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7. Giant intracranial aneurysms: Natural history and 1-year case fatality after endovascular or surgical treatment

Author

Dengler, Julius, Rüfenacht, Daniel, Meyer, Bernhard, Rohde, Veit, Endres, Matthias, Lenga, Pavlina, Uttinger, Konstantin, Rücker, Viktoria, Kursumovic, Adisa, Hong, Bujung, Mielke, Dorothee, Schmidt, Nils Ole, Burkhardt, Jan-Karl, Bijlenga, Philippe, Boccardi, Edoardo, Cognard, Christophe, Heuschmann, Peter U., Vajkoczy, Peter, Bauknecht, H.C., Bohner, G., Liebig, T., Wiener, E., Gläsker, S., Klingler, J.-H., Scheiwe, C., van Velthoven, V., Zentner, J., Durner, G., König, R., Pedro, M.T., Wirtz, R., Fiss, I., Kombos, T., Guhl, S., Schroeder, H.W.S., Strowitzki, M., Eicker, S., Steiger, H., Turowski, B., Abdulazim, A., Etminan, N., Haenggi, D., Kalff, R., Walter, J., Brawanski, A., Schebesch, K.M., Ardeshiri, A., Sure, Ulrich, Wrede, Karsten, Schmidt, N.O., Regelsberger, J., Westphal, M., Hosch, H., Moskopp, D., Hohaus, C., Meisel, H.J., Lehmberg, J., Wostrack, M., Ganslandt, O., Hopf, N., Musahl, C., Graewe, A., Meier, U., Krauss, J., Nakamura, M., Grote, A., Güresir, E., Schramm, J., Simon, M., Vatter, H., Rath, S.A., Boxhammer, E., Hoffmann, K.T., Diepers, M., Fandino, J., Marbacher, S., Familiari, P., Raco, A., Schaller, K., Gruber, A., Knosp, E., Wang, W.T., Rüfenacht, D.A., Wanke, I., Piano, M., Hernesniemi, J., Lehecka, M., Niemelä, M., Nurminen, V., Burkhardt, J.K., Bozinov, O., Maldaner, N., Regli, L., Eliava, S.S., Shekhtman, O.D., Helthuis, J., van Doormaal, T., van der Zwan, A., Dammers, R., Dirven, C.M.F., Gawlitza, M., Guenego, A., Fiedler, J., Kato, N., Murayama, Y., Dabus, G., Linfante, I., Starosciak, A.K., Miran, M.S., Suri, M.F.K., and Neurosurgery

Subjects
Male, Risk, medicine.medical_specialty, Subarachnoid hemorrhage, Medizin, Aneurysm, Ruptured, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, medicine.artery, Case fatality rate, medicine, Aphasia, Humans, Giant intracranial aneurysm, cardiovascular diseases, Aneurysm rupture, Prospective Studies, Registries, Surgical treatment, Prospective cohort study, Aged, Retrospective Studies, Movement Disorders, business.industry, Endovascular Procedures, Angiography, Digital Subtraction, Vascular disorders, Retrospective cohort study, Intracranial Aneurysm, General Medicine, Middle Aged, medicine.disease, ddc:616.8, 3. Good health, Surgery, Natural history, Europe, Hospitalization, Treatment Outcome, 030220 oncology & carcinogenesis, Relative risk, cardiovascular system, Female, Internal carotid artery, business, Vascular Surgical Procedures, 030217 neurology & neurosurgery
Abstract

OBJECTIVEClinical evidence on giant intracranial aneurysms (GIAs), intracranial aneurysms with a diameter of at least 25 mm, is limited. The authors aimed to investigate the natural history, case fatality, and treatment outcomes of ruptured and unruptured GIAs.METHODSIn this international observational registry study, patients with a ruptured or unruptured GIA received conservative management (CM), surgical management (SM), or endovascular management (EM). The authors investigated rupture rates and case fatality.RESULTSThe retrospective cohort comprised 219 patients with GIAs (21.9% ruptured GIAs and 78.1% unruptured GIAs) whose index hospitalization occurred between January 2006 and November 2016. The index hospitalization in the prospective cohort (362 patients with GIAs [17.1% ruptured and 82.9% unruptured]) occurred between December 2008 and February 2017. In the retrospective cohort, the risk ratio for death at a mean follow-up of 4.8 years (SD 2.2 years) after CM, compared with EM and SM, was 1.63 (95% CI 1.23–2.16) in ruptured GIAs and 3.96 (95% CI 2.57–6.11) in unruptured GIAs. In the prospective cohort, the 1-year case fatality in ruptured GIAs/unruptured GIAs was 100%/22.0% during CM, 36.0%/3.0% after SM, and 39.0%/12.0% after EM. Corresponding 1-year rupture rates in unruptured GIAs were 25.0% during CM, 1.2% after SM, and 2.5% after EM. In unruptured GIAs, the HR for death within the 1st year in patients with posterior circulation GIAs was 6.7 (95% CI 1.5–30.4, p < 0.01), with patients with a GIA at the supraclinoid internal carotid artery as reference. Different sizes of unruptured GIAs were not associated with 1-year case fatality.CONCLUSIONSRupture rates for unruptured GIAs were high, and the natural history and treatment outcomes for ruptured GIAs were poor. Patients undergoing SM or EM showed lower case fatality and rupture rates than those undergoing CM. This difference in outcome may in part be influenced by patients in the CM group having been found poor candidates for SM or EM.Clinical trial registration no.: NCT02066493 (clinicaltrials.gov)

Published
2021

8. Quality of life after poor-grade aneurysmal subarachnoid haemorrhage – prospective data from the hWFNS trial

Author

Goldberg, J, Z´Graggen, WJ, Branca, M, Marbacher, S, D'Alonzo, D, Fandino, J, Stienen, MN, Neidert, MC, Burkhardt, JK, Regli, L, Hlavica, M, Seule, M, Roethlisberger, M, Guzman, R, Zumofen, DW, Maduri, R, Daniel, RT, El Rahal, A, Corniola, MV, Bijlenga, P, Schaller, K, Rölz, R, Scheiwe, C, Shah, M, Heiland, DH, Schnell, O, Beck, J, Raabe, A, and Fung, C

Subjects
ddc: 610, Medicine and health, humanities
Abstract

Objective: Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with high mortality and poor outcome. Data on quality of life (QoL) among survivors is scarce. Here we present QoL- and outcome-data from the prospective multicentric hWFNS-trial (NCT02304328). Methods: This study enrolled [for full text, please go to the a.m. URL]

Published
2022
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17. Development and characterisation of a dual saccular elastase-digested aneurysm rabbit model

Author

Boillat, G, Franssen, T, Grüter, B, Wanderer, S, Catalano, K, Casoni, D, Widmer, HR, Andereggen, L, Remonda, L, Fandino, J, and Marbacher, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Intracranial aneurysm rupture is a devastating condition leading to high mortality and morbidity. The development of preclinical animal models with hemodynamic, morphologic and histologic characteristics close to humans one plays a key role in our understanding of the pathophysiological processes[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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18. Aspirin treatment protects again inflammation in experimental bifurcation aneurysms with different wall conditions in New Zealand white rabbits

Author

Wanderer, S, Grüter, B, Strange, F, Boillat, G, Sivanrupan, S, Rey, J, von Gunten, M, Remonda, L, Widmer, HR, Casoni, D, Andereggen, L, Fandino, J, and Marbacher, S

Subjects
ddc: 610, cardiovascular system, cardiovascular diseases, 610 Medical sciences, Medicine
Abstract

Objective: In the past decades endovascular therapies have become increasingly popular in treating unruptured and ruptured intracranial aneurysms. Aneurysm wall degeneration is linked to aneurysm growth and rupture in preclinical and clinical studies. The aim of this study was to analyze the impact [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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30. Decompressive craniectomy for space occupying hemispheric and cerebellar ischemic strokes: Swiss recommendations

Author

Michel, P., Arnold, M., Hungerbühler, H.-J., Müller, F., Staedler, C., Baumgartner, R. W., Georgiadis, D., Lyrer, P., Mattle, H. P., Sztajzel, R., Weder, B., Tettenborn, B., Nedeltchev, K., Engelter, S., Weber, S. A., Basciani, R., Fandino, J., Fluri, F., Stocker, R., Keller, E., Wasner, M., Hänggi, M., Gasche, Y., Paganoni, R., and Regli, L.

Published
2009
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33. Emergency load shedding to avoid risks of voltage instability using indicators

Author

Tuan, T. Quoc, Fandino, J., Hadjsaid, N., Sabonnadiere, J.C., and Vu, H.

Subjects
Electric power system stability -- Safety and security measures, Electric power-plants -- Load, Voltage -- Protection and preservation, Business, Electronics, Electronics and electrical industries
Abstract

This paper presents a new method to determine a viable load shedding scheme. This scheme presents to the system operator the location and amount of load to be shed to avoid a voltage collapse. In order to develop such a scheme in a timely fashion, indicators are developed to assess the risk of voltage collapse at a particular bus, and a sensitivity matrix coupling the amount of load to be shed and the indicator is computed. The method takes into account non-linearities caused by generators reaching their limits of reactive power output. The advantages of the proposed method are viable network security, short computing times and low memory requirements due to the use of sparse vector techniques. The method developed has been tested with the 30 bus New-England test system and with a 206 bus 400 kV simplified French network with satisfactory results.

Published
1994

34. Fast contingency screening for voltage-reactive considerations in security analysis

Author

Hadjsaid, N., Benahmed, M., Fandino, J., Sabonnadiere, J.C., and Nerin, G.

Subjects
Electric power systems -- Research, Interconnected electric utility systems -- Research, Business, Electronics, Electronics and electrical industries
Abstract

This paper presents an efficient contingency screening method for voltage limit violations. The essential points are: 1) The Q-mismatches are calculated exactly for the buses situated in the vicinity of the outaged element and approximately for the buses that are electrically away from the perturbation. In this step, the convergence rate of individual nodes outside the perturbation area is exploited and the small Q-mismatches are zeroed. 2) It uses the electrical distance concept to predict the buses on which major voltage shifts can occur after the contingency. Computational efforts are saved using the approximate Q-mismatch calculations and by using the sparse vector techniques for the non-zero mismatches (Fast Forward/Back solutions). The number of bus voltages to be solved is drastically reduced and the accuracy of the solution remains good. Results of tests with a 206 buses-299 branches of 400 kV reduced French network are given to illustrate the performance of the method.

Published
1993

42. Neointima Formation and Thrombus Organization after Coil and Stent Treatment Is Mediated by Cell Migration from the Adjacent Vital Vessel Wall in Rat Sidewall Aneurysms

Author

Grüter, B., additional, Nevzati, E., additional, Täschler, D., additional, Strange, F., additional, Rey, J., additional, Grandgirard, D., additional, Leib, S., additional, von Gunten, M., additional, Widmer, H., additional, Remonda, L., additional, Fandino, J., additional, Coluccia, D., additional, and Marbacher, S., additional

Published
2018
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46. The Swiss Pituitary Registry—SwissPit

Author

Berkmann, S., additional, Schütz, P., additional, Röthlisberger, M., additional, Mariani, L., additional, Kothbauer, K., additional, Fischli, S., additional, Fournier, J., additional, Bilz, S., additional, Regli, L., additional, and Fandino, J., additional

Published
2018
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