Search

Your search keyword '"Fallon, Ciara"' showing total 15 results
Start Over Author "Fallon, Ciara"
15 results on '"Fallon, Ciara"'

4. Culture: your firm's greatest asset... PwC's Ciara Fallon and David Keane explain how leaders can enhance their organisation's culture in 10 simple steps

Author

Fallon, Ciara and Keane, David

Subjects
Accounting services, Banking, finance and accounting industries, Business, Business, international
Abstract

The environment in which we work has changed dramatically over the past 20 years. There has been the unprecedented impact of e-commerce and information technology with global online traffic increasing [...]

Published
2017

9. Evidence to Underpin Vitamin A Requirements and Upper Limits in Children Aged 0 to 48 Months: A Scoping Review

Author

Hooper, Lee, Esio-Bassey, Chizoba, Brainard, Julii, Fynn, Judith, Jennings, Amy, Jones, Natalia, Tailor, Bhavesh V., Abdelhamid, Asmaa, Coe, Calvin, Esgunoglu, Latife, Fallon, Ciara, Gyamfi, Ernestina, Hill, Claire, Howard Wilsher, Stephanie, Narayanan, Nithin, Oladosu, Titilopemi, Parkinson, Ellice, Prentice, Emma, Qurashi, Meysoon, Read, Luke, Getley, Harriet, Song, Fujian, Welch, Ailsa A., Aggett, Peter, Lietz, Georg, Hooper, Lee, Esio-Bassey, Chizoba, Brainard, Julii, Fynn, Judith, Jennings, Amy, Jones, Natalia, Tailor, Bhavesh V., Abdelhamid, Asmaa, Coe, Calvin, Esgunoglu, Latife, Fallon, Ciara, Gyamfi, Ernestina, Hill, Claire, Howard Wilsher, Stephanie, Narayanan, Nithin, Oladosu, Titilopemi, Parkinson, Ellice, Prentice, Emma, Qurashi, Meysoon, Read, Luke, Getley, Harriet, Song, Fujian, Welch, Ailsa A., Aggett, Peter, and Lietz, Georg

Abstract

Vitamin A deficiency is a major health risk for infants and children in low- and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children aged 0 to 48 months, using health-based or modelling-based approaches. Structured searches were run on Medline, EMBASE, and Cochrane Central, from inception to 19 March 2021. Titles and abstracts were assessed independently in duplicate, as were 20% of full texts. Included studies were tabulated by question, methodology and date, with the most relevant data extracted and assessed for risk of bias. We found that the most recent health-based systematic reviews and trials assessed the effects of supplementation, though some addressed the effects of staple food fortification, complementary foods, biofortified maize or cassava, and fortified drinks, on health outcomes. Recent isotopic tracer studies and modelling approaches may help quantify the effects of bio-fortification, fortification, and food-based approaches for increasing vitamin A depots. A systematic review and several trials identified adverse events associated with higher vitamin A intakes, which should be useful for setting upper limits. We have generated and provide a database of relevant research. Full systematic reviews, based on this scoping review, are needed to answer specific questions to set vitamin A requirements and upper limits.

Published
2022

10. Evidence to Underpin Vitamin A Requirements and Upper Limits in Children Aged 0 to 48 Months: A Scoping Review

Author

Hooper, Lee, primary, Esio-Bassey, Chizoba, additional, Brainard, Julii, additional, Fynn, Judith, additional, Jennings, Amy, additional, Jones, Natalia, additional, Tailor, Bhavesh V., additional, Abdelhamid, Asmaa, additional, Coe, Calvin, additional, Esgunoglu, Latife, additional, Fallon, Ciara, additional, Gyamfi, Ernestina, additional, Hill, Claire, additional, Howard Wilsher, Stephanie, additional, Narayanan, Nithin, additional, Oladosu, Titilopemi, additional, Parkinson, Ellice, additional, Prentice, Emma, additional, Qurashi, Meysoon, additional, Read, Luke, additional, Getley, Harriet, additional, Song, Fujian, additional, Welch, Ailsa A., additional, Aggett, Peter, additional, and Lietz, Georg, additional

Published
2022
Full Text
View/download PDF

11. Nutraceutical Targeting of the Bile Acid Receptor, Farnesoid X Receptor, for Intestinal Disease

Author

Fallon, Ciara

Subjects
Animal cell and molecular biology, Cystic Fibrosis Transmembrane Conductance Regulator, Inflammatory Bowel Diseases, Bile Acids and Salts, Intestinal Diseases, FOS: Biological sciences, Dietary Supplements, Other biological sciences not elsewhere classified, Pentacyclic Triterpenes, Colorectal Neoplasms, Molecular Biology, Plant cell and molecular biology, 69999 Biological Sciences not elsewhere classified, Biological Sciences not elsewhere classified
Abstract

Bile acids, classically known for their roles in dietary fat absorption, are now recognised as hormones critical to regulating many aspects of intestinal physiology, including mucosal immune responses, epithelial proliferation/apoptosis, and transepithelial transport and barrier function. Downregulation of the nuclear bile acid receptor, farnesoid X receptor (FXR), in the intestinal epithelium has been shown to be associated with inflammatory bowel disease and colorectal cancer, whereas FXR activation prevents disease progression in preclinical models. Furthermore, treatment with FXR agonists improves symptoms of diarrhoeal disease, both in preclinical models and in patients with bile acid diarrhoea. Thus, strategies to upregulate epithelial FXR expression and activate FXR signalling have been proposed to treat such intestinal disorders. The ���xxxx���, xxxx, contains pentacyclic triterpenes (PCTs), a particular class of plant-derived phytochemicals, that have been previously proposed to modulate FXR activity. The primary goal of this thesis was to investigate the potential for developing extracts of xxxx as a novel nutraceutical-based approach to treat/prevent intestinal diseases. These studies show that PCTs and xxxx extracts, confirmed to contain PCTs, upregulate colonic epithelial FXR expression and activity in a range of human and murine in vitro, ex vivo and in vivo models. Furthermore, we report novel anti-secretory effects of PCTs and PCT-rich xxxx extracts via FXR-induced downregulation of colonic epithelial cystic fibrosis transmembrane conductance regulator (CFTR) expression. In summary, this thesis demonstrates that PCTs and PCT-containing xxxx extracts modulate expression and activity of the nuclear bile acid receptor, FXR, in colonic epithelial cells. Given the critical roles of FXR in maintenance of gut health, such extracts have significant therapeutic and commercial potential to be developed as a novel first-in-class ���FXR-targeted nutraceutical��� for treatment and prevention of common intestinal disorders.

Published
2021
Full Text
View/download PDF

15. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling

Author

Ní Cheallaigh, Clíona, primary, Sheedy, Frederick J., additional, Harris, James, additional, Muñoz-Wolf, Natalia, additional, Lee, Jinhee, additional, West, Kim, additional, McDermott, Eva Palsson, additional, Smyth, Alicia, additional, Gleeson, Laura E., additional, Coleman, Michelle, additional, Martinez, Nuria, additional, Hearnden, Claire H.A., additional, Tynan, Graham A., additional, Carroll, Elizabeth C., additional, Jones, Sarah A., additional, Corr, Sinéad C., additional, Bernard, Nicholas J., additional, Hughes, Mark M., additional, Corcoran, Sarah E., additional, O’Sullivan, Mary, additional, Fallon, Ciara M., additional, Kornfeld, Hardy, additional, Golenbock, Douglas, additional, Gordon, Stephen V., additional, O’Neill, Luke A.J., additional, Lavelle, Ed C., additional, and Keane, Joseph, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results