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1. DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Author

Issarapu, Prachand, Arumalla, Manisha, Elliott, Hannah R., Nongmaithem, Suraj S., Sankareswaran, Alagu, Betts, Modupeh, Sajjadi, Sara, Kessler, Noah J., Bayyana, Swati, Mansuri, Sohail R., Derakhshan, Maria, Krishnaveni, G. V., Shrestha, Smeeta, Kumaran, Kalyanaraman, Di Gravio, Chiara, Sahariah, Sirazul A., Sanderson, Eleanor, Relton, Caroline L., Ward, Kate A., Moore, Sophie E., Prentice, Andrew M., Lillycrop, Karen A., Fall, Caroline H. D., Silver, Matt J., and Chandak, Giriraj R.

Published
2023
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2. Maternal age is related to offspring DNA methylation: A meta‐analysis of results from the PACE consortium

Author

Yeung, Edwina, primary, Biedrzycki, Richard J., additional, Gómez Herrera, Laura C., additional, Issarapu, Prachand, additional, Dou, John, additional, Marques, Irene Fontes, additional, Mansuri, Sohail Rafik, additional, Page, Christian Magnus, additional, Harbs, Justin, additional, Khodasevich, Dennis, additional, Poisel, Eric, additional, Niu, Zhongzheng, additional, Allard, Catherine, additional, Casey, Emma, additional, Berstein, Fernanda Morales, additional, Mancano, Giulia, additional, Elliott, Hannah R., additional, Richmond, Rebecca, additional, He, Yiyan, additional, Ronkainen, Justiina, additional, Sebert, Sylvain, additional, Bell, Erin M., additional, Sharp, Gemma, additional, Mumford, Sunni L., additional, Schisterman, Enrique F., additional, Chandak, Giriraj R., additional, Fall, Caroline H. D., additional, Sahariah, Sirazul A., additional, Silver, Matt J., additional, Prentice, Andrew M., additional, Bouchard, Luigi, additional, Domellof, Magnus, additional, West, Christina, additional, Holland, Nina, additional, Cardenas, Andres, additional, Eskenazi, Brenda, additional, Zillich, Lea, additional, Witt, Stephanie H., additional, Send, Tabea, additional, Breton, Carrie, additional, Bakulski, Kelly M., additional, Fallin, M. Daniele, additional, Schmidt, Rebecca J., additional, Stein, Dan J., additional, Zar, Heather J., additional, Jaddoe, Vincent W. V., additional, Wright, John, additional, Grazuleviciene, Regina, additional, Gutzkow, Kristine Bjerve, additional, Sunyer, Jordi, additional, Huels, Anke, additional, Vrijheid, Martine, additional, Harlid, Sophia, additional, London, Stephanie, additional, Hivert, Marie‐France, additional, Felix, Janine, additional, Bustamante, Mariona, additional, and Guan, Weihua, additional

Published
2024
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3. Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study

Author

Sandu, Anca-Larisa, Waiter, Gordon D., Staff, Roger T., Nazlee, Nafeesa, Habota, Tina, McNeil, Chris J., Chapko, Dorota, Williams, Justin H., Fall, Caroline H. D., Chandak, Giriraj R., Pene, Shailesh, Krishna, Murali, McIntosh, Andrew M., Whalley, Heather C., Kumaran, Kalyanaraman, Krishnaveni, Ghattu V., and Murray, Alison D.

Published
2022
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5. Health and development from preconception to 20 years of age and human capital

Author

Black, Robert E, Liu, Li, Hartwig, Fernando P, Villavicencio, Francisco, Rodriguez-Martinez, Andrea, Vidaletti, Luis P, Perin, Jamie, Black, Maureen M, Blencowe, Hannah, You, Danzhen, Hug, Lucia, Masquelier, Bruno, Cousens, Simon, Gove, Amber, Vaivada, Tyler, Yeung, Diana, Behrman, Jere, Martorell, Reynaldo, Osmond, Clive, Stein, Aryeh D, Adair, Linda S, Fall, Caroline H D, Horta, Bernardo, Menezes, Ana M B, Ramirez-Zea, Manuel, Richter, Linda M, Patton, George C, Bendavid, Eran, Ezzati, Majid, Bhutta, Zulfiqar A, Lawn, Joy E, and Victora, Cesar G

Published
2022
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9. Maternal age is related to offspring DNA methylation : a meta-analysis of results from the pace consortium

Author

Yeung, Edwina, Biedrzycki, Richard J., Gómez Herrera, Laura C., Issarapu, Prachand, Dou, John, Marques, Irene Fontes, Mansuri, Sohail Rafik, Page, Christian Magnus, Harbs, Justin, Khodasevich, Dennis, Poisel, Eric, Niu, Zhongzheng, Allard, Catherine, Casey, Emma, Berstein, Fernanda Morales, Mancano, Giulia, Elliott, Hannah R., Richmond, Rebecca, He, Yiyan, Ronkainen, Justiina, Sebert, Sylvain, Bell, Erin M., Sharp, Gemma, Mumford, Sunni L., Schisterman, Enrique F., Chandak, Giriraj R., Fall, Caroline H. D., Sahariah, Sirazul A., Silver, Matt J., Prentice, Andrew M., Bouchard, Luigi, Domellöf, Magnus, West, Christina E., Holland, Nina, Cardenas, Andres, Eskenazi, Brenda, Zillich, Lea, Witt, Stephanie H., Send, Tabea, Breton, Carrie, Bakulski, Kelly M., Fallin, M. Daniele, Schmidt, Rebecca J., Stein, Dan J., Zar, Heather J., Jaddoe, Vincent W. V., Wright, John, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Sunyer, Jordi, Huels, Anke, Vrijheid, Martine, Harlid, Sophia, London, Stephanie, Hivert, Marie-France, Felix, Janine, Bustamante, Mariona, Guan, Weihua, Yeung, Edwina, Biedrzycki, Richard J., Gómez Herrera, Laura C., Issarapu, Prachand, Dou, John, Marques, Irene Fontes, Mansuri, Sohail Rafik, Page, Christian Magnus, Harbs, Justin, Khodasevich, Dennis, Poisel, Eric, Niu, Zhongzheng, Allard, Catherine, Casey, Emma, Berstein, Fernanda Morales, Mancano, Giulia, Elliott, Hannah R., Richmond, Rebecca, He, Yiyan, Ronkainen, Justiina, Sebert, Sylvain, Bell, Erin M., Sharp, Gemma, Mumford, Sunni L., Schisterman, Enrique F., Chandak, Giriraj R., Fall, Caroline H. D., Sahariah, Sirazul A., Silver, Matt J., Prentice, Andrew M., Bouchard, Luigi, Domellöf, Magnus, West, Christina E., Holland, Nina, Cardenas, Andres, Eskenazi, Brenda, Zillich, Lea, Witt, Stephanie H., Send, Tabea, Breton, Carrie, Bakulski, Kelly M., Fallin, M. Daniele, Schmidt, Rebecca J., Stein, Dan J., Zar, Heather J., Jaddoe, Vincent W. V., Wright, John, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Sunyer, Jordi, Huels, Anke, Vrijheid, Martine, Harlid, Sophia, London, Stephanie, Hivert, Marie-France, Felix, Janine, Bustamante, Mariona, and Guan, Weihua

Abstract

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.

Published
2024
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22. sj-docx-1-aph-10.1177_10105395231151730 – Supplemental material for The Long-Term Consequences of Early Life Exposure to Tsunami and Conflict on Adolescents in Sri Lanka

Author

Devakumar, Delan, Busert, Laura, Sathiadas, Manoji Gitanjali, Jayawardana, Pushpika, Arulpragasam, Angela, Osmond, Clive, Fall, Caroline H. D., Wells, Jonathan C. K., and Wickramasinghe, V. Pujitha

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-aph-10.1177_10105395231151730 for The Long-Term Consequences of Early Life Exposure to Tsunami and Conflict on Adolescents in Sri Lanka by Delan Devakumar, Laura Busert, Manoji Gitanjali Sathiadas, Pushpika Jayawardana, Angela Arulpragasam, Clive Osmond, Caroline H. D. Fall, Jonathan C. K. Wells and V. Pujitha Wickramasinghe in Asia Pacific Journal of Public Health

Published
2023
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27. Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

Author

Derakhshan, Maria, primary, Kessler, Noah J, additional, Ishida, Miho, additional, Demetriou, Charalambos, additional, Brucato, Nicolas, additional, Moore, Gudrun E, additional, Fall, Caroline H D, additional, Chandak, Giriraj R, additional, Ricaut, Francois-Xavier, additional, Prentice, Andrew M, additional, Hellenthal, Garrett, additional, and Silver, Matt J, additional

Published
2022
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28. Body Composition and Cardiometabolic Risk Markers in Children of Women who Took Part in a Randomized Controlled Trial of a Preconceptional Nutritional Intervention in Mumbai, India

Author

Sahariah, Sirazul Ameen, Gandhi, Meera, Chopra, Harsha, Kehoe, Sarah H., Johnson, Matthew J., di Gravio, Chiara, Patkar, Deepak, Sane, Harshad, Coakley, Patsy J., Karkera, Aarti H., Bhat, Dattatray S., Brown, Nick, Margetts, Barrie M., Jackson, Alan A., Kumaran, Kalyanaraman, Potdar, Ramesh D., Fall, Caroline H. D., Sahariah, Sirazul Ameen, Gandhi, Meera, Chopra, Harsha, Kehoe, Sarah H., Johnson, Matthew J., di Gravio, Chiara, Patkar, Deepak, Sane, Harshad, Coakley, Patsy J., Karkera, Aarti H., Bhat, Dattatray S., Brown, Nick, Margetts, Barrie M., Jackson, Alan A., Kumaran, Kalyanaraman, Potdar, Ramesh D., and Fall, Caroline H. D.

Abstract

Background Maternal nutrition influences fetal development and may permanently alter ("program") offspring body composition and metabolism, thereby influencing later risk of diabetes and cardiovascular (cardiometabolic) disease. The prevalence of cardiometabolic disease is rising rapidly in India. Objectives To test the hypothesis that supplementing low-income Indian women with micronutrient-rich foods preconceptionally and during pregnancy has a beneficial impact on the children's body composition and cardiometabolic risk marker profiles. Methods Follow-up of 1255 children aged 5-10 y whose mothers took part in the Mumbai Maternal Nutrition Project [Project "SARAS"; International Standard Randomised Controlled Trial Number (ISRCTN)62811278]. Mothers were randomly assigned to receive a daily micronutrient-rich snack or a control snack of lower micronutrient content, both made from local foods, in addition to normal diet, from before pregnancy until delivery. Children's body composition was assessed using anthropometry and DXA. Their blood pressure, plasma glucose, insulin, and lipid concentrations were measured. Outcomes were compared between allocation groups with and without adjustment for confounding factors. Results Overall, 15% of children were stunted, 34% were wasted, and 3% were overweight. In the intention-to-treat analysis, there were no differences in body composition or risk markers between children in the intervention and control groups. Among children whose mothers started supplementation >= 3 mo before conception (the "per protocol" sample) the intervention increased adiposity among girls, but not boys. BMI in girls was increased relative to controls by 2% (95% CI: 1, 4; P = 0.01); fat mass index by 10% (95% CI: 3, 18; P = 0.004); and percent fat by 7% (95% CI: 1, 13; P = 0.01) unadjusted, with similar results in adjusted models. Conclusions Overall, supplementing women with micronutrient-rich foods from before pregnancy until delivery did not alte

Published
2022
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29. Health and development from preconception to 20 years of age and human capital

Author

UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, Black, Robert E, Liu, Li, Hartwig, Fernando P, Villavicencio, Francisco, Rodriguez-Martinez, Andrea, Vidaletti, Luis P, Perin, Jamie, Black, Maureen M, Blencowe, Hannah, You, Danzhen, Hug, Lucia, Masquelier, Bruno, Cousens, Simon, Gove, Amber, Vaivada, Tyler, Yeung, Diana, Behrman, Jere, Martorell, Reynaldo, Osmond, Clive, Stein, Aryeh D, Adair, Linda S, Fall, Caroline H D, Horta, Bernardo, Menezes, Ana M B, Ramirez-Zea, Manuel, Richter, Linda M, Patton, George C, Bendavid, Eran, Ezzati, Majid, Bhutta, Zulfiqar A, Lawn, Joy E, Victora, Cesar G, UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, Black, Robert E, Liu, Li, Hartwig, Fernando P, Villavicencio, Francisco, Rodriguez-Martinez, Andrea, Vidaletti, Luis P, Perin, Jamie, Black, Maureen M, Blencowe, Hannah, You, Danzhen, Hug, Lucia, Masquelier, Bruno, Cousens, Simon, Gove, Amber, Vaivada, Tyler, Yeung, Diana, Behrman, Jere, Martorell, Reynaldo, Osmond, Clive, Stein, Aryeh D, Adair, Linda S, Fall, Caroline H D, Horta, Bernardo, Menezes, Ana M B, Ramirez-Zea, Manuel, Richter, Linda M, Patton, George C, Bendavid, Eran, Ezzati, Majid, Bhutta, Zulfiqar A, Lawn, Joy E, and Victora, Cesar G

Abstract

Optimal health and development from preconception to adulthood are crucial for human flourishing and the formation of human capital. The Nurturing Care Framework, as adapted to age 20 years, conceptualises the major influences during periods of development from preconception, through pregnancy, childhood, and adolescence that affect human capital. In addition to mortality in children younger than 5 years, stillbirths and deaths in 5–19-year-olds are important to consider. The global rate of mortality in individuals younger than 20 years has declined substantially since 2000, yet in 2019 an estimated 8·6 million deaths occurred between 28 weeks of gestation and 20 years of age, with more than half of deaths, including stillbirths, occurring before 28 days of age. The 1000 days from conception to 2 years of age are especially influential for human capital. The prevalence of low birthweight is high in sub-Saharan Africa and even higher in south Asia. Growth faltering, especially from birth to 2 years, occurs in most world regions, whereas overweight increases in many regions from the preprimary school period through adolescence. Analyses of cohort data show that growth trajectories in early years of life are strong determinants of nutritional outcomes in adulthood. The accrual of knowledge and skills is affected by health, nutrition, and home resources in early childhood and by educational opportunities in older children and adolescents. Linear growth in the first 2 years of life better predicts intelligence quotients in adults than increases in height in older children and adolescents. Learning-adjusted years of schooling range from about 4 years in sub-Saharan Africa to about 11 years in high-income countries. Human capital depends on children and adolescents surviving, thriving, and learning until adulthood.

Published
2022

31. Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort

Author

Joglekar, Mugdha V., primary, Kunte, Pooja S., additional, Wong, Wilson K.M., additional, Bhat, Dattatray. S., additional, Satoor, Sarang N., additional, Patil, Rohan R., additional, Karandikar, Mahesh S., additional, Fall, Caroline H. D., additional, Yajnik, Chittaranjan S., additional, and Hardikar, Anandwardhan A., additional

Published
2022
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32. Body Composition and Cardiometabolic Risk Markers in Children of Women who Took Part in a Randomized Controlled Trial of a Preconceptional Nutritional Intervention in Mumbai, India

Author

Sahariah, Sirazul Ameen, primary, Gandhi, Meera, additional, Chopra, Harsha, additional, Kehoe, Sarah H, additional, Johnson, Matthew J, additional, di Gravio, Chiara, additional, Patkar, Deepak, additional, Sane, Harshad, additional, Coakley, Patsy J, additional, Karkera, Aarti H, additional, Bhat, Dattatray S, additional, Brown, Nick, additional, Margetts, Barrie M, additional, Jackson, Alan A, additional, Kumaran, Kalyanaraman, additional, Potdar, Ramesh D, additional, and Fall, Caroline H D, additional

Published
2022
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33. Additional file 5 of DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Author

Antoun, Elie, Issarapu, Prachand, di Gravio, Chiara, Shrestha, Smeeta, Betts, Modupeh, Saffari, Ayden, Sahariah, Sirazul A., Sankareswaran, Alagu, Arumalla, Manisha, Prentice, Andrew M., Fall, Caroline H. D., Silver, Matt J., Chandak, Giriraj R., and Lillycrop, Karen A.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 5. Online supplementary methods.

Published
2022
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44. Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN): a Healthy Life Trajectories Initiative (HeLTI) Study

Author

Kumaran, Kalyanaraman, primary, Krishnaveni, Ghattu V, additional, Suryanarayana, Kumar Gavali, additional, Prasad, Manohar Prabhu, additional, Belavendra, Antonisamy, additional, Atkinson, Stephanie, additional, Balasubramaniam, Ramaswamy, additional, Bandsma, Robert H J, additional, Bhutta, Zulfiqar A, additional, Chandak, Giriraj Ratan, additional, Comelli, Elena M, additional, Davidge, Sandra T, additional, Dennis, Cindy-Lee, additional, Hammond, Geoffrey L, additional, Jha, Prabhat, additional, Joseph, K S, additional, Joshi, Sadhana R, additional, Krishna, Murali, additional, Lee, Kang, additional, Lye, Stephen, additional, McGowan, Patrick, additional, Nepomnaschy, Pablo, additional, Padvetnaya, Vivek, additional, Pyne, Saumyadipta, additional, Sachdev, Harshpal Singh, additional, Sahariah, Sirazul Ameen, additional, Singhal, Nalini, additional, Trasler, Jacquetta, additional, Yajnik, Chittaranjan S, additional, Baird, Janis, additional, Barker, Mary, additional, Martin, Marie-Claude, additional, Husain, Nusrat, additional, Sellen, Daniel, additional, Fall, Caroline H D, additional, Shah, Prakesh S, additional, and Matthews, Stephen G, additional

Published
2021
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49. Intergenerational change in anthropometry of children and adolescents in the New Delhi Birth Cohort.

Author

Sinha, Sikha, Shah, Dheeraj, Osmond, Clive, Fall, Caroline H D, Bhargava, Santosh K, and Sachdev, Harshpal Singh

Subjects
COHORT analysis, ANTHROPOMETRY, BODY mass index, TEENAGERS, PRESCHOOL children
Abstract

Background: A comparison of the anthropometry of children and adolescents with that of their parents at the same age may provide a more precise measure of intergenerational changes in linear growth and body mass index (BMI).Methods: New Delhi Birth Cohort participants (F1), born between 1969 and 1972, were followed up for anthropometry at birth and at 6-monthly intervals until 21 years of age. At variable intervals 1447 children, aged 0-19 years (F2) and born to 818 F1 participants, were measured (weight and height), providing 2236 sets of anthropometries. Intergenerational changes (F2-F1) in height and BMI [absolute and standard deviation (SD) units] were computed by comparing children with their parents at corresponding ages.Results: F2 children were taller (P < 0.001) than their parents at corresponding ages; the increase {mean [95% confidence interval (CI)] World Health Organization SD units} was 0.97 (0.83, 1.11), 1.21 (1.10, 1.32), 1.09 (0.98, 1.19), 1.10 (1.00, 1.21) and 0.75 (0.65, 0.85) for age categories of 0-5, 5-7.5, 7.5-10, 10-12.5 and >12.5 years, respectively. In absolute terms, this increase ranged from 3.5 cm (0-5-year-olds) to 7.5 cm (10-12.5-year-olds). The corresponding increases in BMI SD scores were 0.32 (0.18, 0.47), 0.60 (0.45, 0.75), 1.13 (0.99, 1.27), 1.30 (1.15, 1.45) and 1.00 (0.85, 1.15), respectively. The absolute BMI increase ranged from 1-3 kg/m2 at >5 years age to ∼3 kg/m2 at >10-years of age. The intergenerational increases were comparable in both sexes, but were greater in children born and measured later. A positive change in socioeconomic status was associated with an increase in height across the generations.Conclusions: Children and adolescents, throughout the ages 0-19 years, have become considerably taller and have a higher BMI than their parents at corresponding ages in an urban middle-class Indian population undergoing socioeconomic improvements. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Prevalence, incidence and predictors of cardiovascular risk factors: longitudinal data from rural and urban South India and comparison with global data

Author

Vasan, Senthil K, primary, Antonisamy, Belavendra, additional, Gowri, Mahasampath, additional, Selliah, Hepsy Y, additional, Geethanjali, Finney S, additional, Jebasingh, Felix S, additional, Paul, Thomas V, additional, Thomas, Nihal, additional, Karpe, Fredrik, additional, Johnson, Matthew, additional, Osmond, Clive, additional, and Fall, Caroline H D, additional

Published
2020
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