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9. Bone Marrow Edema: Overview of Etiology and Treatment Strategies

Author

Tarantino, Umberto, Greggi, Chiara, Cariati, Ida, Caldora, Patrizio, Capanna, Rodolfo, Capone, Antonio, Civinini, Roberto, Colagrande, Stefano, De Biase, Pietro, Falez, Francesco, Iolascon, Giovanni, Maraghelli, Davide, Masi, Laura, Cerinic, Marco Matucci, Sessa, Giuseppe, and Brandi, Maria L.

Published
2021
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12. Bone Marrow Edema: Overview of Etiology and Treatment Strategies

Author

Tarantino, Umberto, Greggi, Chiara, Cariati, Ida, Caldora, Patrizio, Capanna, Rodolfo, Capone, Antonio, Civinini, Roberto, Colagrande, Stefano, De Biase, Pietro, Falez, Francesco, Iolascon, Giovanni, Maraghelli, Davide, Masi, Laura, Cerinic, Marco Matucci, Sessa, Giuseppe, and Brandi, Maria L.

Published
2022
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24. Bone Marrow Edema

Author

Tarantino, Umberto, primary, Greggi, Chiara, additional, Cariati, Ida, additional, Caldora, Patrizio, additional, Capanna, Rodolfo, additional, Capone, Antonio, additional, Civinini, Roberto, additional, Colagrande, Stefano, additional, De Biase, Pietro, additional, Falez, Francesco, additional, Iolascon, Giovanni, additional, Maraghelli, Davide, additional, Masi, Laura, additional, Cerinic, Marco Matucci, additional, Sessa, Giuseppe, additional, and Brandi, Maria L., additional

Published
2021
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32. Modular titanium alloy neck failure in total hip replacement: analysis of a relapse case

Author

Ceretti Marco and Falez Francesco

Subjects
Modular neck, Prosthesis, Fatigue fracture, Total hip arthroplasty, Orthopedic surgery, RD701-811
Abstract

Modular neck hip prosthesis born in the 1990 with the aim of allowing the surgeon to modify CCD angle, offset and femoral anteversion intra-operatively restoring patient’s original biomechanics. In order to achieve the best biomechanics of the reconstructed hip, preoperative planning is essential. In the last few years modularity has been questioned and an argument made for the return to mono block stems due to events of breakage or disconnection of modular components. Fretting or crevice corrosion may lead to failure of such modular device due to the contamination inside the modular coupling or to high loads. We present a case of repetitive modular femoral neck prosthesis fracture.

Published
2016
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33. Ceramic-on-metal coupling in THA: long term clinical and radiographic outcomes using two different short stems.

Author

Logroscino, Giandomenico, Saracco, Michela, Maccauro, Giulio, Urbani, Andrea, Ciavardelli, Domenico, Consalvo, Ada, Ferraro, Daniele, and Falez, Francesco

Subjects
TOTAL hip replacement, CHROMIUM ions, HIP osteoarthritis, ION analysis, ADHESIVE wear, REOPERATION, RESEARCH evaluation, COBALT, ARTIFICIAL joints, BIOMEDICAL materials, PROSTHESIS design & construction, LONGITUDINAL method
Abstract

Background: Hip prosthetic replacement surgery is the gold standard for patients affected by symptomatic osteoarthritis. The ceramic-on-metal hybrid hard-on-hard bearing was initially launched on the market with the purpose of reducing adhesive and corrosion wear, loss of metal debris and ions and risk of fracture and squeaking. However, this bearing was withdrawn from the market, in the apprehension of local and systemic toxicity. The aim of this study is to evaluate the reliability and safety of ceramic-on-metal bearing at long term follow-up.Methods: From 2 cohorts of patients suffering of hip osteoarthritis who underwent total hip arthroplasty using ceramic-on-metal bearing with two different short stems, 19 of the GROUP A and 25 of the GROUP B were suitable for this study. All patients were compared clinically using the Harris Hip Score (HHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS), 12-item Short Form Health Survey (SF12P/M), and radiographically. Blood samples were collected in order to evaluate chromium and cobalt ions level. The two groups were compared in terms of metal ions blood levels, and finally all the implanted prostheses were compared with a healthy control group.Results: All the implanted stems were well-positioned and osseointegrated at a mean follow-up of 114 months. Improvements were observed for all clinical scores comparing preoperative and postoperative values in both groups. Radiographic evaluation showed a good ability to restore proper articular geometry. Chromium and cobalt ion analysis revealed values below the safety threshold except for 1 case in GROUP A (cup malposition) and 2 cases in GROUP B (6.1%). No revision occurred.Conclusions: Ceramic-on-metal bearing is safe and reliable at long term follow-up in association to short stems arthroplasty, if the implant is correctly positioned. Chromium and cobalt metal ions blood levels evaluation should be performed annually. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study

Author

Massari, Leo; https://orcid.org/0000-0001-6198-2122, Benazzo, Francesco, Falez, Francesco, et al, Massari, Leo; https://orcid.org/0000-0001-6198-2122, Benazzo, Francesco, Falez, Francesco, and et al

Abstract

Background Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time. Methods The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain. Results 319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing: = 0.63 ( < 0.0001). Average score value was 7.3 ± 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823. Conclusions This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.

Published
2018

41. Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study

Author

Massari, Leo, primary, Benazzo, Francesco, additional, Falez, Francesco, additional, Cadossi, Ruggero, additional, Perugia, Dario, additional, Pietrogrande, Luca, additional, Aloj, Domenico Costantino, additional, Capone, Antonio, additional, D’Arienzo, Michele, additional, Cadossi, Matteo, additional, Lorusso, Vincenzo, additional, Caruso, Gaetano, additional, Ghiara, Matteo, additional, Ciolli, Luigi, additional, La Cava, Filippo, additional, Guidi, Marco, additional, Castoldi, Filippo, additional, Marongiu, Giuseppe, additional, La Gattuta, Alessandra, additional, Dell’Omo, Dario, additional, Scaglione, Michelangelo, additional, Giannini, Sandro, additional, Fortina, Mattia, additional, Riva, Alberto, additional, De Palma, Pier Luigi, additional, Gigante, Antonio Pompilio, additional, Moretti, Biagio, additional, Solarino, Giuseppe, additional, Lijoi, Francesco, additional, Giordano, Giovanni, additional, Londini, Pier Giorgio, additional, Castellano, Danilo, additional, Sessa, Giuseppe, additional, Costarella, Luciano, additional, Barile, Antonio, additional, Borrelli, Mariano, additional, Rota, Attilio, additional, Fontana, Raffaele, additional, Momoli, Alberto, additional, Micaglio, Andrea, additional, Bassi, Guido, additional, Cornacchia, Rossano Stefano, additional, Castelli, Claudio, additional, Giudici, Michele, additional, Monesi, Mauro, additional, Branca Vergano, Luigi, additional, Maniscalco, Pietro, additional, Bulabula, M’Putu, additional, Zottola, Vincenzo, additional, Caraffa, Auro, additional, Antinolfi, Pierluigi, additional, Catani, Fabio, additional, Severino, Claudio, additional, Castaman, Enrico, additional, Scialabba, Carmelo, additional, Tovaglia, Venceslao, additional, Corsi, Pietro, additional, Friemel, Paolo, additional, Ranellucci, Marco, additional, Caiaffa, Vincenzo, additional, Maraglino, Giovanni, additional, Rossi, Roberto, additional, Pastrone, Antonio, additional, Caldora, Patrizio, additional, Cusumano, Claudio, additional, Squarzina, Pier Bruno, additional, Baschieri, Ugo, additional, Demattè, Ettore, additional, Gherardi, Stefano, additional, De Roberto, Carlo, additional, Belluati, Alberto, additional, Giannini, Antonio, additional, Villani, Ciro, additional, Persiani, Pietro, additional, Demitri, Silvio, additional, Di Maggio, Bruno, additional, Abate, Guglielmo, additional, De Terlizzi, Francesca, additional, and Setti, Stefania, additional

Published
2018
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47. Application of Bone Morphogenetic Proteins on Solid Implants.

Author

Benazzo, Francesco, Falez, Francesco, Dietrich, Martin, Mollenhauer, J. A., Jandt, K. D., and Hortschansky, P.

Abstract

Bone Morphogenetic Proteins (BMP) induce and propagate skeletal wound healing. They enable osteoinductive mechanisms. Applied in combination with osteoconductive solid implant materials, BMP might accelerate and enhance bone regeneration even in individuals with compromised bone metabolism, such as osteoporotic or elderly patients. Presently, soluble BMP released from rapidly degrading carriers such as collagen is favored. Here we present structural and functional aspects of bioactivity from small quantities of implant surface-fixed BMP, potentially resulting in a more controlled topical action. Solid implants such improved may prevent untoward effects from overdosing and may exhibit better storage properties than present preparations of BMP. [ABSTRACT FROM AUTHOR]

Published
2006
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49. Future applications in ceramics.

Author

Benazzo, Francesco, Falez, Francesco, Dietrich, Martin, Merkert, P., and Kuntz, M.

Abstract

Obviously the development of future applications inevitably depends on the well-engineered total system with 3 key factors 1.The high performance ceramic articulating bodies.2.The tailored functional interface to the biological environment.3.Compliance of the surgical technique and instrumentation. High-performance ceramics steadily expand into new fields of arthroplastic surgery. This development is only possible with steadily growing mutual comprehension of ceramic technology and biomechanical engineering. Alumina matrix composite ceramics are distinguished to other materials by a unique combination of physical and chemical properties which provide that basis to the excellent suitability in arthroplasty. It is the challenge of the developing engineers to integrate this material into customized systems The growing experience in this field announces further future applications — e.g. for shoulder, finger or ankle joints — which is already discussed in the surgeon community. [ABSTRACT FROM AUTHOR]

Published
2006
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50. 32mm alumina on alumina hip replacement for femoral neck fracture.

Author

Benazzo, Francesco, Falez, Francesco, Dietrich, Martin, Solarino, G., Piazzolla, A., Tartaglia, N., Scialpi, L., and Solarino, G. B.

Abstract

Hip replacement is considered the best option for treatment of displaced intracapsular fracture of the femoral neck (FFN). The size of the femoral head is an important factor that influences the outcome when a total hip arthroplasty (THA) is performed: implants with a 28mm femoral head are prone to dislocate more than ones with a 32mm. Obviously a large head coupled to a polyethylene inlay can lead to more wear, osteolysis and failure of the implant. Ceramic provides less friction and minimal wear even with larger heads. 31 THAs were performed for displaced intracapsular FFN, using a 32mm alumina-alumina coupling: at an average follow-up of 64 months, 29 have been reviewed clinically and radiologically. None of the implants had been revised for any reason, none of the cups were considered failed, no dislocations and no breakage of the ceramic components have been recorded. One anatomic cementless stem was probably loose radiologically. [ABSTRACT FROM AUTHOR]

Published
2006
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