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5. Molecular mimicry between Helicobacter pylori and the host

Author

Appelmelk, B. J., Straver, S., Verboom, T., Kuipers, E. J., Claeys, D., Faller, G., Kirchner, T., Negrini, R., Krakowka, S., De Pont, J. J. H. H. M., Simoons-Smit, I., Maaskant, J. J., VandenBroucke-Grauls, C. M. J. E., Hunt, Richard H., editor, and Tytgat, Guido N. J., editor

Published
1998
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10. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach

Author

Wittschier, N., Faller, G., and Hensel, A.

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Helicobacter pylori -- Analysis -- Research, Geraniums -- Research -- Dosage and administration -- Analysis, Biological sciences, Health, Science and technology
Abstract

Abstract Root extract from Pelargonium sidoides DC is used therapeutically as antimicrobial agent against infections of the respiratory system. In order to elucidate possible modes of actions we investigated the [...]

Published
2007

13. Histopathologische Diagnostik der Barrett-Schleimhaut und ihrer Neoplasien: Ergebnisse einer Konsensus-Konferenz der Arbeitsgemeinschaft "Gastroenterologische Pathologie der Deutschen Gesellschaft für Pathologie" am 22. September 2001 in Erlangen

Author

Faller, G., Berndt, R., Borchard, F., Ell, C., Fuchs, K.-H., Geddert, H., Gossner, L., Günther, T., Kirchner, T., Koch, H. K., Langner, C., Lüttges, J., May, A., Müller, S., Oberhuber, G., Seitz, G., Stolte, M., Tannapfel, A., Vieth, M., Walch, A., and Rüschoff, J.

Published
2003
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36. Unklarer Tumor der Keilbeinhöhle bei einer Patientin mit Horner-Syndrom

Author

Runge, S, Dimmler, A, Faller, G, and Mertens, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Tumoren der Nasennebenhöhlen sind mit 0,2–0,8% aller Malignome selten und lediglich ein kleiner Anteil hiervon sind Fernmetastasen anderer Tumorentitäten. Das Mammakarzinom wird in der Literatur als der dritthäufigste Tumor, der in die Nasennebenhöhlen fernmetastasiert, beschrieben. Fallbeschreibung: Berichtet wird von einer 60-jährigen Patientin die uns durch die Augenklinik des Hauses mit einem Horner-Syndrom vorgestellt wurde. Seit einer Woche bestünden Doppelbilder, eine subjektive Sehminderung sowie eine Lidschwäche des rechten Auges, des Weiteren diffuse Kopfschmerzen. In der Vorgeschichte bestand ein 2005 erstdiagnostiziertes pT1 pN0 M0 ductal-invasives Mammakarzinom, seit 2011 kam es zum Auftreten von Fernmetastasen, ohne Befall des Schädels bis dato. Die Bildgebung erbrachte eine beidseitige Verlegung der Keilbeinhöhle sowie der hinteren Siebbeinzellen, die in Kombination mit den angegebenen Kopfschmerzen initial auf einen eher entzündlichen Prozess schließen ließen. Des Weiteren war eine inhomogene Knochenbinnenstruktur im Bereich des Clivus auffällig. Im Rahmen einer endonasalen Siebbein- und Keilbeinhöhlenoperation ergaben sich histologisch ausgedehnte Mammakarzinominfiltrate beidseits. Schlussfolgerungen: Symptome bei Metastasen der Nasennebenhöhlen sind meistens unspezifisch und können eine akute Sinusitis mit begleitender orbitaler Komplikation vortäuschen. Neben der arteriellen hämatogenen Metastasierung erfolgt ein möglicher Tumorbefall der Keilbeinhöhle über Venenplexus im Bereich des Clivus, wie auch in unserem Fall denkbar. Schlussfolgernd sollte bei bekannter Tumorerkrankung in der Vorgeschichte und unklarer Sinusitis bzw. Nasennebenhöhlenverschattung in der Bildgebung immer auch an eine mögliche Fernmetastasierung gedacht werden. Der Erstautor gibt keinen Interessenkonflikt an., GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; 11:Doc107; ISSN 1865-1038

Published
2015
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40. Immune Response to H. pylori Heat Shock Protein 60 strongly correlates with Chronic Inflammation in Gastric Mucosa but not with the Development of Atrophy or Presence of Anticanalicular Autoantibodies

Author

Vorobjova, T., Ananieva, O., Maaroos, H., Sipponen, P., Faller, G., Utt, M., Nilsson, I., Wadstrom, T., Villako, K., and Uibo, R.

Subjects
Helicobacter infections -- Research, Helicobacter pylori -- Research, Gastrointestinal diseases -- Research, Health, Research
Abstract

T. Vorobjova [1] O. Ananieva [1] H. Maaroos [2] P. Sipponen [3] G. Faller [4] M. Utt [5] I. Nilsson [5] T. Wadstrom [5] K. Villako [2] R. Uibo [1] [...]

Published
2001

47. Solitary fibrous tumor in the tongue. Case report and review of the literature [Solitärer fibröser tumor der zunge. Fallbericht und literaturübersicht]

Author

Nkenke, E. Fenner, M. Lell, M. Vairaktaris, E. Neukam, F.W. Faller, G.

Abstract

Solitary fibrous tumors (SFT) are rare, mostly fibroblastic tumors usually situated in the pleura. Extrapleural manifestations have been described. However, the oral cavity is an uncommon localisation of this tumor. We report the very unusual case of an SFT affecting the tongue that could be removed completely because of its clear delineation. Intraoperative incisional biopsies were used to exclude malignancy. For definitive classification of the tumor, additional histopathologic examinations had to be carried out. Because SFT exhibit malignant behavior only in exceptional cases and their recurrence after complete removal has never been encountered, surgery can focus on the preservation of undisturbed function of the tongue. © 2006 Springer Medizin Verlag.

Published
2007

48. Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa.

Author

Lewandowski, L. B., Schanberg, L. E., Thielman, N., Phuti, A., Kalla, A. A., Okpechi, I., Nourse, P., Gajjar, P., Faller, G., Ambaram, P., Reuter, H., Spittal, G., and Scott, C.

Subjects
SYSTEMIC lupus erythematosus, JUVENILE diseases, LUPUS nephritis, PHENOTYPES, CYCLOPHOSPHAMIDE, METHOTREXATE, CHRONIC kidney failure, CHILDREN
Abstract

Background Systemic lupus erythematosus (SLE) is a life-threatening multisystem autoimmune disease that is more severe in patients of African ancestry and children, yet pediatric SLE on the African continent has been understudied. This study describes a cohort of pediatric SLE (PULSE) patients in South Africa. Methods Patients with a diagnosis of SLE (1997 American College of Rheumatology criteria) diagnosed prior to age 19 years in Cape Town, South Africa, were enrolled in this cross-sectional study from September 2013 to December 2014. Information on clinical and serological characteristics was extracted from medical records. Results were compared to a well-described North American pediatric SLE cohort. Results Seventy-two South African patients were enrolled in the study; mean age 11.5 years; 82% were girls. The racial distribution was 68% Coloured, 24% Black, 5% White and 3% Asian/Indian. Most patients presented with severe lupus nephritis documented by renal biopsy (61%). Of patients with lupus nephritis, 63% presented with International Society of Nephrology/Renal Pathology Society class III or IV. Patients in the PULSE cohort were more likely to be treated with cyclophosphamide, methotrexate and azathioprine. The PULSE cohort had high disease activity at diagnosis (mean Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K) 20.6). The SLEDAI-2K at enrolment in the PULSE cohort (5.0) did not differ from the North American pediatric SLE cohort (4.8). Sixty-three per cent of the PULSE cohort had end organ damage with Systemic Lupus International Collaborating Clinics Damage Index (SLICC-DI) score >0 (mean SLICC-DI 1.9), compared to 23% in a previously reported US cohort. Within the PULSE cohort, nine (13%) developed end-stage renal disease with six (8%) requiring transplant, strikingly higher than North American peers (transplant rate <1%). Conclusions The PULSE cohort had highly active multiorgan disease at diagnosis and significant disease damage at enrolment in the South African registry. South African patients have severe lupus nephritis and poor renal outcomes compared to North American peers. Our study revealed a severe disease phenotype in the PULSE cohort resulting in poor outcomes in this high-risk population. [ABSTRACT FROM AUTHOR]

Published
2017
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