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12. Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides.

Author

Xu, Jin-Yuan, He, Ye, Zhang, Ai-Wen, Lu, Yun, Chen, Guang-Tong, Yang, Min, and Fan, Bo-Yi

Subjects
ACIDS, AGLYCONES, GLYCOSIDES, HYDROLYSIS
Abstract

Two new glycosidic acids, evolvulic acids B and C (1 and 2), along with a known one, evolvulic acid A (3), were isolated from the glycosidic acid fraction afforded by alkaline hydrolysis of crude resin glycosides from Evolvulus alsinoides whole plants. Their structures were characterized by the spectroscopic data and chemical evidences. Compounds 1 and 2 are both defined as tetrasaccharides, composed of D-fucose, D-glucose, L-rhamnose or D-galactose units. Their aglycones are identified to be a distinctive 3S,11R,14R-trihydroxyhexadecanoic acid, which is only discovered from E. alsinoides up to now. The cytotoxic and anti-migration activities of compounds 1–3 were also tested. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis.

Author

Lu, Yun, He, Ye, Yang, Min, and Fan, Bo-Yi

Subjects
ACIDS, HYDROLYSIS, GLYCOSIDES, PREGNANE
Abstract

Alkaline hydrolysis of the resin glycoside fraction of the whole plants of Convolvulus arvensis gave two new glycosidic acids, named arvensic acids K and L (1 and 2). Their structures were characterized on the basis of spectroscopic data as well as chemical evidence. They possessed a same pentasaccharide chain, composed of one D-fucose, three D-glucose and one L-rhamnose units. The aglycone of compound 1 was identified to be rarely existing 11S-hydroxyheptadecanoic acid, while compound 2 possessed 11S-hydroxyhexadecanoic acid as the aglycone. Their cytotoxic and anti-migration activities were also evaluated. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Biotransformation of Betulonic Acid by the Fungus Rhizopus arrhizusCGMCC 3.868 and Antineuroinflammatory Activity of the Biotransformation Products

Author

Song, Kai-Nan, Lu, You-Jia, Chu, Cheng-Jiao, Wu, Yan-Ni, Huang, Hui-Lian, Fan, Bo-Yi, and Chen, Guang-Tong

Abstract

Biotransformation of betulonic acid (1) by Rhizopus arrhizusCGMCC 3.868 resulted in the production of 16 new (3, 5, 6, and 9–21) and five known compounds. Structures of the new compounds were established by analysis of spectroscopic data. Hydroxylation, acetylation, oxygenation, glycosylation, and addition reactions involved the C-20–C-29 double bond. Antineuroinflammatory activities of the obtained compounds in NO production were tested in lipopolysaccharides-induced BV-2 cells. Compared with the substrate betulonic acid, biotransformation products 3, 8, 9, 14, and 21exhibited an improved inhibitory effect, with IC50values of 10.26, 11.09, 5.38, 1.55, and 4.69 μM, lower than that of the positive control, NG-monomethyl-l-arginine.

Published
2021
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21. Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review.

Author

Chen, Guang‐Tong, Lu, Yun, Yang, Min, Li, Jian‐Lin, Fan, Bo‐Yi, Chen, Guang-Tong, Li, Jian-Lin, and Fan, Bo-Yi

Subjects
THERAPEUTIC use of plant extracts, DRUG therapy, ANIMAL experimentation, CENTRAL nervous system, CENTRAL nervous system diseases, DRUGS, HERBAL medicine, MEDICINAL plants, MOLECULAR structure, PHARMACOLOGY, PLANTS, SYSTEMATIC reviews, PHYTOCHEMICALS, PLANT extracts, TREATMENT effectiveness, PHARMACODYNAMICS, PHYSIOLOGY, THERAPEUTICS
Abstract

Central nervous system (CNS) disorders play a major impact on individual lives and place a severe strain on health care resources. Convolvulaceae is a family comprising approximately 1,600-1,700 species grouped in 55-60 genera, and many species are reported to have an effect on CNS functions. A systematic review of the literature studies was carried out to summarize available evidences on Convolvulaceae plants with CNS efficacies. This review is based on various data sources such as Google Scholar, Web of Science, Scopus, PubMed, and Wanfang Data. A total of 200 related articles were included in this review. According to the research result, 54 Convolvulaceae species are suggested to display CNS efficacies historically, and 46 species have been evaluated for their CNS efficacies. In addition, 67 compounds from 16 Convolvulaceae species are recognized to possess CNS efficacies. Despite great progress made through pharmacology and phytochemistry studies on CNS active Convolvulaceae species, more exploratory research is needed to gain a better understanding of the CNS efficacies of this plant family. [ABSTRACT FROM AUTHOR]

Published
2018
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26. Cytotoxic Resin Glycosides from Ipomoea aquaticaand Their Effects on Intracellular Ca2+Concentrations

Author

Fan, Bo-Yi, Gu, Yu-Cheng, He, Ye, Li, Zhong-Rui, Luo, Jian-Guang, and Kong, Ling-Yi

Abstract

Eleven new resin glycosides, aquaterins I–XI (1–11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1–11were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic acid B and operculinic acids A and C. The site of the aglycone macrolactonization was placed at C-2 or C-3 of the second saccharide moiety, while the two acylating residues could be located at C-2 (or C-3) of the second rhamnose unit and at C-4 (or C-3) on the third rhamnose moiety. All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Compound 4exhibited the most potent activity against HepG2 cells with an IC50value of 2.4 μM. Cell cycle analysis revealed 4to inhibit the proliferation of HepG2 cells via G0/G1arrest and apoptosis induction. In addition, compounds 1–4, 7, 9, and 10were found to elevate Ca2+in HepG2 cells, which might be involved in the regulation of the cytotoxic activities observed.

Published
2014
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