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ObjectiveTo analyze the epidemiological characteristics of tetrodotoxin poisoning events in China from 2011 to 2020 and provide a scientific basis for precise measures to prevent and control tetrodotoxin poisoning.MethodsDescriptive epidemiological methods were used to analyze the epidemiological characteristics of tetrodotoxin poisoning incidents reported through the National Foodborne Disease Outbreak Monitoring System from 2011 to 2020.ResultsFrom 2011 to 2020， 92 cases of tetrodotoxin poisoning reports were received through the National Foodborne Disease Outbreak Monitoring System； 339 people were poisoned and 15 were dead， with a case fatality rate of 4.4%. Tetrodotoxin poisoning was mainly concentrated in the coastal areas of China. The food carriers of tetrodotoxin included pufferfish （71.7%， 66/92）， dried pufferfish （13.0%， 12/92）， Nassariidae （7.6%， 7/92）， horseshoe crabs （5.4%， 5/92）， and Acentrogobius nebulosus （2.2%， 2/92）. Each year， a high incidence of poisoning occurs from March to April.ConclusionTo effectively prevent and control tetrodotoxin poisoning， it is necessary to establish a method for detecting tetrodotoxins in biological samples， improve the ability to identify the pathogenic factors of tetrodotoxin poisoning， strengthen the supervision and popularization of science in the circulation process， and change the dietary habits of people who eat wild pufferfish.

ObjectiveAnalysis of the epidemiological and spatio-temporal clustering of aconite poisoning incidents in China from 2010 to 2020 was performed to provide a reference for the development of precise prevention and control measures and the construction of an early warning system.MethodsCollection of reports of aconite poisoning incidents in surveillance data from 2010 to 2020 with descriptive analysis and spatio-temporal scan analysis was performed.ResultsFrom 2010 to 2020， a total of 380 outbreaks of aconite poisoning with 1 889 illnesses and 75 deaths were reported in China， with a case fatality rate of 3.97% （75/1 889）. The highest number of outbreaks occurred from October to December with 787 cumulative illnesses， accounting for 41.66% （787/1 889） of all cases. More than 86.84% （330/380） of the outbreaks occurred in Yunnan Province and households accounted for 90.26% （343/380） of all outbreak locations. Improper processing resulting in 171 outbreaks， accounting for 45.00% （171/380）. The results of the spatio-temporal scan showed a total of five agglomerative regions， including a category one agglomeration centered in Kunming， Yunnan Province， with an agglomeration period from June 2015 to November 2020， as well as four second-class aggregation areas， including 20 municipalities.ConclusionWe should focus on prevention and control in areas with clusters of aconite poisoning， and publicize and popularize high-risk consumption methods to raise awareness on protection and reduce the occurrence of poisoning incidents before the arrival of the high months.

The electrophysiological activities of head direction (HD) cells under visual and vestibular input dissociation are important to understanding the formation of the sense of direction in animals. In this paper, we fabricated a PtNPs/PEDOT:PSS-modified MEA to detect changes in the discharge of HD cells under dissociated sensory conditions. The electrode shape was customized for the retrosplenial cortex (RSC) and was conducive to the sequential detection of neurons at different depths in vivo when combined with a microdriver. The recording sites of the electrode were modified with PtNPs/PEDOT:PSS to form a three-dimensional convex structure, leading to closer contact with neurons and improving the detection performance and signal-to-noise ratio of the MEA. We designed a rotating cylindrical arena to separate the visual and vestibular information of the rats and detected the changes in the directional tuning of the HD cells in the RSC. The results showed that after visual and vestibular sensory dissociation, HD cells used visual information to establish newly discharged directions which differed from the original direction. However, with the longer time required to process inconsistent sensory information, the function of the HD system gradually degraded. After recovery, the HD cells reverted to their newly established direction rather than the original direction. The research based on our MEAs revealed how HD cells process dissociated sensory information and contributes to the study of the spatial cognitive navigation mechanism. [ABSTRACT FROM AUTHOR]