellstein, Anton, additional, Riegel, Anna T., additional, and Sharif, Ghada M., additional

Published
2023
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18. Data from Prevention of Lipid Peroxidation–derived Cyclic DNA Adduct and Mutation in High-Fat Diet–induced Hepatocarcinogenesis by Theaphenon E

Author

Coia, Heidi, primary, Ma, Ning, primary, Hou, Yanqi, primary, Dyba, Marcin D., primary, Fu, Ying, primary, Cruz, M. Idalia, primary, Benitez, Carlos, primary, Graham, Garrett T., primary, McCutcheon, Justine N., primary, Zheng, Yun-Ling, primary, Sun, Bing, primary, Kallakury, Bhaskar V., primary, Ma, Junfeng, primary, Fang, Hong-Bin, primary, Berry, Deborah L., primary, Muralidaran, Vinona, primary, and Chung, Fung-Lung, primary

Published
2023
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19. Supplementary Data from Prevention of Lipid Peroxidation–derived Cyclic DNA Adduct and Mutation in High-Fat Diet–induced Hepatocarcinogenesis by Theaphenon E

Author

Coia, Heidi, primary, Ma, Ning, primary, Hou, Yanqi, primary, Dyba, Marcin D., primary, Fu, Ying, primary, Cruz, M. Idalia, primary, Benitez, Carlos, primary, Graham, Garrett T., primary, McCutcheon, Justine N., primary, Zheng, Yun-Ling, primary, Sun, Bing, primary, Kallakury, Bhaskar V., primary, Ma, Junfeng, primary, Fang, Hong-Bin, primary, Berry, Deborah L., primary, Muralidaran, Vinona, primary, and Chung, Fung-Lung, primary

Published
2023
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22. Data from Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Stadtmauer, Edward A., primary, Aqui, Nicole, primary, Vogl, Dan, primary, Chew, Anne, primary, Fang, Hong-Bin, primary, Janofsky, Stephen, primary, Yager, Kelly, primary, Veloso, Elizabeth, primary, Zheng, Zhaohui, primary, Milliron, Todd, primary, Westphal, Sandra, primary, Cotte, Julio, primary, Huynh, Hong, primary, Cannon, Andrea, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tan, Ming, primary, Virts, Kristen, primary, Ruehle, Kathleen, primary, Harris, Carolynn, primary, Philip, Sunita, primary, Vonderheide, Robert H., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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23. Supplementary Table 1 from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Aqui, Nicole A., primary, Stadtmauer, Edward A., primary, Vogl, Dan T., primary, Xu, Yin Yan, primary, Kalos, Michael, primary, Cai, Ling, primary, Fang, Hong-Bin, primary, Weiss, Brendan M., primary, Badros, Ashraf, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tsao, Patricia, primary, Cross, Alan, primary, Mann, Dean, primary, Philip, Sunita, primary, Kerr, Naseem, primary, Brennan, Andrea, primary, Zheng, Zhaohui, primary, Ruehle, Kathleen, primary, Milliron, Todd, primary, Strome, Scott E., primary, Salazar, Andres M., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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24. Supplementary Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia

Author

Gojo, Ivana, primary, Tan, Ming, primary, Fang, Hong-Bin, primary, Sadowska, Mariola, primary, Lapidus, Rena, primary, Baer, Maria R., primary, Carrier, France, primary, Beumer, Jan H., primary, Anyang, Bean N., primary, Srivastava, Rakesh K., primary, Espinoza-Delgado, Igor, primary, and Ross, Douglas D., primary

Published
2023
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25. Supplementary Data from Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Stadtmauer, Edward A., primary, Aqui, Nicole, primary, Vogl, Dan, primary, Chew, Anne, primary, Fang, Hong-Bin, primary, Janofsky, Stephen, primary, Yager, Kelly, primary, Veloso, Elizabeth, primary, Zheng, Zhaohui, primary, Milliron, Todd, primary, Westphal, Sandra, primary, Cotte, Julio, primary, Huynh, Hong, primary, Cannon, Andrea, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tan, Ming, primary, Virts, Kristen, primary, Ruehle, Kathleen, primary, Harris, Carolynn, primary, Philip, Sunita, primary, Vonderheide, Robert H., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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27. Supplementary Figure 2 from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Aqui, Nicole A., primary, Stadtmauer, Edward A., primary, Vogl, Dan T., primary, Xu, Yin Yan, primary, Kalos, Michael, primary, Cai, Ling, primary, Fang, Hong-Bin, primary, Weiss, Brendan M., primary, Badros, Ashraf, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tsao, Patricia, primary, Cross, Alan, primary, Mann, Dean, primary, Philip, Sunita, primary, Kerr, Naseem, primary, Brennan, Andrea, primary, Zheng, Zhaohui, primary, Ruehle, Kathleen, primary, Milliron, Todd, primary, Strome, Scott E., primary, Salazar, Andres M., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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28. Supplementary Figure Legends from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Aqui, Nicole A., primary, Stadtmauer, Edward A., primary, Vogl, Dan T., primary, Xu, Yin Yan, primary, Kalos, Michael, primary, Cai, Ling, primary, Fang, Hong-Bin, primary, Weiss, Brendan M., primary, Badros, Ashraf, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tsao, Patricia, primary, Cross, Alan, primary, Mann, Dean, primary, Philip, Sunita, primary, Kerr, Naseem, primary, Brennan, Andrea, primary, Zheng, Zhaohui, primary, Ruehle, Kathleen, primary, Milliron, Todd, primary, Strome, Scott E., primary, Salazar, Andres M., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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29. Supplementary Figure 3 from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Aqui, Nicole A., primary, Stadtmauer, Edward A., primary, Vogl, Dan T., primary, Xu, Yin Yan, primary, Kalos, Michael, primary, Cai, Ling, primary, Fang, Hong-Bin, primary, Weiss, Brendan M., primary, Badros, Ashraf, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tsao, Patricia, primary, Cross, Alan, primary, Mann, Dean, primary, Philip, Sunita, primary, Kerr, Naseem, primary, Brennan, Andrea, primary, Zheng, Zhaohui, primary, Ruehle, Kathleen, primary, Milliron, Todd, primary, Strome, Scott E., primary, Salazar, Andres M., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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30. Supplementary Figure 1 from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

Author

Rapoport, Aaron P., primary, Aqui, Nicole A., primary, Stadtmauer, Edward A., primary, Vogl, Dan T., primary, Xu, Yin Yan, primary, Kalos, Michael, primary, Cai, Ling, primary, Fang, Hong-Bin, primary, Weiss, Brendan M., primary, Badros, Ashraf, primary, Yanovich, Saul, primary, Akpek, Gorgun, primary, Tsao, Patricia, primary, Cross, Alan, primary, Mann, Dean, primary, Philip, Sunita, primary, Kerr, Naseem, primary, Brennan, Andrea, primary, Zheng, Zhaohui, primary, Ruehle, Kathleen, primary, Milliron, Todd, primary, Strome, Scott E., primary, Salazar, Andres M., primary, Levine, Bruce L., primary, and June, Carl H., primary

Published
2023
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34. Subgroup Identification in Survival Outcome Data Based on Concordance Probability Measurement.

Author

An, Shengli, Zhang, Peter, and Fang, Hong-Bin

Subjects
SURVIVAL rate, TREATMENT effectiveness, CLINICAL trials, SURVIVAL analysis (Biometry), OVERALL survival, RECEIVER operating characteristic curves, SUBGROUP growth
Abstract

Identifying a subgroup of patients who may have an enhanced treatment effect in a randomized clinical trial has received increasing attention recently. For time-to-event outcomes, it is a challenge to define the effectiveness of a treatment and to choose a cutoff time point for identifying subgroup membership, especially in trials in which the two treatment arms do not differ in overall survival. In this paper, we propose a mixture cure model to identify a subgroup for a new treatment that was compared to a classical treatment (or placebo) in a randomized clinical trial with respect to survival time. Using the concordance probability measurement (K-index), we propose a statistic to test the existence of subgroups with effective treatments in the treatment arm. Subsequently, the subgroup is defined by a limited number of covariates based on the estimated area under the curve (AUC). The performance of this method in different scenarios is assessed through simulation studies. A real data example is also provided for illustration. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Dependence Structure Analysis and Its Application in Human Microbiome.

Author

Li, Shilan, Shi, Jianxin, Albert, Paul, and Fang, Hong-Bin

Subjects
HUMAN microbiota, DISTRIBUTION (Probability theory), GAMMA distributions, INFERENTIAL statistics, INDIVIDUALIZED medicine
Abstract

The human microbiome has been recently shown to be associated with disease risks and has important implications in risk stratification and precision medicine. Due to abundant taxa in the human body, microbiome data are high-dimensional and compositional. Dirichlet distributions and their generalization are used to characterize the dependence structures of microbial data. Another existing method for fitting microbiome data employed Gaussian graphical model using the centered log-transformation (CLR). However, Dirichlet distributions are not able to infer networks or to estimate some extremely rare probabilities. On the other hand, it is hard to interpret the network analysis results using CLR. Furthermore, the data analysis showed that there is a lack of efficient multivariate distributions for fitting microbiome data, which results in inadequate statistical inferences. In this paper, we propose new multivariate distributions for modeling the dependence structures of the high dimensional and compositional microbiome data using inverse gamma distributions and copula techniques. The data analysis in the American gut project shows our proposed methods perform well. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Stochastic functional linear models for gene-based association analysis of quantitative traits in longitudinal studies

Author

Zhang, Bingsong, primary, Wang, Shuqi, additional, Mei, Xiaohan, additional, Han, Yue, additional, Wang, Runqiu, additional, Fang, Hong-Bin, additional, Chiu, Chi-Yang, additional, Ding, Jun, additional, Wang, Zuoheng, additional, Wilson, Alexander F., additional, Bailey-Wilson, Joan E., additional, Xiong, Momiao, additional, and Fan, Ruzong, additional

Published
2022
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49. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma

Author

Rapoport, Aaron P., Aqui, Nicole A., Stadtmauer, Edward A., Vogl, Dan T., Fang, Hong-Bin, Cai, Ling, Janofsky, Stephen, Chew, Anne, Storek, Jan, Akpek, Gorgun, Badros, Ashraf, Yanovich, Saul, Tan, Ming T., Veloso, Elizabeth, Pasetti, Marcela F., Cross, Alan, Philip, Sunita, Murphy, Heather, Bhagat, Rita, Zheng, Zhaohui, Milliron, Todd, Cotte, Julio, Cannon, Andrea, Levine, Bruce L., Vonderheide, Robert H., and June, Carl H.

Published
2011
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