5 results on '"Fan Qing-wen"'
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2. Finite Element Analysis of Radiation Dosimetric Model during Lift-Off
- Author
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Zhou Mingcong, Wang Ke, Fan Qing-wen, Xiong Liangying, Sun Fenghui, Dong Xiangping, Jiang Wenjun, Wang Jun-feng, and Pei Hongliang
- Subjects
RDM ,Spacecraft ,business.industry ,Computer science ,Acoustics ,Modal analysis ,Radiation ,Response spectrum ,business ,Statics ,Imaging phantom ,Space environment - Abstract
Space rays can cause serious damage to the vital organs of astronauts. To assess the radiation safety of astronauts in the space environment, the most direct and effective way is to send radiation equivalent phantoms equipped with various radiation sensors into space through the spacecraft, and collect relevant radiation data. The phantom will be subjected to a large impact load during the lift-off of spacecraft, leading the various layers of the phantom to be dislocated or crushed, which will affect the collection of radiation data. Based on the Chengdu Dosimetric Phantom (CDP) and according to the distribution and installation requirements of radiation sensors, the phantom is sliced in multiple layers and connected by a center rod to obtain a model for space radiation dose collection, called Radiation Dosimetric Model (RDM). According to the mechanical parameters of the spacecraft during lift-off, we use Ansys Workbench Software to conduct Statics, Modal and Response Spectrum analysis of the RDM. Under a static load of 6.5g, we calculate the stress and deformation of the layers and the center rod of the RDM, as well as their size and distribution, carry out modal analysis, and calculate the maximum response of the RDM under a given acceleration spectrum with a load peak value of 6.5g. The result shows that under the dynamic and static load of 6.5g, the layers and the center rod will not be dislocated, crushed, etc. This ensures the safety of Radiation Dosimetric Model during the lift-off process, and has important theoretical significance and practical value.
- Published
- 2020
- Full Text
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3. Research on Magnetic Field Uniformity of Compensated Helmholtz Coil
- Author
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Jiang Wenjun, Fan Qing-wen, Xiong Liangying, Zhou Mingcong, Pei Hongliang, Sun Fenghui, Dong Xiangping, and Wang Ke
- Subjects
Electromagnetic field ,Physics ,Quantitative Biology::Biomolecules ,Helmholtz coil ,genetic structures ,Acoustics ,Physics::Medical Physics ,Radius ,equipment and supplies ,Biomagnetism ,Magnetic field ,Electromagnetic induction ,Electromagnetic coil ,human activities ,Intensity (heat transfer) - Abstract
Electromagnetic field has an important effect on the proliferation and differentiation of osteoblasts. The necessary condition for the study of the electromagnetic field effect on the proliferation and differentiation of osteoblasts is the uniform magnetic field with controllable magnetic induction intensity. At present, the main device to produce controllable uniform magnetic field is Helmholtz coil, but the uniform magnetic field produced by standard Helmholtz coil cannot meet the requirements of medical experimental space. In this paper, a model of compensated Helmholtz coil is proposed. A compensation coil with the same parameters as the main coil is added to the middle of the standard Helmholtz coil, and the axial distance of the three coils is equal to the radius of the coil. The mathematical model of the spatial magnetic field of the compensated Helmholtz coil is given, under the condition that the current ratio of the main coil to the compensation coil is fixed, the magnetic induction intensity of any point in the space is proportional to the current of the main coil. The magnetic field distribution of the compensated Helmholtz coil is simulated by COMSOL software, and the current proportional coefficient between the main coil and the compensation coil is optimized, and the maximum effective uniform magnetic field cross section area is obtained. For the compensated Helmholtz coil whose diameter is 300mm, the effective uniform magnetic field cross-sectional area is the largest when the current ratio coefficient between the main coil and the compensation coil is 1.57. On the premise that the magnetic induction intensity of the central point and magnetic field uniformity are the same, compared with the standard Helmholtz coil, the effective uniform magnetic field cross-sectional area of the compensated Helmholtz coil is increased by 80%. The compensated Helmholtz coil has the advantages of good magnetic field uniformity, large effective uniform magnetic field cross-sectional area and increasing the ratio of magnetic induction intensity to the current of the main coil. It can meet the requirements of uniform magnetic field space in medical experiments, and has important theoretical significance and practical value.
- Published
- 2020
- Full Text
- View/download PDF
4. Extraction of pulmonary Trachea by dynamic tubular edge contour algorithm
- Author
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Fan, Qing-Wen, primary, Pei, Hong-Liang, additional, Luo, Feng-Ming, additional, Li, Xiao-Ou, additional, Wang, Ke, additional, and Jiang, Wen-Jun, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Integrated Assays of Genome-Wide Association Study, Multi-Omics Co-Localization, and Machine Learning Associated Calcium Signaling Genes with Oilseed Rape Resistance to Sclerotinia sclerotiorum .
- Author
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Wang XY, Ren CX, Fan QW, Xu YP, Wang LW, Mao ZL, and Cai XZ
- Subjects
- Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genomics methods, Multiomics, Ascomycota pathogenicity, Machine Learning, Disease Resistance genetics, Genome-Wide Association Study, Plant Diseases microbiology, Plant Diseases genetics, Brassica napus genetics, Brassica napus microbiology, Brassica napus immunology, Calcium Signaling genetics
- Abstract
Sclerotinia sclerotiorum (Ss) is one of the most devastating fungal pathogens, causing huge yield loss in multiple economically important crops including oilseed rape. Plant resistance to Ss pertains to quantitative disease resistance (QDR) controlled by multiple minor genes. Genome-wide identification of genes involved in QDR to Ss is yet to be conducted. In this study, we integrated several assays including genome-wide association study (GWAS), multi-omics co-localization, and machine learning prediction to identify, on a genome-wide scale, genes involved in the oilseed rape QDR to Ss. Employing GWAS and multi-omics co-localization, we identified seven resistance-associated loci (RALs) associated with oilseed rape resistance to Ss. Furthermore, we developed a machine learning algorithm and named it Integrative Multi-Omics Analysis and Machine Learning for Target Gene Prediction (iMAP), which integrates multi-omics data to rapidly predict disease resistance-related genes within a broad chromosomal region. Through iMAP based on the identified RALs, we revealed multiple calcium signaling genes related to the QDR to Ss. Population-level analysis of selective sweeps and haplotypes of variants confirmed the positive selection of the predicted calcium signaling genes during evolution. Overall, this study has developed an algorithm that integrates multi-omics data and machine learning methods, providing a powerful tool for predicting target genes associated with specific traits. Furthermore, it makes a basis for further understanding the role and mechanisms of calcium signaling genes in the QDR to Ss., Competing Interests: The authors declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
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