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The emergence of nanotechnology in the medical field shows the high expectations for new nanotechnology-based health products. The DeDNAed project aims to develop a cutting-edge bioanalytical biosensor platform with advanced sensitivity and versatility using Surface Enhanced Raman Spectroscopy (SERS) as an ultrafast optical analysis method. The platform is based on the assembly and integration of sensing elements (transducer and bioreceptor) using DNA origami. The DNA origami will serve as a “nano-breadboard” to precisely control the position of these elements and thus the sensor architecture at the nanometer scale, enhabling highly sensitive SERS measurements. During the development and innovation process, clarity about the safety surrounding new technologies is one of the most important prerequisites for technology acceptance. Eliminating hazards at the design or planning stage is often easier and cheaper to achieve than making changes later when the hazards become real risks. Thus, throughout the DeDNAed project, we will implement the Safe-by Design (SbD) approach, which refers to identifying the risks and uncertainties concerning humans and the environment at an early phase of the innovation process so as to minimize uncertainties, potential hazard(s) and/or exposure. The SbD approach addresses the safety of the material/product and associated processes throughout the entire life cycle: from the Research and Development (R&D) phase to production, use, recycling and disposal. In the present work we present first approaches on the SbD implementation within an early stage nanoenabled biosensor multicomponent device that will develop new nanoscale components. Some sustainability considerations will be presented as first impressions for a more sustainable development of innovations.

Biological assays have been shifting towards miniaturization increasing lab work efficiency and enabling high-throughput. Microfluidics have shown intrinsic ability to manipulate very small volumes of fluids in a variety of integrated ways including sample processing, accurate control of fluids and delivery of results with a fast time. Huge potential of advanced automated point-of-care (POC) systems is expected. The founded association Microfluidics Innovation Hub (MIH) of the NextGenMicrofluidics OITB offers customers a single-entry point service catalog to a wide range of existing cutting-edge microfluidic technologies to accelerate the demonstration of scientific breakthroughs towards a working prototype and beyond into mass manufacturing. Here, we present preliminary results of the Safety & Sustainability assessment of next generation microfluidic devices for diagnostics applications.

This report describes how a car sun visor can be designed in order to meet a sustainability certification called Cradle to Cradle Certified® (C2C). The thesis is a final project for the university program Mechanical Engineering: Product Development and Design at School of engineering, Jönköping University. The thesis is in a collaboration with Polestar, a performance electric car brand with the goal to build sustainable electric cars and help create a sustainable society. One way to take this sustainability work forward is to apply C2C certifications to their products. The aim of the project was therefore to present how a sun visor from a Polestar model would meet the C2C requirements, and to develop a concept and prototype that can potentially receive a C2C certification. The project also aimed to present important conclusions about how C2C affects the product development process. The project was divided into two main sections, one deeper study of C2C and one conceptual design study. The work began with examining the structure and requirements of C2C. These were then compared to Polestar’s sun visor. Several product development phases were carried out with Bootcamp bootleg and the C2C process to develop concepts that could meet C2C´s and Polestar´s requirements. The concepts were then presented to a focus group in order to select a concept for further development. The result is a conceptual sun visor that is well adapted for C2C. The concept has a big focus on sustainable and safe materials, functions for circularity, with an extra focus on a simple disassembly process. According to the project group, the concept is assessed to possess the potential for the third highest ranking in the C2C certification. The project also resulted in a prototype to present the concept, functions and materials. I denna rapport redovisas hur solskyddet i en bil kan designas i syfte att uppfylla en hållbarhetscertifiering kallad Cradle to Cradle Certified® (C2C). Examensarbetet är ett slutprojekt för högskoleprogrammet Maskinteknik: Produktutveckling och design vid Tekniska Högskolan i Jönköping. Examensarbetet genomförs i samarbete med Polestar, ett prestanda elbilsmärke som arbetar med att skapa hållbara elbilar för att bidra till ett hållbart samhälle. Ett sätt att föra detta hållbarhetsarbete framåt, är att tillämpa C2C-certifieringar på sina produkter. Målet med projektet blev därför att presentera hur ett solskydd från en Polestar modell uppfyller C2C-kraven, samt att ta fram ett koncept och prototyp som potentiellt kan få en C2C-certifiering. Projektet syftade även till att presentera viktiga slutsatser om hur C2C påverkar produktutvecklingsprocessen. Projektet delades in i två huvuddelar, en djupare studie av C2C och en konceptuell designstudie. Arbetet började med att undersöka uppbyggnaden samt kraven för C2C. Dessa jämfördes sedan mot Polestars solskydd. Flera produktutvecklingsfaser genomfördes med Bootcamp bootleg- och C2C processen för att ta fram koncept som kunde möta kraven från C2C och Polestar. Dessa presenterades sedan för en fokusgrupp i syfte att välja ut ett koncept att utveckla vidare. Resultatet är ett konceptuellt solskydd som är väl anpassat för C2C. Konceptet har stort fokus på hållbara och säkra material, gedigna funktioner för cirkuläritet, med ett extra fokus på en enkel demonteringsprocess. Konceptet bedöms enligt projektgruppen besitta potentialen för den tredje högsta rankingen i C2C certifieringen. Projektet resulterade även i en fysisk prototyp för att presentera konceptet, funktioner och material.

Safe-by-design and EU funded NanoSafety projects is a contribution of the EU NanoSafetyCluster (NSC), supporting the SbD-study of the European Commission, March 2021 Editors: Andreas Falk, Flemming R. Cassee and Eva Valsami-Jones (NSC coordination team) This document is based on the voluntary contributions delivered by the project consortia of the projects mentioned in chapter 1 and 2. The contributions have been edited without further interpretation or commenting about those inputs. It was delivered to the European Commission to answer their request to contribute to their study on the state-of-the-art and ongoing research in the field of safe-and-sustainable-by-design. The editors kindly acknowledge the colleagues from NanoSafetyCluster community, who have contributed the information about their project to this document.

Die bis dato eher verhaltene Nachfrage nach Smart-Home-Systemen gibt Anlass zu der Frage nach den maßgeblichen Adoptionsbarrieren. In Anbetracht des potentiellen Nutzens dieser Technologien für das Leben der Bewohner – besonders auch im fortschreitenden Alter – besteht darüber hinaus Forschungsbedarf, ob und in welcher Art sich das Alter(n) auf die Technologieakzeptanz auswirkt. Insbesondere sind auf subjektiver Wahrnehmung basierende Alterskonstrukte bisher kaum im Zusammenhang mit der Technologieadoption untersucht worden. Die Arbeit befasst sich mit den Determinanten der Akzeptanz von Smart-Home-Anwendungen seitens potentieller Übernehmer anhand populärer Theorien und Modelle zum individuellen Adoptionsverhalten und mit Blick auf die Einflusswirkung des chronologischen Alters bzw. des subjektiv empfundenen Alterns. Das gewählte Untersuchungsmodell basiert auf dem in der wissenschaftlichen Forschung weit verbreiteten und empirisch bewährten Technology Acceptance Model (Davis, Bagozzi & Warshaw, 1989). Zusätzlich werden alternativ externe Variablen in Form des chronologischen Alters bzw. der Future Time Perspective (Carstensen & Lang, 1996) einbezogen, um insbesondere die Wirkung auf den wahrgenommenen Nutzwert und die empfundene Einfachheit der Nutzung von Hausautomatisierung zu untersuchen. Betrachtetet werden zudem Mediator- und Moderatoreffekte hinsichtlich der nachgelagerten Einstellungsbildung und Übernahmeintention. Die Ergebnisse stützen die Hypothese, dass die subjektive Future Time Perspective (mit Blick auf die im Leben verbleibenden Möglichkeiten) einen größeren Erklärungsbeitrag zur individuellen Adoption von Smart Home-Systemen leisten kann als das chronologische Alter. The currently rather restrained demand for smart home systems raises the question of relevant adoption barriers. Given the technology’s potential benefits for residents’ lives, particularly with advancing age, there is a need to understand how age(ing) affects the acceptance of technology. Especially perceived age constructs have hardly been studied in technology adoption. The thesis investigates the determinants of smart home technology acceptance by potential adopters using popular theories and models of individual adoption behavior and moreover paying particular attention to the influence of chronological and perceived age. The research model is based on the widely used and empirically validated Technology Acceptance Model (Davis, Bagozzi & Warshaw, 1989), but integrates additional external variables to explore how chronological age and the Future Time Perspective (Carstensen & Lang, 1996) affect determining factors of home automatization acceptance. The effect on perceived usefulness and perceived ease of use is considered as well as mediator- and moderator-effects regarding downstream attitude formation and behavioral intention. The results support the hypothesis that the subjective future time perspective (focusing on opportunities remaining in life) has greater explanatory power for the individual adoption of smart home systems than chronological age.

Bringing nano-enabled developments to the market still faces challenges along up-scaling processes and safety evaluation [1] and needs to be addressed in a structured way [2]. In addition, a major aim is to assess the safety profiles of engineered nanomaterials (ENMs) at low, nonlethal dosages and extended repetitive exposures, which could help to understand long-term consequences of ENMs’ interactions with biological environments and further expedite their translation into products and applications. To enable this translation, data plays a prominent role. And here is where NanoCommons[3], the e-infrastructure project, as one of the three EU-H2020 data relevant projects (together with NanoSolveIT and NanoinformaTIX) can help nanosafety researchers from industry, academia and regulatory bodies to access the state-of-the-art data management expertise. Thus, users/collaborators can take advantage of the NanoCommons services, facilities and knowledge to advance their work, solve problems and take their research to the next level. Within this contribution, it is presented, how NanoCommons, by means of its transnational actions (TAs), brings benefits to its users/collaborators: (i) EU funded access to expertise in data management and nanoinformatics tools; (ii) Facilitate open access data to help reduce duplication of tests, regulation, animal-testing, bureaucracy…; (iii) Assistance with capture and databasing of data to comply with EU open data initiatives and achieve FAIR data principles[4]; (iv) model development; and many more.

The Horizon 2020 (H2020) project NanoCommons is establishing a long-term infrastructure to benefit nanotechnology and nanosafety research. This means that the data, tools and services integrated and/or developed during the project’s duration will remain live and usable beyond its lifetime. This has been a substantial issue for European Union (EU) projects to date, the data from which remains, in many cases, disparate and poorly accessible, and as such is essentially lost with no re-use potential. To address these issues, NanoCommons, is actively working towards gaining value from and adding value to EU, National and International nanotechnology and nanosafety projects, by enhancing the openness and FAIRness (Findability, Accessibility, Interoperability and Re-usability) of their data. NanoCommons will provide value through the integration of data, tools and services that will be used to meet the needs of, and add value to, the different stakeholder groups, which were presented in detail in deliverable D1.2 – Dissemination Strategy. At the same time, NanoCommons will add value to the outputs of partners, participating projects and other stakeholders through the enrichment of the data and tools integrated within the NanoCommons KnowledgeBase. Such enrichment may refer, in the case of scientific data, to enabling relevant data harvesting and combination with data from publicly available resources. This can lead to more robust analysis, result refinement, the uncovering of hidden patterns, or in the case of modelling the refinement and calibration of the produced models. For the tools and services offered through NanoCommons, the added value will translate into their further development through the use of varied types of data and the experience gained from use in different nanoscience fields and the feedback received from users.

Non-paper Safe-by-design of materials and chemicals: Towards an innovation programme in Horizon Europe In the global transition to a safe and circular economy, the EU can play a leading role by developing innovative, safer and sustainable materials, chemicals, products and services. EU innovation policy, as a complement to chemicals policy, could stimulate the development and adoption of such innovations. An informal working group of experts from government, academia and industry has developed a non-paper about the main topics for an innovation programme, in Horizon Europe or other European programmes, that could accelerate the design, development and adoption of safer alternatives to new and existing applications (materials, chemicals, products and services) where safety hazards (may) arise. The document proposes three funding areas for a Horizon Europe programme: developing and improving methodologies for safe (re)design of chemicals and materials to ensure that toxicity and other lifecycle considerations (including circularity) are integrated into design processes; thematic Research, Development and Innovation (RD&I) to overcome technical and scientific challenges in areas where it has been difficult to find safer alternatives; creating an enabling environment: Knowledge exchange, education and supply chain cooperation to set up safe-by-design as a new interdisciplinary approach., van der Waals J.F.M., Falk A., Fantke P., Filippousi P., Flipphi R.C.H., Mottet D., Trier X. (2019). Safe-by-design for materials and chemicals: Towards an innovation programme in Horizon Europe.

Unter den zahlreichen hochschuldikaktischen Methoden stellt das Blended Learning (Integriertes Lernen) unter Verwendung des Inverted Classroom Models (ICM) eine effiziente und zeitgemäße Lehr- und Lernmethodik dar. Die Kombination von individuellem Online-Lernen der grundsätzlichen Zusammenhänge (Vorlesungsinhalte) durch Verinnerlichen von kurzen Videos durch die Studierenden und von Präsenzphasen, die unter Lernbegleitung durch den Lehrenden nahezu ausschließlich dem Lösen von Problemstellungen aus dem Ingenieuralltag gewidmet sind, stellen sowohl für den Lehrenden als auch für die Lernenden eine zeitgemäße Herangehensweise dar, um effektiv und nachhaltig vom Wissen zum Können zu gelangen. In diesem Beitrag werden am Beispiel der Vermittlung ingenieurwissenschaftlicher Grundlagen praxisorientierte Hinweise gegeben, wie Blended Learning unter Verwendung eines Tablet-PC, eines digitalen Notizbuches, einer Aufzeichnungs-Software, eines Kopfmikrofons und einer Lernplattform gelingen kann. Dabei wird auf eine Auswahl von Funktionalitäten der ILIAS-Lernplattform eingegangen. Hierzu zählen insbesondere die Möglichkeiten der Gestaltung von Lernmodulen und der Formulierung von Testfragen. Es wird herausgearbeitet, dass eine Lernplattform mehr als nur ein Ablageort für Dateien ist und dass Blended Learning dazu führen kann, dass Lehrende vom Vorlesenden zum Lerncoach werden. (DIPF/Orig.)

In the global transition to a safe and circular economy, the EU can play a leading role by developing innovative, safer and sustainable materials, chemicals, products and services. EU innovation policy, as a complement to chemicals policy, could stimulate the development and adoption of such innovations. An informal working group of experts from government, academia and industry has developed a non-paper about the main topics for an innovation programme, in Horizon Europe or other European programmes, that could accelerate the design, development and adoption of safer alternatives to new and existing applications (materials, chemicals, products and services) where safety hazards (may) arise. The document proposes three funding areas for a Horizon Europe programme: developing and improving methodologies for safe (re)design of chemicals and materials to ensure that toxicity and other lifecycle considerations (including circularity) are integrated into design processes; thematic Research, Development and Innovation (RD&I) to overcome technical and scientific challenges in areas where it has been difficult to find safer alternatives; creating an enabling environment: Knowledge exchange, education and supply chain cooperation to set up safe-by-design as a new interdisciplinary approach.

A variety of climate mitigation strategies is available to mitigate climate impacts of buildings. Several studies evaluating the effectiveness of these strategies have been performed at the building stock level, but do not consider the technological change in building material manufacturing. The objective of this study is to evaluate the climate mitigation effects of increasing the use of biobased materials in the construction of new residential dwellings in Sweden under future scenarios related to technological change. A model to estimate the climate impact from Swedish new dwellings has been proposed combining official statistics and life cycle assessment data of seven different dwelling typologies. Eight future scenarios for increased use of harvested wood products are explored under different pathways for changes in the market share of typologies and in energy generation. The results show that an increased use of harvested wood products results in lower climate impacts in all scenarios evaluated, but reductions decrease if the use of low-impact concrete expands more rapidly or under optimistic energy scenarios. Results are highly sensitive to the choice of climate impact metric. The Swedish construction sector can only reach maximum climate change mitigation scenarios if the low-impact building typologies are implemented together and rapidly. Funding details: EnWoBio 2014-172, Svenska Forskningsrådet Formas

Nano-products and nano-enabled applications need a clear and easy-to-follow human and environmental safety framework for the development along the innovation chain from initial idea to market and beyond that facilitates navigation through the complex regulatory and approval processes under which different product categories fall. The missing framework results in a lack of (i) solid data regarding roadblocks to market penetration of nano-enabled products as well as the absence of (ii) transparency in terms of which products (e.g. containing nanomaterials (NMs); nano-enabled products) are on the market (e.g. registries) and voluntary schemes and labelling requirements for cosmetics and food, which processes are used for manufacturing nano-enabled products, and (iii) meager inclusiveness in the dialogue (between all stakeholders) most likely exist as a result of the missing framework. The Closer-to-the-Market-Roadmap (abbrev. CTTM) aims at speeding up the progress towards market implementation of nanotechnologies by outlining the steps needed to develop such a framework. In its current form it is addressed towards policy makers, but the ultimate framework will be designed for use by SME and enterprise organisations. The CTTM identifies the key challenges to be tackled immediately and outlines a stepby-step approach to establishing a framework to deliver of nano-enabled products to the market: (i) building an inclusive collaboration network, (ii) bringing together the scientific and entrepreneurial experts, (iii) strengthening dialogue of all stakeholders (inclusiveness!) and exchange to raise synergies and safe resources, (iv) implementing of a novel risk assessment framework supported by the regulatory initiatives and implemented by contract research organisations, and (v) building service provider platforms which function as consulting agencies assisting companies to bring their products towards market implementation. Along these actions, the respective skillset development, educational training and formation of job profiles and recognition certificates shall be established. The accompanying tasks will be to continue the dialogue (e.g. risk communication, safety awareness, dissemination dialogue, needs assessment, debate on key topics, consultation on proposed activities/solutions, etc.) with different stakeholder groups (such as e.g. public authorities, broad public, opinion leaders, NGO´s, etc.) with the objective to increase the level of information via visualization and communication, in order to address all the current gaps listed within the CTTM. This will enable a transparent and open communication process. Along with facilitating the market implementation of nano-products and nano-enabled applications, the consumers and end users of these products shall be provided with a clear and validated declaration regarding the use and function of NMs in products. Such information will show, in a balanced and standardized way the risks and benefits of the nano-enabled vs. the previously established products and of course addressing the unique new products and applications enabled by nanotechnology. This will increase understanding (and potentially support building trust) among stakeholders about safety issues, reduce the uncertainties for SMEs and enterprises about how to address the nanoenabled products (and NMs) properly, and minimise the impact of risk and safety assessment processes on hampering the innovation potential. Following the recommendations of the EU REACH system (Article 13) and regarding ethical aspects, the risk assessment procedures should be performed with possible CTTM_NSC_Roadmap_final_for_NSC 7 reduction of living animals’ use. Whenever possible, alternative methods such as in vitro and in silico (computational) testing should be applied for replacing experiments with higher animals. Moreover, the use of computational modelling for supporting Safer-byDesign (SbD) and High Throughput Screening (HTS) might be an interesting option for the innovative industry, since it enables to extend the number of considered solutions without increasing costs. The actions proposed in the CTTM will reduce the uncertainties for all stakeholders, increase the safety of nano-enabled products while reducing their time to market, and increase the market confidence in this technology and the acceptance of the safe nanoenabled products by businesses and consumers.

In recent years, wood as a building material has gained renewed focus and, in parallel, new production methods and further refined timber products have been developed. Many of these novel timber building materials have gained significantly enhanced technical qualities, and the question is whether this is at the expense of wood’s sensuous and poetic qualities. The proposed method to deal with these questions is to develop a discursive model that can clarify aspects essential for analyzing and discussing the materiality of timber in its contemporary engineered forms. Firstly, this paper presents a theoretical review of different approaches to materials in the field of architecture, including a pragmatic as well as an abstract approach. Secondly, based on the theoretical foundation a discursive model is developed. Here, it is suggested that in order to reach a thorough insight into the qualities of a material, one need to consider three aspects; technology, material and materiality. Furthermore, three perspectives; entity, enclosure, and transition, are included in the model, in order to tie the perception of the material to the architectural frame. Together these six aspects constitute a model that enables analysis and evaluation of materials and their role in architecture.

Träbyggandet i Sverige förutsätter nya kunskaper, attityder, affärsmodeller och en fortsatt utveckling av träbyggnadstekniken. Olika utbildningar som handlar om träbyggande måste också samarbeta mer tvärfunktionellt. I en exjobbsskola genomfördes våren 2015 tre examensarbeten, som belyser olika utmaningar för träbyggandet. Medverkande parter: Svenskt Trä, Moelven Byggmodul AB, Linköpings Universitet, KTH och SLU. En träbyggnadsteknisk aspekt, fuktsäkerhetsdimensionering av väggelement, utforskades av Carl Dahlström and Emma Giesen, KTH. Attityder till och kunskaper om träbyggande bland konstruktörer studerades av Anders Gräns, SLU. Anders Roos, Lotta Woxblom, Tomas Nord, Andreas Falk och Johan Larsson Affärsmodeller och outsourcing av de expanderande industriella träbyggandets värdekedjor var temat för exjobbet av Viktor Widmark och Kim Zemrén, LiU. Seminarier och möten organiserades under arbetets gång där exjobbarna redovisade sina framsteg, utbytte erfarenheter och diskuterade frågeställningar inbördes och med branschföreträdare. Projektet visar på styrkan i att skapa plattformar för samarbete och utbyte mellan olika expertområden och marknadsaktörer, och att sådana samarbeten är speciellt värdefulla för unga yrkespersoner, som ska verka i träbyggsektorn.

Todays stock market is dominated by algorithmic trading either as helpful tool for trading decisions or as a fully automatic trader. We test howa fully automated trading algorithm using MACD signals as indicatorsperform on historical stock data. The purpose of this essay is to seehow a simple algorithm performs and get a better understanding ofeconomical forecasting.