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Your search keyword '"Fan, Weiyang"' showing total 18 results
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18 results on '"Fan, Weiyang"'

13. Pharmacodynamic and Metabolomics Studies on the Effect of Kouyanqing Granule in the Treatment of Phenol-Induced Oral Ulcer Worsened by Sleep Deprivation

Author

Chen, Pan, primary, Yao, Hongliang, additional, Su, Weiwei, additional, Zheng, Yuying, additional, Fan, Weiyang, additional, Zhang, Liping, additional, Chen, Tingting, additional, Wu, Shuling, additional, Zhang, Weijian, additional, He, Yan, additional, Yan, Zenghao, additional, Wang, Yonggang, additional, and Li, Peibo, additional

Published
2020
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17. Effects of Naringin on the Activity and mRNA Expression of CYP Isozymes in Rats

Author

Cheng, Keling, Zeng, Xuan, Wu, Hao, Su, Weiwei, Fan, Weiyang, Bai, Yang, Yao, Hongliang, and Li, Peibo

Abstract

Naringin (NRG) is a common dietary flavonoid in citrus fruits and has been documented to possess multiple pharmacological activities, including anti-oxidant, anti-inflammatory, and neuroprotective effects. Naringin is frequently consumed in combination with common clinical drugs. To date, the effects of NRG on cytochrome P450 enzymes have not been fully investigated yet. In this study, the activities of hepatic CYP1A2, CYP2D2, CYP2C9, CYP2C19, and CYP2E1 in rats after the continuous oral administration of NRG (50 and 500 mg/kg) were evaluated using cocktail probe-drug method. The concentrations of 5 probe drugs (phenacetin, dextromethorphan, diclofenac sodium, omeprazole, and chlorzoxazone) in rat plasma were simultaneously determined with a validated HPLC-MS/MS (high performance liquid chromatography-tandem mass spectrometry) method and then used to calculate corresponding pharmacokinetic parameters. Compared with the control group, the AUC(0-t), AUC(0-∞), t1/2, and Cmaxof each probe drug in treatment groups showed no significant differences. Meanwhile, fluorescence quantitative polymerase chain reaction (FQ-PCR) analysis revealed that NRG did not significantly affect the mRNA expressions of genes CYP1a2, CYP2d2, CYP2c6, CYP2c11, and CYP2e1 in rat liver. Based on these results, it could be concluded that NRG showed no significant effects on the activities and mRNA expressions of tested CYP450 in rats.

Published
2020
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18. Characterization, in Vitro and in Vivo Evaluation of Naringenin-Hydroxypropyl-ß-Cyclodextrin Inclusion for Pulmonary Delivery.

Author

Guan M, Shi R, Zheng Y, Zeng X, Fan W, Wang Y, and Su W

Subjects
Administration, Oral, Animals, Calorimetry, Differential Scanning, Cell Line, Female, Flavanones chemistry, Flavanones pharmacokinetics, Humans, Male, Nebulizers and Vaporizers, Proton Magnetic Resonance Spectroscopy, Rats, Rats, Sprague-Dawley, Solubility, X-Ray Diffraction, 2-Hydroxypropyl-beta-cyclodextrin chemistry, Flavanones administration & dosage, Lung chemistry
Abstract

Naringenin, a flavonoid compound which exists abundantly in Citrus fruits, is proven to possess excellent antitussive and expectorant effects. However, the clinical applications of naringenin are restricted by its poor solubility and low local concentration by oral administration. The aim of the present study is to prepare a naringenin-hydroxypropyl-β-cyclodextrin (naringenin-HPβCD) inclusion as an inhalation solution for pulmonary delivery. The naringenin-HPβCD inclusion was characterized by phase solubility study, XRD, differential scanning calorimetry (DSC), proton nuclear magnetic resonance ( 1 HNMR), and two-dimensional rotating frame Overhauser effect spectroscopy (2D ROESY). The in vitro permeability of the inclusion was evaluated on Calu-3 cells and the pharmacokinetic profile of pulmonary delivery was investigated in Sprague-Dawley (SD) rats. Based on the linear model of phase solubility study, the relationship between naringenin and HPβCD was identified as A L type with a 1:1 stoichiometry. XRD, DSC, and NMR studies indicated that the entire naringenin molecule is encapsulated into the cavity of HPβCD. HPβCD could increase the concentration of naringenin in the epithelium-lining fluid (ELF) of Calu-3 cells and act as a sustained release system for naringenin. The pharmacokinetic profile of naringenin-HPβCD inclusion showed rapid response and higher local concentration by pulmonary delivery. In conclusion, pulmonary delivery of naringenin-HPβCD inclusion is a promising formulation strategy, which could provide a new possibility for the clinical application of naringenin., Competing Interests: The authors declare no conflicts of interest.

Published
2020
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