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20 results on '"Falvo D'urso Labate, Giuseppe"'

6. Do Bioreactor Designs with More Efficient Oxygen Supply to Ovarian Cortical Tissue Fragments Enhance Follicle Viability and Growth In Vitro?

Author

Catapano, Gerardo, primary, Fragomeni, Gionata, additional, Falvo D’Urso Labate, Giuseppe, additional, De Napoli, Luigi, additional, Barbato, Vincenza, additional, Di Nardo, Maddalena, additional, Costanzo, Valentina, additional, Capriglione, Teresa, additional, Gualtieri, Roberto, additional, and Talevi, Riccardo, additional

Published
2019
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11. Bioreactor-based model platform for cardiac tissue

Author

Massai, Diana, Pisani, Giuseppe, Rodriguez, Andres, Logrand, Federica, FALVO D'URSO LABATE, GIUSEPPE VITTORIO UGO, XU XIAO, Yun, Bignardi, Cristina, Tarone, Guido, and Morbiducci, Umberto

Published
2014

14. A Versatile Bioreactor for Dynamic Suspension Cell Culture. Application to the Culture of Cancer Cell Spheroids

Author

Massai, Diana, primary, Isu, Giuseppe, additional, Madeddu, Denise, additional, Cerino, Giulia, additional, Falco, Angela, additional, Frati, Caterina, additional, Gallo, Diego, additional, Deriu, Marco A., additional, Falvo D’Urso Labate, Giuseppe, additional, Quaini, Federico, additional, Audenino, Alberto, additional, and Morbiducci, Umberto, additional

Published
2016
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16. Using Lacunarity to Characterize Pore Distribution in Scaffolds

Author

FALVO D'URSO LABATE, GIUSEPPE VITTORIO UGO, Pennella, Francesco, Schiavi, Alessandro, Massai, DIANA NADA CATERINA, Deriu, MARCO AGOSTINO, Montevecchi, Franco Maria, and Morbiducci, Umberto

Subjects
porosity, scaffolds, lacunarity, pore distribution
Published
2011

17. Upgrade of a bioreactor for soft tissue engineering

Author

FALVO D'URSO LABATE, GIUSEPPE VITTORIO UGO, Mastrangelo, Francesco, D'Agostino, FABIO SALVATORE, Rodriguez Ruiz, A. F., Gentile, Piergiorgio, Deriu, MARCO AGOSTINO, Morbiducci, Umberto, and Montevecchi, Franco Maria

Published
2010

20. Do Bioreactor Designs with More Efficient Oxygen Supply to Ovarian Cortical Tissue Fragments Enhance Follicle Viability and Growth In Vitro?

Author

Vincenza Barbato, Valentina Costanzo, Riccardo Talevi, Gionata Fragomeni, Roberto Gualtieri, Teresa Capriglione, Giuseppe Falvo D'Urso Labate, Luigi De Napoli, Maddalena Di Nardo, Gerardo Catapano, Catapano, Gerardo, Fragomeni, Gionata, Falvo D’Urso Labate, Giuseppe, De Napoli, Luigi, Barbato, Vincenza, Di Nard, Maddalena, Costanzo, Valentina, Capriglione, Teresa, Gualtieri, Roberto, and Talevi, Riccardo

Subjects
0301 basic medicine, medicine.medical_treatment, design, Bioengineering, Biology, lcsh:Chemical technology, Cryopreservation, lcsh:Chemistry, 03 medical and health sciences, Follicle, bioreactor, 0302 clinical medicine, in vitro culture, Bioreactor, medicine, Chemical Engineering (miscellaneous), lcsh:TP1-1185, ovarian tissue, 030219 obstetrics & reproductive medicine, In vitro fertilisation, Process Chemistry and Technology, Oxygen transport, In vitro, Cell biology, Transplantation, 030104 developmental biology, lcsh:QD1-999, Cancer cell, transport, oxygen
Abstract

Background: Autotransplantation of cryopreserved ovarian tissue is currently the main option to preserve fertility for cancer patients. To avoid cancer cell reintroduction at transplantation, a multi-step culture system has been proposed to obtain fully competent oocytes for in vitro fertilization. Current in vitro systems are limited by the low number and health of secondary follicles produced during the first step culture of ovarian tissue fragments. To overcome such limitations, bioreactor designs have been proposed to enhance oxygen supply to the tissue, with inconsistent results. This retrospective study investigates, on theoretical grounds, whether the lack of a rational design of the proposed bioreactors prevented the full exploitation of follicle growth potential. Methods: Models describing oxygen transport in bioreactors and tissue were developed and used to predict oxygen availability inside ovarian tissue in the pertinent literature. Results: The proposed theoretical analysis suggests that a successful outcome is associated with enhanced oxygen availability in the cultured tissue in the considered bioreactor designs. This suggests that a rational approach to bioreactor design for ovarian tissue culture in vitro may help exploit tissue potential to support follicle growth.

Published
2019

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